Thanks Jacquie.

It was a bit long - you may have missed the bit at the end:

"Do you follow Jennifer's "test, test, test" regimen?"

:-)

Cheers, Alan, T2, Australia.
d&e, metformin 1500mg, ezetrol 10mg
Everything in Moderation - Except Laughter.
--
http://loraldiabetes.blogspot.com
Latest:Valderee, Valderah. Or, I love To Go A-wandering...

Hi Quentin:

Some recent MedScape CME had reference for pro-atherogenic HDL.  In
other words, high HDL in itself is not necessarily an indication of a
good lipid profile.   pro-oxidant+HDL - http://tinyurl.com/59udnx.  I
really have not digested the topic, but still feel that high HDL is good
in the majority of subjects with type 2 DM. An experimental drug -
torcetrapib - successfully raised HDL to high levels, but it had adverse
results otherwise. Obviously HDL is not a cut and dried topic.

"HDL With Defective Antiatherogenic Function

HDL undergoes pronounced structural and functional modification in
dyslipidemia associated with an acute-phase response and inflammation
(Figure 1B).[26,27] HDL levels of apo AI might be reduced because of
decreased apo AI synthesis, accelerated HDL catabolism and apo AI
replacement by serum amyloid A.[26,27] This acute-phase protein is
mainly of hepatic origin, and circulating levels can be induced to
increase up to 1,000-fold in the presence of inflammation.[28] Serum
amyloid A can displace apo AI and other HDL apolipoproteins from the
surface of HDL particles upon induction of the acute phase; small HDL3
is a major plasma carrier of apo AI.[28] Like C-reactive protein,
elevated plasma levels of serum amyloid A represent an important,
although weaker, cardiovascular risk factor.[29] The proatherogenic
properties of serum amyloid A might result from its capacity to enhance
HDL binding to proteoglycans, to promote HDL immobilization in the
arterial wall, to accelerate HDL clearance from the circulation, or a
combination of these.[28,30] Furthermore, HDL-associated enzymes,
including paraoxonase 1, platelet-activating factor acetylhydrolase and
lecithin:cholesterol acyltransferase, can become dysfunctional, depleted
or both under inflammatory conditions,[18] in metabolic diseases
involving low HDL levels, such as metabolic syndrome and type 2
diabetes,[8,9,10] and in CHD.[31] Attenuated function of HDL
apolipoproteins and enzymes might result from covalent modification,
such as oxidation by arterial wall cells and nonenzymatic glycation in
the presence of high levels of glucose.[32,33]

HDL lipid composition might equally be altered in dyslipidemia and
inflammation (Figure 1B). Enrichment in triglycerides is the most
frequent abnormality in HDL lipid composition, and occurs in
hypertriglyceridemic states associated with decreased activity of
lipoprotein lipase, hepatic lipase, lecithin:cholesterol acyltransferase
or a combination of these; all these metabolic alterations are
frequently observed in the acute phase.[26] In addition, HDL
triglyceride content can be raised in hypertriglyceridemia as a
consequence of elevated CETP activity.[34] CETP-mediated replacement of
cholesteryl esters by triglycerides in the HDL core results in decreased
plasma HDL-cholesterol levels, which is another feature of the
acute-phase response[26] and of the dyslipidemias of metabolic syndrome
and type 2 diabetes.[35]" source: Antiatherogenic Small, Dense HDL --
Guardian Angel of the Arterial Wall? -
http://www.medscape.com/viewarticle/525041_print

"There is no clear biological explanation how HDL can become
proatherogenic." HDL Cholesterol, HDL Particle Size and Apolipoprotein
A-I: Significance for Cardiovascular Risk — The IDEAL & EPIC-Norfolk
Studies - http://www.medscape.com/viewarticle/571347_print.

Thanks Quentin...How are you?
Jacquie

Can I be you when I grow up? The explanation I snipped was a keeper.

Yes dropping the carbs and raising the fats had a slightly negative
effect on my LDL but noticeably positive effects on HDL and especially
in nailing the trigs to the floor, which fixed the ratios but good.
Somehow I got it into my head that the Omega 3/Omega 6 balance was
also related to HDL levels. Probably I read it on usenet

sorry <G>

I was wondering - have you tried the Enteric Coated version of fish
oil capsules?  The coating means they don't disolve in the stomach,
just in the intestines.  That might be a solution to the upset stomach
problem.

I swim as long as my pool stays warm...living in the desert and with the
help of solar panels and a pool cover the water stays warm for a while. I do
swim strokes and I also will take a pool noodle (long round float thingy)and
hold on to it and bicycle around the pool...Physical Therapy taught me to
hold on to the side of the pool and bicycle but I like moving to music so
the noodle keeps me afloat while I "pedal" around the pool. That is a great
workout. I also do water aerobics holding onto weights and put a couple of
pounds on my ankles too.
jacquie

It's a Schwinn that's just like a stand-alone exercycle only with hand-grips
instead of foot-pedals & it cranks in both directions. It was a gift after
my 2nd shoulder surgery & rehab & it wasn't cheap.

There are some table-top models for arm-use (you can also put them on the
floor for foot-use) that aren't too pricey but I don't know how well they
work. You could ask your physical therapist. It's also good to have an
assortment of methods & exercises so you don't get bored. Even with just
running I don't go in the same place all the time!
bj