Medical Forum / Diseases and Disorders / Epilepsy / December 2005
Clonazepam
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smiles69 - 05 Dec 2005 09:23 GMT I have now started my chnages in the medication I take. Although taking 1200mg Tegratol I have been told to take the above drug at night time (I have ni idea what this drug is for or what it does). But since Friday of last week I have 5 very nasty seizures. I am also due to integrate another tablet, it is new to the UK (but has been used in the USA for a while). I feel exhausted all the time since taking Clonazepan, and feel worse if anything.
Q1. Has anyome else out there experienced difficulties with Tegratol/Clonazepan.
Q2. Does anyome believe this combination had a positive impact on their seizures (as I am not a believer right now)
Thanks Ross
bugs@bugs.com - 05 Dec 2005 15:06 GMT > I have now started my chnages in the medication I take. Although taking > 1200mg Tegratol I have been told to take the above drug at night time (I [quoted text clipped - 9 lines] > Q2. Does anyome believe this combination had a positive impact on their > seizures (as I am not a believer right now) I have a script for Klonopin and they give me Clonazepam as the generic version of it. I take it when I feel a seizure coming on, which isn't much anymore because I don't get much of a warning any longer. I can also take them if I am having small seizures and they will stop the smaller ones. I simply place a pill under my tongue and let it dissolve and the seizures will stop rather quickly. I haven't found that it does anything for the major seizures, but then again you can't take it while in the midst of a grand mal now can you? ;o) Maybe if you could it would help stop them as well who knows.
I also do not take tegratol any longer I take Topamax and Mysoline.
 Signature I wish you all the best Tim Wise
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G.Ross - 05 Dec 2005 16:12 GMT I'll need someone else with experience with Clonazepam? to comment on how it's used and whether it works that fast. Its operation sounds somewhat similar to Ativan Sublingual (Lorazepam), that I've used, in case that name is in same family as mine. Before I was fully controlled I carried some Ativan with me and if I had an aura before onset, one tablet under my tongue would dissolve in under 5 minutes. (There are blood vessels there that absorb the medicinal properties far faster than Swallowing the tablet. In fact I think if this was swallowed mine might produce erratic levels of control or be destroyed by stomach acids etc.) It was common for me within a couple of hours of using my Lorazepam (a relaxant) to relax off into a snooze of 1-2 hours. Quite nice, and relaxing actually. And that probably helped my type of szr. to pass, as it might have been more likely, due to blood levels of oxygen or ?? that caused the auras (simple partials) I was getting ahead of a szr. /G.
>> I have now started my chnages in the medication I take. Although taking >> 1200mg Tegratol I have been told to take the above drug at night time (I >> have no idea what this drug is for or what it does). But since Friday of >> last week I have 5 very nasty seizures. *** Does it say to swallow the tablet or use as a Sublingual as I described above? If you swallow it, does it say to add Juice, Milk or Food to help with dissolving in your stomach? Note that *Grapefruit juice should Never be used with Tegretol. It's yucky and disgusting anyway, so a good opportunity to put it into the landfill and use Hot Chocolate, apple juice, or something more enjoyable. But one of the acids in G.fruit conflicts with Tegretol, that's not in other juices that do Not contain the grapefruit. G./
I am also due to integrate another
>> tablet, it is new to the UK (but has been used in the USA for a while). I >> feel exhausted all the time since taking Clonazepan, and feel worse if >> anything. ** Probably once you've added the secondary tablet and Slowly reduced the Tegretol, the 2 will work together better than what you have so far and you'll start to see some daylight. I removed my night dose of 2x200mg Tegretol CR (solid tablets) over a period of 8 weeks, and about week 4 we added my second tablet for Complex Partial type szrs. (Temporal Lobe szrs. on some sites). My 2ndary tablet happened to be Clobazam (Frisium) and we started with half tablet (5mg) as night dose - when I had a szr. 3-4 weeks later, we added half tablet With A.M. Tegretol I still take (200mg), later a full tablet of Frisium alone at night, and finally full tablet Frisium with Tegretol as above. Last dose change I did was about 1996, last szr. I had was June 1998 with that combination.
That isn't necessarily how your's might work out, but the synergy of a Second Tablet with a Primary Anti Ep. Drug can provide seizure control in some of us without the side effects that a single Med. alone might produce. I rarely have any tiredness like I had on pure Tegretol CR, unless I'm up late on this computer... :-< but had none of the sensations I once related to pills I was taking (Dilantin or Tegretol alone). I didn't notice Any side effects with my 2nd pill after it was fully added and at final dose change 9 years ago. G./
>> Q1. Has anyome else out there experienced difficulties with >> Tegratol/Clonazepan. [quoted text clipped - 13 lines] > > I also do not take tegratol any longer I take Topamax and Mysoline. Sofia - 05 Dec 2005 15:54 GMT > Q1. Has anyome else out there experienced difficulties with > Tegratol/Clonazepan. > > Q2. Does anyome believe this combination had a positive impact on their > seizures (as I am not a believer right now) Hi Smiles, I thought I'd tell you a bit about my experience with Clonazepam. Although at the moment I'm on a steady dose of 800mg Tegretol and 1500 Keppra twice daily, I had to go through several mix n match combinations with my Tegretol before I finally got here and Tegretol/Clonazepan were one of them.
It was awful, my co-ordination comletely went, and I was falling over all over the place. I found it extremely mind bending too, making me see and hear things that weren't actually there. I began to think I was going mental, as I said and did a lot of strange things I didn't know I was doing.
Firstly my neuro told me what I was experiencing was just the side effects of the drug, and that they would go away after a while, but as they just got worse, I decided it simply wasn't doing anything for me exept making me look like a lunatic to everyone else around me.
I was immediatly taken off it, and have absolutely nothing positive to say about this combination at all. If the Tegretol/Clonazepan partneship isn't working for you either, then I suggest that next time you see your neuro, you tell him/her to take you straight off it!!
All the best
Sofie
 Signature Please visit my deviantART page: http://sofen.deviantart.com/
needhamleonards - 05 Dec 2005 19:43 GMT Ross, I had a similar experience - Clonazepan caused a dramatic increase in my absense seizures. My advice would be to stop taking it immediately. In my case it was prescribed for anxiety. Jack
> I have now started my chnages in the medication I take. Although taking > 1200mg Tegratol I have been told to take the above drug at night time (I [quoted text clipped - 12 lines] > Thanks > Ross Mike Kelliher - 06 Dec 2005 05:19 GMT Clonazapam(clonazepan), Lorazapam, Diazapam(valium) they are all benzodiazepine's. They are not very good for seizures as you eventually need to increase the med as your body gets used to it. At least that is what my Neuro stated. I was on it for awhile myself and it worked great except I had side effects I didn't like. Nothing new. Why would you take a drug that you have no idea what it is or what it does???? I don't understand people who don't question. They(doctors) are only human and you are paying them (a lot) so they OWE you answers. You are your only true advocate. Good luck Mike
>I have now started my chnages in the medication I take. Although taking > 1200mg Tegratol I have been told to take the above drug at night time (I [quoted text clipped - 12 lines] > Thanks > Ross G.Ross - 06 Dec 2005 06:36 GMT I didn't realize it was in the same family as Lorazepam (bottom here). See my earlier note on this thread about how sublingual works (If your Pill bottle says Sublingual on it, you should have been dissolving these under your Tongue alone, without liquids or other things, and Not Swallowing it.)
. As listed below by Mike, they are potentially habit forming and aren't intended for Long Term Use. It was a Stupid thing to give you without instructions on how it works or how to use it. It is a relaxant, that can compliment some types of treatments, for some types of seizures. It is potentially habit forming and might stop working over a period of use, and it's not intended to be used over a long period.
When he prescribes the Second (Tegretol Supplement) Tab, *I'd consider taking the script to a Second Doctor for another opinion before filling it. I think I listed on an earlier post about how **slowly I reduced the Tegretol I was taking when a second tablet was added. Do *not stop taking Tegretol abruptly -- Doctor or not-- it should be reduced slowly over a period measured in weeks, if the dose is reduced when a second tablet is added. That's what I did with mine -- ~8 weeks to remove 2x200mg solid tablets. I still use 2 tablets x 200mg with a second pill for CP Seizure control. (I can list in more detail how we reduced the Solid Tegretol Tablets as an example, if you don't see anything in the history file or talking to the pharmacist, *if they decide to reduce your dosage. If a second pill is added for seizure control, it would be normal to reduce (first) some of the current Tegretol, so the 2 don't over-medicate you.)
And as Mike noted in post below, my second (complimentary) tablet, **wasn't Lorazepam.
Those are Not Smarties (Candy).. The Pharmacy at a minimum should have given you a printout describing what it is, how it's used and what Not to do with it. I don't know who is worse for this lack of patient information, the Chemist or the one who wrote the prescription.
There's probably an entry under the U.S. Ep. Foundation Website, under medications, then scroll to pill name or type it and click 'search' or whatever the button says beside the search box. EFA site is at http://efa.org then look for Medications Glossary. (Take out your Pill Bottle and type the exact name that's there, to make sure it finds the correct pill --you're looking for a 1-page printable report on how it's used and what it's for. That is a page similar to what a Pharmacy should have Given you.) /G.
> Clonazapam(clonazepan), Lorazapam, Diazapam(valium) they are all > benzodiazepine's. [quoted text clipped - 26 lines] >> Thanks >> Ross Patsy and Darryl - 06 Dec 2005 12:02 GMT Hi, I found the below at: http://www.drugs.com/cons/PMS_Clonazepam.html "Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking or receiving benzodiazepines it is especially important that your health care professional know if you are taking any of the following:
a.. Central nervous system (CNS) depressants (medicines that cause drowsiness)?The CNS depressant effects of either these medicines or benzodiazepines may be increased; your doctor may want to change the dose of either or both medicines" And the below at: http://www.mentalhealth.com/drug/p30-t01.html
"Induction of hepatic enzymes in response to carbamazepine may have the effect of diminishing or abolishing the activity of certain drugs that are also metabolized in the liver. The dosage of the following drugs may have to be adjusted when administered with carbamazepine: Clobazam, clonazepam, ethosuximide, primidone, valproic acid, alprazolam, corticosteroids (e.g. prednisolone, dexamethasone), cyclosporin, digoxin, doxycycline, felodipine, haloperidol, thioridazine, imipramine, methadone, oral contraceptives, theophylline and oral anticoagulants (warfarin, phenprocoumon, dicumarol)."
I've been taking tegretol, epilim, neurontin and clobazam (which I think is similar to clonazepam) for some time, with little side effects apart from a combination of the usual tiredness and occasional insomnia - strange combination as it may be.
Cheers, Darryl.
>I have now started my chnages in the medication I take. Although >taking [quoted text clipped - 19 lines] > Thanks > Ross pipercub49 - 06 Dec 2005 14:31 GMT Smiles,I was only on Tegretol for a very short time. But I have been on cloazepam for quiet a while. Along with Dilantin, Zonegran,Keppra and Diastat as needed. I have been on almost very AED there is. There are two I can't go back on because I got Pancreatitis. That would be Tegretol and Depakote. But at the time I was on Tegretol and Cloazepam and the other med AED's. I do not remember having any bad side effects. But then that was just a bit over a year ago and I was having seizures everyday. Now The seizures have decreased and I can truely say I know how I feel now. I take the Cloazepam twice a day and I am not so tired unless I have a seizure. The other seizure meds I think I have gotten use to but then maybe I just forgot what it is like not to me drugged up. But it is far better then having Gran Mal seizures everyday. Any med you have to give it a chance. There were some I took for just 3 days and would not take anymore. But that was rare. Just hang in there. Hope all goes well. Maybe you should tell your DR. M.
smiles69 - 07 Dec 2005 11:10 GMT Thanks to all that replied to my post.
I have been able to get little "official" advice quickly(this is the NHS for you). And so I have had to design my own reduction programme. I have only been on this for 3 weeks now, and I was taking 1mg at night (2x0.5mg) pills. For the last 3 nights I have reduced this to a single pill, and was goling to reduce down to half a pill tonight. This seems a safe way to reduce a tablet, but with me unable to get the info I need I have to make decisions.
Q1. Has anyome else reduced themselves off this pill?
Thanks Ross
Patsy and Darryl - 07 Dec 2005 12:21 GMT I wouldn't recommend reducing ANY AED without consulting a neuro first (though I must admit I've done it myself - never was too good at taking my own advice). Now that the official disclaimer is out of the way................. I think that you should reduce it very slowly. Go down one step as you have done and STAY at that level for two or three weeks before dropping down to the next level. It's always better to drop too slow rather than too fast. This is the way I've reduced clobazam (which I believe to be a similar drug, but could be wrong) in the past and it's worked well for me. Generally it's easier to INCREASE a medication than to DECREASE it. So reducing levels needs to be done slower than any increases are done. All the best. Darryl.
> Thanks to all that replied to my post. > [quoted text clipped - 16 lines] > Thanks > Ross smiles69 - 08 Dec 2005 10:34 GMT Daryl,
I could not agree more and if I was on a bigger dose or had been on it for longer, or it was my main tablet I would never consider a "self reduction" programme.
I also take 1200mg of Tegratol and the Clonazepam was aimed at a night time drug only. I have taken 1 tablet for the last 3 days, instead of 2 and will continue to do so for another 4 days. I will then take 1/2 a tablet for a week.
Since starting Clonazepam I have had more absences than ever before. And it has some nasty side effects that are of a more personal nature (not good when looking at a family) I have also come out in acne (at 36 this is not good)
Thanks for yours and everyones elses input here.
Merry Xmas Ross
pipercub49 - 08 Dec 2005 12:30 GMT Smiles, I am just saying what my Neuro. told me. This is by NO means any medical advice. But I did mention I was on 4 AED and Clonazempam being one. I really do not notice any side effects. But I do get tired and need to nap during the day.I am on .5mg in the am and .5mg in the pm. What he told me was if I did decide to stop taking it. Which at this point he does not want me to. To not just stop. Take a half of the morning dose. But not to just stop it. He also told me to not stop the pm dose. But if you are going to stop it do it a little like you said at a time. 3 weeks may not seem like to long. But to our bodies it can seem like a long time. Becareful and Safe. I hope you feel better. M. Finney
Chris Lesurf - 15 Dec 2005 07:23 GMT I have never taken Clonazepam but I have taken 10mg/night clobazam for years and was allowed to keep a stock of 10mg diazepam tablets to take when I wanted to before they became recognised as being addictive (ie losing their effect with time). They are both benzodiazepines. I take clobazam in the middle of the night because it helps me to get back to sleep and I used to take diazepam the night before a day when it was more important than usual not to have a fit. It may have been that the latter jsut acted as a placebo.
Something that may be of interest to others is that Keppra caused fluid retention which made joints uncomfortable and nealry led to my having an operation for carpal tunnel suyndrome. The neurologist had no idea about that side effect and so I suffered for a year. I suggest having enough courage to mention your opinion strongly.
Cheers,
Chris
In article <0b08849dcdc0bd9440645ea5d9a936fe@localhost.talkaboutsupport.com>,
> Daryl,
> I could not agree more and if I was on a bigger dose or had been on it for > longer, or it was my main tablet I would never consider a "self reduction" > programme.
> I also take 1200mg of Tegratol and the Clonazepam was aimed at a night > time drug only. I have taken 1 tablet for the last 3 days, instead of 2 > and will continue to do so for another 4 days. I will then take 1/2 a > tablet for a week.
> Since starting Clonazepam I have had more absences than ever before. And > it has some nasty side effects that are of a more personal nature (not > good when looking at a family) I have also come out in acne (at 36 this is > not good)
> Thanks for yours and everyones elses input here.
> Merry Xmas > Ross Sofia - 15 Dec 2005 23:20 GMT > Something that may be of interest to others is that Keppra caused fluid > retention which made joints uncomfortable and nealry led to my having an > operation for carpal tunnel suyndrome. Hi Chris, is there anywhere we could get more information on this - it's just that I've never heard of it before, but have always had fluid retention, for years before I was put on Keppra?
Couldn't fluid retention also be the after effects of several other meds or natural day to day conditions?
All the best
Sofie
 Signature Please visit my deviantART page: http://sofen.deviantart.com/
G.Ross - 18 Dec 2005 04:49 GMT >> Something that may be of interest to others is that Keppra caused fluid >> retention which made joints uncomfortable and nealry led to my having an [quoted text clipped - 8 lines] > All the best > Sofie I think within the U.S. Ep. Foundation website there's a Medications Glossary. You either type in the name of the pill and click 'search' or 'go' and it give you a one page summary like you should get from the Pharmacy if you had a prescription filled for a particular pill. If it's a pill you haven't used, it will still give a good description of what it is, how it's used and what not to use with it -- usually alcohol, but I found the Grapefruit and Tegretol conflict (I think) on the EFA site too, before my Druggist added it to their printout.
The EFA site should be at http://efa.org . Gordon. (I don't remember where you are :-< but I think Chris is in the UK, so although the pill names are often similar, sometimes they have slightly different names, but can be found on the EFA site anyway. ) Let me know if that site doesn't have the Pill Glossary easy to find, and I'll look for a more accurate link in the Morning !! Gordon.
smiles69 - 21 Dec 2005 15:33 GMT I have since slowly weaned myself off these pills. Clonazepam demonstarted more downs the benefits in my view. I have also just asked to change Neuro's as I am not happy with the level of consultation time. I am oging private to have a full 2 hour assessment to look more deeply into the whole issue of medication and side effects at the National Centre For Epilepsy in the UK. You have to get referred from the GP but it is worth the money for a real piece of mind on the options.
I feel much better now I am back to 1200mg of Tegratol.
Merry Xmas to you all
Ross
Chris Lesurf - 22 Dec 2005 03:26 GMT It obviously does have other causes but my fluid retention was definitely caused by Keppra as it started and stopped at the same time.
I can't even remember where I found out about fluid retention but I'll check in my British Medical Association reference book, 'Complete Family Health' and let you know if I find anything useful.
By the way, I hope that many of you will continue to chat over Christmas as my husband and I never go out to do anything very interesting over public holidays and having only the same person's company for 24hrs/day is too much, even if you love each other dearly.
Fortunately, I've come out of a 4 month long low into a bipolar high in time for Christmas which means I do have ideas for rewarding activities to plan and then develop in the New Year.
Wishing you all a Happy Hogmanay,
Chris L.
> > Something that may be of interest to others is that Keppra caused fluid > > retention which made joints uncomfortable and nealry led to my having an > > operation for carpal tunnel suyndrome.
> Hi Chris, is there anywhere we could get more information on this - it's > just that I've never heard of it before, but have always had fluid > retention, for years before I was put on Keppra?
> Couldn't fluid retention also be the after effects of several other meds > or natural day to day conditions?
> All the best
> Sofie
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