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Medical Forum / Diseases and Disorders / Epilepsy / September 2005Seizures / oxidative stress / lithium and valproate / vitamin E
Can J Neurol Sci. 1979 Feb;6(1):43-5. Related Articles, Links Vitamin E deficiency and seizures in animals and man. Ogunmekan AO. Study of 100 children with grand mal convulsive disorders and 100 medically healthy children of matching age showed significantly lower plasma levels of vitamin E in the former (means 632.2 +/- 17.3 and 822.5 +/- 21.8 micrograms/dl respectively; p less than 0.001). This finding accords with the ability to prevent seizures in rodents by giving alpha-tocopherol before exposing them to a convulsion-inducing environment. PMID: 122540 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------------- Chronic Treatment with Mood Stabilizers Lithium and Valproate Prevents Excitotoxicity by Inhibiting Oxidative Stress in Rat Cerebral Cortical Cells. Shao L, Young LT, Wang JF Biol Psychiatry. 2005 Jul 6; BACKGROUND: Recent studies indicate that chronic treatment with the mood-stabilizing drugs lithium and valproate produces a neuroprotective effect against excitotoxicity. In this study, we aimed to determine whether inhibiting oxidative damage plays a role in a neuroprotective effect of lithium and valproate against excitotoxicity. METHODS: Intracellular free calcium concentration was measured with the fluorescent calcium ion indicator fluo-3. Malondialdehyde, an end product derived from peroxidation of polyunsaturated fatty acid, and protein carbonyls were used to assess oxidative damage to lipid and protein. Excitotoxicity was assayed by measuring cell viability with the MTT [3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl tetrazolium bromide] method and by measuring deoxyribonucleic acid (DNA) fragmentation with TUNEL (terminal deoxynucleotidyltransferase-mediated deoxyuridine triphosphate nick end labeling) staining. RESULTS: We found that chronic treatment with lithium and valproate at their therapeutically relevant concentrations significantly inhibited the glutamate-induced increase of intracellular free calcium concentration, lipid peroxidation, protein oxidation, DNA fragmentation, and cell death in primary cultured rat cerebral cortical cells. This treatment had no effect on basal intracellular free calcium concentration, lipid peroxidation, protein oxidation, DNA fragmentation, and cell death. CONCLUSIONS: Our results suggest that chronic treatment with lithium and valproate inhibits oxidative damage to lipid and protein and in turn produces a neuroprotective effect against excitotoxicity. Abstract · PubMed · FullText · SFX · GS · Order · Clip · Citation · BibTeX · Related · TouchGraph · Scopus · References · Tag Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Square planar bis(imino)pyridine iron halide and alkyl complexes. Bouwkamp MW, Bart SC, Hawrelak EJ, Trovitch RJ, Lobkovsky E, Chirik PJ. Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853, USA. Square planar iron methyl complexes containing bis(imino)pyridine (PDI) ligands have been prepared by reductive alkylation of the corresponding ferrous dichloride; dialkylation is observed upon treatment with a larger alkyl lithium. PMID: 15997279 [PubMed - in process] Well at least you were able to incorporate .. something .. although .. vaguely related .. TO .. the thread .. Finally learned one of the basics of .. 'on topic' .. in .. the use of the internet .. newsgroups .. Eh .. doofus .. Jeez .. it seems it may even employ .. iron chelation .. Increased IP6 / inositol hexakisphosphate .. an iron .. chelator .. Psychopharmacol Bull 2001 Summer;35(3):5-18 Inositol, lithium, and the brain. Agranoff BW, Fisher SK Departments of Biochemistry and Psychiatry, Mental Health Research Institute, Neuroscience Laboratory, University of Michigan, 1103 East Huron Street, Ann Arbor, MI 48104-1687, USA. agranoff@umich.edu [Medline record in process] This review of the background and present state of knowledge of the interactions of inositol metabolism and lithium commemorates the 150th anniversaries of the discovery of inositol and, independently, of first attempts to use lithium as a therapeutic agent. We review the inositol depletion hypothesis, which proposes that lithium's beneficial action in the treatment of bipolar disorder is attributable to its inhibition of the enzymatic breakdown of inositol phosphates to free inositol. A resulting reduction in free intracellular inositol is proposed to slow the recycling of inositol-containing metabolites required for signal transduction. We offer an alternative hypothesis, which is also based on lithium's blockade of inositol phosphatase, but proposes that neural signal transduction is suppressed as a consequence of lithium-induced inositol phosphate accumulation rather than of inositol depletion. PMID: 12397875, UI: 22285581 Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > Study of 100 children with grand mal convulsive disorders and 100 > medically healthy children of matching age showed significantly lower > plasma levels of vitamin E in the former Hmmm? Is there a scientific study, or website, or even just something more substantial than your word that can prove any of this? I mean, wouldn't the neurologists have told us that vitamin E deficiency could be the problem of our tonic-clonic seizures if it were true? Besides, even if you were right, and all you say is true, then what about people amongst us who *have* been taking high doses of vitamin E in our food since we were children, and have never had anything wrong with our plasma in our lives, but are still getting an extremely large amount of grand mal seizures? Sofie  SignaturePlease visit my deviantART page: http://sofen.deviantart.com/ >>Study of 100 children with grand mal convulsive disorders and 100 >>medically healthy children of matching age showed significantly lower [quoted text clipped - 13 lines] > Sofie > Well, one of my old neuro's did tell me that vitamen E and calcium and magnesium supplements _might_ help. I tried them for a couple of years. Can't say if they helped or hurt. I've actually been wondering about this recently.
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