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Medical Forum / Diseases and Disorders / Diabetes / May 2008Aspirin Reduces Blood Glucose
This would go along with the increased iron hypothesis because aspirin is proposed to be simply a substance produced by a plant to grab iron. Published: 06:20 EST, April 29, 2008 http://www.physorg.com/news128668808.html Aspirin-like compounds increase insulin secretion in otherwise healthy obese people Aspirin-like compounds (salicylates) can claim another health benefit: increasing the amount of insulin produced by otherwise healthy obese people. Obesity is associated with insulin resistance, the first step toward type 2 diabetes. Aspirin and other salicylates are known to reduce blood glucose in diabetic patients. New research accepted for publication in the Journal of Clinical Endocrinology & Metabolism reveals a similar beneficial effect among obese individuals by increasing the amount of insulin secreted into the bloodstream. "The administration of a salicylate led to the lowering of serum glucose concentrations," said Jose-Manuel Fernandez-Real of the Institut d'Investigacio Biomedica de Girona and CIBEROBN Fisiopatologia de la Obesidad, Spain, and lead author of the study. "These findings highlight the importance of further research on the possible therapeutic benefit of aspirin in the fight against type 2 diabetes." For their study, Fernandez-Real and his colleagues evaluated the effects of triflusal (a derivative of salicylate) on 28 subjects (nine men and 29 women). The average age of the participants was 48 years old and their average Body Mass Index (BMI) was 33.9. A BMI of over 30 is considered obese. During three, four-week treatment periods, the study participants received a 600 mg dose, a 900 mg dose, or a placebo once per day. The researchers found that administration of triflusal led to decreased fasting serum glucose. Contrary to their expectations, insulin sensitivity did not significantly change during the trial. Insulin secretion, however, significantly increased in relation to the dose size. In conjunction with the human studies, the researchers also conducted laboratory studies on insulin-producing cells (known as islets of Langerhans) from mice and humans. The researchers observed that triflusal significantly increased the insulin secreted by these cells. "Aspirin therapy has been recognized to improve glucose tolerance and to reduce insulin requirements in diabetic subjects," said Fernandez- Real. "To our knowledge, this is the first study to show that salicylates lowered serum glucose in non-diabetic obese subjects. We believe that this effect was due to a previously unsuspected increase in insulin secretion rather than enhanced insulin sensitivity." Source: The Endocrine Society ----------------------------------------------- Iron Imbalance in Brain May Cause Migraine Updated: Fri, Sep 28 6:22 PM EDT By Will Boggs, MD NEW YORK (Reuters Health) - Abnormalities in the way the brain's pain control center handles iron may lead to the development of migraine attacks and headaches, according to a study by Kansas researchers. During migraine, a portion of the brain known as the periaqueductal gray matter (PAG) may fail to "switch on" to prevent pain, Dr. K. Michael Welch of the University of Kansas Medical Center in Kansas City told Reuters Health. "In migraine, a trigger such as stress activates the PAG but it does not switch on because it is dysfunctional," he explained, "or else switches on an abnormal part." The result? "Pain instead of no pain," according to Welch. His team studied levels of iron in the PAG of patients with either migraine headaches or recurrent, non-migraine headaches and compared them to levels in people without headache or migraine. Changes in iron levels can reflect changes in the way the cells of the PAG work, the authors pointed out. According to the report, published in a recent issue of the journal Headache, iron levels in the PAG were significantly increased in patients with migraine and those with headache compared to the headache-free group. In fact, the researchers pointed out, the longer patients had experienced headaches, the higher the iron levels in the PAG were, though iron levels at the beginning of their illness were still clearly higher than normal. Increased iron levels may be both a cause of migraine attacks and a result of repeated headaches, the investigators noted. "Thus, we believe that the increased (iron levels) in our migraine groups reflect impaired iron (balance), possibly associated with (nerve) dysfunction or damage," the authors concluded. "Perhaps the PAG abnormality is essential to the cause of the headache in migraine," Welch said. "The gradual deposition of iron increases dysfunction, and headaches coalesce from episodic to continuous." How, then, might one minimize the damage from increased iron stores? Welch advised, "Treat episodes quickly and prevent (attacks) whenever possible." SOURCE: Headache 2001;41:629-637. ------------------------------------------------------------ http://en.wikipedia.org/wiki/Salicylic_acid Salicylic acid is an enol of a β-keto carbonic acid and therefore forms purple complexes with iron(III) salts. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk "This would go along with the increased iron hypothesis because aspirin is proposed to be simply a substance produced by a plant to grab iron." There is no such "iron hypothesis" with which to agree. Jesus ate a mediterranean diet. On Apr 30, 6:31 am, pa...@ferris.com wrote: There is no such "iron hypothesis" with which to agree. << Explain the clinical trial .. then .. since it has been PROVEN iron in excess causes diabetes .. where is the iron coming from. You talk the big talk but cannot seem to come up with even a .. pathetic .. explanation. How come. Eh .. Because .. ? You are a stupid .. medical .. professional .. who cannot seem to do anything but experiments which would make Mengele .. cringe. You kill kids .. old people and pregnant women and fetuses Isn't that .. right .. http://www.clinicaltrials.gov/show/NCT00230087 Iron Depletion Therapy for Type 2 DM and NAFLD This study is currently recruiting patients. Verified by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) March 2006 Sponsored by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Information provided by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ClinicalTrials.gov Identifier: NCT00230087 Purpose The purpose of this study is to find out whether lowering the amount of iron in the body will result in less resistance to insulin and improved liver function in patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease. This may result in better diabetes control and/or a decrease in the amount of liver fat. Condition Intervention Phase Non-Alcoholic Fatty Liver Disease Diabetes Mellitus Procedure: iron depletion by phlebotomy Phase II MedlinePlus related topics: Diabetes Study Type: Interventional Study Design: Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Efficacy Study Official Title: Iron Depletion Therapy for Patients With Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease Further study details as provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): Primary Outcomes: · Improved insulin sensitivity as determined by:; (1) hyperinsulinemic euglycemic clamp method; (2) HOMA model- determined by the OGTT method Secondary Outcomes: · Change in serum aminotransferase levels; · Change in levels of serum, plasma and urinary markers of oxidative stress; · Changes in intrahepatic and intraabdominal fat content as determined by CT scan; · Change in serum levels of proinflammatory cytokines (ie IL-6, TnF-aR2) Expected Total Enrollment: 15 Study start: September 2005; Expected completion: January 2008 Last follow-up: October 2007; Data entry closure: December 2007 Nonalcoholic fatty liver disease (NAFLD) is a common liver disease in the United States. NAFLD can lead to severe liver disease in some patients. Patients with NAFLD develop resistance to the normal action of insulin. Insulin is important for processing sugar and fat and increased resistance to insulin leads to fat in the liver. There is a correlation between the amount of iron in a person's body and the ability of insulin to work properly. Several small studies suggest that removal of iron may improve both diabetes and NAFLD by lowering insulin resistance. The goal of this pilot study is to determine the effect of iron depletion on insulin sensitivity in patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease. This study will be performed as an ancillary P&F study to the NASH CRN; all participants will be recruited from the NASH CRN Database Study. Secondary outcome measures will include the effect of iron depletion on hepatic necroinflammation, markers of oxidative stress and intrahepatic fat content. Insulin resistance will be directly measured using a two- step hyperinsulinemic euglycemic clamp procedure, before and after iron depletion by phlebotomy. Oral glucose tolerance tests will also be performed in order to evaluate the efficacy of using the indirect, but less cumbersome, HOMA model to derive values of insulin resistance in this patient cohort. This study will advance our understanding of the role of body iron stores in the pathophysiology of type 2 diabetes mellitus and non-alcoholic fatty liver disease. If iron depletion results in improved insulin sensitivity, reduced hepatic necroinflammation and/or intrahepatic fat content, a large scale, randomized, controlled trial of iron depletion in patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease will be planned. Eligibility Ages Eligible for Study: 18 Years - 65 Years, Genders Eligible for Study: Both Criteria Inclusion Criteria Histological evidence of NAFLD and enrollment in NASH CRN Database Study Type 2 DM treated with diet or a stable dose of non-insulin sensitizing oral hypoglycemic agents for > 3 mo. Hemoglobin HbA1c level = 8 % Serum ALT levels =1.3 x ULN Between 18-65 years of age Exclusion Criteria Hereditary hemochromatosis or hepatic iron overload defined as any of the following: 2+ iron on hepatic iron staining Hepatic Iron Index = 1.9 C282Y homozygous or C282Y/H63D compound heterozygous HFE genotype Use of insulin or thiazolidinediones for the treatment of diabetes Use of anti-NASH drugs (thiazolidinediones, vitamin E, UDCA, SAM-e, betaine, milk thistle, gemfibrozil, anti-TNF therapies, probiotics) Serum ferritin <50µg/L Serum transferrin-iron saturation <10 % Hemoglobin <10 mg/L Hematocrit <38 % Voluntary blood donation or therapeutic phlebotomy within the previous twelve months (except routine lab tests) Pregnant or lactating women Prior history of coronary artery disease, myocardial infarction, exertional dyspnea or chronic chest pain at rest. Evidence of myocardial infarction as determined by an ECG Location and Contact Information Please refer to this study by ClinicalTrials.gov identifier NCT00230087 Jim E Nelson, PhD 206-221-4537 jam...@medicine.washington.edu Virginia Mugford, BS 206-221-4538 virgin...@medicine.washington.edu Washington University of Washington Medical Center, Seattle, Washington, 98195, United States; Recruiting Jim Nelson, PhD 206-221-4537 jam...@medicine.washington.edu Study chairs or principal investigators Kris V Kowdley, MD, Principal Investigator, University of Washington More Information Study ID Numbers: DK 61728-S1 Last Updated: March 6, 2006 Record first received: September 29, 2005 ClinicalTrials.gov Identifier: NCT00230087 Health Authority: United States: Federal Government ClinicalTrials.gov processed this record on 2006-06-28 U.S. National Library of Medicine, Contact NLM Customer Service National Institutes of Health, Department of Health & Human Services Copyright, Privacy, Accessibility, Freedom of Information Act Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Thank you for the confirmation, there is no "iron hypothesis" with which to agree. On Apr 30, 7:27 am, pa...@ferris.com wrote: Thank you for the confirmation, there is no "iron hypothesis" with which to agree. << The iron hypothesis is pretty easy to see by someone with any rudimentary .. skill. That leaves you and your ilk pretty much out in the cold .. "Iron is present in high amounts in diabetes and we will remove this iron to see if it cures the diabetes" .. Pretty easy .. iron .. hypothesis .. Way too hard for you and your .. ilk .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk ""Iron is present in high amounts in diabetes and we will remove this iron to see if it cures the diabetes" .." Answer is already known, there is no hypothesis where the answer is known. In a large population study those who gave blood and lowered iron did not change their chance of getting diabetes. Jesus ate a mediterranean diet. On Apr 30, 7:10 am, ironjustice <teamtan...@hotmail.com> wrote: kill kids .. old people and pregnant women and fetuses << Might as well throw in more groups of people they kill on a regular basis .. "Young, fit climbers or trekkers" "Many climbers have died of HAPE when they were mistakenly treated for pneumonia" I guess this might be all the pneumonia .. COPD .. bronchitis we see down here .. on level ground caused by erythrocytosis .. http://www.basecampmd.com/expguide/hape.shtml HAPE - High Altitude Pulmonary Edema Another form of severe altitude illness is High Altitude Pulmonary Edema, a potentially deadly condition that develops because the lung arteries develop excessive pressure in response to low oxygen, resulting in overflow of fluid in the lungs. Though it often occurs with AMS, it is not felt to be related and the classic signs of AMS may be absent. Signs and symptoms of HAPE include any of the following: - Extreme fatigue - Breathlessness at rest - Fast, shallow breathing - Cough, possibly productive of frothy or pink sputum - Gurgling or rattling breaths - Chest tightness, fullness, or congestion - Blue or gray lips or fingernails - Drowsiness HAPE usually occurs on the second night after an ascent, and is more frequent in young, fit climbers or trekkers. In some persons, the hypoxia of high altitude causes constriction of some of the blood vessels in the lungs, shunting all of the blood through a limited number of vessels that are not constricted. This dramatically elevates the blood pressure in these vessels and results in a high-pressure leak of fluid from the blood vessels into the lungs. Exertion and cold exposure can also raise the pulmonary blood pressure and may contribute to either the onset or worsening of HAPE. Immediate descent is the treatment of choice for HAPE; unless oxygen is available delay may be fatal. Descend to the last elevation where the victim felt well upon awakening. Descent may be complicated by extreme fatigue and possibly also by confusion (due to inability to get enough oxygen to the brain); HAPE frequently occurs at night, and may worsen with exertion. These victims often need to be carried. It is common for persons with severe HAPE to also develop HACE, presumably due to the extremely low levels of oxygen in their blood (equivalent to a continued rapid ascent). HAPE usually resolves rapidly with descent, and one or two days of rest at a lower elevation may be adequate for complete recovery. Once the symptoms have fully resolved, cautious re-ascent is acceptable. Summary of HAPE treatment DESCENT, rest, oxygen, rehydration, and for severe cases, nifedipine, salmeterol, acetazolamide, sildenafil or tadalafil and dexamethasone may be used. Nifedipine, acetazolamide, sildenafil/tadalafil and dexamethasone have all been shown to lower the pulmonary hypertensive response to hypoxia, but they are prescription medicines for a good reason -- they may be hazardous to use without appropriate medical supervision and advice. Salmeterol is more commonly used as an asthma medication, but it also can hasten the body's ability to re-absorb edema fluid that clogs up the airways in HAPE. It is also a prescription medication in most of the world. HAPE can be confused with a number of other respiratory conditions: High Altitude Cough and Bronchitis are both characterized by a persistent cough with or without sputum production. There is no shortness of breath at rest, no severe fatigue. Normal oxygen saturations (for the altitude) will be measured if a pulse oximeter is available. Pneumonia can be difficult to distinguish from HAPE. Fever is common with HAPE and does not prove the patient has pneumonia. Coughing up green or yellow sputum may occur with HAPE, and both can cause low blood levels of oxygen. The diagnostic test (and treatment) is descent - HAPE will improve rapidly. If the patient does not improve with descent, then consider antibiotics. HAPE is much more common at altitude than pneumonia, and more dangerous; many climbers have died of HAPE when they were mistakenly treated for pneumonia. Asthma might also be confused with HAPE. Fortunately, asthmatics seem to do better at altitude than at sea-level. If you think it's asthma, try asthma medications, but if the person does not improve fairly quickly assume it is HAPE and treat it accordingly.. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Apr 30, 6:31 am, pa...@ferris.com wrote: > There is no such "iron hypothesis" with which to agree. [quoted text clipped - 180 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk Nope, the altitude hypothesis does not make it either. Jesus ate a mediterranean diet. On Apr 30, 1:08 pm, pa...@ferris.com wrote: Nope, the altitude hypothesis does not make it either. << Actually that was placed to evidence stupidity .. It was placed to show deaths caused by .. stupidity .. You didn't recognize the post was made ABOUT .. stupidity .. ? I wonder why .. Heh .. heh .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Many climbers have died of HAPE when they were mistakenly treated for pneumonia Ah, now we have the "stupidity" hypothesis do we? Jesus ate a mediterranean diet. On Apr 30, 2:49 pm, pa...@ferris.com wrote:Ah, now we have the "stupidity" hypothesis do we? << No I don't really think it is a hypothesis .. It may have BEEN a hypothesis at one time. I think the stupidity hypothesis has pretty much been .. accepted. The sheer number of deaths which have been shown to be directly attributable to the medical profession has the hypothesis .. proven .. ? There can be no other explanation .. Can you come up with another hypothesis for this .. body count .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Ah, now we have the "stupidity" hypothesis do we? > > Jesus ate a mediterranean diet. "Can you come up with another hypothesis for this .. body count .. ?" They lived in upper floors, altitude, and each and every one of them had iron in every cell in their body. Jesus ate a mediterranean diet. Jesus ate a mediterre In article <0201dfbd-9939-4d7a-a5d8-a1c26adf1814@b9g2000prh.googlegroups.com>, > This would go along with the increased iron hypothesis because aspirin > is proposed to be simply a substance produced by a plant to grab iron. [quoted text clipped - 49 lines] > believe that this effect was due to a previously unsuspected increase > in insulin secretion rather than enhanced insulin sensitivity." Decreasing glucose by increasing insulin is just trading one evil for another. Unless you are actually diabetic and not producing enough insulin, what you want are substances that increase insulin sensitivity and glucose uptake WITHOUT increasing insulin. The reasons to take aspirin remain to be that's it's anti-inflammatory and an AGE inhibitor/blocker/breaker (I forget which). On May 4, 8:06 am, noname <nos...@aol.com> wrote:Decreasing glucose by increasing insulin is just trading one evil for another. Unless you are actually diabetic and not producing enough insulin, what you want are substances that increase insulin sensitivity and glucose uptake WITHOUT increasing insulin. << This was done in obese people. Chances are very high they have pre-diabetes / metabolic syndrome and therefore pretty much can be considered to BE .. diabetic. This in no way reflects on those not in this 'category' / pre/ andormetabolic/diabetic .. until of course they too contract the disease category. Sooo .. contrary to what you seem to be trying to imply .. ? .. the underlying cause is still the iron and removing said iron seems to improve ones' recovery as evidenced in many recent studies culmonating in a very large clinical trial sponsoiron depred by the NIH of iron depletion for diabetes and / or non-alcoholic fatty liver disease .. ? Yep .. New research accepted for publication in the Journal of Clinical Endocrinology & Metabolism reveals a similar beneficial effect among **obese individuals** by increasing the amount of insulin secreted into the bloodstream Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > In article > <0201dfbd-9939-4d7a-a5d8-a1c26adf1...@b9g2000prh.googlegroups.com>, [quoted text clipped - 62 lines] > > - Show quoted text - |
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