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Medical Forum / Diseases and Disorders / Epilepsy / June 2006

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Resistant to Epilim?

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crocks - 30 May 2006 16:27 GMT
Hiya Group!

I have been taking Epilim ever since I was 14 yrs old. I have Grand-Mal

Epilepsy and Epilim has so far controlled my Epilepsy up to my 27th
Birthday with only the occasional fit. Recently my fits have increased
in frequency (from one every few years to one every six months) and
intensity and I "ordered" my GP to refer me to a neuro consultant.
About 3 months ago The consultant increased my daily medication of
Epilim by a quarter from 2 tablets a day to 3, however this seems to
have had no effect as last week I had a really bad fit while on holiday

I am starting to wonder if its possible to become resistant over time
to Epilim and wonder what are the options for me? I have alerted my
Consultant of the new attack today, and am awaiting an appointment
again (I think I am in some huge queue but not high up!)

What do you think group?

JC
Maria C - 05 Jun 2006 16:16 GMT
Hi,

I am John's wife and i would like to add some more detail to what has
happened in recent days.  On Saturday just gone, John suffered from a
Major Grand Mal Seizure on Saturday in which i had to resusertate him.
He was sent to the hospital because is pulseox was very low as well as
his blood pressure and his heart was running into the high 100's.  This
was the first major grand mal that he has had and apart from scaring me
to death (i am 23 weeks pregnant) he seems to be fine now.  We saw the
doctor today and was advised that because John has an underlining chest
infection that this could have caused this seizure to happen as well as
the one that he had 10 days ago.  I have also contacted his neurologist
to advise her of the situation in the hope that he will be seen a bit
sooner than they were planning but we are waiting to hear on that
front.  I am petrified of leaving him alone because if i had not been
there he would have died that day.

Has anyone had this type of seizure which is known to have been caused
by an underlining infection.  I would like some feed back as i would
like my own mind to be put at rest that this sort of thing can happen
so that i can look out for him not being well and getting it sorted out
quickly in order that we do not go through this type of thing again.

Any help or advice would be grateful accepted.

Thanks for listerning.

Maria Crocker
Sofia - 05 Jun 2006 23:10 GMT
> I am John's wife and i would like to add some more detail to what has
> happened in recent days.  On Saturday just gone, John suffered from a
[quoted text clipped - 6 lines]
> infection that this could have caused this seizure to happen as well as
> the one that he had 10 days ago.

Hi Maria, I wanted to tell you about what I read the causes of epilepsy
were in a book called "the encyclopaedia of epilepsy" edited by Professor
David Chadwick.

"Brain injury/disease and Hereditary Factors...

Damage to the brain with or without scarring as a result of:
1. injury to the head
2. infections of the brain or brain meninges (encephalitis or meningitis)

Malformation of the brain

Degeneration of the brain

Metabolic (biochemical) disorder as a result of:
1. low blood glucose
2. low calcium level
3. drugs, particularly alcohol

Brain tumours

Hereditary Factors"

I thought maybe John might have fallen into the category written in this
line-up headed under the Metabolic disorder section, as many diabetics
also have very high blood pressure, and glucose is also mentioned.

Sorry, can't help much more

Sofie

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wester@laway.net - 05 Jun 2006 23:17 GMT
>Hi,
>
>I am John's wife and i would like to add some more detail to what has
>happened in recent days.  On Saturday just gone, John suffered from a
>Major Grand Mal Seizure on Saturday in which i had to resusertate him.

Dear Ma'am:

Sorry for the scare and for his discomfort. In the event this happens
again in your presence, the best thing to do is roll him on his side
so his tongue does not block his esophagus. BTW, all grand mal
seizures are major.

>He was sent to the hospital because is pulseox was very low as well as
>his blood pressure and his heart was running into the high 100's.  This
[quoted text clipped - 7 lines]
>front.  I am petrified of leaving him alone because if i had not been
>there he would have died that day.

Unfortunately, anything (or nothing) can trigger a seizure. I've not
heard of an underlying infection being the cause, but I don't see why
not, either.

>Any help or advice would be grateful accepted.
>
>Thanks for listerning.

Best of luck to you. Ask your neuro about putting him on Keppra. I had
grand mals for over 20 years even while being on various combinations
of this, that, and the other. Since I've been on Keppra, I've been
seizure-free for over a year. Maybe it'll work for him. Yes, it's
expensive. But for me, it's been worth it. I can't remember how many
times I'd come to with a chewed-beyond-recognition tongue, black eyes
from punching myself, and general little stuff like cracked ribs, etc.

Good luck, and hang in there!

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