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Medical Forum / Diseases and Disorders / Epilepsy / March 2004XR & CR difference
What is the difference - if any of XR and CR Tegretol? Those are the two I have. Also, I am curious if it's possible to have XR and CR in tablet form. The stuff I get from my doctor is in capsule form. (blue and black) the stuff I get from Canada is tablet form Long oval shape and brownish. Also, the depakote in Canada is called depakene but it looks the same and is made by the same lab. Abbot. I know xr is is extended release and cr is controlled release but do the react differently in the body or have different effects? Thanks, Greg Someone around here who's used XR (+ your description below) will have to response what each pill looks like. My understanding was that the XR version is a hollow plastic tube? with a powder inside it. The plastic opens in the stomach, and the tube passes out the 'behind' ? unused. (I think what you describe below is the hollow plastic tube.) I think each CR dose has a different colour? plus has a slot across the centre I described elsewhere yesterday so it can be broken in half to make half doses, if those were to work better getting a balance. My 200mg CR are a 'pinkish' solid tablet with that slot. I've never used other mg tablets (100? or 400), but was under the impression they were different colours, although solid also, so that the types (mgs) could be told apart by the user, doctor and pharmacist. Both are intended to get past the stomach and acids there? to be absorbed 'downstream' into the blood to give your target levels, and stable levels over a longer time period. A couple of people complained 2-3? years ago at capsules opening in their mouths, or just after swallowing, and were more awkward to take because of that in some cases. My solid ones are completely solid (possibly coated), but without a 'discardable plastic' shell flowing through my system. When my 'pink one' dissolves with food or juice, that's all that's there. No extra outside materials. I haven't used the other (depakote), but wonder if the difference is the same formula, but a different tablet merely to tell which country was the Manufacture site? if problems arose, and mgs or each type. Some medications, like some AEDs, are manufactured in Asia or Europe, then exported, and there's probably some bureaucratic reason to mark separate makers in case problems start showing up in one type of tablet, made at a particular facility. (We're having a couple in Inquests right now in Toronto with some patients who were accidentally given the wrong *Heart medication since 2 separate pills by 2 separate manufacturers 'looked the same', except one proved lethal to innocent people who were given the wrong drug for their heart condition.) I'd be happy to have them ALL look different even if they function predominantly the same way, but come from a different factory. Just my opinion. G. > What is the difference - if any of XR and CR Tegretol? Those are the > two I have. Also, I am curious if it's possible to have XR and CR in [quoted text clipped - 9 lines] > Thanks, > Greg > Someone around here who's used XR (+ your description below) will have to > response what each pill looks like. My understanding was that the XR [quoted text clipped - 9 lines] > although solid also, so that the types (mgs) could be told apart by the > user, doctor and pharmacist. g'day gr the 400mg tegretol tablets that i take are a light orange colour and shaped like a capsule pablo > Both are intended to get past the stomach and acids there? to be absorbed > 'downstream' into the blood to give your target levels, and stable levels [quoted text clipped - 36 lines] > > Thanks, > > Greg Hi. But are they a hollow 'plastic tube' with powder inside? or Solid Tablet with a slot across the centre (like my Tegretol CR are) ?? I had thought one of the versions had that Powder version, so doses weren't as easy to split in half by the patient. (Mine are Pale Orange, but solid like an aspirin for example) G.R. > "gaross" <> wrote in message > > Someone around here who's used XR (+ your description below) will have to > > response what each pill looks like. My understanding was that the XR > > version is a hollow plastic tube? with a powder inside it. The plastic > > opens in the stomach, and the tube passes out the 'behind' ? unused. (I > > think what you describe below is the hollow plastic tube.) > > > > I think each CR dose has a different colour? plus has a slot across the > > centre I described elsewhere yesterday so it can be broken in half to make > > half doses, if those were to work better getting a balance. My 200mg CR are > > a 'pinkish' solid tablet with that slot. I've never used other mg tablets > > (100? or 400), but was under the impression they were different colours, [quoted text clipped - 49 lines] > > > Thanks, > > > Greg Howdy! I don't think there's any difference. The XR that I had was an undigestable shell with a tiny hole in it. the drug took 24 hours to escape. You can tell that they are XRs because the tablets come out in your stool.  SignatureDave ???? "Noli illigitemi carborundum decendus" http://www.howdydave.com > Hi. But are they a hollow 'plastic tube' with powder inside? or Solid > Tablet with a slot across the centre (like my Tegretol CR are) ?? I had [quoted text clipped - 77 lines] > > > > Thanks, > > > > Greg The CR tablet is a solid orange (the 200mg ones) like an aspirin. (That's why they can be snapped in 2 to make a 100mg dose, at the scored indent-line on them. The plastic shell ones can't or the powder would spill out? ) The CR ones don't have plastic shells with powder inside like others have described that I assumed were the XR version. I don't usually check the 'downstream effects' , but expect my type fully dissolve. :-< G. > Howdy! > I don't think there's any difference. [quoted text clipped - 14 lines] > > thought one of the versions had that Powder version, so doses weren't as > > easy to split in half by the patient. (Mine are Pale Orange, but solid like > > an aspirin for example) G.R. > > > > > "gaross" <> wrote in message > > > > Someone around here who's used XR (+ your description below) will have to > > > > respond what each pill looks like. My understanding was that the XR > > > > version is a hollow plastic tube? with a powder inside it. The plastic > > > > opens in the stomach, and the tube passes out the 'behind' ? unused. (I > > > > think what you describe below is the hollow plastic tube.) > > > > I think each CR dose has a different colour? plus has a slot across the > > > > centre I described elsewhere yesterday so it can be broken in half to make > > > > half doses, if those were to work better getting a balance. My 200mg CR are > > > > a 'pinkish' solid tablet with that slot. I've never used other mg tablets > > > > (100? or 400), but was under the impression they were different colours, > > > > although solid also, so that the types (mgs) could be told apart by the > > > > user, doctor and pharmacist. > > > > > > g'day gr > > > the 400mg tegretol tablets that i take are a light orange colour and shaped > > > like a capsule > > > pablo > > > > > > > > Both are intended to get past the stomach and acids there? to be absorbed > > > > 'downstream' into the blood to give your target levels, and stable levels > > > > over a longer time period. A couple of people complained 2-3? years ago at > > > > capsules opening in their mouths, or just after swallowing, and were more > > > > awkward to take because of that in some cases. > > > > My solid ones are completely solid (possibly coated), but without a > > > > 'discardable plastic' shell flowing through my system. When my 'pink one' > > > > dissolves with food or juice, that's all that's there. No extra outside materials G. > > > > > What is the difference - if any of XR and CR Tegretol? Those are the > > > > > two I have. Also, I am curious if it's possible to have XR and CR in > > > > > tablet form. The stuff I get from my doctor is in capsule form. (blue > > > > > and black) the stuff I get from Canada is tablet form Long oval shape > > > > > and brownish. > > > > > Also, the depakote in Canada is called depakene but it looks the same > > > > > and is made by the same lab. Abbot. > > > > > > > > > > I know xr is is extended release and cr is controlled release but do > > > > > the react differently in the body or have different effects? > > > > > Thanks, > > > > > Greg The ones I'm talking about have a casing almost like some sort of ceramic material SignatureDave ???? "Noli illigitemi carborundum decendus" http://www.howdydave.com > The CR tablet is a solid orange (the 200mg ones) like an aspirin. (That's > why they can be snapped in 2 to make a 100mg dose, at the scored indent-line [quoted text clipped - 91 lines] > > > > > > Thanks, > > > > > > Greg > The CR tablet is a solid orange (the 200mg ones) like an aspirin. Yes, that is right. It is a tablet. The 400mg tablets are darker more brownish and yes they can be split, they do have a line. The Blue and Grey ones are capules which if you break them in half the powder will all fall out. I would like to thank you actually, the juice and cracker thing really works. For 2 straight days, I have had no blurry vision and no stomach problems. I think that was the solution. For so many years I was switching coffee from caf, to decaf, then half and half and cutting the icecream down, but now it seems it's just a acid balance and the food is the trick. I'll keep a journal to see what works. Thanks, Greg (That's > why they can be snapped in 2 to make a 100mg dose, at the scored indent-line > on them. The plastic shell ones can't or the powder would spill out? ) [quoted text clipped - 90 lines] > > > > > > Thanks, > > > > > > Greg > > The CR tablet is a solid orange (the 200mg ones) like an aspirin. > [quoted text clipped - 11 lines] > Thanks, > Greg G. -- I found the Milk, Food or Juice thing on (our) Canada Shopper's Drug Mart printout that came with first Prescription. The Grapefruit part was added for Tegretol soon after I took in a Printout I got from efa.org medications site, or on the uk newsgroup? when it was active ~1998/9. One of the acids in G.fruit that's not in other juices without it, neutralizes some of the active ingredients in Tegretol (Carbamazepine). Several of the ANTI Ep Drugs, on their own can mess up or get messed up by mixing with pure stomach acids. Adding Juice or Food with some of them, ensures they are broken down to be absorbed but not Defeated before they get to bloodstream. (Some of those upset stomach meds. can neutralize acids, but also the medicine in tablets that are needed.) Glad a simple Fix can give better (or complete) control. No point us each learning some of this from scratch each time, when some of us already accidentally became the 'beta tests' for what doesn't work !! :-< G.R. > (That's why they can be snapped in 2 to make a 100mg dose, at the scored indent-line > > on them. The plastic shell ones can't or the powder would spill out? ) > > The CR ones don't have plastic shells with powder inside like others have [quoted text clipped - 4 lines] > > > I don't think there's any difference. > > > The XR that I had was an undigestable shell with a tiny hole in it. the drug > > > took 24 hours to escape. > > > [quoted text clipped - 5 lines] > > > "gaross" <> wrote in message > > > > Hi. But are they a hollow 'plastic tube' with powder inside? or Solid > > > > Tablet with a slot across the centre (like my Tegretol CR are) ?? I had > > > > thought one of the versions had that Powder version, so doses weren't as > > > > easy to split in half by the patient. (Mine are Pale Orange, but solid like > > > > an aspirin for example) G.R. > > > > > > > > > > > > > What is the difference - if any of XR and CR Tegretol? Those are the > > > > > > > two I have. Also, I am curious if it's possible to have XR and CR in > > > > > > > tablet form. The stuff I get from my doctor is in capsule form. (blue > > > > > > > and black) the stuff I get from Canada is tablet form Long oval shape > > > > > > > and brownish. > > > > > > > > > > > > > > I know xr is is extended release and cr is controlled release but do > > > > > > > the react differently in the body or have different effects? > > > > > > > Thanks, > > > > > > > Greg > Hi. But are they a hollow 'plastic tube' with powder inside? or Solid > Tablet with a slot across the centre (like my Tegretol CR are) ?? I had > thought one of the versions had that Powder version, so doses weren't as > easy to split in half by the patient. (Mine are Pale Orange, but solid like > an aspirin for example) G.R. g'day gr, they're a solid tablet scored across the middle pablo > > Hi. But are they a hollow 'plastic tube' with powder inside? or Solid > > Tablet with a slot across the centre (like my Tegretol CR are) ?? I had [quoted text clipped - 6 lines] > they're a solid tablet scored across the middle > pablo The XR** and CR Both? The ones we (you and I) use are the pinkish orange Solid *CR, but I was under the impression that in UK? and other places, the XR version were hollow 'clear plastic capsules', that if you pulled them apart the soft powder would fall out the centre. That's why (somewhere earlier) when I talked about snapping mine in 2 (along the imprinted slot) to get a half dose would work with mine (ours), it wouldn't work with the clear capsule type that had powder in them. (Both types, I think, are intended to be absorbed by the Kidneys? or Liver? downstream of stomach acids etc. I think that's why some of them come with (earlier posts) instructions to take them with Milk, Juice or Food. ) I was mainly trying to confirm if the XR were like that, or *solid like the CR and Retard versions. G./ G'day gr, i was always led to believe that tegretol was metabolised in the liver hence the reason grapefruit is a no-no because it can affect the enzyme which metabolises it. not being a chemist i wouldn't swear to this of course. pablo "> The XR** and CR Both? The ones we (you and I) use are the pinkish orange > Solid *CR, but I was under the impression that in UK? and other places, the > XR version were hollow 'clear plastic capsules', that if you pulled them [quoted text clipped - 9 lines] > I was mainly trying to confirm if the XR were like that, or *solid like > the CR and Retard versions. G./ Oh, go ahead. Sounds good to me. G./ "Pablo" <> wrote in message > G'day gr, > i was always led to believe that tegretol was metabolised in the liver hence > the reason grapefruit is a no-no because it can affect the enzyme which > metabolises it. not being a chemist i wouldn't swear to this of course. > pablo
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