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Medical Forum / Diseases and Disorders / Diabetes / March 2008Potent Mind-altering Antioxidant
Cannabis may limit damage from strokes and Alzheimer's Independent, The (London), Jul 6, 1998 by Steve Connor Science Editor CANNABIS COULD protect brain cells against the effects of a stroke and may help to slow the mental deterioration associated with neurological disorders such as Alzheimer's and Parkinson's diseases. Scientists have found that a component of marijuana acts as a powerful antioxidant in the brain which can prevent cells being damaged when a blood vessel in the head becomes blocked during a stroke. Experiments revealed that cannabidiol, which is a harmless constituent of marijuana and does not produce a "high", is a more powerful antioxidant than vitamins C and D, which are known to neutralise the highly damaging free radicals released during a stroke. Dr Aidan Hampson, a British-born researcher at the United States National Institute of Mental Health, near Washington DC, said the discovery could eventually lead to a treatment for stroke based on the cannabis plant. "We have reason to believe we are on to a good thing here. Cannabidiol was given to humans in large doses in other clinical trials with no significant adverse effects," Dr Hampson said. "We could synthesise it and administer it to patients as a pill, in an inhaler or even as a suppository, although that would not be as popular. It is non- psychoactive which makes it particularly useful." The research, which is published in the Proceedings of the National Academy of Science, also found that the mind-altering ingredient of cannabis - tetrahyrocannabinol (THC) - also behaved as a potent antioxidant which protected brain cells against the sort of oxygen starvation caused by a stroke. The US National Academy of Sciences, which publishes the proceedings, said: "These findings suggest that cannabidiol may be a promising treatment for stroke and other neurological disorders including Parkinson's and Alzheimer's diseases, (which are) also thought to involve oxidative damage." Dr Hampson said that when a blood vessel in the brain becomes blocked a complex set of reactions takes place that culminates in the power houses of the cell, called mitochondria, pumping out free radicals. When he exposed the nerve cells of laboratory animals to cannabidiol he found it significantly reduced the damage resulting from the release of free radicals. The dose levels were similar to those known to be safe in humans. "These are the very first results and I would be surprised if we get through all the stages of drug trials for humans in less than five or six years," Dr Hampson said. However, the research findings do not explain whether people who smoke cannabis are less likely to suffer ill effects following a stroke. "We don't know whether smoking produces these levels of cannabidiol," he said. Copyright 1998 Newspaper Publishing PLC Provided by ProQuest Information and Learning Company. All rights Reserved. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk On Mar 11, 10:45 am, ironjustice <teamtan...@hotmail.com> wrote:cannabidiol << Published online on August 1, 2000, 10.1073/pnas.160105897 PNAS | August 15, 2000 | vol. 97 | no. 17 | 9561-9566 Immunology The nonpsychoactive cannabis constituent cannabidiol is an oral anti- arthritic therapeutic in murine collagen-induced arthritis A. M. Malfait*,, R. Gallily,, P. F. Sumariwalla*, A. S. Malik*, E. Andreakos*, R. Mechoulam, and M. Feldmann*,§ * Kennedy Institute of Rheumatology, 1 Aspenlea Road, Hammersmith, London W6 8LH, United Kingdom; and Hebrew University, Hadassah Medical School, P.O.B. 12272, Jerusalem 91120, Israel Edited by Anthony Cerami, The Kenneth S. Warren Laboratories, Tarrytown, NY, and approved June 2, 2000 (received for review March 10, 2000) Abstract The therapeutic potential of cannabidiol (CBD), the major nonpsychoactive component of cannabis, was explored in murine collagen- induced arthritis (CIA). CIA was elicited by immunizing DBA/1 mice with type II collagen (CII) in complete Freund's adjuvant. The CII used was either bovine or murine, resulting in classical acute CIA or in chronic relapsing CIA, respectively. CBD was administered after onset of clinical symptoms, and in both models of arthritis the treatment effectively blocked progression of arthritis. CBD was equally effective when administered i.p. or orally. The dose dependency showed a bell-shaped curve, with an optimal effect at 5 mg/kg per day i.p. or 25 mg/kg per day orally. Clinical improvement was associated with protection of the joints against severe damage. Ex vivo, draining lymph node cells from CBD-treated mice showed a diminished CII-specific proliferation and IFN- production, as well as a decreased release of tumor necrosis factor by knee synovial cells. In vitro effects of CBD included a dose-dependent suppression of lymphocyte proliferation, both mitogen-stimulated and antigen- specific, and the blockade of the Zymosan-triggered reactive oxygen burst by peritoneal granulocytes. It also was found that CBD administration was capable of blocking the lipopolysaccharide-induced rise in serum tumor necrosis factor in C57/ BL mice. Taken together, these data show that CBD, through its combined immunosuppressive and anti-inflammatory actions, has a potent anti- arthritic effect in CIA. Cannabidiol (CBD) is one of the major components of Cannabis sativa, marijuana (1). Marijuana contains approximately 80 constituents, termed cannabinoids (2, 3). CBD is not psychoactive, unlike the other major component of cannabis, 9-tetrahydrocannabinol (9THC) (4, 5). A vast literature documents the immune modulating effects of cannabinoids, in vivo and in vitro, mainly of 9THC and synthetic analogues such as CP55,940 (reviewed in ref. 6). A nonexhaustive list of in vitro effects includes inhibition of the proliferative responses of T lymphocytes (7), inhibition of cytotoxic T cell activity (8), suppression of macrophage function and antigen presentation (9, 10), and inhibition of NO production by macrophages (11). Reports on the in vitro effects of CBD on immune cells are scarce and include the modulation of tumor necrosis factor (TNF), IL-1, and IFN- by human peripheral blood mononuclear cells (12, 13) and the suppression of chemokine production by a human B cell line (14). These potentially anti-inflammatory properties of CBD, together with the lack of psychotropic effect and low toxicity (15), prompted us to test the potential of CBD as a therapeutic agent in collagen-induced arthritis (CIA). CIA, a murine model for rheumatoid arthritis (RA), is elicited by immunizing DBA/1 mice with type II collagen (CII) in complete Freund's adjuvant (16). The immune response to CII involves both humoral and cellular mechanisms (17, 18), and the cellular response is T helper 1-mediated (19). CIA is characterized by rapid onset of clinical joint inflammation, resulting in destruction of joint tissues and cartilage/ bone erosions. Suppression of the inflammatory process by blocking TNF with mAbs has proven an effective treatment of CIA (20, 21), and these findings led to the successful use of TNF blockade in multiple phase I, II, and III clinical trials with RA patients (reviewed in ref. 22), thus validating the predictive value of CIA as a model for RA. In the present study, we report that CBD has a beneficial therapeutic action on established CIA, and we explore its mode of action. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Cannabis may limit damage from strokes and Alzheimer's > Independent, The (London), Jul 6, 1998 by Steve Connor Science [quoted text clipped - 65 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk On Mar 11, 11:16 am, ironjustice <teamtan...@hotmail.com> wrote:cannabidiol has a beneficial therapeutic action on established CIA, and we explore its mode of action << I assume everyone can speak .. German .. ? Article Interaction of Trivalent Iron with Some Cannabinoids and their related compounds Dr. Z. Mobarak 1 *, Dr. H. Aly 2, Dr. D. Bieniek 3 1The National Center of Social and Criminological Research, Awkaf City, Gezira P.O., Cairo, A.R. Egypt 2Atomic Energy Establishment, Cairo, A.R. Egypt 3Institute for Ecological Chemistry, 8042 Neuherberg/FRG *Correspondence to Z. Mobarak, The National Center of Social and Criminological Research, Awkaf City, Gezira P.O., Cairo, A.R. Egypt Abstract Translated Abstract Wechselwirkung zwischen Eisen(III)-Ionen und einigen Cannabinoiden und verwandten Verbindungen Die Reaktion zwischen Orcinol, Olivetol oder Cannabidiol und dreiwertigem Eisen wurde spektroskopisch untersucht. Zwischen Eisen(III)-Ionen und Orcinol bzw. Olivetol bilden sich in Methanol 1:3 Komplexe (Dissoziationskonstanten 1,5 × 10-5 bzw. 2,5 × 10-7). Keine Wechselwirkung konnte unter analogen Bedingungen zwischen Fe3+-ionen und Cannabidiol beobachtet werden. -------------------------------------------------------------------------------- Received: 7 March 1979 Digital Object Identifier (DOI) 10.1002/prac.19803220303 About DOI Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk cannabidiol << Jeez .. Dronabinol / cannabidiol [Sativex; Bayer, GW Pharmaceuticals] has been approved by Health Canada for adults with moderate to severe cancer pain Source: Inpharma, Volume 1, Number 1600, 2007-08-11 , pp. 23-23(1) Publisher: Adis International --------------------------- http://tinyurl.com/366gow Cannabinoids: Their Role in Pain and Palliation Author: McCarberg, Bill H.1 Source: Journal of Pain & Palliative Care Pharmacotherapy, Volume 21, Number 3, 24 August 2007 , pp. 19-28(10) Publisher: Haworth Press Abstract: Controversy is associated with the issue of cannabis and cannabinoids in clinical care in the United States. Recent research has demonstrated the underlying mechanisms of cannabinoid analgesia via endocannabinoids, an endogenous system of retrograde neuromodulatory messengers that work in tandem with endogenous opioids. Additional receptor and non-receptor mechanisms of cannabinoid drugs have pertinent activity, including anti-carcinogenesis and neuroprotection, that may be of key importance in aging and terminal patient populations. The results of clinical trials with synthetic and plant-based cannabinoids suggest that the role of formulation and delivery system is critical in optimizing the risk-benefit profile of cannabinoid products. Synergy between opioids and cannabinoids may produce opioid-sparing effects, as well as extend the duration of analgesia and reduce opioid tolerance and dependence. This article reviews the mechanism of action of cannabinoids, examines marketed agents and those in clinical trials, and addresses their role in treatment of chronic pain, cancer, neurodegenerative diseases, and HIV/ AIDS. The ability of cannabinoid medicines to treat pain, associated sleep disorders, appetite loss, muscle spasm and a wide variety of other symptoms suggests that such agents may in the future play an important role in palliative care. doi:10.1300/J354v21n03_04 Keywords: Cannabis; cannabinoids; pain; analgesia; THC; cannabidiol; palliative care Document Type: Research article DOI: 10.1300/J354v21n03_04 Affiliations: 1: Founder and Director, Department of Family Medicine, Pain Management Program, Kaiser Permanente, Escondido, CA, 92025, Email: Bill.H.Mccarberg@kp.org --------------------------- Dronabinol/cannabidiol is effective for the treatment of neuropathic pain Source: Inpharma, Volume 1, Number 1614, 2007-11-17 , pp. 20-20(1) Publisher: Adis International --------------------------- Health Canada has issued a Qualifying Notice for the approval of dronabinol/cannabidiol Source: Inpharma, Volume 1, Number 1594, 2007-06-30 , pp. 23-23(1) Publisher: Adis International --------------------------- Will Medicinal Cannabinoids Prove to be Useful Clinically? Author: Smith, Paul F.1 Source: Current Drug Therapy, Volume 2, Number 2, May 2007 , pp. 143-150(8) Publisher: Bentham Science Publishers Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk < previous article | next article > | view search results Key: - Free Content - New Content - Subscribed Content - Free Trial Content Abstract: In some parts of the world, medicinal cannabinoids have already been used to treat nausea and vomiting associated with chemotherapy and wasting in diseases such as AIDS and terminal cancer. However, over the last several years, currently used cannabinoids, such as dronabinol, as well as newly developed cannabis-based medicines such as Sativex(R) (narrow ratio combination of Δ9-tetrahydrocannabinol and cannabidiol), have been investigated for the treatment of spasticity, chronic pain, disruption of sleep and urinary dysfunction associated with multiple sclerosis and other neurological disorders. Although some clinical trials have yielded positive results, others have not and there has been controversy regarding the use of subjective rating scales to measure pain and spasticity. Adverse side effects have been generally mild and transient; however, researchers and clinicians are still concerned about the prospect of long-term adverse side effects. This review will summarise and critically evaluate the currently available clinical trial data. Keywords: Cannabinoids; cannabis; multiple sclerosis; pain; spasticity Document Type: Research article Affiliations: 1: Dept. of Pharmacology and Toxicology, School of Medical Sciences, University of Otago, Dunedin, New Zealand. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Mar 11, 10:45 am, ironjustice <teamtan...@hotmail.com> > wrote:cannabidiol << [quoted text clipped - 159 lines] > > - Show quoted text - On Mar 12, 11:26 am, ironjustice <teamtan...@hotmail.com> wrote:cannabidiol << "Non- psychoactive cannabis constituent CBD inhibited the accumulation of prion proteins" Sunday, September 16 2007 @ 11:05 AM EDT Edited by: Michael Hess Cannabidiol May be Effective in Preventing Bovine Spongiforme Enzephalopathy (Mad Cow Disease) BBSNews 2007-09-16 -- (IACM) According to basic research of scientists of the National Centre for Scientific Research in Valbonne, France, cannabidiol (CBD) may prevent the development of prion diseases, the most known being BSE (bovine spongiforme enzephalopathy), which is often called mad cow disease. It is believed that the BSE may be transmitted to human beings. In humans, it is known as Creutzfeldt- Jakob disease. The infectious agent in prion diseases is believed to be a specific type of misfolded protein called prion. Misfolded prion proteins carry the disease between individuals and cause deterioration of the brain. The French researchers reported that the non- psychoactive cannabis constituent CBD inhibited the accumulation of prion proteins in both mouse and sheep prion- infected cells, whereas other cannabinoids were either weak or not effective. Moreover, after infection with mouse scrapie, a prion disease, CBD limited accumulation of the prion protein in the brain and significantly increased the survival time of infected mice. CBD inhibited the nerve damaging effects of prions in a concentration-dependent manner. Researchers noted that CBD may be a promising agent for the treatment of prion diseases. (Source: Dirikoc S, Priola SA, Marella M, Zsuerger N, Chabry J. Nonpsychoactive cannabidiol prevents prion accumulation and protects neurons against prion toxicity. J Neurosci 2007;27(36):9537-44.) Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > cannabidiol << > [quoted text clipped - 233 lines] > > - Show quoted text - On Mar 12, 11:38 am, ironjustice <teamtan...@hotmail.com> wrote:cannabidiol << It kills cancer. 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid Authors: Massi, P.1; Valenti, M.2; Vaccani, A.2; Gasperi, V.3; Perletti, G.2; Marras, E.2; Fezza, F.; Maccarrone, M.; Parolaro, D.2 Source: Journal of Neurochemistry, Volume 104, Number 4, February 2008 , pp. 1091-1100(10) Publisher: Blackwell Publishing Abstract: It has been recently reported that cannabidiol (CBD), a non- psychoactive cannabinoid, is able to kill glioma cells, both in vivo and in vitro, independently of cannabinoid receptor stimulation. However, the underlying biochemical mechanisms were not clarified. In the present study, we performed biochemical analysis of the effect of CBD both in vivo, by using glioma tumor tissues excised from nude mice, and in vitro, by using U87 glioma cells. In vivo exposure of tumor tissues to CBD significantly decreased the activity and content of 5-lipoxygenase (LOX, by ∼ 40%), and of its end product leukotriene B4 (∼ 25%). In contrast cyclooxygenase (COX)-2 activity and content, and the amount of its end product prostaglandin E2, were not affected by CBD. In addition, in vivo treatment with CBD markedly stimulated (∼ 175%) the activity of fatty acid amide hydrolase (FAAH), the main anandamide- degrading enzyme, while decreasing anandamide content (∼ 30%) and binding to CB1 cannabinoid receptors (∼ 25%). In vitro pre-treatment of U87 glioma cells with MK-886, a specific 5-LOX inhibitor, significantly enhanced the antimitotic effect of CBD, whereas the pre- treatment with indomethacin (pan-COX inhibitor) or celecoxib (COX-2 inhibitor), did not alter CBD effect. The study of the endocannabinoid system revealed that CBD was able to induce a concentration-dependent increase of FAAH activity in U87 cells. Moreover, a significantly reduced growth rate was observed in FAAH-over-expressing U87 cells, compared to wild-type controls. In conclusion, the present investigation indicates that CBD exerts its antitumoral effects through modulation of the LOX pathway and of the endocannabinoid system, suggesting a possible interaction of these routes in the control of tumor growth. Keywords: cannabidiol; cyclooxygenase; endocannabinoid system; glioma; lipoxygenase Document Type: Research article DOI: 10.1111/j.1471-4159.2007.05073.x Affiliations: 1: Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Milan, Italy 2: Department of Structural and Functional Biology, Pharmacology Section, Center of Neuroscience, University of Insubria, Busto Arsizio, Italy 3: Department of Biomedical Sciences, University of Teramo, Teramo, Italy Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Mar 12, 11:26 am, ironjustice <teamtan...@hotmail.com> > wrote:cannabidiol << [quoted text clipped - 233 lines] > > - Show quoted text - Not to rain on your parade but who know's what will kill ya nowadays :) just a thought, keep up the good work 'Ironjustice' :) Antioxidant Supplements Actually Raise Risk of Cancer thedermblog.com - "It has been drilled into the public by countless magazines, product ads, and television commercials. Vitamin C, pomegranate, resveratrol, coffeeberry: Eat them! Apply them to your face! Add them to your cereal! Surely soaking up bad free radicals must protect you against cancer, no?"More. (Health) 184 Comments ShareBury supernova17 made popular 6 hr 20 min ago http://digg.com/health/Antioxidant_Supplements_Actually_Raise_Risk_of_Cancer ------------------------------------------------------------------------------------------------- > Cannabis may limit damage from strokes and Alzheimer's > Independent, The (London), Jul 6, 1998 by Steve Connor Science [quoted text clipped - 68 lines] > DEAD PEOPLE WALKING > http://tinyurl.com/zk9fk > Not to rain on your parade but who know's what will kill ya nowadays :) just > a thought, keep up the good work 'Ironjustice' :) We've had 10,000 years experience with weed, and not one attributable death. On Mar 11, 5:00 pm, Father Haskell > We've had 10,000 years experience with weed, and not > one attributable death. As in Mary-Jane Magdalene > On Mar 11, 5:00 pm, Father Haskell > > We've had 10,000 years experience with weed, and not > > one attributable death. > > As in Mary-Jane Magdalene Or Dawn "Mary Ann" Wells. >> Not to rain on your parade but who know's what will kill ya nowadays :) >> just >> a thought, keep up the good work 'Ironjustice' :) > > We've had 10,000 years experience with weed, and not > one attributable death. Well then this buds for you... mark another 10,ooo please... >Not to rain on your parade but who know's what will kill ya nowadays :) just >a thought, keep up the good work 'Ironjustice' :) please do not encourage the mentally ill to stay ill. Google: Keyword: aioe.org One post in particular talks about AIOE.org and says its a home to cowards and terrorists From what I figured out AIOE.org is a free server. Possibly used to cover one's tracks when posting? The only way AMF is going to rid AMF of its abusers is to report the abuses. One can contact the Clarksville, Nashville and or Memphis Tennessee FBI or send a direct complaint to: https://tips.fbi.gov/ The US Department of Justice was notified in 2001 upon an emailed death threat, threatening to stab to death my family members and myself. The US DOJ put me in touch with the FBI here in Tennessee. Death Threat Jan 20, 2001 http://groups.google.com/group/alt.med.fibromyalgia/search?hl=en&group=alt.med.f ibromyalgia&q=death+threat+%2B+rosemarie+shiver&qt_g=Search+this+group CB utilizes multiple alias's so if Queen Wakini shows up on this thread be safe, be aware and be alert. AMF http://groups.google.com/group/alt.med.fibromyalgia/topics?lnk=srg&hl=en Soft hugs to all the non abusers. Diana Saba Message from discussion Potent Mind-altering Antioxidant View parsed - Show only message text Path: g2news1.google.com!news4.google.com!feeder1-2.proxad.net! proxad.net!feeder1-1.proxad.net!club-internet.fr!feedme- small.clubint.net!aioe.org!not-for-mail From: Queen Wakini <qu...@wakini.com> Newsgroups: alt.med.fibromyalgia Subject: Re: Potent Mind-altering Antioxidant Date: Tue, 11 Mar 2008 23:41:50 -0400 Organization: Queen Wakini Lines: 10 Message-ID: <fr7je2$b02$2@aioe.org> References: <a1c33e7c-a752-4dfb-b237- be1b5fbb32a3@d4g2000prg.googlegroups.com> <D4CBj. 20720$Ls6.19526@trnddc01> <2f436058-3918-48c9- a7c1-46dcfca7679f@u10g2000prn.googlegroups.com> <9e23f0ed-0a7b-459e- b7a0-7f6e818fd005@m3g2000hsc.googlegroups.com> Reply-To: qu...@wakini.com NNTP-Posting-Host: EA8nGIfDLBKJ03+jIbKxlg.user.aioe.org Mime-Version: 1.0 Content-Type: text/plain; charset=ISO-8859-1; format=flowed Content-Transfer-Encoding: 7bit X-Complaints-To: abuse@aioe.org In-Reply-To: User-Agent: Thunderbird 2.0.0.12 (Windows/20080213) I get muh mind altered when I read dgsaba dramas... J666 wrote: > On Mar 11, 5:00 pm, Father Haskell > > We've had 10,000 years experience with weed, and not > > one attributable death. > > As in Mary-Jane Magdalene > From what I figured out AIOE.org is a free server. Possibly used to > cover one's tracks when posting? unlike some of the free servers, aioe specifically caches the ip numbers of users for up to 6 months. available to legal authorrity upon proper service. |
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