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Medical Forum / Diseases and Disorders / Glaucoma / April 2005

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New glaucoma drugs?

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halterb@aol.com - 19 Mar 2005 21:41 GMT
I wonder what the newest glaucoma medications might be. I am familiar
with Alphagan, AlphaganP, Travatan, Lumigan, Cosopt and the older
Timoptic, Pilocarpine, but wonder if there are any more recent ones
that have been helpful with POAG.

Thanks
Hubert Mak - 20 Mar 2005 06:40 GMT
I guess you already try one or more of these eyedrops(drugs). Why you
need more?  It will benefit to all readers in this group if you
can post your experience with these eyedrops(drugs).

Thanks in advance.
--------------------------------------------------------

> I wonder what the newest glaucoma medications might be. I am familiar
> with Alphagan, AlphaganP, Travatan, Lumigan, Cosopt and the older
> Timoptic, Pilocarpine, but wonder if there are any more recent ones
> that have been helpful with POAG.
>
> Thanks
halterb@aol.com - 20 Mar 2005 20:46 GMT
> I guess you already try one or more of these eyedrops(drugs). Why you
> need more?  It will benefit to all readers in this group if you
> can post your experience with these eyedrops(drugs).
>
> Thanks in advance.
> --------------------------------------------------------

Good suggestion. In random order, Pilocarpine does a decent job on
pressure but constricts the pupil to the point where not much light
comes through, making vision quite dim in the eye in which it's
used--also, there are cautions about possibly causing cataracts.
Timoptic (and Cosopt since the same drug is in it) also does a good job
on pressure, but tends to reduce respiratory capacity in a person with
an asthma history, and seems to affect urination. Cosopt also seems
good with pressure, but is irritating to me and has the Timoptic
effects, plus I'm concerned about the other ingredients affect of red
blood cells since I have a family history of anemia. Xalatan, again, is
good with pressure but I'm starting to get some discoloration of my
eyelids, and notable iris darkening. Alphagan and AlphaganP are good on
pressure, but are very difficult for me to use as my eyes get quite
red, burning and itching. Both Travatan and Lumigan made my eyes feel
unbearably uncomfortable and had to be discontinued rather quickly.
Currently I'm using Xalatan at night, and Cosopt night and morning.

Hope this information is helpful to you, and others.
Tom - 21 Mar 2005 06:14 GMT
> > I guess you already try one or more of these eyedrops(drugs). Why you
> > need more?  It will benefit to all readers in this group if you
[quoted text clipped - 21 lines]
>
> Hope this information is helpful to you, and others.

I havent heard of the urination problem with timoptic.  What is that?  Also,
I am not sure if timoptic has
effect on red blood cells although it certainly has
an effect on the heart.
halterb@aol.com - 22 Mar 2005 00:26 GMT
> I havent heard of the urination problem with timoptic.  What is that?
Also,
> I am not sure if timoptic has
> effect on red blood cells although it certainly has
> an effect on the heart.

"Urination difficulties" is listed on the package insert with timolol
maleate. Carbonic anhydrase inhibitors (a Cosopt ingredient) are
reported to accululate in red blood cells and possibly affect blood
cells in a manner similar to sulfonamids.
Al C. - 04 Apr 2005 13:29 GMT
. Xalatan, again, is
> good with pressure but I'm starting to get some discoloration of my
> eyelids, and notable iris darkening.

I sometimes feel like I'm pouring lemon juice in my eyes with Xalatan and
other times no stinging at all? Anyone know why this is?

Al C.
Sherry - 04 Apr 2005 19:23 GMT
> . Xalatan, again, is
>> good with pressure but I'm starting to get some discoloration of my
[quoted text clipped - 4 lines]
>
> Al C.

Al,

Never had any pain problems with Xalatan (Trusopt was another story!)  
Not sure why the stinging would be inconsistent like that though.

You could try putting a lubricant drop in about 10-15 min before using
the Xalatan (no sooner - you don't want to dilute the Xalatan!)

Sherry
 
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