I've had diabetes for 15 years (type 1). I used to have severe
nocturnal leg cramps in both legs due to diabetic microangiopathy. My
endocrinologist recommended pycnogenol (30 mg) before bedtime. I've
been taking it for 14 months and I haven't had a cramp since, starting
on the very first night!

Pycnogenol is extracted from French maritime pine bark. It's available
at most health food stores and most supplement sellers online. The
best price I've found for a four month supply (120 capsules) is at
www.puritansale.com for $17.27.

From www.pycnogenol.com:

"Cramps and Muscular Pain in diabetic microangiopathy

Some individuals with diabetic microangiopathy suffer from frequent
episodes of muscle pain and cramps in their legs even after walking
only short distances. The impaired blood supply causes rapid muscle
fatigue and cramping pain.

In a pilot trial with 22 patients with frequent leg cramps and pain
with diagnosed diabetic microangiopathy treatment with Pycnogenol®
dramatically improved symptoms which were significant as compared to
placebo treatment [Vinciguerra et al., 2006]. The average number of
leg cramping episodes in a week decreased from 8.9 to 3 after
treatment with Pycnogenol® for weeks, whereas numbers in the placebo
group decreased from average 9 to 7.8. The assessment of leg muscle
pain by a visual analogue scale revealed a significant decrease by
79.2% in the Pycnogenol® group, whereas pain reduction in the placebo
group was only 15.4%."

I hope this helps.

Regards,
John

P.S. I have not interest, personal or financial, in either website
above.