On Mar 21, 8:11 pm, J666 <jeaa...@gmail.com> wrote: What I do have a
problem with is idiots like you and Chung.
in your case it is iron, hence the 2Fe Schlock (Fe is the simple for
iron). <<

"Iron overload causes type 1 diabetes" ..

Iron overload is being targeted in diabetes in a very large clinical
trial .. about 4000 people ..

And what are .. you ..

A two bit piece of crap on the internet ..

Whoodeefkgdoo ..

YOU "don't like the poster" ..

Well .. fk you .. cowboy ..

Khalifa AS, Salem M, Mounir E, El-Tawil MM, El-Sawy M, Abd Al-Aziz
MM.

<<snip>>
Type 1 diabetes mellitus  is believed to be due to the damage
inflicted by iron
overload of the pancreatic beta cells
<<snip>>

Pediatr Diabetes. 2004 Sep;5(3):126-32.  Related Articles, Links

Abnormal glucose tolerance in Egyptian beta-thalassemic patients:
possible
association with genotyping.

Khalifa AS, Salem M, Mounir E, El-Tawil MM, El-Sawy M, Abd Al-Aziz
MM.

Department of Pediatrics, Faculty of Medicine, Ain Shams University,
Cairo,
Egypt.

Abnormal glucose tolerance in Egyptian beta-thalassemic patients:
possible
association with genotyping.
Khalifa AS, Salem M, Mounir E, El-Tawil MM, El-Sawy M, Abd Al-Aziz
MM.
Abstract:
Background:
Type 1 diabetes mellitus (DM) is a
frequent complication in patients with beta-thalassemia.
It is believed to be due to the damage inflicted by iron overload of
the
pancreatic beta cells.
Liver disorders and genetic influences seem to be additional
predisposing
factors. Objective:
To study the prevalence of diabetes and impaired glucose tolerance
(IGT) in
transfusion-dependent Egyptian beta-thalassemic patients and
to evaluate the possible role of genotyping in the pathogenesis of
diabetes
associated with beta-thalassemia.
Research design and methods: A total of 56 transfusion-dependent
beta-
thalassemic
patients aged 10-31 (mean age = 15.9 +/- 5.7 yr), 32 males and 24
females, including
48 thalassemia major and eight thalassemia intermedia; compared to 15
age- and
sex-matched controls.
All were subjected to history and examination, laboratory
investigations: complete
blood count (CBC), serum ferritin, liver function tests, hepatitis B
and C markers,
fasting blood glucose, oral glucose tolerance test (OGTT) and fasting
C-peptide.
Genotyping for 16 mutations was assessed in thalassemic patients
with abnormal glucose tolerance. Results:
The prevalence of diabetes was 10.4%
(5 of 48) and IGT was 14.6% (7 of 48) among thalassemia major,
whereas, none of
thalassemia intermedia had abnormal glucose tolerance.
Fasting C-peptide was lower in beta-thalassemic patients compared to
controls (p < 0.001); the level was significantly higher in patients
complicated
by diabetes or IGT compared with other thalassemic patients (p <
0.001).
Chronic hepatitis C was detected in all patients (100%) with abnormal
glucose
tolerance.
Genotyping showed that IVS II nt 745 was detected in 77.7% of cases
with abnormal
glucose tolerance.
Conclusions: Abnormal glucose tolerance is common in multiply
transfused
beta-thalassemia major patients, which could be attributed to
progressive and
early loss of beta-cell mass, along with persistent insulin
resistance.
Chronic hepatitis C may play a role in the development of abnormal
glucose tolerance.
An association between diabetes and genotyping IVS II nt 745 was
found.
Patients with this particular genotype are advised to check their
blood glucose
every 6 months to detect early occurrence of diabetes.

PMID: 15450007 [PubMed - in process]

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