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Medical Forum / Diseases and Disorders / Epilepsy / March 2005

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Taurine / metal-stimulated oxidation

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ironjustice@aol.com - 27 Feb 2005 20:01 GMT
Neurotox Res. 2000 Jan;2(1):1-15. Related Articles, Links

Taurine inhibition of metal-stimulated catecholamine oxidation.

Dawson R Jr, Baker D, Eppler B, Tang E, Shih D, Hern H, Hu M.

Department of Pharmacodynamics, College of Pharmacy, JHMHC Box 100487,
University of Florida, Gainesville, FL 32610, USA.

Taurine is an abundant amino acid found in mammalian tissues and it has
been suggested to have cytoprotective functions. The aim of the present
study was to determine if taurine had the potential to reduce oxidative
stress associated with metal-stimulated catecholamine oxidation.
Taurine and structural analogs of taurine were tested for their ability
to inhibit metal-stimulated quinone formation from dopamine or L-dopa.
Oxidative damage to proteins and lipids were also assessed in vitro and
the effects of taurine were determined. Taurine (20 mM) was found to
decrease significantly ferric iron (50-500 microM)- and manganese (10
microM)-stimulated L-dopa or dopamine oxidation. Taurine had no effect
on zinc-induced dopamine oxidation and slightly potentiated copper- and
NaIO(4)-stimulated quinone formation. Ferric iron-stimulated lipid
peroxidation was not affected by taurine (1-20 mM). Protein carbonyl
formation induced by ferric iron (500 microM) and L-dopa (500 microM)
was significantly reduced by 10 mM taurine. The cytotoxicity of L-dopa
(250 microM) and ferric chloride (75 microM) to LLC-PK(1) cells was
attenuated by 10 mM taurine or hypotaurine. Homotaurine alone
stimulated L-dopa oxidation and potentiated the cytotoxic effects of
ferric iron. Homotaurine was found to be cytotoxic when combined with
L-dopa or L-dopa/iron. In contrast, hypotaurine inhibited quinone
formation and protected LLC-PK(1) cells. These studies suggest that
taurine may exhibit cytoprotective effects against the oxidation
products of catecholamines by acting as a scavenger for free radicals
and cytotoxic quinones.

PMID: 15545001 [PubMed - in process]

--------------------------------------------------------------------------------

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Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
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http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
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ironjustice@aol.com - 28 Feb 2005 15:41 GMT
Amino Acids. 2002 Jun;22(4):351-68. Related Articles, Links

Effects of sulfur containing amino acids on iron and nitric oxide
stimulated catecholamine oxidation.

Biasetti M, Dawson R Jr.

Department of Pharmacodynamics, College of Pharmacy, JHMHC Box 100487,
University of Florida, Gainesville, FL 32610, U.S.A.

Taurine is a free amino acid found in high concentrations in tissues
containing catecholamines. The ability of taurine and its metabolic
precursors to inhibit or stimulate catecholamine oxidation and
subsequent quinone formation was examined. Ferric chloride was used as
the catalyzing agent to stimulate L-dopa or norepinephrine oxidation
and NO donors were also examined for their actions to stimulate quinone
formation. Taurine attenuated iron-stimulated quinone formation from
catecholamines suggesting that it may function as an endogenous
antioxidant. Several other sulfur-containing amino acids (homocysteic
acid, cysteine sulfinic acid and SAM) were found to inhibit
catecholamine oxidation. Among other amino acids tested, homocysteine
had biphasic effects; attenuating L-dopa oxidation catalyzed by ferric
chloride and potentiating norepinephrine's oxidation catalyzed by both
ferric chloride and sodium nitroprusside (SNP). Homotaurine and
homocysteine (1 or 10 mM) greatly stimulated SNP-induced norepinephrine
oxidation. Homotaurine potentiated quinone formation in the presence of
ferric iron and this effect was attenuated by desferroxamine. In order
to exclude a possible NO/iron interaction in SNP's oxidizing action,
SIN-1 chloride, a specific NO-donor, was tested as an oxidizing agent.
The failure of desferroxamine or taurine to attenuate SIN-1 oxidation
of norepinephrine suggests that peroxynitrite-mediated oxidation was
likely the dominant mechanism. Our results show that endogenous sulfur
containing amino acids, like taurine, could serve a protective role to
reduce cellular damage associated with both NO and metal-stimulated
catecholamine oxidation.

PMID: 12107762 [PubMed - in process]

--------------------------------------------------------------------------------

Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
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PIPER - 01 Mar 2005 04:17 GMT
Some of this I can understand but not all, could you put in layman (sp?)
terms please?

thanks

piper hall
Michael - 01 Mar 2005 06:25 GMT
PIPER said:

> Some of this I can understand but not all, could you put in layman
> (sp?) terms please?

Your0 request isn't an easy one to fulfill.

Problem:
In order to explain it it in layman's terms, Tom would have first to
understand it.

He doesn't, of course... hence the difficulty.

May I suggest at this point that you'd be more swiftly satisfied by asking
about the requisite number of angels for pinhead-dancing?
PIPER - 01 Mar 2005 10:23 GMT
Ah I see, so he isnt legit. Got it, thanks.This kind of caught my eye since
i have heard about taurine for blood sugar control.

piper

>  PIPER said:
>
[quoted text clipped - 11 lines]
> May I suggest at this point that you'd be more swiftly satisfied by asking
> about the requisite number of angels for pinhead-dancing?
Mike-UK - 03 Mar 2005 01:13 GMT
http://tinyurl.com/6vwgs

may be of some use to you.

Enjoy. :)

> Ah I see, so he isnt legit. Got it, thanks.This kind of caught my eye since
> i have heard about taurine for blood sugar control.
[quoted text clipped - 16 lines]
> > May I suggest at this point that you'd be more swiftly satisfied by asking
> > about the requisite number of angels for pinhead-dancing?

Signature

---------------------------
http://tinyurl.com/4872c

Have a nice day, it really does do you good! :)

Michael Baugh - 01 Mar 2005 11:02 GMT
What a wonderfully apt analogy.

> May I suggest at this point that you'd be more swiftly satisfied by asking
> about the requisite number of angels for pinhead-dancing?
Johan - 01 Mar 2005 13:35 GMT
> What a wonderfully apt analogy.

Michael's very good at that.:)

> > May I suggest at this point that you'd be more swiftly satisfied by asking
> > about the requisite number of angels for pinhead-dancing?

The answer to that question depends on whether they're doing a Pavane,
Minuet, Waltz, Tango, Fox Trot, Morris Dancing, Square Dancing, or plain
Two-Step.

Texas Line-Dancing even angels wonder about. (It's a favorite debate
question at the Bi-Millenial All-Universe Solipsism Tournament. i.e
Resolved: No more than "X" angels can line-dance upon the head of a pin.)

Interpretive Dance often requires only one.
Deirdre - 02 Mar 2005 00:47 GMT
<Line-Dancing even angels wonder about. (It's a favorite debate
question at the Bi-Millenial All-Universe Solipsism Tournament. i.e
Resolved: No more than "X" angels can line-dance upon the head of a
pin.)
Interpretive Dance often requires only one.>

Okay. Interpretive dance, hum. Let me me. How about someone actually
went through the drill (*again*) to make sure everything still works
on the cellular (pin-point) level - as previously determined many,
many times? just in case people don't believe that life happens at all
- and especially just in case people think substances are "dangerous"
and want to ban 'em all?

Actually it's quite interesting to see everything still works and that
someone can actually get away with a re-affirmation and - somehow -
scrape together the $$ to do it, submit the thing for PR and someone
will actually publish it?

I thnk it's kinda sweet. Something like "Songs from Pippa Passes".
"God's in his / her heaven, all's right / wrong with the world." IOW
it's okay.

I'm really impressed that someone actually used the word "solipsism".
Crashing reminder of the unused vocabultary - what's the incidence of
this word in common use? I hope it's still in the Oxford.

You have to ujnderstand the Thomas. He is - or used to be - a
vegetarian. If I've had any influence at all he is at least wavering
and considering his patriotic duty to consume Alberta beef in large
quantities. Of if he can get it, British Columbia beef is even better.
Anyway I owe the Thomas (aka the Clanking  One - a vote of thanks
since I finally got my serum ferritin done just to rule out
hemochromatosis which was the one remote possibility that iron would
cause any problems whateoever. Anyway as it transpired last fall, so
far was I from a case of hemochromatosis that I have an IRON
DEFICIENCY ANEMIA - and that's a no brainer considering I have Crohn's
disease so what else would have been new? so now I take my iron
tablets and am begining - SLOWLY - to feel MUCH better and - ta DA -
my BRAIN is much less FOGGY.

I'm now willing to attribute Fibrofog to IDA and say "get your serum
ferritin checked" because ta the same brood draw I had a NORMAL CBC
(of course "normal" is just ridiculous) but hemoglobin
"fine" (according to doctor) and no microcytic anemia - so how would
he ever have known I had an IDA if I had not asked for a serum
ferritin, and I never would have asked for it if I hadn't been reading
the Clanking One's posts for the past six years on and off - but of
course he's been posting about the supposed evils of iron
supplementation and the eating of red meat - so thereyago. It's an
important point and he raised it. It only took me SIX years to get the
test done and to act on the results and start treating this HORRIBLE
deficiency disease. Which has NOTHING to do with diet.

So not to worry about the Clanking One - we just have to keep telling
each other "don't forget to get your serum ferritin and your serum
vitamin D done" and gradually, gee, maybe after a few years we
wouldn't have much of a newsgroup left. Except no, I don't think so. I
think we're always going to have some people here trying to find out
how they can get their body/brains back - I'm just beginning to get
mine back and one of my first thoughts - after giving all the
appropriate thanks - including thanks to the Clanking One for keeping
this debate alive and up here (no matter how inadvertant that might
have been) - I am planning my Next Move which is to go back and finish
what I started a Long Time Ago. ;-)))

Cheers from Mrs Magoo who gives credit where credit is due (~Q'Q~)

> > What a wonderfully apt analogy.
>
[quoted text clipped - 12 lines]
>
> Interpretive Dance often requires only one.
Chip Orange - 02 Mar 2005 03:43 GMT
And neither do you, but that doesn't stop you from spewing forth every time
he posts an abstract of a paper.  It really is more annoying than his
abstracts.

> PIPER said:
>
[quoted text clipped - 11 lines]
> May I suggest at this point that you'd be more swiftly satisfied by asking
> about the requisite number of angels for pinhead-dancing?
Michael - 02 Mar 2005 03:59 GMT
Chip Orange said:

> And neither do you,

Ah, but I do.   Not everything, or fully - I'm not trained at all in the
field - but I do have the help of a molecular biologist for clarifying
things when I'm stuck.

> but that doesn't stop you from spewing forth
> every time he posts an abstract of a paper.  It really is more
> annoying than his abstracts.

I'm sorry you feel that way.

((U))
 M

>> PIPER said:
>>
[quoted text clipped - 11 lines]
>> May I suggest at this point that you'd be more swiftly satisfied by
>> asking about the requisite number of angels for pinhead-dancing?
Dave ???? - 02 Mar 2005 16:36 GMT
Howdy!

The orthadox answer to "How many angels can dance on the head of a pin?" is:

AS MANY AS WANT TO!

Signature

Dave ????

http://www.howdydave.com

>
>  PIPER said:
[quoted text clipped - 12 lines]
> May I suggest at this point that you'd be more swiftly satisfied by asking
> about the requisite number of angels for pinhead-dancing?
rose - 02 Mar 2005 16:41 GMT
Dave ©¿©¬ wrote:
> Howdy!

back atcha, dave!  ;->

> The orthadox answer to "How many angels can dance on the head of a pin?" is:
>
> AS MANY AS WANT TO!

hmmm...i'd heard that the 'proper' answer is ZERO -- because angels are
non-corporeal beings, they would not dance 'on' anything, be it pin or
dance floor!  ;->

rose
Deirdre - 03 Mar 2005 08:43 GMT
> Dave =A9=BF=A9=AC wrote:
> > Howdy!
[quoted text clipped - 9 lines]
> non-corporeal beings, they would not dance 'on' anything, be it pin or
> dance floor!  ;->

> rose

Howdy. What a pleasure meeting y'all here. I'd like to take up the
matter of the nature of angels.

I believe Dante established their corporeal nature in "The Inferno",
when he and his friend ascended from the horrors of the Flaming Pit.

I heard Dante's translator (or I guess one of them, this one is
current) describing how the corporeal - non corporeal thing was not
really documented with any definition before Dante wrote his "Inferno"
- it seems the most impressive aspect of his creative genius lay in
his actually described in terms generally used of a real corporeal
existence every imaginable detail of the Infernal Regions.

And most tellingly, he described his ascent from the Inferno which he
and his friend accmplished by clambering with considerable difficulty
on and over and up the clearly corporeal body of Satan. It was my
understanding from that discussion that Dente had more or less cast
the various technical details in A Form. Till his day anyone could
have any idea of the details of Paradise and Hell and the terrestrial
world. I suppose Dante would have been working along lines similar to
that of a natural historian. It seems Dante thought the terrestrial
world the most beautiful of all the spheres of existence.

It's interesting that someone let this matter slither away here to
examine the matter of interpretive dance which was done by one. ;-)

Mrs Magoo (~Q'Q~)
Dave ???? - 05 Mar 2005 17:31 GMT
> > Dave =A9=BF=A9=AC wrote:
> > > Howdy!
[quoted text clipped - 39 lines]
>
> Mrs Magoo (~Q'Q~)

Howdy Mrs. M!

Sorry to say... Dante didn't establish anything! He only made some
speculations.

As with any other speculation that can neither be confirmed nor denied by
physical evidence, in the end their existance is all a matter of personal
faith.

His interpretation of the spheres of existance is a matter of cultural
upbringing. You would get a quite different point of view  if Dante had
lived in India, China, South America or aboriginal Australia.

Signature

Dave ????

http://www.howdydave.com

ironjustice@aol.com - 05 Mar 2005 19:26 GMT
>>Some of this I can understand but not all, could you put in layman<<

Taurine is .. good ..

Taurine does not allow the bad things which happen because of .. rust
..

Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
 
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