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Medical Forum / Diseases and Disorders / Diabetes / August 2005

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Glucagon

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Alan Hardy - 21 Aug 2005 06:42 GMT
Can anyone plz tell me about when this should be used, and how to use it? i
have seen it mentioned in pumping threads, and other T1 threads, but not in
T2. Google gives so many hits that i didn't know where to start.

tyvm

Alan H

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Do, or do not. There is no try.

Yoda, The Empire Strikes Back

Never go to bed mad. Stay up and fight!

Phyllis Diller

Guys - 21 Aug 2005 07:02 GMT
>Can anyone plz tell me about when this should be used, and how to use it? i
>have seen it mentioned in pumping threads, and other T1 threads, but not in
[quoted text clipped - 3 lines]
>
>Alan H

It is used in severe hypos where oral input of food is not possible.

In my case my wife is trained in mixing the med and administering
the injection.  That may be a hard thing to do when the diabetic
still is not fully unconscious.  The medics (911) will check blood
glucose to make sure it is a hypo and then administer a
dextrose IV.  My recovery is usually quite fast.

You will see mention of it by those describing parts of the
internal glucose control system. Old  Al is well versed on that
aspect.

It is an expensive item.

                                 Guy
oldal4865 - 21 Aug 2005 12:49 GMT
Alan Hardy wrote in message ...
>Can anyone plz tell me about when this should be used, and how to use it? i
>have seen it mentioned in pumping threads, and other T1 threads, but not in
[quoted text clipped - 3 lines]
>
>Alan H

   Mostly for unconscious hypos.     It would work for any hypo but why
spend $80 to kill a hypo when sugar is around.

You buy it as a powder inside a vial.   If needed,  you inject water
(provided in the kit) into the vial,  dissolve the powder, then draw the
solution back into the syringe.     Inject into a large muscle.     (The
patient,  usually unconscious, does none of this)

Photo,  instructions and some interesting links at:

http://www.childrenwithdiabetes.com/d_0n_022.htm

". . .Glucagon, like insulin, must be injected. Within the glucagon kit are
a syringe pre-filled with a liquid and a vial of powdered glucagon. You
prepare the glucagon for injection immediately before use by following the
instructions that are included with the glucagon kit. In general, small
children (under 20 kg, or 44 pounds) are given 1/2 cc (half the syringe),
while older children and adults are given 1cc (the entire syringe). . ..
There is no danger of overdose, however. Injection is given in a large
muscle, such as the buttocks, thigh or arm. (The needle on the syringe is
usually larger than those on insulin syringes.). . ."

Glucagon "commands" the liver to start releasing glucose.

Insulin "commands" the liver to not-release glucose.   Glucagon overrides
the insulin "not-release"  command.

Humans manufacture and use glucagon as part of their total
counter-regulatory system.   It's sometimes called the insulin
counter-hormone.

Regards
 Old Al
Alan Hardy - 21 Aug 2005 13:19 GMT
> Alan Hardy wrote
>>Can anyone plz tell me about when this should be used, and how to use it?
[quoted text clipped - 29 lines]
> muscle, such as the buttocks, thigh or arm. (The needle on the syringe is
> usually larger than those on insulin syringes.). . ."

I sorta thought it was only for emergency use, as yu confirm. It certainly
won't be any use whatsoever for me with all the preparation, coz i live
alone, mostly work alone, and if i'm unconcscious -- well yu get the
picture.

TY

Alan H
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Do, or do not. There is no try.

Yoda, The Empire Strikes Back

Never go to bed mad. Stay up and fight!

Phyllis Diller

None Given - 21 Aug 2005 20:26 GMT
> I sorta thought it was only for emergency use, as yu confirm. It certainly
> won't be any use whatsoever for me with all the preparation, coz i live
> alone, mostly work alone, and if i'm unconcscious -- well yu get the
> picture.

It could come in handy if you can't keep anything down to treat a bad hypo.

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Guys - 21 Aug 2005 21:20 GMT
>> I sorta thought it was only for emergency use, as yu confirm. It certainly
>> won't be any use whatsoever for me with all the preparation, coz i live
>> alone, mostly work alone, and if i'm unconcscious -- well yu get the
>> picture.
>
>It could come in handy if you can't keep anything down to treat a bad hypo.

Ordinarily it is used on an unconscious person

For instance, I can handle a moderate low blood sugar
situation bur may hit every thing in the kitchen getting
some sugary food. NOt exactly a rational endeavor.

Hypo to me means a nightmare situation or completely
unconscious..   It is not a nice scene.

Once I lay out for two hours until my wife came home.
The medic said the first blood sugar did not read;

There are all variations here.,

Before this situation developed I would feel low blood sugar
and grab some sugar and set down quietly for a while. Then
resume my activities.

I would prefer to get a garbage bag and empty out my diabetes items.
But we have to be realistic and deal with the problem.

The posting here gives all of us a big plus but hope some
aspects never develop.

Most of the biggies we discuss came as a complete surprise to me.

All we had were some "junk books" :-)  and  bad word of mouth.
Didn't work well for me.   TODAY   you can not clam that excuse.

Even today I grab any scrap of paper with the word  diabetes on it
No ADD on diabetes for me.
                                             Guy
Alan Hardy - 21 Aug 2005 22:03 GMT
> Alan Hardy wrote
>> I sorta thought it was only for emergency use, as yu confirm. It
[quoted text clipped - 5 lines]
> It could come in handy if you can't keep anything down to treat a bad
> hypo.

Even with a moderate hypo of only 54 to 60 i lose concentration and
co-ordination. There is no way i need glucagon injected at that level, and i
still could not manage the mixing and shooting at such a level. So, avoid
the hypos is the right way for me, and thus far on the pump i have. Yeah,
only 4 weeks, but i used to be hypo 3-5 time per week [down to 36 or 45],
and seriously spiked once or twice [over 350]. Now on the pump i get not one
of either, and weight increasing, and i can eat what i want when i want.

And 2 years and more ago i was seriously opposed to the idea of pumping.
Read too much Bernstein, y'see.

Alan H
Vicki Beausoleil - 21 Aug 2005 13:00 GMT
> Can anyone plz tell me about when this should be used, and how to use it? i
> have seen it mentioned in pumping threads, and other T1 threads, but not in
[quoted text clipped - 12 lines]
>
> Phyllis Diller

Glucagon is a drug that forces your liver to dump. It should only be
used for very severe hypoglycemia (unconscious or almost unconscious),
so it has to be used by someone else.

Each kit is one adult dose. It has to be mixed and then injected like
insulin. A glucagon injection will usually cause nausea and you really
feel crappy when you come out of the hypo, but at least you come out of
it.

Here's the instructions from the kit:

1. Glucagon is an emergency drug to be used only under the direction of
a physician. People in regular contact with a person with diabetes
should become familiar with the following instructions before an
emergency arises.

2. In case of insulin coma or severe insulin reactions, where
carbohydrates cannot be taken, administer glucagon and call physician
promptly.

3. Act quickly. Prolonged unconsciousness may be harmful.

4. Inject glucagon in the same way that insulin is injected (see
following directions). Turn the patient on his/her side. The patient
usually awakens within 15 minutes. Feed the patient as soon as he/she
awakens and is able to swallow.

6. There is no danger of overdose.

7. If recommended by a physician, give half of the mixed dose of
glucagon to small children.

TO PREPARE GLUCAGON FOR USE   

1. Remove flip-off seal from bottle of glucagon.

2. Remove the needle protector from the syringe, and inject the entire
contents of the syringe into the bottle of glucagon. Remove the syringe
from the bottle.

3. Swirl bottle gently until the glucagon dissolves completely.    GLUCAGON
SHOULD NOT BE USED UNLESS THE SOLUTION IS CLEAR AND OF A WATER-LIKE
CONSISTENCY.   

-then it gives instructions on how to inject, but it's just like
insulin.

Hubby gets annual training with the expired kit and an orange. He dreads
the thought of having to give me a shot, but he dreads the severe hypos
even more. He's never had cause to use it on me. I didn't start getting
a kit until my endo confirmed I was T1 and I was on MDI. It was the R &
N regimen before MDI that caused all the bad hypos.

Alan, if you live alone it's somewhat pointless to have one. EMTs carry
kits in the ambulance. Discuss with the doc, obviously.

HTH

Vicki
sechumlib - 21 Aug 2005 13:50 GMT
A glucagon injection will usually cause nausea and you really
> feel crappy when you come out of the hypo, but at least you come out of
> it.

Actually, that's not true for everyone. In the one or two instances when
I have been treated with glucagon, I didn't feel any worse when I came
out of it than I usually do. (And I usually feel fine!)
Vicki Beausoleil - 21 Aug 2005 15:43 GMT
> A glucagon injection will usually cause nausea and you really
> > feel crappy when you come out of the hypo, but at least you come out of
[quoted text clipped - 3 lines]
> I have been treated with glucagon, I didn't feel any worse when I came
> out of it than I usually do. (And I usually feel fine!)

I've never had cause to use the stuff, so my info is second-hand. I
think it was Nico or Mack that posted in the past the glucagon makes
them vomit and gives a headache afterwards.

The instructions also warn that the glucagon may cause vomiting, that's
why the instructions say to turn the patient on their side to prevent
choking.

Vicki
Guys - 21 Aug 2005 18:25 GMT
>> A glucagon injection will usually cause nausea and you really
>> > feel crappy when you come out of the hypo, but at least you come out of
[quoted text clipped - 13 lines]
>
>Vicki

We get selfish and think we are the only true diabetic..
Each person is different.  I like the group because it allows me to
see a much wider world.  And some of the irrationality at times.

The important thing here is the knowledge of Glucagon and
we must decide if it is for us.

I need it  since if it works  I spend  $70  instead of
around $700 for a 911 run.

Hypos are a bear for me and I feel horrible for a
long time.  I do have memories of the nightmare
situation where I was aware I was in trouble,
The surrounding were very strange and I was fighting to
get away from the nightmare.

Other times I was normal and then I slowly woke up
trying to figure out where I was.  Once under a
earth moving machine, once with the 911 people
working on me in my driveway.

My problem started when I was given an insulin
resistance drug and l lost my glucose release mechanism
that normally protect us from hypos  I still have to carry
higher blood sugars to avoid problems.

A young ER doc finally gave me the clue that
allowed a control of the problem.  I have posted
on this over the years.

The potential for problems is still out there.
I never inject enough insulin for my system
to go below 50. One reason  I use the
measure, calculate, and inject method.
   
                          Guy,

The reason for posting this is to help diabetics
understand what may come up in their case.
I was totally ignorant when I was hit first.

That compounds the problem.
David - 21 Aug 2005 17:12 GMT
> A glucagon injection will usually cause nausea and you really
>
[quoted text clipped - 4 lines]
> I have been treated with glucagon, I didn't feel any worse when I came
> out of it than I usually do. (And I usually feel fine!)
I've had glucagon 3 or 4 times and feel like crap afterwards, but it
beats the alternative.  My bg will sore well over 350 in a matter of
minuts and I get nauseated but not to the point of upchucking.

Dave
David - 21 Aug 2005 17:15 GMT
> I've had glucagon 3 or 4 times and feel like crap afterwards, but it
> beats the alternative.  My bg will sore well over 350 in a matter of

DOH!  "soar"; not "sore".  sigh.
sechumlib - 21 Aug 2005 17:28 GMT
>> I've had glucagon 3 or 4 times and feel like crap afterwards, but it
>> beats the alternative.  My bg will sore well over 350 in a matter of
>
> DOH!  "soar"; not "sore".  sigh.

Well, it makes me sore if my BG soars that high. Fortunately, that
hasn't happened to me when I had to have glucagon administered. Nor has
the "feeling like crap".
Ma¢k - 22 Aug 2005 17:18 GMT
On Sun, 21 Aug 2005 05:42:34 GMT, "Alan Hardy"
<Kemo.Sabe@loneranger.com> Huffed and Puffed the following into the
madness of usenet:

>Can anyone plz tell me about when this should be used, and how to use it? i
>have seen it mentioned in pumping threads, and other T1 threads, but not in
[quoted text clipped - 3 lines]
>
>Alan H

type 2s rarely would have a need.  are you having severe hypos that
cause you to black out or come very close to blacking out?

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Alan Hardy - 22 Aug 2005 17:34 GMT
> Alan Hardy Huffed and Puffed the following into the
> madness of usenet:
[quoted text clipped - 11 lines]
> type 2s rarely would have a need.  are you having severe hypos that
> cause you to black out or come very close to blacking out?

i was on beef neutral, and b4 that on NPH, Novolog, and Mixtard. Not now. i
queried because i saw that some of the other and more experienced pumpers
mentioned it. No other reason for my enquiry.

Alan H
 
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