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Medical Forum / Diseases and Disorders / Diabetes / October 2005

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Creatinine/Blood glucose levels Etc.?

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kumar - 27 Sep 2005 11:23 GMT
Hello,

Can you tell me that whether persistent higher blood glucose level come
down or controlled in a diabetic T2 patient who is either on oral
hypogycemic medicines or on Insulin on his serum creatinine level is
elevated? Whether elevated serum creatinine level can lower persetent
higher BG level? Of yes how?

Furthur, Is there any compesating balance of carbs, fats & protien in
blood/body? I mean, if level of one is higher in blood, can level of
other be lower compensating it to maintain energy & blood
viscosity/flow?
REP - 27 Sep 2005 12:06 GMT
> Hello,
>
[quoted text clipped - 3 lines]
> elevated? Whether elevated serum creatinine level can lower persetent
> higher BG level? Of yes how?

Uncontrolled BG levels will almost always lead to compromised kidney
function. That said, a high BG one day will not led to a high serun
creatinine level that day. Over time, a person with uncontrolled BG (an
HbA1c of 8% or higher) is much more likely to experience diabetic
nephropathy than a person with a well-controlled BG (not set in stone,
however; a peson with perfect control can still have DN). The usual
course of kidney dysfunction in diabetics is an initial period of
'hyperclearance,' with a very low serum creatinine and a very high
24-hour urine creatinine as the kidneys are overclearing - as one bok
puts it, burning themselves out. During this time, the patient may also
begin to have albumenuria or frank proteinuria. After a period (which
can be years), the kidneys 'slow down' and the serum creatinine creeps
up while the urine creatinine goes down.

In short, controlling BG to as close as possible to normal (that is,
non-diabetic levels) in diabetics can help prevent or slow down the
progress of diabetic nephropathy, but day-to-day BG and serum creatinine
levels aren't that closely linked. If you go in with a BG of 220 today
and your serum creatinine is .7 and tomorrow your BG is 120, your serum
creatinine is likely again to be .7. Dehydration, overexertion and
overconsumption of caffienated drinks (at least according to the lab
hand-outs I'm given) are more likey to have an immediate effect on serum
creatinine results.

> Furthur, Is there any compesating balance of carbs, fats & protien in
> blood/body? I mean, if level of one is higher in blood, can level of
> other be lower compensating it to maintain energy & blood
> viscosity/flow?

Erm, not sure what you're asking, but if the serum creatinine is high,
then no, nothing is compensating. If the serum creatinine is outside the
normal range, a nephrologist needs to be consulted for, among other
things, dietary restrictions appropriate to the patient.

If this query is about your lab results and BG, be sure to ask your
doctor for information, guidance and advice. Kidney disease is nothing
to play around with.

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kumar - 28 Sep 2005 05:20 GMT
Thanks. Btw, can hyperclearace of insulin(low creatnine level) due to
polyuria in diabetic patients be a cause of persistent high blood
glucose?

My second question is not related to creatnine level. I just want to
know that whether there is a homeostatis or dependance of on one
nutrient on the level of other? Suppose a patient has high BG, cn he
have low TG levels or oppsite?
REP - 28 Sep 2005 09:21 GMT
> Thanks. Btw, can hyperclearace of insulin(low creatnine level) due to
> polyuria in diabetic patients be a cause of persistent high blood
> glucose?

Renal hyperclearance is not the overclearance of insulin; it's the
overclearance of creatinine. As with almost all kidney diseases, the
exact cause of diabetic nephropathy is poorly understood; while a
patient with poorly controlled BG is much more likely to develop DN,
diabetics with excellent control still can and do develop it. Higher
than normal BG undoubtedly plays a role, as does high blood pressure
(when present), but it is also likely that there are autoimmune
responses at work to account for the damage of DN.

> My second question is not related to creatnine level. I just want to
> know that whether there is a homeostatis or dependance of on one
> nutrient on the level of other? Suppose a patient has high BG, cn he
> have low TG levels or oppsite?

Well, sure, someone with diabetes can have hypo/hyperthyrodoism.
Hypothyroidism is not uncommon with autoimmune diseases, such as lupus,
Addison's disease or type 1 (insulin-dependent) diabetes (etc).

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"Did Father shoot him? I will eat Grandfather for dinner."
- Helen Keller, on learning of the death of her grandfather

Kumar - 30 Sep 2005 05:10 GMT
Thanks. Can you tell me something about renal loss/clearance of insulin
in urine? Whether there is less or more urinary loss/clearance of
insulin? It looks that, this aspect  is bit poorly studied?
REP - 30 Sep 2005 05:58 GMT
> Thanks. Can you tell me something about renal loss/clearance of insulin
> in urine?

I can't, but here's an article:

http://www.pubmedcentral.com/articlerender.fcgi?artid=297095

Signature

"Did Father shoot him? I will eat Grandfather for dinner."
- Helen Keller, on learning of the death of her grandfather

Hawki63@sbcglobal.net - 30 Sep 2005 17:32 GMT
>> Hello,
>>
[quoted text clipped - 41 lines]
> doctor for information, guidance and advice. Kidney disease is nothing
> to play around with.

excellent response and explanation...

another caveat..from a nurse who worked in dialysis for 18 years....last
stat I remember was somewhere around 25% of folks with kidney failure are
diabetics...

with that knowledge...AND the above facts that explain how long and gradual
kidney damage is in a diabetic...the most important "prevention" strategy is
to aim for the lowest HgbA1C you can...

all diabetics need careful monitoring and follow up...and prompt referral to
a nephrologist when creatinine is rising..

good luck
Kumar - 02 Oct 2005 04:31 GMT
Thanks. Rep, that link don't give all details. I think I should post
this aspect in new topic.
REP - 03 Oct 2005 10:46 GMT
> Thanks. Rep, that link don't give all details.

No, but it's a place for you to start to do your own research. Medline
and Google are your friends.

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"Did Father shoot him? I will eat Grandfather for dinner."
- Helen Keller, on learning of the death of her grandfather

 
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