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Medical Forum / Diseases and Disorders / Epilepsy / October 2005

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Seizures and hypothroidism and Codeine

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belindaas@dodo.com.au - 18 Oct 2005 04:14 GMT
Hi

I have a history of complex partial seizures. I was seizure free with
tegretol for a few years until last year when I had a car accident
(Didn't hit head) and took panadeine for the pain. I had a numb arm and
felt lousy and doctors looked for nerve damage from the accident.No
nerve damage but I finally figured out why I was having seizures at
night - the codeine - they stopped as soon as I stopped taking the
panadeine (codeine).

Now I have started having night seizures again. The only thing I have
done recently is stopped taking my thyroid medication (I have a low
thyroid). Can anyone shed any light on why I would have seizures now?
Does the thyroid hormone increase the effectiveness of Tegretol and I
have upset the balance or does a low thyroid make one with epilepsy
more prone to seizures. I must add that I didn't have less seizures
when going on thyroid medication many years ago.

Has anyone else had seizures with codeine and what are we able to take
if we get a really bad headache?? I have also notice that I am more
prone to seizures if I take asthma steriods, I can't think of the name
right now as my brain doesn't feel like working properly right now.....

Any light shed on this would be great

Thanks

Bel
Patsy and Darryl - 18 Oct 2005 04:47 GMT
> Hi
>
[quoted text clipped - 24 lines]
>
> Bel

Hi Bel,

There are some doctors who say that having seizures makes it easier to have
more seizures and there are some who disagree. Whilst I'm certainly no
doctor, in my opinion the first group is right. I believe that each seizure
you have burns a path within your brain and later seizures use the same
path.

If that is the case, it may be that although you were free of seizures for a
time, when you reacted to the codeine and it triggered your seizures to
begin again it then became more likely that you would have yet more
seizures. It may be necessary to address your anti-epileptic medication
levels to get your seizures under control again and hopefully they will
eventually go away.

Just my opinion for what it's worth.

I just did a search on google and found this site:
http://www.drugs.com/codeine.html
On that site it said the below:

"Who should not take codeine?
    .  Codeine is habit forming and should only be used under close
supervision if you have an alcohol or drug addiction.
    .  Before taking this medication, tell your doctor if you have
        · kidney disease;
        · liver disease;
        · asthma;
        · urinary retention;
        · an enlarged prostate;
        · hypothyroidism;
        · seizures or epilepsy;
        · gallbladder disease;
        · a head injury; or
        · Addison's disease"

By the way, the asthma steroid is called Symbicort.

Darryl.
belindaas@dodo.com.au - 18 Oct 2005 14:15 GMT
HI Daryl

THanks for that. I have remembered the asthma medicine was prednisolone
now. I am starting to feel its not a case of what other medications we
cannot take but what CAN we take with AEDS? In both cases my doctors
have been surprised at the interactions!

Bel

> Hi Bel,
>
[quoted text clipped - 35 lines]
>
> Darryl.
Patsy and Darryl - 18 Oct 2005 23:31 GMT
HI Daryl

THanks for that. I have remembered the asthma medicine was prednisolone
now. I am starting to feel its not a case of what other medications we
cannot take but what CAN we take with AEDS? In both cases my doctors
have been surprised at the interactions!

Bel

> Hi Bel,
>
[quoted text clipped - 38 lines]
>
> Darryl.

Hi Bel,

That same website I mentioned said this about Prednisolone - similar to what
it said about codeine:

"Who should not take prednisolone?
.  Do not take prednisolone if you have a serious bacterial, viral, or
fungal infection. Prednisolone weakens the body's immune response and thus
its ability to fight infection.
.  Before taking this medication, tell your doctor if you have
     · kidney disease,
     · liver disease,
     · high blood pressure or heart disease,
     · ulcerative colitis, diverticulitis, or stomach ulcers,
     · hypothyroidism,
     · a psychiatric condition,
     · osteoporosis,
     · myasthenia gravis,
     · diabetes mellitus, or
     · any other medical conditions.
.  You may not be able to take prednisolone, or you may require a dosage
adjustment or special monitoring during treatment if you have any of the
conditions listed above.
.  Prednisolone is in the FDA pregnancy category C. This means that it is
not known whether prednisolone will harm an unborn baby. Do not take this
medication without first talking to your doctor if you are pregnant."

Darryl
G.Ross - 18 Oct 2005 04:58 GMT
> Hi
>
[quoted text clipped - 18 lines]
> prone to seizures if I take asthma steriods, I can't think of the name
> right now as my brain doesn't feel like working properly right now.....

  I was told I could use Tylenol, if I ever needed to, for headaches.  (I
use Tegretol CR and Clobazam (Frisium) for CP Seizure control.)  I don't
know if  Tylenol describes the product you can get without a prescription
for colds or headaches.  I'd expect it would be a similar name where you
are, since that is the Patent owner's product name.
 The only stuff I've used above is the Tegretol.  In case you missed an
earlier post, I show all medications that. I buy for colds (I rarely have
now) or headaches, to the *pharmacist who fills my prescriptions.  She told
me that some use Alcohol as a carrier and that can mess up Tegretol levels.
  Also by accident I found that Grapefruit Juice will also interfere, in
case you've used that recently, with Tegretol.  One of the acids in G.Frt.
conflicts with the Tegretol.  Other juices don't have that problem.
   I had the numb arm effect you describe at top once or twice during the
first year or two I was using Tegretol CR. (I've used it now since about
1994- in 1996 we lowered the dose but added Frisium (Clobazam) that had just
been approved in Canada.)   Last CP seizure I had with that combination and
same med. strength was June 1998.   (But I don't take the other pills you
have to.)
   Did the Dr. or Pharmacy say anything about the thyroid meds. you had
been using, vs. how fast it should be removed?  In other words, if that was
recent,  did they stop those abruptly or slowly reduce them?   I know some
of the pills (like my former Dilantin and Tegretol)  if I lower doses, that
was done over periods of 2-4 weeks rather than a few days.     G.

> Any light shed on this would be great
> Thanks
> Bel

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