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Medical Forum / Diseases and Disorders / Epilepsy / December 2008

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Change of Medicine

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weird0 - 21 Nov 2008 20:03 GMT
I have been taking Epival 250 mg for the last 8 years. The med. keeps
my fists in control but the side-effects are unbearable. It effects my
digestive system the most and causes excessive hunger. Over-eating
takes place and then causes indigestion.

I have also observed hair loss in this medicine, but then i got my
hair cut short.

Now, this new neurosurgeon, has recommended me Keppra 250 mg ( 1 + 0 +
2 )  and Rivotril and dropping on Epival, so the side-effects are
minimized.

Keppra, according my observation, is causing weakness and drowsiness.

Should I be taking any Multi-vitamin to kill the weakness and fatigue.
How do i counteract to the side-effects of keppra 250 mg, if this new
med. keeps my fists in control ?

Please, feel free to make recommendations. Any advice would be helpful.
Sofia - 30 Nov 2008 04:52 GMT
> I have been taking Epival 250 mg for the last 8 years. The med. keeps
> my fists in control but the side-effects are unbearable. It effects my
[quoted text clipped - 3 lines]
> I have also observed hair loss in this medicine, but then i got my
> hair cut short.

Ugh, I've never heard of Epival but it sounds absolutely gruesome...
are you sure it's an anti - epileptic med? I've been offered
practically every med on the list, but I've never come across this drug
before, thank goodness! I'd hate to get excessively fat, and lose all
my long, thick dark hair... I'd have a heart attack!! :)    

> Now, this new neurosurgeon, has recommended me Keppra 250 mg ( 1 + 0 +
> 2 )  and Rivotril and dropping on Epival, so the side-effects are
> minimized.
>
> Keppra, according my observation, is causing weakness and drowsiness.

I was recently weaned off Keppra as it didn't do much for me other than
give me excessive sweating. I was also taking it with Tegretol Retard
which, slowly goes through my blood throughout the day.

Although I've been on Tegretol Retard for years now, I've never wanted
to swap it as it works for me. As for the Keppra, I suppose it made me
feel tired and drowsy, but I don't know of one med I've been on that
doesn't make me feel the same way - you just lose a lot of your
concentration most of the day and have to do your best to try to stay
awake.


> Should I be taking any Multi-vitamin to kill the weakness and fatigue.
> How do i counteract to the side-effects of keppra 250 mg, if this new
> med. keeps my fists in control ?

I doubt 250 mg can do you much harm though - I was on 500mg Keppra
twice daily + 800 mg Tegretol Retard twice daily, and it did
practically nothing to me. I suppose then again we always have the
fact that different meds react in different ways with each different
individual! What you are experiencing is your own little individual
after effects to the drug!

I usually take a multivitamin, a B-complex, a cod liver oil capsule,
and a vitamin E capsule. I've been doing so for years simply for good
health sake... nothing more.

I suppose you could supplement with vitamins if you like, but I doubt
it with help your seizures, or your fists. I can't be sure whether you
have the same problem as I've had ever since I was a child (I'm 43 early
January) and first started to get my seizures, but if I'm sitting
watching TV, eating or drinking something perhaps, and a seizure
suddenly comes on, I can get these muscle spasms in my wrists and
fingers, never letting go. My fingers can clench the cup I'm holding
tightly, and refuse to let hubby take hold of it, usually spilling hot
tea and coffee over most of my clothing.  Same thing if I'm eating,
when I hold onto a piece of cutlery, never letting it go, - the end
result being that my dinner is all over my lap and on the floor instead
of inside my mouth.

If your seizures are the same as mine, then you're never going to get
rid of them for good as they are part of the type of seizures you are
getting. Your neurologist can only give you drugs to help try and
control these seizures, which your muscle spasms are part of,  but
they will never get rid of them completely.

I should know, I've had so many different types of seizures throughout
my life, and I still have these clenching muscle spasms too - they drive
hubby crazy, as he always ends up having to clean the aftermath as
well.  I've now just resulted to feeling more sorry for him, than I
ever was for myself.

If you're going to have one, you're going to have one, so my best
advice to you would be to simply forget they are there for now, until
one occurs and just enjoy life to the fullest. Feeling sorry for
yourself will only make you feel depressed/suicidal perhaps, it did
with me,  which is why I try to be happy nowadays, going to an
exhibition, or the movies perhaps to make me forget I have them!

Best of luck in finding your perfect med

Sofie
 
   

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Robert A. Fink, M. D. - 30 Nov 2008 23:15 GMT
>Ugh, I've never heard of Epival but it sounds absolutely gruesome...
>are you sure it's an anti - epileptic med? I've been offered
>practically every med on the list, but I've never come across this drug
>before, thank goodness! I'd hate to get excessively fat, and lose all
>my long, thick dark hair... I'd have a heart attack!! :)    

Epival is a non-USA trade name for one of the Valproate derivatives
(Valproic acid, Divalproex) and is a common and effective
anticonvulsant.  It does have some side-effects, as stated above, but
these are relatively uncommon.  Talk to your doctor; it may be a
perfectly good medicine for you.

Best,

Bob

Robert A. Fink, M. D.
Neurological Surgery
2500 Milvia Street  Suite 222
Berkeley, CA  94704-2636  USA
510-849-2555

**********************************
NOTE:  The material above is not "medical
advice".  Medical advice can only be
given after an in-person contact between
doctor and patient.
**********************************
Sofia - 07 Dec 2008 00:31 GMT
> Epival is a non-USA trade name for one of the Valproate derivatives
> (Valproic acid, Divalproex) and is a common and effective
> anticonvulsant.  It does have some side-effects, as stated above, but
> these are relatively uncommon.  Talk to your doctor; it may be a
> perfectly good medicine for you.

Thanks Robert,

I've actually had Sodium Valproate (Epilim) before though. It was the
very first drug I was put on as a child, and when it did nothing for me
then, my paediatrician further added phenytoin to it when I went into
my teens. I was so completely doped up as a kid, I couldn't concentrate
on any of my lessons at school properly, which resulted in my failing
over half of my exams at school. I also became over 3st (42lbs)
overweight as they also had this awful side effect of adding weight to
it's user.

I was taken off this med at the age of 17 when I left school to go to
college to take my Art A' level. My weight immediatly dropped without
any particular changes in my diet or appetite, and my concentration
returned right back to reality. All I really felt was a little
tiredness through my course and ended up passing my exams.

I've learnt more about WW1 & WW2 History lessons, Shakespeare,
the Sciences and mathematics, from watching TV documentaries, going to
the cinema and watching war films, and going to science/art
museums. I've also picked up much more on Shakespeare from going
to the theatre and watching TV films, and reading his collected works at
home.      

The moral of the story is... if I hadn't been so doped up with Sodium
Valproate at school,  I would have passed those exams and wouldn't have
been thought of as a dummy by all my class mates!! At least my Tegretol
Retard helps me think throughout the day... and I'm a much more
intelligent and alert person for it!!

All the best,

Sofie

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