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Medical Forum / Diseases and Disorders / Diabetes / September 2007

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ping Helen Back

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rk - 27 Sep 2007 01:59 GMT
figured this would get lost in the sea of replies,
but I wanted to let you know.... GAD testing
usually takes upwards to 2-4weeks to get back.
it's not a quicky blood test.  testing for GAD
will usually come back as negative or positive,
though, some labs these days are putting numbers
to them. such as <20 and you're at 18 (just an example)

you should also ask for a C-peptide and Ia2 (iirc)
and theres one more antibodies test but I can't remember.
because adults are kinda funky and don't often have the
same antibodies as kids do.  as for a T1, they'll usually
have 2 of the 3 antibodies as well as a low cpeptide for
a LADA usually they only have GAD and missing the
other 2 antibodies.  it's also possible to be LADA and not
have any GAD.... this would then be confirmed with a low
to zero cpeptide most often.

one things for sure... if you're "low carbing" and can keep
your glucose within check then even it's doubtful of being
a LADA.  most LADA even have a hard time early on
keeping their glucose within range which is why many press
for further testing.

one last thing... if you are a LADA, don't worry much about
your trigs, hdl, ldl as once you're on insulin, they'll drop naturally.
they work in conjunction with high glucose too when you lack
insulin in the body they naturally go up.  but once your glucose
gets into check then they naturally lower.  I can't say the same
thing about being a T2.

best of luck and hope it all works out.. I also have to concure
your diabetic nurse sounds completely like a bozo the clown
who don't know her a.s from a hole in the ground! :P

rk, t1
happy pumper
Helen Back - 27 Sep 2007 09:31 GMT
> figured this would get lost in the sea of replies,
> but I wanted to let you know.... GAD testing
[quoted text clipped - 33 lines]
> rk, t1
> happy pumper

Hi there, rk - thanks for the PING!! :))

Well. the nurse seems to think that the GAD result will come back the
same week as my routine blood test - so, yes, she is most probably a
bozo!!  She told me to go for my blood and GAD test the week before I
will be seeing the new doctor who has an interest in diabetes.

The thing is, I havent seen one EXPERT yet, so when you suggest things
like "you should also ask for a C-peptide and Ia2 (iirc)
> and theres one more antibodies test" - I presume that the doctor will not possibly understand the why's and how's.  Could you be a bit more specific, so I can word it right to him!!!  This is all so new to me and so many people have made suggestions and recommendations on how my treatment should be kicked off - but it appears that my medical care is less than competent.  I mean, if my own GP doesnt want to know (fobbed me straight off to a diabetic nurse), the nurse is incompetent and the new doc I am seeing 3 weeks into October only has an interest and not specialised in diabetes -what the hell am I supposed to do?  How can I get myself someone knowledgeable and skilled medically for my condition?  Its very frustrating!

Thanks for input :)))
Nicky - 27 Sep 2007 12:50 GMT
>The thing is, I havent seen one EXPERT yet, so when you suggest things
>like "you should also ask for a C-peptide and Ia2 (iirc)
>> and theres one more antibodies test" - I presume that the doctor will not possibly understand the why's and how's.  Could you be a bit more specific, so I can word it right to him!!!  

You might get a C-peptide if your GAD results come back positive - but
almost certainly not if you're a plain old T2. C-peptide is produced
as a byproduct of insulin production, on a 1-1 basis; it's much more
stable than insulin, so easier to test, and dead useful to find out
how much insulin you're actually kicking out. It's also a feed into
the HOMA calculator to measure insulin resistance. However, my doc
CAN'T order one for a T2 - I haven't bottomed out whether that's a
NICE or PCT restriction. Damned irritating, either way. I once asked
at a BUPA screening (paid for by work) if I could add either the
C-peptide or a fasting insulin in as an extra; they wanted to charge
me £200. I left it...

Nicky.
T2 dx 05/04 + underactive thyroid
D&E, 100ug thyroxine
Last A1c 5.6%  BMI 25
rk - 27 Sep 2007 21:23 GMT
| > figured this would get lost in the sea of replies,
| > but I wanted to let you know.... GAD testing
[quoted text clipped - 40 lines]
| bozo!!  She told me to go for my blood and GAD test the week before I
| will be seeing the new doctor who has an interest in diabetes.

bozo is putting it kindly from what I've seen she's said. :) well, guess
we
can only wait and see how long it actually takes. sadly, IF she was
concerned
you had any GAD antibodies, the test imho, should have been done
immedately.
It's not a test that needs to be fasted for.

| The thing is, I havent seen one EXPERT yet, so when you suggest things
| like "you should also ask for a C-peptide and Ia2 (iirc)
| > and theres one more antibodies test" - I presume that the doctor will not possibly understand the why's and how's.  Could you be a bit more
specific, so I can word it right to him!!!

here is a wonderful page that explains much. it's from a brilliant author
who's written "Using Insulin" &
"Pumping Insulin" I find his methods and information far more
understanding and more important truthful!
then Bernsquack. Which makes much difference when you're starting out
trying to find what works for
you and trying to understand a method that no human who wants a life can
follow.. anyhow, the page is
here http://www.diabetesnet.com/diabetes_types/whatype.php (read the
entire site, it's owned by the
author John Walsh who's diabetic himself as well as a CDE)

But the tests you might want to request are ICA, IA2, IAA, C-Peptide along
with the GAD. I'll break
them down a bit more for you. The ICA is autoantibodies to islet
cellsautoantibodies to antibodies to the Islet Cells, the IAA are
antibodies to Insulin. Here's an excerpt from a page I've had saved, don't
recall where I
saw it just kept it for my reference when I was dx'd to give to my doctor
who was an utter moron at that time.

"Type 1 diabetes, commonly referred to as insulin-dependent diabetes
(IDDM), is caused by pancreatic beta-cell destruction that leads to an
absolute insulin deficiency.1 The clinical onset of diabetes does not
occur until 80% to 90% of these cells have been destroyed. Prior to
clinical onset, type 1 diabetes is often characterized by circulating
autoantibodies against a variety of islet cell antigens, including
glutamic acid decarboxylase (GAD), tyrosine phosphatase (IA2), and
insulin.2,3,4,5,6,7 The autoimmune destruction of the insulin-producing
pancreatic beta cells is thought to be the primary cause of type 1
diabetes. The presence of these autoantibodies provides early evidence of
autoimmune disease activity, and their measurement can be useful in
assisting the physician with the prediction, diagnosis, and management of
patients with diabetes. Autoantibodies to IA2, a tyrosine phosphatase-like
protein, are found in 50% to 75% of type 1 diabetics at and prior to
disease onset. These autoantibodies are generally more prevalent in
younger onset patients. Because the risk of diabetes is increased with the
presence of each additional autoantibody, the positive predictive value of
the IA2 antibody test is enhanced when measured in conjunction with
antibodies to GAD and insulin."

Another page to read is this:  http://www.medscape.com/viewarticle/503725

I know it's ALL very hard to understand, worse yet to try to explain it.
But bottom line, most times, someone
with LADA has more symptoms of being a T1 then they do being a T2.  That
is thinking in the respect of
"hindsight is 20/20" mode.

There are home tests you could do (which I figured out myself), to
determine which way you're leaning and
what I used them for was to take into my doctor to prove to him I needed
this additional testing done. Well
that bozo refused and therefore I fired his a.s and found one to listen to
me. Once he read my ER report, I
didn't really need to say much more to him. He's the one that confirmed to
me that I entered the ER in DKA
and I should have been forced to stay instead of them allowing me to
leave.  Sadly, because I was a 33yr
old woman, they considered me a "typical" type 2 based upon my age...
which often that is more the mode
of the medical profession then not.  Now I actually have medical persons
ask me if I'm a T1 or T2.

| This is all so new to me and so many people have made suggestions and recommendations on how my treatment
| should be kicked off - but it appears that my medical care is less than
competent.  I mean, if my own GP doesnt |  want to know (fobbed me
straight off to a diabetic nurse), the nurse is incompetent and the new
doc I am seeing | 3 weeks into October only has an interest and not
specialised in diabetes -what the hell am I supposed to do?

You keep on fighting until you find a doctor to listen to you. Honestly,
even though you all have socialized
medicine there in the UK, from what everyones said about how their doctor
behaves towards them, I personally
will keep what we have here.  I've never seen a bunch of more ignorant
fools in all my life and I used the think
US doctors were idiots. lol... sorry, nothing personal but check the
archives, it's pretty scary at times what
some Brits have said their doctors and nurses have told them.

| How can I get myself someone knowledgeable and skilled medically for my condition?  Its very frustrating!

What you need to do is get a copy of ALL your labs, demand copies. From
what I know, even in the UK
you are entitled to a copy of your labs. Then learn what each one means,
learn what is the right area for you
with that lab test. Then spend the funds if you have too and test like a
mad fool in the beginning to learn all
you can about YOU.  Never mind this test at 1hr crap.  If that were
important, then Insulin makers would
be having those on Insulin testing at 1hr to see if the insulin is working
correctly, but they don't they tell us
that immedate release insulin starts working within 10-15mins from
injection and peak of that insulin is around
90mins to 2hrs, which is when they've made it to work on the human peaking
times. (sorry, but much
research went into making insulin and one person came in here and spouted
to test at 1hr now many
think it's mandatory) Do yourself a favor and learn when YOU peak.. What I
did was start testing every
15mins for the first week to see what graphs I got, then learned when I
peaked which happened to be
within the time the insulin was peaking to cover my natural peak.  Some
claim it's different for T2's, I don't
think so.. otherwise, they have insulin for T1's and T2's.. but they
dont'.. Just some claim they know more
then the researchers do... perhaps they do.. more so, I think not.  I know
what I know, but I don't know
more then the researchers do.

Anyhow, it all boils down to you learning what your body needs and how it
works and then find a doctor
who's willing to listen to you and you both work together as a team.  Such
as if he tells you to eat 200gm
a day in carbs and you tell him thats too much, then try 200gm and slowly
lower it to what works for you
then go back and say, "hey, check it out.. I tried the 200, I got this, I
slowly lowered it and did this and
this is now what I got, that I'm more happy with" Words go a long way with
trying to manipulate (lol like
that word) your medical team.  And if you can only eat 50gm a day, the so
be it.. but just remember,
having to add or take medication isn't a bad thing for diabetics.  There
are many medications out there
that actually have good things about them like Metformin.  I personally
take more "prevention" medications
then I do actual meds for things that are wrong with me.

| Thanks for input :)))

You're welcomed, just hope I didn't scare you or write your ear off. Just
remember, asking questions
is what's going to help you to learn what you need to live a long healthy
life being a diabetic.

rk, t1
happy pumper
Jackie Patti - 28 Sep 2007 20:55 GMT
> here is a wonderful page that explains much. it's from a brilliant author
> who's written "Using Insulin" &
[quoted text clipped - 7 lines]
> entire site, it's owned by the
> author John Walsh who's diabetic himself as well as a CDE)

I found "Pumping Insulin" very informative even though I don't pump.
It's a great book for understanding how to change dosing on a flexible
schedule.  Unfortunately, it completly ignores protein, which is
significant for me since I low-carb and most of my bg is made from
protein rather than carb.

Bernstein does discuss dosing for protein, but he uses an inflexible
system where you eat the same amount for breakfast every day, etc.  I
have never been able to be as consistent in my lifestyle as he demands
and while I do low-carb, I don't go nearly as low as he recommends, so
his method didn't quite "fit" me either.  He does add an excellent
system for correcting lows that I think should be much more widely known.

In order to figure out how to dose for myself, I basically had to
combine the info from both sources and figure out my own method.  I
worked my basal dosing out via a combination of their recommendations in
a pretty straightforward manner.  For bolusing, I figured out both a
carb ratio and a protein ratio.

This is a lot more complex than either system as given, and was pretty
damned complicated to figure out initially.  But it provides a great
deal of flexibility on a day-to-day basis and I can pretty much keep my
preprandials under 110 and my postprandials under 140 with the system I
worked out using the info from both sources.

> Do yourself a favor and learn when YOU peak.. What I
> did was start testing every
[quoted text clipped - 7 lines]
> what I know, but I don't know
> more then the researchers do.

I don't know if it's different based on T1 or T2 status or not.

As a T2, my own peak was at around 1 hour before insulin.  Then when I
began on Lantus/Humalog, my peak was at 2 hours.  When I switched to
Lantus/Regular, my peak moved back to one hour.  It's freaking confusing
to know what to aim at when the target moves around like that.

I realize the insulins have different peaks, but I changed the timing of
the shots to correspond to their peaks, so I dunno what the heck
happened.  I take Regular 45 minutes before a meal vs. Humalog 15
minutes before, and I still get very different bg peaks postprandially.
 It's weird.

I also did a bunch of tests at 3 and 4 hours with high-fat meals
(including pizza itself) to see if I had higher bg further out due to
the whole "pizza effect" thing.  I'll be damned if I can located a
"pizza effect" in my body!  I find my 2-hour number is nearly identical
to my next preprandial every time no matter the macronutrient makeup of
my meals (except on Humalog when my peak is at 2 hours, then it's my 3
hr number that stays the same until my next meal).

The information in books gives you a starting place, but you really have
to test how stuff works in your OWN body cause it can vary a lot.

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rk - 29 Sep 2007 00:10 GMT
| > here is a wonderful page that explains much. it's from a brilliant author
| > who's written "Using Insulin" &
[quoted text clipped - 13 lines]
| significant for me since I low-carb and most of my bg is made from
| protein rather than carb.

heh, then you weren't reading "Pumping Insulin" by John Walsh, because
reading his book is WHERE I first learned about the effects of Protein
and how to counter them.  Bernsquack made no mention of it. (then again,
I only got a few chapters into his book when I realized he wasn't living
on
the same planet as the rest of us earthlings)

| Bernstein does discuss dosing for protein, but he uses an inflexible
| system where you eat the same amount for breakfast every day, etc.  I
[quoted text clipped - 14 lines]
| preprandials under 110 and my postprandials under 140 with the system I
| worked out using the info from both sources.

Congrats, good for you.

| > Do yourself a favor and learn when YOU peak.. What I
| > did was start testing every
[quoted text clipped - 14 lines]
| Lantus/Regular, my peak moved back to one hour.  It's freaking confusing
| to know what to aim at when the target moves around like that.

Personally, I don't believe it's a one set time peak anyhow. I believe
just as
ones glucose changes moment by moment, as does our peak times. I've found
that mine isn't constant and that I have a good 15-20min window of Peak.
It's
also very dependant upon what I've eaten. If I eat a lower carb meal, such
as
a small potato, salad and fish and skip the dessert, then my peak is
closer to
70mins.  If I eat the same meal and add in a slice of pie and 1 scoop of
vanilla
ice cream then my peak is closer to 100mins.

I did extensive testing of this after the second time of using a CGMS and
noticed
a trend with my post meal peak times.

| I realize the insulins have different peaks, but I changed the timing of
| the shots to correspond to their peaks, so I dunno what the heck
| happened.  I take Regular 45 minutes before a meal vs. Humalog 15
| minutes before, and I still get very different bg peaks postprandially.
|  It's weird.

See above. Perhaps the same is happening to you as well.

| I also did a bunch of tests at 3 and 4 hours with high-fat meals
| (including pizza itself) to see if I had higher bg further out due to
[quoted text clipped - 3 lines]
| my meals (except on Humalog when my peak is at 2 hours, then it's my 3
| hr number that stays the same until my next meal).

I think those who have closer to no natural insulin production find
they're
hit harder with the Pizza effect.  I also find that T1's seem to be
effected
moreso from Protein then apparently T2's. There's a few T2's here that
claim Protein doesn't effect T2's at all.  Which I find hard to believe
other
then the fact, their own natural insulin handles the load and/or they
don't
test at the right time(s) to find the peak effect of the Protein.

I find Protein effects me closer to 6-8hrs after eating.  Such as if I eat
a
8oz Rib-eye steak, I won't see the effects of the Protein until I wake up
the following morning.  I have my pump set perfectly to combat DP for
me. But it never fails, after that steak dinner, I'll see a good 50-100pt
rise the following morning.

| The information in books gives you a starting place, but you really have
| to test how stuff works in your OWN body cause it can vary a lot.

Yes, I believe that as well. When I first arrived I learned that my body
was
a testing board and I soon began to think of "my" diabetes as a game. A
game
that I was going to WIN! When I'd post about some of my experiments I used
to get well, not the nicest comments. Some felt I was putting myself at
risk and
by posting it putting it out there for others to read and perhaps put them
at risk
as well. *shrug* I figured I had to learn somehow. Questions I was asking
couldn't
be answered because no one knew most of the answers I needed... so I
became
my own lab experiment.

From learning as much as I have... I asked to guess speak at the new
diabetics
conference my doctors office holds quarterly.

rk, t1
Jackie Patti - 30 Sep 2007 00:47 GMT
> heh, then you weren't reading "Pumping Insulin" by John Walsh, because
> reading his book is WHERE I first learned about the effects of Protein
> and how to counter them.  

That is what I read, but since I got it from the library, I may have had
an out-of-date version.

The only thing I found in it that mentioned protein was that if you ate
a lot of protein at a meal, you might get high bg.  The "answer" given
for that was to see a nutritionist to learn how to not eat so much
protein.

What is his system for dosing for protein?

> Bernsquack made no mention of it. (then again,
> I only got a few chapters into his book when I realized he wasn't living
> on
> the same planet as the rest of us earthlings)

I have two versions of Bernstein.  Both show calculating insulin doses
based on grams of carbohydrate and ounces of protein food in each meal.

I've posted his actual math here, though I didn't find it at all useful
myself as the "answers" obviously assumed no insulin resistance.

> | This is a lot more complex than either system as given, and was pretty
> | damned complicated to figure out initially.  But it provides a great
[quoted text clipped - 3 lines]
>
> Congrats, good for you.

Thank you.

> Personally, I don't believe it's a one set time peak anyhow. I believe
> just as
[quoted text clipped - 12 lines]
> noticed
> a trend with my post meal peak times.

That sounds much more like the whole "pizza effect" idea.  Personally, I
just never saw my peak change like that whether I ate actual pizza or a
salad.

> I think those who have closer to no natural insulin production find
> they're
[quoted text clipped - 6 lines]
> don't
> test at the right time(s) to find the peak effect of the Protein.

I think that there is some carb:protein that pushes the metabolism
towards gluceoneogeneis.  So many feedback loops are involved that I
suspect the ratio might be different for some people.

I also think there's a big difference in even insulin-using T2s vs. T1s.
 My body seems to "modulate" things more than what I've read from T1s.

> I find Protein effects me closer to 6-8hrs after eating.  Such as if I eat
> a
> 8oz Rib-eye steak, I won't see the effects of the Protein until I wake up
> the following morning.  I have my pump set perfectly to combat DP for
> me. But it never fails, after that steak dinner, I'll see a good 50-100pt
> rise the following morning.

That's interesting.  I'm going to have to look at my data a bit and see
if I can find a similar effect.

> Yes, I believe that as well. When I first arrived I learned that my body
> was
[quoted text clipped - 10 lines]
> became
> my own lab experiment.

That is *very* much the same attitude I had.

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Jackie Patti - 27 Sep 2007 10:05 GMT
> one last thing... if you are a LADA, don't worry much about
> your trigs, hdl, ldl as once you're on insulin, they'll drop naturally.
> they work in conjunction with high glucose too when you lack
> insulin in the body they naturally go up.  but once your glucose
> gets into check then they naturally lower.  I can't say the same
> thing about being a T2.

Works for T2s also.  It even seems to work for nondiabetics; improved
lipid panels are a common "side effect" of low-carbing.

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rk - 27 Sep 2007 18:42 GMT
| > one last thing... if you are a LADA, don't worry much about
| > your trigs, hdl, ldl as once you're on insulin, they'll drop naturally.
[quoted text clipped - 5 lines]
| Works for T2s also.  It even seems to work for nondiabetics; improved
| lipid panels are a common "side effect" of low-carbing.

I didn't say anything about low-carbing. I simply stated once she
gets her glucose under control by whatever means her lipid profile
will improve. I certainly don't low carb (150-200gm) and my lipid
profile is fantastic other then my HDL because I simply cannot do
much exercise and my doctor knows that.
John - 27 Sep 2007 20:12 GMT
> figured this would get lost in the sea of replies,
> but I wanted to let you know.... GAD testing
[quoted text clipped - 13 lines]
> have any GAD.... this would then be confirmed with a low
> to zero cpeptide most often.

I had the islet cell antibodies and tyrosine phosphatase antibodies
tests in addition to the GAD-65 test and C-peptide. I also thought I
saw insulin antibody test on the orders, but I may be mistaken about
that.

John C.
 
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