It's one of the many that my arthritis specialist tried me on (another
was Vioxx - before they found out the heart-related side effects!).
But that was way before I got to be T2[1].

Phil.

[1] Since discovered that not only do my mother and her brother have t2
diabetes but their mother and her brother did too. Ho hum. You can
choose your friends but not your genetics :-(

Hi Nicky,
it is prescribed for chronic pain , so there is a chance that it will
relieve neuropathic pain for someone (???) and not only prevent it.A few
COX2 inhibitors were retracted though  for their nasty side effects  :(

The strange thing with neuropathy for me is that I personally think that it
might be one of those things hampered by our habit to put things in
boxes.....

Does the pain stems from nerves or arteries ?

Maybe this is the wrong question.The bloodflow is controlled by nerves and
the nerves are fed by the arteries.So maybe the destinction between nerves
and arteries is just antropomorphic.The "thing" consisting of what we call
now nerves and arteries is broken !!!

I not only have pain in my hands and feet but they are always cold.So if the
problem has more to do with arteries then nerves than you got periferal
arterie desease.This condition can be medicated by ..... aspirin.

There is a lot of literature about the beneficial effect of aspirin on
arteries and if you have had a heart attack the standard procedure is a baby
aspirin.The sad thing is that there is also a lot of literature that aspirin
does not help the diabetes population , the population that needs it most.

So diabetes patients are said to be aspirin risistent : their periferal
arterie desease is not relieved by aspirin , it does not increase their
bloodflow.

I just found 1 article where the aspirin resistance is found to be caused by
......  bad glycemic control !!!! So if your bg is well under control you
are nolonger aspirin resistant and a baby aspirin a day will make your blood
thinner , increase the bloodflow and relieve the neuropathic pain because
the nerves are now better fed and the damage is repaired.

Here is the abstract :

J Thromb Haemost. 2007 Jul;5(7):1562-4. Epub 2007 Apr 19.
High levels of low-density lipoprotein cholesterol and triglycerides and
suboptimal glycemic control predict diminished ex vivo aspirin
responsiveness in patients with Type 2 diabetes.

Increased platelet aggregability contributes to the high incidence of
cardiovascular events in Type 2 diabetes [1]. The inhibition of platelet
aggregation by aspirin is effective in reducing cardiovascular events.
However, evidence of a beneficial effect in primary prevention in diabetic
patients is surprisingly scarce. Various studies using low-dose aspirin (£
100 mg) showed no event reduction in diabetic patients [2,3]. The failure of
aspirin to inhibit platelet function ex vivo (aspirin non-responsiveness) is
considered to be an explanation of the apparently attenuated benefit of
aspirin in this subgroup. Indeed, a reduced inhibition of platelet function
by aspirin was found in diabetic patients [4]. It is suggested that higher
aspirin dosages might overcome inadequate platelet inhibition [5]. Yet, in
patients with diabetes, it is unclear which factors determine the effect of
aspirin. To determine predictors of aspirin nonresponsiveness and to assess
differential effects of aspirin 300 mg compared to 100 mg, we evaluated
platelet aggregation in patients with Type 2 diabetes without cardiovascular
events in a randomized placebo-controlled crossover trial. We studied
subjects with Type 2 diabetes (n = 40). In conclusion, in our study, 18% of
diabetic patients showed ex vivo aspirin non-responsiveness, which was
predicted by high levels of LDL-cholesterol, triglycerides and suboptimal
glycemic control. Because in patients using aspirin 300 mg collagen-induced
aggregation was more inhibited and a lower incidence of non-responsiveness
was suggested, larger studies are warranted to test the hypothesis that an
increase in dosage may improve aspirin effectiveness in patients with Type 2
diabetes.

PMID: 17456193

So , as usual they would like to increase the amount of medication instead
of the glycemic control......

I just bought a few packs of baby aspirin to see if it helps against the
neuropathic pain.Aspirin is a very in-effective COX2 inhibitor however , so
the combination of Aspirin , for increasing bloodflow and a COX2 inhibitor
like Celecoxib might the the solution.... Who knows

Gys