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Medical Forum / Diseases and Disorders / Glaucoma / August 2005Alphagan problem
I get my Alphagan in a small greenish opaque bottle. I take one drop in my left eye each night. I usually get a 90 day supply from my mail order pharmacy. I never had a big problem with refills as the bottle usually lasts me until I reorder. This time, however, I am woefully short. Today is 7-27-05 and the pharmacy will not take my order until 8-7-05 (about 83 days). I can't see what's inside the bottle, but from shaking it, I can tell I haven't many days left, and it will not last until 8-7-05. I've always had an extra drop or two ooze out of the bottle on occasion when I put it in at night, but the leakage never caused such a shortfall. Has the bottle changed without my noticing it? Did the pharmacy short me--how could I ever tell that? Does anyone else have this problem with Alphagan? (I take Xalatan and Cosopt, and neither ooze extra drops--both bottles of the latter give a precise single drop. Only Alphagan oozes when you just tip it -- no squeezing necessary. > I get my Alphagan in a small greenish opaque bottle. I take one drop in > my left eye each night. [quoted text clipped - 3 lines] > I never had a big problem with refills as the bottle usually lasts me > until I reorder. I have the exact same regimen and I never get more than 50 days out of a bottle. There was a study done recently (I don't recall the citation but it should be searchable in Google) which showed an embarassingly large deviation from bottle to bottle. >> I get my Alphagan in a small greenish opaque bottle. I take one drop in >> my left eye each night. [quoted text clipped - 8 lines] >should be searchable in Google) which showed an embarassingly large >deviation from bottle to bottle. I use 10 ml green bottles of Alphagan P. I have a laboratory type (+- 0.01 g) pan balance ($300). New 10 ml bottles always contain very close to 10.00 ml. They usually last me about 50 days for 2 eyes 2x/day. I often have erratic drop problems. Seems to depend on temperature and fullness, or maybe it's Bush's fault. :-) With any critical medicine it's a good idea to keep a little extra tn the fridge. Manufacturing interruptions do occur. And if there is a flu pandemic!!?? John > I use 10 ml green bottles of Alphagan P. I have a laboratory > type (+- 0.01 g) pan balance ($300). New 10 ml bottles always > contain very close to 10.00 ml. They usually last me about 50 > days for 2 eyes 2x/day. I often have erratic drop problems. You get about twice the mileage as I do. Your drop size of .05 ml/drop seems rather small. The bottle HAS to contain 10.0 ml, or the manufacturer runs big time afoul of the FDA. I also doubt that composition of the contents varies much from lot to lot. Assuming surface tension and viscosity (composition dependent) are constant, the size and shape of the orfice and the resistance of the body of the bottle to deformation probably account for most of the lot-to-lot variation. Wide swings in temperature will also affect the outcome, although small temperature deviations should be a minor contributor to variance. I doubt that the bottles undergo the same level of statistical process control (except for cleanliness) as the pharmaceuticals they contain. >> I use 10 ml green bottles of Alphagan P. I have a laboratory >> type (+- 0.01 g) pan balance ($300). New 10 ml bottles always [quoted text clipped - 17 lines] >I doubt that the bottles undergo the same level of statistical process >control (except for cleanliness) as the pharmaceuticals they contain. Bottles that blow air bubbles are very close to empty. Store them cap down at that point. There are several more treatments that drain down inside the bottle between applications. Some of my drops cost about a dollar a drop and I want to recover all of them. >> I get my Alphagan in a small greenish opaque bottle. I take one drop in >> my left eye each night. [quoted text clipped - 8 lines] >should be searchable in Google) which showed an embarassingly large >deviation from bottle to bottle. Which would explain why I tend to get 3-5 weeks out of my bottles. Shaking the bottle that I opened on Jul 15, it seems I'll be needing a new one in a few days. Consumption rates of my other drops tend to be more regular & predictable. - --- Norman Please reply via group. E-mail ID does not exist. |
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