Hi everybody,

   I've a question for you all.
I live far from the place where I take PegIntron.
So they gave me quite a big amount of Interferon to go on for 6 weeks.

The problem is that my fridge started to not to work properly a few hours
after I had my first shot.
Last monday I noticed that my fridge temperature had gone over the allowed
range for pegIntron.
As you know this is between 5 and 8 Celsius. My fridge had gone up to 12/13
for about 12 or (I don't know for sure) 24 hours.
I became paranoid.
I mean, I had 5 boxes of pegIntron there and the idea that it had become
useless or harmful made me feel really sick.
First of all I called my doc who told me that she would have called Shering
Europe to have more details about the fact.
I did it on my own.
I could talk with a doc at Shering here in Italy who was very kind and told
me that pegIntron can stay out of the above range during its production
chain.
More into details, he told me that pegIntron can be manipulated, during its
production, in environments which have a temperature of up to 25 Celsius,
for a maximum of 72 hours.
He told me that this actually never happens, too.
He also told me that meds like pegIntron can become ineffective if they
aren't stored at the right temperature but it's quite difficult that they
become dangerous too, as they should be changhing their molecular structure.
This can be caused by a *very high* temperature, not like 12 or 13 Celsius.

Reported all this to my doc, who told me to go on with shots.

So I had my second shot saturday night. I took Paracetamol as soon as I had
the shot and went to bed.
I slept all night long. The day after, sunday, I had a constant temperature
of 37,5 Celsius but no other side effect. I just felt all right.
It seemed to me that sides were too mild. I mean, I was happy and I did hope
that my reaction to the med was mild.
But I started to think also that second shot had no effect on me or it had a
light effect.
I called my doc back again.
She said: ".. it's possible that you had a severe reaction to the first shot
(I had high temperature the first night and lower the day after, I felt ok
on monday) and a milder to the second... but, in any case, we'll be asking
for PegIntron boxes to be replaced..."

So, here are the questions:
1)    I do suspect that PegIntron became partially ineffective because of
the temperature. What do you think about?
2)    Is there anybody who had mild sides on second shot being sick on the
first one?
3)    I felt very strange during all the week after the first shot: dry
skin, swet et cetera. I'm feeling just all right today. Do you think it's
normal?
4)    Assuming the first point is true, does anybody knows whether a
"lighter" shot (the 2nd) can compromise the treatment.

Thanks for reading.
Any help would be appreciated.

jeeb.