Keppra, in general, is one of the better tolerated "newer" anti-epileptic
drugs on the market. It has to date, no significant drug intercations and
has a very good reputation, based on data, of having long term seizure
freedom sustainability. It also does NOT put on weight. In fact, Keppra is
weight neutral, so it does not make you pick up weight or lose it. It has,
however, had some patients have behavoural changes, such as aggression,
depression, but due to the fact that a quarter of patients with epilepsy
suffer from behavioural/psychiatric adverse events, it is not always the
drug to blame. Around 29% of epilepsy patients suffer from depression and
epilepsy is likely 4 to 6 times higher risk in patients who have
depression...so a vicious circle. Perhaps a reduction in dosage is the
answer, although this may cause a breakthrough seizure to take place, but it
may not, as Keppra seems effective at lower doses as well.

I would question the weight gain issue, as Depakote is well known for it's
weight gain side effects.