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Medical Forum / Diseases and Disorders / Glaucoma / February 2006

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Glucosamine lowers pressure significantly

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rob44k@yahoo.co.uk - 12 Feb 2006 14:13 GMT
I started using glucosamine for joint pain that I thought was caused by
my Lumigan eyedrops. After using glucosamine for 6 months my pain
disappeared and my eye pressure dropped from 27 to 18.
In this newsgroup I found a posting of May 5,1999 by Dr. Robert Ritch:
McCarty MF: Primary open-angle glaucoma may be a hyaluronic acid
deficiency disease: potential for glucosamine in prevention and
therapy. Medical Hypotheses 1998;51:483-484.

On the internet I found this:
http://www.pharmcast.com/Patents100/Yr2005/Nov2005/112905/6969514_Glaucoma112905.htm

Anyone else had this experience? Any news about its application as a
medicine for glaucoma?
Anthony - 12 Feb 2006 19:38 GMT
Can you buy this in a supplement? What exactly does glucosamine do for you?

>I started using glucosamine for joint pain that I thought was caused by
> my Lumigan eyedrops. After using glucosamine for 6 months my pain
[quoted text clipped - 9 lines]
> Anyone else had this experience? Any news about its application as a
> medicine for glaucoma?
iop - 12 Feb 2006 23:24 GMT
I buy it in a supermarket. On the internet you can find many sites
about glucosamine.

> Can you buy this in a supplement? What exactly does glucosamine do for you?
>
[quoted text clipped - 11 lines]
> > Anyone else had this experience? Any news about its application as a
> > medicine for glaucoma?
Frank Gannon - 14 Feb 2006 18:41 GMT
In the USA itt has been sold in malls and supermarkets for years under
the brand name "Osteo Biflex" and others. No prescription required.

>Can you buy this in a supplement? What exactly does glucosamine do for you?
>
[quoted text clipped - 11 lines]
>> Anyone else had this experience? Any news about its application as a
>> medicine for glaucoma?

++++++++++++++++++++++++++++++++++++++++++

REMEMBER TO VOTE... "NONE OF THE ABOVE"
iop - 15 Feb 2006 05:40 GMT
On the site of the consumer organization ConsumerLab is more info. Best
is to take Glucosamine only, so no chondroitin/MSM:
http://www.consumerlab.com/results/gluco.asp
gudrun17 - 13 Feb 2006 16:04 GMT
> I started using glucosamine for joint pain that I thought was caused by
> my Lumigan eyedrops. After using glucosamine for 6 months my pain
[quoted text clipped - 9 lines]
> Anyone else had this experience? Any news about its application as a
> medicine for glaucoma?

Interesting. For the past few months I've been taking glucosamine along
with chondroitin sulfate for my bad knee, which it has helped, but I've
also had about a three point drop in IOP.  It didn't occur to me there
might be a connection.
-Gudrun
iop - 13 Feb 2006 16:28 GMT
> > I started using glucosamine for joint pain that I thought was caused by
> > my Lumigan eyedrops. After using glucosamine for 6 months my pain
[quoted text clipped - 15 lines]
> might be a connection.
> -Gudrun

Yes, it is really amazing!
>From what I understand you'd best take glucosamine without or not much
chondroitin in it.
When you get older some people get a hyaluronic acid deficiency
(=glucosamine) > glaucoma as a result.
The patent page of Pharmcast mentions
http://www.pharmcast.com/Patents100/Yr2005/Nov2005/112905/6969514_Glaucoma112905.htm:

"According to the present invention, a method for reducing elevated
intraocular pressure in an eye comprises administering to the eye
modified hyaluronidase in an amount effective to reduce the intraocular
pressure to a normal level.
...
By treating an eye of a glaucoma patient with modified hyaluronidase,
the intraocular pressure may be reduced. Such a method may be effective
at relieving the intraocular pressure because the trabecular meshwork
of the eye contains hyaluronic acid. As described above, the
hyaluronidase serves to break down the hyaluronic acid by cleaving the
glycosidic bonds, thereby relieving the pressure by breaking down some
of the hyaluronic acid in the trabecular meshwork, which is the main
drainage area for the aqueous humor fluid in the eye. This partial
breakdown will enhance the outflow of aqueous humor and thus lower the
intraocular pressure. If a series of administrations of such modified
hyaluronidase drops is administered to an eye, the intraocular
pressures may be lowered for a prolonged period of time.
...
Traditionally, if a patient's intraocular pressure were significantly
elevated, it would have been necessary to administer large doses of
carbonic anhydrase inhibitors or topical eyedrops, such as
beta-blockers or Alpha II agonists, in order to decrease aqueous
formation and/or increase aqueous outflow. These agents all have
significant side effects and, in some instances, are contraindicated in
patients with various types of medical conditions, such as breathing
problems, heart disease or high blood pressure. However, the use of
modified hyaluronidase in these situations will eliminate the necessity
of giving such patients large doses of these drugs.

Consequently, the topical use of modified hyaluronidase in the form of
drops, gels, ointments or sprays, for example, has many advantages over
traditional medications used to treat glaucoma, and is thus attractive
as a new form of treatment that does not have known side effects. Such
a modified hyaluronidase treatment thus fulfills a long-felt need in
the art for a glaucoma treatment which is effective, does not cause
significant undesirable side effects, and which is appropriate even in
patients with existing medical conditions. "

Any expert on glucosamine out there?
iop - 13 Feb 2006 17:44 GMT
Invention is by David B. Soll:

http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=/
netahtml/srchnum.htm&r=1&f=G&l=50&s1=6,969,514.WKU.&OS=PN/6,969,514&RS=PN/6,969,
514

 
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