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Medical Forum / Diseases and Disorders / Diabetes / April 2008From Rosaglitazone to Pioglitazone ?
Just had my 6 monthly check-up at the Doctors. All went well - no problems mentioned - HB1AC in the consistently good range ... yet my GP has changed me from Avandamet (Metformin & Rosaglitazone 2 x 1000mg daily) to Competact (Metformin & Pioglitazone 2 x 850mg daily) .. Anyone know the difference between the two ? Should I be worried ? Cheers Jim! > Just had my 6 monthly check-up at the Doctors. All went well - no > problems mentioned - HB1AC in the consistently good range ... yet my > GP has changed me from Avandamet (Metformin & Rosaglitazone 2 x 1000mg > daily) to Competact (Metformin & Pioglitazone 2 x 850mg daily) .. > > Anyone know the difference between the two ? Should I be worried ? The change has probably been made because there are stories around, concerning links between rosiglitazone and, I believe, heart complaints. I don't really understand what it's all about though... Jonathan. >> Just had my 6 monthly check-up at the Doctors. All went well - no >> problems mentioned - HB1AC in the consistently good range ... yet my [quoted text clipped - 8 lines] > > Jonathan. yes, that's correct, a higher incidence of heart complications was experienced when someone did a 'meta analysis' of a lot of studies for Avandia my endo indicated that the first 3 months of Avandia are the critical months to follow to ensure that you are not one of these people who has heart problems associated with Avandia, and that the longer you are on Avandia, the less chance that you are one of these people at risk in other words, he didn't feel there need be a change in my meds, but if i wasn't going to take the Avandia, he would prescribe the Actos instead recent studies show that Avandia AND Actos 'clean the arteries' in diabetic patients, as well, so that's another plus for being on one of these meds :) kate >>> Just had my 6 monthly check-up at the Doctors. All went well - no >>> problems mentioned - HB1AC in the consistently good range ... yet my [quoted text clipped - 24 lines] >diabetic patients, as well, so that's another plus for being on one of >these meds :) Yes that's very much how I also read the real information rather than the panics. They are both contraindicated in a small subset of patients for whom they can actually be dangerous. This subset is somewhat smaller for Actos than for Avandia. AND this was clearly stated on the prescribing information . . . >>>> Just had my 6 monthly check-up at the Doctors. All went well - no >>>> problems mentioned - HB1AC in the consistently good range ... yet my [quoted text clipped - 32 lines] > This subset is somewhat smaller for Actos than for Avandia. AND this > was clearly stated on the prescribing information . . . yes........... AND if you are one of the 'at risk' people, typically your ankles and legs swell up noticeably in no time at all, causing you to gain weight if my legs and ankles were to swell up, i would be back in the Dr's office right away !  Signaturekate type 1 since 1987 www.diabetic-talk.org >>>>> Just had my 6 monthly check-up at the Doctors. All went well - no >>>>> problems mentioned - HB1AC in the consistently good range ... yet my [quoted text clipped - 39 lines] >if my legs and ankles were to swell up, i would be back in the Dr's >office right away ! Isn't it ironic when they ban perfectly good drugs just because a minority of individuals have problems with them? If the penicillins or aspirin had only just been invented they'd almost certainly never get to market. Yet at the same time a GP who prescribed penicillin to an allergic patient would get into trouble. But the same GP could prescribe a high carb diet to someone with a carb intolerance and get into trouble only if they recommended the opposite . . . >Yet at the same time a GP who prescribed penicillin to an allergic >patient would get into trouble. But the same GP could prescribe a high >carb diet to someone with a carb intolerance and get into trouble only >if they recommended the opposite . . . I learnt I was allergic to penicillin as a result of an injection of the stuff. I came down in a few hours with what looked like the Bubonic plague - HUGE blood blisters under my arms & in my groin. Spectacular. But it takes years to show bad effects from a high carb diet; a doc isn't going to get their nose rubbed in the bad decision because the feedback is too slow. Then there's stupidity - I remember the dietician simply not believing my diet/test log because I showed a high response to low-GI foods like rice and wholemeal bread. OTOH, I was stupid too - I actually ate the oatmeal she recommended... once... Nicky. T2 dx 05/04 + underactive thyroid D&E, 100ug thyroxine Last A1c 5.6% BMI 25 >>Yet at the same time a GP who prescribed penicillin to an allergic >>patient would get into trouble. But the same GP could prescribe a high [quoted text clipped - 10 lines] >high response to low-GI foods like rice and wholemeal bread. OTOH, I >was stupid too - I actually ate the oatmeal she recommended... once... My sympathies on both counts. When I was in hospital they brought in a guy for an appendectomy. Which went well, until they pulled his drip the following day. He was previously on a IV cephalosporin which was replaced by an oral one almost identical. Within minutes of taking the first pill he turned red and started sweating, then collapsed in anaphylaptic shock. VERY scary but at least it happened in the right place. It caused some consternation because the doctors had never seen someone show no allergy to one cephalosporin and such a horrendous reaction to a similar but different one, the rest of the day doctors from other wards were popping in just to *look* at him . . . Yes in much of medicine it's the patient not the doctor who's supposed to be "in denial" - diabetes is one of the few conditions where the opposite is true And when you show them the results they take your meter/strips away . . . snip >> This subset is somewhat smaller for Actos than for Avandia. AND this >> was clearly stated on the prescribing information . . . [quoted text clipped - 5 lines] > if my legs and ankles were to swell up, i would be back in the Dr's > office right away ! I gained 30 lbs. over the 7 months I was on Avandia. Doc did the liver test thing, twice. They say longterm heart damage isn't seen, I sure hope so, especially because it did SFA for my BG. Didn't have swelling at all. Vicki |
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