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Medical Forum / Diseases and Disorders / Epilepsy / March 2005

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Indian chemists torture epilepsy patients

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deprofundis@rediffmail.com - 03 Feb 2005 22:16 GMT
Indian chemists torture epilepsy patients

Drug shortages hit epilepsy, anxiety post-operative care

P.T. Jyothi Datta

Mumbai , Feb. 2

PATIENTS consuming the anti-epileptic drug Gardenal for several years
are now being faced with a shortage of the medicine in the market.

"Anti-epilepsy drugs have to be consumed everyday to prevent epileptic
fits from coming on," says an official with the drug company Nicholas
Piramal - who is already receiving letters from patients and doctors
asking for supply of the medicine, following the shortage in the
market.

Gardenal, Valium, Garoin (also for epilepsy), Rivotril (an anxiety
drug) etc. are just few of the estimated Rs 1,000 crore basket of
psychotropic and central nervous system (CNS) drugs that are hit by
the fear-psychosis sp reading among chemists and medicine retailers
across the country.

In a self-imposed freeze effective from Tuesday, wholesalers and
retailers have stopped purchasing this segment of drugs from companies
- for fear of raids from the Narcotics Control Bureau (NCB).

And the shortage of drugs will get more acute across the country, as
the existing socks of the medicine dry-up, says Mr J.S. Shinde,
General Secretary of the All India Organisation of Chemists and
Druggists (AIOCD).

According to him, chemists and medicine retailers are witnessing
increased raids by the NCB to prevent the abuse of medicines that come
under the Narcotic Drugs and Psychotropic Substances Act (NDPS), 1985.
Chemists are expected to maintain records on the purchase of these
drugs from the companies and it's subsequent sale to patients for a
period of two-years. And the absence of this can throw them behind
bars without bail, says Mr Shinde.

Repeated efforts by the AIOCD to meet the Union Health Minister have
not fructified, he said and the organisation is now set to intensify
its stir. The AIOCD wants this segment of drugs to be brought only
under the Drugs and Cosmetics Act, away from the NDPS Act.

The abuse of these drugs as intoxicants can be fixed through other,
less harassing methods, the AIOCD official feels.

Caught in this stalemate are companies such as Torrent, Cipla,
Ranbaxy, Sun Pharma, Nicholas Piramal, Wockhardt, Intas, Zydus, Ajanta
Pharma, Novartis... .the list goes on.

Ranbaxy for instance markets Pentazocine, a drug used as a
post-operative in surgeries such as cancer. It also markets Diazepam,
or anti-depressant better known as Calmpose.

While sales from these drugs are small, a Ranbaxy spokesperson said
"sales have come to a virtual halt for these products," as a result of
the AIOCD call.

Wockhardt too admitted to "some confusion" in the market, with
retailers being reluctant to stock it's product dextropropoxyphene or
the Proxyvon range of medicines.

And as the stalemate remains to be sorted out by the Government,
consumers are already taking the brunt of the dead-lock.

http://www.thehindubusinessline.com/2005/02/03/stories/2005020302521000.htm
Sofia - 10 Mar 2005 03:17 GMT
On Thu, 03 Feb 2005 14:16:02 -0800, deprofundis wrote:

> Indian chemists torture epilepsy patients
>
> Drug shortages hit epilepsy, anxiety post-operative care

You mention how the Indian chemists were putting drug restrictions on some
of the medicines that epilepsy patients were taking, but I just wanted to
tell you about how I have recently had a similar experience with a Belgium
manufacturer.

Many other people in this newsgroup, as well as myself, have probably also
experienced the same little battle. What I'm actually talking about are
the 250mg tabs of keppra. Twice daily, other than taking 400mg tegretol, I
also take 1250mg keppra. When I attempted to collect my medicine from my
local pharmacist though, I was told that although the manufacturer still
did my 1000mg tabs, there were a lot of problems in trying to get the
250mg ones.

She told me that she wasn't sure whether they were either stopping them
completely, or they'd just put a small delay on making them for a while.
The pharmacist was very nice about it though, and she ordered me a pack of
500mg tabs instead, in order that I could bite them in half as a
substitution.

It tastes absolutely disgusting, but its better than nothing, and with any
luck, I'm keeping my fingers crossed that it is just a delay, or else I
might just have this awful taste with me for a lot longer than I
particularly want.    

Sofie
G.Ross - 10 Mar 2005 05:27 GMT
I deleted soc.culture.indian as I don't subscribe to that newsgroup (from
your post below, probably from an older message that's expired already here
on my reader?).  I didn't reply to the original poster you quoted since I
don't use those pills, and the poster didn't sound like someone who had
Epilepsy.

Regarding your comment below about difficulty getting half doses of pills
you need
--> Check the 500mg tablets of Keppra when they arrive (***s below).
  If any of the tablets you refer to are solid ones, most have a horizontal
slot across the centre so they can be snapped in two.
  I don't know if Keppra is a solid tablet like that, but Dilantin,
Tegretol and Frisium (Clobazam) I have used, all have a slot across the
centre of the hard tablet, so it can be snapped in half,  without needing to
bite into it. Failing that, most of my pills listed here also said to take
them with Milk, Food or Juice.  If Keppra is like that, the Juice will clear
any aftertaste.  Many of the pills are not intended to be chewed (as
bitten), but swallowed whole, as some of the chemicals might irritate the
mouth or throat.    G./

> On Thu, 03 Feb 2005 14:16:02 -0800, deprofundis wrote:
>
[quoted text clipped - 26 lines]
> particularly want.
> Sofie
Sofia - 15 Mar 2005 04:17 GMT
> --> Check the 500mg tablets of Keppra when they arrive (***s below).
>    If any of the tablets you refer to are solid ones, most have a horizontal
[quoted text clipped - 7 lines]
> bitten), but swallowed whole, as some of the chemicals might irritate the
> mouth or throat.

I checked the keppra 500s, and unfortunately for me, they were like both
my 1000s, and the 250s I used to get by the same manufacturer - with no
slot so they can be snapped in two. I always swallow my tablets down
though, and have never chewed them in my life. I always take a glass of
Ribena down after my breakfast anyway, so I think I'll take your advice on
taking them down with a glass of fruit juice.

Sofie

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