I have had what is probably very unusual experience.  I am allergic to
all the drugs, esp Xalatan and Lumigan.  With Lumigan, I was suicidal
and had all the side effects of atopine, or belladonna, i.e., rapid,
rapid heart beat, extremely sensitive to light, including suicidal
ideation.  The light sensitivity was the thing that finally got me to
see it was the drugs.  Luckily, the doctor believed me and over the
course of the last two years have had two laser surgeries to maintain
healthy pressures.  Just after the last one, done only on my right eye
with the new technology, I was VERY light sensitive, unable to have a
lightbulb on in the room for two days.  It resolved, but had some
experience with dry eyes.

I took a job subsequently with a poor monitor and lighting.  I took
over the counter Refresh tears, got a glare screen, wore a visor but
it continued.  I then got the gel, after which I had all the effects
mentioned above, including mania, UNQUENCHABLE thirst, inability to
sleep, loss of short term memory, irritable, sense of urgency that
didn't exist, horrific constipation.  In such a manic phase, I lost my
job (contract).  And it was the job of my dreams. ;o(

I have always had a difficult time with visits to the glaucoma
specialist, as the drops make me sick, depressed, enough to put me to
bed for a day (hard to do, usually).  I mentioned to my regular doctor
that having my eyes dilated was punishing, giving me the suicidal
ideation, but knowing it would pass as the stuff got out of my system.
He's the one who came up with the atopine/belladonna dynamic, which I
have researched on the web.  I am not naive enough to believe
everything I read on the web, but much has been enlightening.
My glaucoma doctor referred me to an occular neurologist.

I have an appt with an occular neurologist this week.  My guess is
that there is something wrong with the blood/brain barrier probably
resulting from encephalitus when I was 18.

Has anyone out there had anything similar?