 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / Diseases and Disorders / Diabetes / May 2008Green Tea May Prevent Type 2 Diabetes
Green tea extract may help prevent type-2 diabetes through improved glucose tolerance (NewsTarget) A new study by DSM Nutritional Products shows that epigallocatechin gallate, commonly known as EGCG, improves glucose tolerance in diabetic rodents and could be a positive addition to dietary prevention of type 2 diabetes, if the results can be applied to humans. "To our knowledge, we provide the first evidence that EGCG consumed in the diet exerts potent antidiabetic activity in vivo in a dose- dependent manner," wrote lead author Swen Wolfram of DSM in the Journal of Nutrition. The study looked at 37 male mice who were severely diabetic, and divided them into four groups. The rats were fed 2.5, 5 or 10 grams of EGCG per kilogram of diet, or a placebo, for seven weeks. At the five-week mark, the researchers tested oral glucose tolerance and found that glucose levels reduced by 23, 35 and 48 percent in the 2.5-, 5- and 10-gram categories respectively. At six weeks into the study, the scientists tested insulin tolerance and blood samples were taken at the end of the test to analyze glucose, free fatty acids and triacylglyceride levels. All improved on a dose-dependent basis. The researchers also studied the effects of 5 grams of EGCG per kilogram of diet over a 10-week period on mildly diabetic rats and found that glucose tolerance, blood glucose levels, and free fatty acid plasma concentrations all improved. Analysis of rat liver cells revealed that EGCG down-regulated the genes involved in gluconeogenesis and the synthesis of fatty acids, triacylglycerol and cholesterol. "Our data suggest that supplementation with EGCG could potentially improve glucose tolerance in humans with type-2 diabetes mellitus," concluded the researchers. "This hypothesis should now be investigated in randomized placebo-controlled trials." Wolfram said that DSM intends to begin such trials soon. In the United States, more than 20 million people suffer from diabetes -- about 7 percent of the population -- and about 19 million people in the European Union are so afflicted -- about 4 percent of the population. The cost of treating the disease is about $132 billion, according to the American Diabetes Association. To learn and for more information visit: http://www.avatrim.com/?aid=128372 >Green tea extract may help prevent type-2 diabetes through improved >glucose tolerance G'day G'day Maggie, Thanks for the post. Readers will realise it is long, long jump from epigallocatechin gallate.EGCG in rodents to green tea drinking by humans. In fact it makes me quite EG if you CG what I mean. EGCG is the active ingredient in tea. To get the equivalent dosage in humans one would have to drink a heck of a lot of tea. At the highest dose rate some T2 diabetics would need 10 x 100 grams of EGCG. That is 1000 grams. Whoops. That is a kilogram of EGCG. Even if tea were pure EGCG which it clearly isn't one would need to make a brew with a kilogram of tea leaves per day. To me it looks suspiciously like a promotion stunt for future supplement sales of green tea extract. As is so often the case exercise and diet does the hard yards. Supplements and for that matter various oral meds supplement the hard work that must first be put in. >(NewsTarget) A new study by DSM Nutritional Products shows that >epigallocatechin gallate, commonly known as EGCG, improves glucose [quoted text clipped - 31 lines] >in randomized placebo-controlled trials." Wolfram said that DSM >intends to begin such trials soon. Best wishes to all those who approach life with a degree of wisdom,  SignatureQuentin Grady ^ ^ / New Zealand, >#,#< [ / \ /\ "... and the blind dog was leading." http://homepages.paradise.net.nz/quentin > >Green tea extract may help prevent type-2 diabetes through improved > >glucose tolerance [quoted text clipped - 12 lines] > Even if tea were pure EGCG which it clearly isn't one would need to > make a brew with a kilogram of tea leaves per day. <read, noted, and snipped> > Best wishes to all those who approach life with a degree of wisdom, Without the LORD, there can be no degree of wisdom or intelligence because HE is the Source of all wisdom and intelligence. Indeed, it remains much smarter to simply eat less, down to the right amount: http://HeartMDPhD.com/BeSmart Here is a simple parable given in hopes of promoting greater understanding: http://HeartMDPhD.com/Parable Life in industrialized nations is life in blessed feedlots ! ! ! Be hungry... be healthy... be hungrier... be euglycemic: http://TheWellnessFoundation.com/BeHealthier Prayerfully in the infinite power and might of the Holy Spirit, Andrew <>< -- Andrew B. Chung, MD/PhD Lawful steward of http://EmoryCardiology.com A latter-day disciple of the KING of kings and LORD of lords. http://HeartMDPhD.com/HolySpirit/DiscipleNow >>Green tea extract may help prevent type-2 diabetes through improved >>glucose tolerance [quoted text clipped - 7 lines] > EGCG is the active ingredient in tea. To get the equivalent dosage in > humans one would have to drink a heck of a lot of tea. One of the recent studies I read suggested 5 to 10 cups of green tea a day would be needed. (green+tea+gluconeogenesis+10+cups - http://tinyurl.com/5bz6au) At higher doses green tea's epigallocatechin gallate (EGCG) can be toxic. There is a dose dependent effect before reaching the "J" curve's toxic level while the two gluconeogenesis inducing enzymes end up still having reduced gene expression. ----- I also began taking green tea extract 2 days ago which is suppose to reduce the gene expression of the key enzymes including phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase that promote gluconeogenesis. (Some of my archived posts on green tea - http://tinyurl.com/5t4bjc. A few more archived posts by eliminating Frank and Jefferson from search terms,i.e., green+tea+gluconeogenesis). Also a scholar.google search for green+tea+gluconeogenesis resulted in 659 finds - http://tinyurl.com/6kzzpp. ----- I have seen other reports that quercetin has a "J" shaped response curve, so the notion that more is better is not the route to take in many instances. Frank >>>Green tea extract may help prevent type-2 diabetes through improved >>>glucose tolerance [quoted text clipped - 31 lines] > >Frank Thanks Frank, What level of quercetin is safe? Quercetin with bromelain is available here as a supplement. So is turmeric. I seem to recall you mentioning it too had a j-curve. With other things on my mind I didn't get to follow up what was a useful safe dose. Best wishes, SignatureQuentin Grady ^ ^ / New Zealand, >#,#< [ / \ /\ "... and the blind dog was leading." http://homepages.paradise.net.nz/quentin Hi Quentin: >>I have seen other reports that quercetin has a "J" shaped response >>curve, so the notion that more is better is not the route to take [quoted text clipped - 10 lines] > things on my mind I didn't get to follow up what was a useful safe > dose. I tried to find a source, but didn't after an hour or so. Some how it seemed to relate as a comparator to resveratrol. If I find it later I will post the dose dependence of quercetin. Words like cytotoxicity and prooxidant did not find a source. Int J Mol Med. 2005 Aug;16(2):275-8.Links Safety of quercetin for clinical application (Review). Okamoto T. Research Laboratories, Nippon Chemiphar Co., Ltd., 1-22 Hikokawato, Misato, Saitama 341-0005, Japan. t-okamoto@chemiphar.co.jp Quercetin is the major flavonoid involved in vegetables and fruits. Quercetin is ingested from the daily diet, but in 1970s it was reported as mutagenic. Quercetin possesses a variety of pharmacological activities, and in order for further clinical application, it is important to evaluate its safety. In Ames test, quercetin is regarded as mutagenic. However, recent in vitro studies indicate that quercetin is protective against genotoxicants, and regarded as antimutagenic. Some in vivo studies including National Toxicology Program reported carcinogenic effect of quercetin in F344 rats. However, the method used in the study was unusual and the result was not reproduced. Most of the results of in vivo studies indicate that quercetin is not carcinogenic. Since 1969, the International Agency for Research on Cancer (IARC) has undertaken a program to evaluate the carcinogenic risk of chemicals. In 1999, IARC concluded that quercetin is not classified carcinogenic to humans. In the U.S. and Europe, supplements of quercetin is commercially available, and beneficial effects of quercetin supplements were reported in clinical trials. Overall, quercetin is genotoxic to salmonella, but its safety upon human application is approved. PMID: 16012761 [PubMed - indexed for MEDLINE Frank >Hi Quentin: >> [quoted text clipped - 47 lines] > >Frank G'day G'day Frank, I'm impressed with the amount of effort you put into sift fact from hearsay. May I be so bold as to remark on what an asset you are to ASD, keeping us on the straight and narrow ... well actually on the complex winding path with a multitude of seemingly contradictory research results. <griN> Best wishes, SignatureQuentin Grady ^ ^ / New Zealand, >#,#< [ / \ /\ "... and the blind dog was leading." http://homepages.paradise.net.nz/quentin |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2008 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.