PPAR-gamma agonists - Why diabetic drugs makes you fat!

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BillW50 - 02 Mar 2008 01:59 GMT

Is this true? Or is Dr. Mercola full of it?

http://articles.mercola.com/sites/articles/archive/2008/2/28/deaths-halt-diabete
s-study.aspx

I think you have to subscribe (free) to read this article. But I will
repost the important part on request. Although basically what he (I
think it is a he) is saying is how they work is by generating more fat
cells (including using insulin). Thus lowering blood sugar. Which works
for awhile until you need higher doses to make more fat cells to absorb
more sugar.

I don't know? If this is how it works, that is just terrible! Most
diabetics I know, generally does get fatter and fatter overtime. Funny
thing is when I didn't treat my diabetes, I got thinner and thinner. Now
I eat almost nothing just to keep my weight the same while accepting
treatment.

Signature

Bill
DX 2002 (ignored till 4/2007)
A1c 04/2007 10.5
A1c 06/2007 7.4
A1c 08/2007 6.8
A1c 02/2008 6.3

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Kurt - 02 Mar 2008 02:44 GMT

> Is this true? Or is Dr. Mercola full of it?
>
[quoted text clipped - 6 lines]
> for awhile until you need higher doses to make more fat cells to absorb
> more sugar.

Didn't subscribe or read the article, but I will respond to the next
paragraph...

> I don't know? If this is how it works, that is just terrible! Most
> diabetics I know, generally does get fatter and fatter overtime. Funny
> thing is when I didn't treat my diabetes, I got thinner and thinner. Now
> I eat almost nothing just to keep my weight the same while accepting
> treatment.

Type 1's I know, including myself, put on weight after diagnosis
mainly because they had lost a lot of weight before diagnosis. The
onset of Type 1 diabetes is sudden and dramatic and the reason someone
loses weight quick is that they are spilling (spilling is a bit
antiquated term, but still makes the point) their glucose into their
urine and losing most everything they consume. Not sure if that's
what happened to you when you don't "treat your diabetes" but that
could be one possible reason you got thinner and thinner.

Kurt

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BillW50 - 02 Mar 2008 02:59 GMT

In
news:718dfdd4-b199-477e-b89f-1a734c120ce3@e23g2000prf.googlegroups.com,
Kurt typed on Sat, 1 Mar 2008 18:44:26 -0800 (PST):

>> Is this true? Or is Dr. Mercola full of it?
>>
[quoted text clipped - 26 lines]
>
> Kurt

Hi Kurt! I'm a type II and the way I understand that type I is like type
II, but far worse. And just managing type II is awful enough, I would
hate to deal with type I. And I take usually less than 40 units of
insulin a day, so I have it better than most. And I appreciate your
experience greatly. Thanks again.

Signature

Bill
DX 2002 (ignored till 4/2007)
A1c 04/2007 10.5
A1c 06/2007 7.4
A1c 08/2007 6.8
A1c 02/2008 6.3

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Andrew B. Chung, MD/PhD - 02 Mar 2008 12:55 GMT

> Is this true?

No.

> Or is Dr. Mercola full of it?

It seems Dr. Mercola suffers from the same delusion that has at one
time or another affected all adults so that he is not able to see the
real reason why people are overeating:

"Being hungry means that one is starving."

> http://articles.mercola.com/sites/articles/archive/2008/2/28/deaths-halt-diabete
s-study.aspx
>
[quoted text clipped - 4 lines]
> for awhile until you need higher doses to make more fat cells to absorb
> more sugar.

The latter occurs obly when we are eating more because the above
delusion is compelling us to irrationally eat more when we are
hungrier (healthier).

> I don't know? If this is how it works, that is just terrible! Most
> diabetics I know, generally does get fatter and fatter overtime.

Friend Jim Chinnis would be a counter-example because he no longer
falsely believes that hunger is bad.

Instead, he knows that hunger is wonderful:

http://HeartMDPhD.com/Hunger

Because of the delusion that hunger is bad, he did have type-2
diabetes.

This is no longer the case since he no longer suffers from the
delusion that hunger is bad.

> Funny
> thing is when I didn't treat my diabetes, I got thinner and thinner.

You were less healthy (less hungry).

> Now
> I eat almost nothing just to keep my weight the same while accepting
> treatment.

With the delusion that hunger is bad, the hungrier we are the less it
**seems** that we are eating...

... until we start weighing our meals.

Therefore, it remains smarter to eat less, down to the right amount:

http://HeartMDPhD.com/BeSmart

Be hungry... be healthy... be hungrier... be euglycemic:

http://TheWellnessFoundation.com/BeHealthy

Prayerfully in the infinite power and might of the Holy Spirit,

Andrew <><
--
Andrew B. Chung, MD/PhD
Lawful steward of http://EmoryCardiology.com
Swordbearer for the KING of kings and LORD of lords.
http://HeartMDPhD.com/Sword

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GysdeJongh - 02 Mar 2008 22:04 GMT

> Is this true? Or is Dr. Mercola full of it?
>
> http://articles.mercola.com/sites/articles/archive/2008/2/28/deaths-halt-diabete
s-study.aspx

Hi BillW50,
I think Dr. Mercola is a bit confused.He confuses the peroxisome with the
adipose tissue cell.The peroxisome is a cell organell.It is a component of
_ANY_ cell.Also of the fat cell.

It was noticed that a cell can increase its number of peroxisomes.A cell can
"proliferate" its peroxisomes : make more of them when needed.The,then
unknown substance,that brought about this proliferation was termed :
"Peroxisome Proliferator" and the receptor for detecting this unknown
substance :"Peroxisome Proliferator Activated Receptor" or PPAR for
short.The ligand for this receptor turned out to be all kind of food
substances and also fat molecules.The pharmaceutical industry also made a
synthetic PPAR : Avandia.

If a cell makes more peroxisomes (when it encounters fat or.... Avandia)
this is actual a good thing for us T2D.Peroxisomes are involved in beta
oxidation : they transform all kind of fats from your diet to their Acetyl
Coenzym A form.That is the form in which they enter the TCA cycle.If the
mitochondrions in your muscle cells use the TCA cycle in that way then your
muscles are burning fat to ride your bike :)

hth
Gys

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