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Medical Forum / Diseases and Disorders / Diabetes / August 2007

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Insulin resistance/hyperinsulinemia and vertigo

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Susan - 05 Aug 2007 19:47 GMT
 Arch Intern Med. 1986 Aug;146(8):1497-500.Links
    Identification and treatment of metabolic abnormalities in patients
with vertigo.
    Lehrer JF, Poole DC, Seaman M, Restivo D, Hartman K.

    Hyperinsulinism, impaired glucose tolerance, and
hypertriglyceridemia may be risk factors for atherosclerotic heart
disease and have also been described in patients with vertigo, whose
symptoms and findings responded to appropriate dietary therapy. We
studied 100 patients in an otolaryngology practice to determine the role
of these abnormalities in identifying patients suitable for dietary
therapy and to assess the efficacy of dietary therapy in the treatment
of vertigo in such selected patients. The determination of
hyperinsulinism and hypertriglyceridemia were of value as supplements to
the traditional glucose tolerance test in detecting reversible metabolic
vertigo. Reactive hypoglycemia was found in only four patients and thus
appears overdiagnosed as a cause of vertigo. *******Insulin resistance
appears to be the basic abnormality in this syndrome, which, in our
series, occurred predominantly in overweight patients. ******

    PMID: 3524492 [PubMed - indexed for MEDLINE]
Jim Chinnis - 05 Aug 2007 21:19 GMT
Susan <nevermind@nomail.com> wrote in part:

>x-no-archive: yes
>
[quoted text clipped - 19 lines]
>
>     PMID: 3524492 [PubMed - indexed for MEDLINE]

This was the prevailing theory for a while, as I recall. And I'm guessing
the "dietary therapy" they were talking about was a low fat diet! I don't
think any of this has panned out over the past 21 years, though the amount
of research in the area is pretty slim.

There's no doubt that Meniere's involves stress hormones, but it's not yet
been sorted out what is cause and what is effect and which hormones are
involved. A few women with Meniere's have "cured" themselves from all
vertigo attacks by taking estrogen supplements...
--
Jim Chinnis   Warrenton, Virginia, USA
Susan - 06 Aug 2007 02:26 GMT
> This was the prevailing theory for a while, as I recall. And I'm guessing
> the "dietary therapy" they were talking about was a low fat diet! I don't
> think any of this has panned out over the past 21 years, though the amount
> of research in the area is pretty slim.

The study I saw that improved tinnitus was low carb and very low
calorie.  Lowers insulin; higher insulin tends to raise cortisol.

> There's no doubt that Meniere's involves stress hormones, but it's not yet
> been sorted out what is cause and what is effect and which hormones are
> involved. A few women with Meniere's have "cured" themselves from all
> vertigo attacks by taking estrogen supplements...

Estrogen raises cortisol binding globulin, thereby lowering free
cortisol and cortisol output by the pituitary because the cells stop
signalling for more cortisol.  That makes perfect sense.

Susan
Jim Chinnis - 06 Aug 2007 03:03 GMT
Susan <nevermind@nomail.com> wrote in part:

>Estrogen raises cortisol binding globulin, thereby lowering free
>cortisol and cortisol output by the pituitary because the cells stop
>signalling for more cortisol.  That makes perfect sense.

Interesting. Thanks.
--
Jim Chinnis   Warrenton, Virginia, USA
Andrew B. Chung, MD/PhD - 06 Aug 2007 11:06 GMT
> convicted neighbor Susan <nevermind@nomail.com> wrote in part:

http://HeartMDPhD.com/Convicts

> >Estrogen raises cortisol binding globulin, thereby lowering free
> >cortisol and cortisol output by the pituitary because the cells stop
> >signalling for more cortisol.  That makes perfect sense.
>
> Interesting. Thanks.

Except the pituitary does not make cortisol.

Cortisol is made by the adrenal glands, which sits atop the kidneys.

Moreover, cortisol binding globulin (CBG) falls significantly when
simply lying down:

http://www.eje-online.org/cgi/content/abstract/146/2/231

This explains why hunger increases at night as folks lie down to go to
sleep.

It is the world's great lie about hunger that causes the irrational
compulsion to snack at night:

http://HeartMDPhD.com/PressRelease

It is the overeating that is causing the VAT, which is causing the
problems.

Be hungry... be healthy... be blessed:

http://HeartMDPhD.com/PressRelease

Prayerfully in Jesus' awesome love,

Andrew <><
--
Andrew B. Chung, MD/PhD
Cardiologist
 
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