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Medical Forum / Diseases and Disorders / Epilepsy / September 2005

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Liver damage from AED

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BillX - 29 Sep 2005 22:39 GMT
Anyone on this group experienced permanent liver damage from taking one
or more AED?

I've been on Dilantin approaching 2.5 years now and my last blood test
showed AST/ALT levels at 89/217.  Upper normal range for ALT is around
50 and my prior highest ALT reading was 115 taken back in 2003.  Anyone
else on Dilantin have same or higher AST/ALT numbers?  I'm waiting for
my neurologist to respond to an email I sent his secretary on the
subject.  From experience doctors don't monitor this stuff very closely
unless the patient brings abnormalities to their attention.
G.Ross - 29 Sep 2005 23:40 GMT
> Anyone on this group experienced permanent liver damage from taking one
> or more AED?
[quoted text clipped - 6 lines]
> subject.  From experience doctors don't monitor this stuff very closely
> unless the patient brings abnormalities to their attention.

   I was never given those numbers you list above during the 18 months I
used it (1993).  I'm not sure what they'd mean to me vs. my Neuro, but
others don't have as good a Neuro as I had.
   Mine told me that Dilantin is one of the oldest, so best studied Med.
and is often given first to those who might be able to use it, as potential
side effects etc. are documented  (I had heard it was used in ~1930s? ),
since it's also cheaper.
   For my type of Complex Partials, I had to phase it out and replace it
with a stronger med (Tegretol) to get control that was more reliable that
what I was getting with just the Dilantin.   (I had erratic seizures,  from
1 a week to one each 4 weeks, back to 1 a week,  with nothing that I could
relate to when a szr. would arise or not. )
   There are some others here who use or have used Dilatin too, but a
couple don't read the group  each day, so keep checking here for more recent
experiences.
   (Did you check http://efa.org  or with your *Pharmacy to see if there
are any things listed to avoid?  Tegretol for example gets messed up with
Grapefruit juice, and it took me a while to relate the few times a month I
used G.fruit to the szr. or auras I had 24-36 hours after.)     G.
mrr5745 - 30 Sep 2005 01:30 GMT
FYI -

I looked up the lab values in a reference book.  It says that AST can be
elevated due to recent seizure activity.  Dilantin can cause increased ALT
levels (the book lists this as an interfering factor with the test, in
other words a falsely elevated level.)

On the other hand, I looked Dilantin up in a drug book and it lists
hepatitis (which is inflammation of the liver) as a dose related adverse
reaction to the drug.  So I would definitely keep on your Dr. about this.

MR
 
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