hemosiderin / iron

Thread view:

Enable EMail Alerts

Start New Thread

Thread rating:

doe - 11 Aug 2003 21:47 GMT

AJNR Am J Neuroradiol. 2003 Feb;24(2):218-24. Related Articles, Links

Magnetization transfer MR imaging in patients with posttraumatic epilepsy.

Kumar R, Gupta RK, Husain M, Vatsal DK, Chawla S, Rathore RK, Pradhan S.

Department of Radiology, Sanjay Gandhi Post-Graduate Institute of Medical
Sciences, Lucknow, UP, India 226014.

BACKGROUND AND PURPOSE: Intractable epilepsy is a well-recognized complication
following head trauma, and many factors have been implicated in its
pathogenesis. This study was performed to determine the severity of tissue
damage after severe head injury as assessed with magnetization transfer (MT) MR
imaging and the relationship of this damage with seizure intractability.
METHODS: Forty-four patients, 13 without seizures (disease controls) and 31
with seizures, underwent T1-weighted MT MR imaging 1-10 years after head
trauma. Phase-corrected gradient-echo (GRE) imaging was also performed in all
patients to look for the presence of hemosiderin. All patients were evaluated
for the presence of an MT abnormality beyond an abnormality seen on T2-weighted
images, an MT abnormality within a T2 abnormality, and hemosiderin deposition.
RESULTS: Patients with an MT abnormality beyond a T2 abnormality had a
significantly higher intractability of seizures compared with those with an MT
abnormality within a T2 abnormality (P <.05). In addition, the mere presence of
hemosiderin deposit was not associated with seizure intractability; however,
gliosis around the hemosiderin as seen on T1-weighted MT images was associated
with seizure intractability. CONCLUSIONS: T1-weighted MT imaging may be of
value in predicting the intractability of the seizure in delayed posttraumatic
epilepsy.

PMID: 12591637 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------
------

Who loves ya.
Tom

Signature

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

Reply to this Message

doe - 13 Aug 2003 23:15 GMT

>Subject: hemosiderin / iron
>From: ironjustice@aol.comdoe (doe)
[quoted text clipped - 43 lines]
>--------------------------------------------------------------------------
>------

1: Biochem Mol Biol Int. 1998 Jun;45(1):11-23. Related Articles, Links

Free radical scavenging activity of fermented papaya preparation and its effect
on lipid peroxide level and superoxide dismutase activity in iron-induced
epileptic foci of rats.

Imao K, Wang H, Komatsu M, Hiramatsu M.

SAIDO Co., Fukuoka, Japan.

Fermented papaya preparation is a natural health food that has been
commercially sold in Japan for 2 years. It is made by yeast fermentation of
Carica Papaya Linn. We examined the antioxidant action of the fermented papaya
preparation on free radicals and lipid peroxidation. Free radicals have been
related with aging and diseases, such as cancer, diabetes and especially in
neurological disorders, for example, Parkinson's disease or Alzheimer's
disease. A diet including variable antioxidant foods may therefore help to
prevent these illnesses. The free radical scavenging activity of the fermented
papaya preparation was examined using an electron spin resonance (ESR)
spectrometer. Fermented papaya preparation (50 mg/ml) scavenged 80% of hydroxyl
radicals (.OH) as spin adducts of spin trap, 5,5-dimethyl-1-pyrroline-N-oxide
(DMPO) (5.27 x 10(15)spins/ml) generated by Fenton reagents. The value of IC50
was 12.5 mg/ml. The oral administration of the fermented papaya preparation for
4 weeks decreased the elevated of lipid peroxide levels in the ipsilateral 30
min after injection of iron solution by iron into the left cortex of rats. The
fermented papaya preparation also increased superoxide dismutase activity in
the cortex and hippocampus of them. These results suggest that the fermented
papaya preparation has antioxidant actions and that it may be prophylactic food
against the age related and neurological diseases associated with free
radicals.

PMID: 9635126 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------
------

Who loves ya.
Tom

Signature

Reply to this Message