 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / Diseases and Disorders / Diabetes / August 2007Venesection improved chronic fatigue and polyarthralgias
Venesection therapy of insulin resistance-associated hepatic iron overload. BACKGROUND/AIMS: The association of hepatic iron overload with metabolic disorders has been coined as the insulin resistance-associated hepatic iron overload syndrome (IR-HIO). METHODS: Fifty-six IR-HIO patients were phlebotomized either weekly (n = 14) or bimonthly (n = 42) and compared with C282Y homozygotes and with ten IR- HIO patients treated by a low calorie diet alone. RESULTS: In venesected patients, the median amount of mobilized iron was 0.6 g in 2.8 months in females and 1.8 g in 5 months in males. Mobilized iron did not differ depending on the frequency of venesections or HFE genotype. When compared with C282Y homozygotes, IR-HIO patients had a similar amount of mobilized iron, but three-fold serum ferritin levels. The presenting symptoms (chronic fatigue and/or polyarthralgias) improved in 6/7 patients. Phlebotomies were well tolerated. In patients treated by a low calorie diet, serum ferritin levels remained stable. CONCLUSIONS: In IR-HIO patients, body iron stores are significantly increased, overestimated by serum ferritin, not modified by a low calorie diet, and safely removed by phlebotomies. Based on these data and on studies indicating that iron excess is associated with increased risk for hepatic fibrosis, cancer and cardiovascular disorders, venesection therapy can be recommended in IR-HIO patients. Keywords: patients, ferritin, serum, calorie, hepatic, mobilized, calorie diet, mobilized iron, serum ferritin, ferritin levels, patients treated, c282y homozygotes, iron overload, compared with, with c282y, hepatic iron Authored by Guillygomarc'h A, Mendler MH, Moirand R, Laine F, Quentin V, David V, Brissot P, Deugnier Y. Clinique des Maladies du Foie, CHU Pontchaillou, Rennes, France. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Gad I have got to get new glasses I thought this read Vasectomy improves chronic fatigue.. Ronnie > Venesection therapy of insulin resistance-associated hepatic iron > overload. [quoted text clipped - 44 lines] > DEAD PEOPLE WALKING > http://tinyurl.com/zk9fk > Gad I have got to get new glasses I thought this read Vasectomy improves > chronic fatigue.. > > Ronnie Well, if the cause of chronic fatigue is an infant that doesn't yet sleep through the night, then a vasectomy could prevent a recurrence... You got that right ;-) Ronnie >> Gad I have got to get new glasses I thought this read Vasectomy improves >> chronic fatigue.. [quoted text clipped - 3 lines] > Well, if the cause of chronic fatigue is an infant that doesn't yet sleep > through the night, then a vasectomy could prevent a recurrence... > You got that right ;-) > [quoted text clipped - 9 lines] > > - Show quoted text - Aloha IJ and All! LOL! So did I!! I had to do a "triple-take" as I had my "V" done back in 1981 after way too many children were brought into this world by this sex-crazed man. I was relieved to re-re-read that the heading didn't say that...whew! Uh, Iron-J, my man? Don't you think you are starting to dig just a little too far for information to post here? Most of us are what you might call, "ordinary, average human beings" just trying to cope and live our lives as best we can with the support and friendship of others here. How many of us do you really believe care very much about this that I've C&P'ed from your OP? "CONCLUSIONS: In IR-HIO patients, body iron stores are significantly increased, overestimated by serum ferritin, not modified by a low calorie diet, and safely removed by phlebotomies. Based on these data and on studies indicating that iron excess is associated with increased risk for hepatic fibrosis, cancer and cardiovascular disorders, venesection therapy can be recommended in IR-HIO patients." I think my left cerebral cortex blew out when I read the above!! ;-) Aloha For Now, Hawaiian Wayne >> On Aug 5, 8:17 pm, Hawaiian Wayne <birdie...@hotmail.com> wrote: "CONCLUSIONS: > In IR-HIO patients, body iron stores are significantly increased, overestimated by serum ferritin, not modified by a low calorie diet, and safely removed by phlebotomies. Based on these data and on studies indicating that iron excess is associated with increased risk for hepatic fibrosis, cancer and cardiovascular disorders, venesection therapy can be recommended in IR-HIO patients." I think my left cerebral cortex blew out when I read the above!! ;-) << You have read these a few times. People with .. pre-diabetes / insulin resistance / IR .. AND with iron overload in their livers / hepatic iron overload / HIO.. were found to be treated .. well .. BY iron reduction. IE: improved chronic fatigue and polyarthralgias Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > "CONCLUSIONS: > In IR-HIO patients, body iron stores are significantly increased, [quoted text clipped - 9 lines] > Aloha For Now, > Hawaiian Wayne LOL, yep, perfect example how the use of fancy words makes things so complicated and unreadable. Why couldn't they have just said that if you give blood periodically, you will reduce the "iron overload" in your liver and if you don't, you can expect to die of a heart attack, stroke, liver disease or cancer. Hey, that might be a good campaign slogan for the Red Cross? LOL Please don't think that I am supporting or defending what our resident ferrinnut digs up and posts, cause believe me, I'm not! It's just your reply made me chuckle Wayne. ;o) Diane On Aug 6, 8:47 am, johnson...@cheshire.net wrote: Please don't think that I am supporting or defending what our resident > ferrinnut digs up and posts, cause believe me, I'm not! << Well I suppose I'll have to .. settle .. for the support OF these very competent researchers .. who are actually recruiting FOR my favorite .. subject . Iron reduction for .. diabetes .. that would be AFTER .. pre-diabetes. That would be the 'pre' .. part of that word. http://www.clinicaltrials.gov/show/NCT00230087 Iron Depletion Therapy for Type 2 DM and NAFLD This study is currently recruiting patients. Verified by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) March 2006 ---------------------------------------------------------------------------??------------------------------ Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk It's just your > reply made me chuckle Wayne. ;o) > > Diane And I suppose NOW since it is curing leukemia .. you can expect to hear more about this .. work you do not .. support. The second article shows .. in anemia .. BY doing JUST that they accidentally / paradoxically .. **cured** .. that is .. **cured** the .. patient. "unexpected reduction in blood transfusion requirement, ultimately resulting in long-lasting transfusion-free survival. " **Cured** Hemoglobin. 2006;30(1):131-7. Links Iron burden and liver fibrosis decrease during a long-term phlebotomy program and iron chelating treatment after bone marrow transplantation. Meo A, Ruggeri A, La Rosa MA, Zangh? L, Morabito N, Duca L. Paediatric Department, "G. Martino" Policlinico University of Messina, Messina, Italy. a...@unime.it In this retrospective study, we report the results of the association of a combined phlebotomy program and chelation in hereditary sideroblastic anemia (HSA) to reduce iron overload after bone marrow transplantation (BMT). A male HSA patient, not responding to pyridoxine treatment, was submitted to successful allogeneic BMT. As there was a persistence of a tissue iron overload, a regular phlebotomy program was started followed by chelation. A significant decrease of iron burden was obtained using a combined treatment with deferoxamine (DFO) and deferiprone (L1) in addition to the phlebotomy program. A 10-year follow-up shows a marked decrease in the concentration of serum ferritin, non-transferrin-bound iron (NTBI), liver iron and normal hemoglobin (Hb), which allows the patient to reach and maintain a good quality of life. PMID: 16540426 [PubMed - indexed for MEDLINE] ------------------------------------------------------------------ <<snip>> resulting in long-lasting transfusion-free survival <<snip>> Correction of anemia in a transfusion-dependent patient with primary myelofibrosis receiving iron chelation therapy with deferasirox (Exjade?, ICL670) Authors: Di Tucci, Anna Angela1; Murru, Roberta1; Alberti, Daniele2; Rabault, Bertrand2; Deplano, Simona1; Angelucci, Emanuele1 Source: European Journal of Haematology, Volume 78, Number 6, June 2007, pp. 540-542(3) Publisher: Blackwell Publishing Abstract: Transfusional iron overload in patients with chronic anemias can result in multiple organ failure. Experience in the management of iron overload in patients with myelodysplastic syndromes is limited, as many do not receive chelation therapy due to short-life expectancy and the difficulties associated with the administration of the current reference standard chelator, deferoxamine. There have, however, been some reports of reduced transfusion requirement associated with chelation therapy in patients with myelodysplastic syndromes and myelofibrosis. Here, we discuss a patient with primary myelofibrosis and related transfusion-dependent anemia who received chelation therapy with the once-daily oral iron chelator, deferasirox. In addition to the reduced iron levels, the patient demonstrated an unexpected reduction in blood transfusion requirement, ultimately resulting in long-lasting transfusion-free survival. Keywords: myelofibrosis; iron overload; chelation Document Type: Research article DOI: 10.1111/j.1600-0609.2007.00840.x Affiliations: 1: Unit? Operativa Ematologia e Centro Trapianti Midollo Osseo, Ospedale Oncologico `Armando Businco', Cagliari, Italy 2: Novartis Pharma AG, Basel, Switzerland Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk On Aug 6, 9:34 am, "ironjust...@aol.com" <ironjust...@aol.com> wrote: > On Aug 6, 8:47 am, johnson...@cheshire.net wrote: Please don't think > that I am supporting or defending what our resident [quoted text clipped - 38 lines] > > - Show quoted text - Objectively speaking do you think you are obsessed with all things "iron"? And I suppose NOW since it is curing leukemia .. you can expect to hear more about this .. work you do not .. support. The second article shows .. in anemia .. BY doing JUST that they accidentally / paradoxically .. **cured** .. that is .. **cured** the .. patient. "unexpected reduction in blood transfusion requirement, ultimately resulting in long-lasting transfusion-free survival. " **Cured** Hemoglobin. 2006;30(1):131-7. Links Iron burden and liver fibrosis decrease during a long-term phlebotomy program and iron chelating treatment after bone marrow transplantation. Meo A, Ruggeri A, La Rosa MA, Zanghì L, Morabito N, Duca L. Paediatric Department, "G. Martino" Policlinico University of Messina, Messina, Italy. a...@unime.it In this retrospective study, we report the results of the association of a combined phlebotomy program and chelation in hereditary sideroblastic anemia (HSA) to reduce iron overload after bone marrow transplantation (BMT). A male HSA patient, not responding to pyridoxine treatment, was submitted to successful allogeneic BMT. As there was a persistence of a tissue iron overload, a regular phlebotomy program was started followed by chelation. A significant decrease of iron burden was obtained using a combined treatment with deferoxamine (DFO) and deferiprone (L1) in addition to the phlebotomy program. A 10-year follow-up shows a marked decrease in the concentration of serum ferritin, non-transferrin-bound iron (NTBI), liver iron and normal hemoglobin (Hb), which allows the patient to reach and maintain a good quality of life. PMID: 16540426 [PubMed - indexed for MEDLINE] ------------------------------------------------------------------ <<snip>> resulting in long-lasting transfusion-free survival <<snip>> Correction of anemia in a transfusion-dependent patient with primary myelofibrosis receiving iron chelation therapy with deferasirox (Exjade®, ICL670) Authors: Di Tucci, Anna Angela1; Murru, Roberta1; Alberti, Daniele2; Rabault, Bertrand2; Deplano, Simona1; Angelucci, Emanuele1 Source: European Journal of Haematology, Volume 78, Number 6, June 2007, pp. 540-542(3) Publisher: Blackwell Publishing Abstract: Transfusional iron overload in patients with chronic anemias can result in multiple organ failure. Experience in the management of iron overload in patients with myelodysplastic syndromes is limited, as many do not receive chelation therapy due to short-life expectancy and the difficulties associated with the administration of the current reference standard chelator, deferoxamine. There have, however, been some reports of reduced transfusion requirement associated with chelation therapy in patients with myelodysplastic syndromes and myelofibrosis. Here, we discuss a patient with primary myelofibrosis and related transfusion-dependent anemia who received chelation therapy with the once-daily oral iron chelator, deferasirox. In addition to the reduced iron levels, the patient demonstrated an unexpected reduction in blood transfusion requirement, ultimately resulting in long-lasting transfusion-free survival. Keywords: myelofibrosis; iron overload; chelation Document Type: Research article DOI: 10.1111/j.1600-0609.2007.00840.x Affiliations: 1: Unità Operativa Ematologia e Centro Trapianti Midollo Osseo, Ospedale Oncologico `Armando Businco', Cagliari, Italy 2: Novartis Pharma AG, Basel, Switzerland Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk On Aug 6, 9:34 am, "ironjust...@aol.com" <ironjust...@aol.com> wrote: > On Aug 6, 8:47 am, johnson...@cheshire.net wrote: Please don't think > that I am supporting or defending what our resident [quoted text clipped - 38 lines] > > - Show quoted text - >> "CONCLUSIONS: >> In IR-HIO patients, body iron stores are significantly increased, [quoted text clipped - 22 lines] > > Diane LOL or you can go back to the old days and try leaching. > johnson...@cheshire.net wrote: > >> "CONCLUSIONS: [quoted text clipped - 27 lines] > > - Show quoted text - Aloha Diane, Steve, Cheeky and Everyone! Thanks Diane. Sometimes I wonder if my "Bloom County bred with The Far Side resulting in The Firesign Theater" type of humor doesn't go way over many peoples heads here since most go by uncommented on. Nice to see someone acknowledge one of my less existential 'ones'. Steve, thanks for mentioning the "iron" thingy. I know that "Ironjustice" has a serious and valid topic to discuss, its just that these quoted scientific studies get so professionally "wordy" that I find myself looking up every other word and writing the meanings down and rereading what he has posted and still don't quite "get it". It all get so tiresome sometimes when one is already dealing with the lifestyle of a CPer....(sigh). Aloha For Now, Hawaiian Wayne |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2009 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.