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Medical Forum / Diseases and Disorders / Diabetes / August 2007Low carb is better because then the brain does knows that you have eaten something
This article concludes that only if T2D your brain will not signal that you eat glucose or any other carbohydrate (?) , so you keep eating , so you get more problems.So low carb is better (?) They tested Glucose itself , one wonders if it works the same for any carbohydrate.I think it should because any carb is converted to glucose within a few minutes when ingested.So If T2D a low carb meal is much more satiating a fact demonstrated before in the literature The article is so new that the citation below is not yet in Pubmed ; please wait a few days for it to appear Diabetes. 2007 Aug 1; [Epub ahead of print] Glucose ingestion fails to inhibit hypothalamic neuronal activity in patients with type 2 diabetes mellitus.Vidarsdottir S, Smeets PA, Eichelsheim DL, van Osch MJ, Viergever MA, Romijn JA, van der Grond J, Pijl H. Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, The Netherlands. Objective: The hypothalamus plays a critical role in the regulation of energy balance and fuel flux. Glucose ingestion inhibits hypothalamic neuronal activity in healthy humans. We hypothesized that hypothalamic neuronal activity in response to an oral glucose load would be altered in patients with type 2 diabetes mellitus. Research Design and Methods: In this randomized, single blind, case-control study, 7 male patients with type 2 diabetes mellitus (BMI 27.9 +/- 2.0 kg/m(2)) and 10 healthy (BMI 26.1 +/- 3.2 kg/m(2)), age-matched men participated. Subjects were scanned twice for 38 minutes on separate days, using functional magnetic resonance imaging. After 8 min, they ingested either a glucose solution (75 g in 300 mL water) or water (300 mL). Results: Glucose ingestion resulted in a prolonged significant blood oxygen level dependent (BOLD) signal decrease in the upper and lower hypothalamus in healthy men, but not in patients with diabetes. Conclusions: Glucose ingestion fails to inhibit hypothalamic neuronal activity in patients with type 2 diabetes mellitus. Failure of neural circuits to properly adapt to nutrient ingestion may contribute to metabolic imbalance in DM2 patients. PMID: 17670916 hth Gys "GysdeJongh" <jongh711@planet.nl> wrote in part: >This article concludes that only if T2D your brain will not signal that you >eat glucose or any other carbohydrate (?) , so you keep eating , so you get [quoted text clipped - 38 lines] >hth >Gys Very, very interesting. Does the hypothalamus respond with inhibited firing to glucose or to insulin? I assume the former, but I'm a novice in this area. -- Jim Chinnis Warrenton, Virginia, USA Jim Chinnis <jchinnis@SPAMalum.mit.edu> wrote in part: >Very, very interesting. Does the hypothalamus respond with inhibited firing >to glucose or to insulin? I assume the former, but I'm a novice in this >area. Sorry. It obviously says the response is to blood oxygen. So how does blood oxygen change from the ingestion of glucose? -- Jim Chinnis Warrenton, Virginia, USA > "GysdeJongh" <jongh711@planet.nl> wrote in part: > >>This article concludes that only if T2D your brain will not signal that >>you eat glucose or any other carbohydrate (?) , so you keep eating , so >>you get more problems.So low carb is better (?) I know I'm peculiar....I mean, "eccentric", I think I'm old enough to say that now :-).... but I didn't think I was quite off the wall. My brain seems to know quite well when I've eaten even if it's very much not low carb. bj >> "GysdeJongh" <jongh711@planet.nl> wrote in part: >> [quoted text clipped - 7 lines] >My brain seems to know quite well when I've eaten even if it's very much not >low carb. You're lucky, BJ. I used to figure out whether or not I'd had enough by what portion size I had. I never felt any different before or after a meal, I could be hungry half an hour after eating... that meant that all my cues were social ones. Nicky. T2 dx 05/04 + underactive thyroid D&E, 100ug thyroxine Last A1c 5.6% BMI 25 >>> "GysdeJongh" <jongh711@planet.nl> wrote in part: >>> [quoted text clipped - 13 lines] > a meal, I could be hungry half an hour after eating... that meant that > all my cues were social ones. My brain is also quite capable of *consciously ignoring* the signals (I'm enjoying the <whatever> too much, it's tasty, etc.) -- why I got so overweight years ago -- i.e. "weak as water" as Mrs. Slocumb would say. I mostly manage not to do that anymore. bj >>>> "GysdeJongh" <jongh711@planet.nl> wrote in part: >>>> [quoted text clipped - 18 lines] >overweight years ago -- i.e. "weak as water" as Mrs. Slocumb would say. >I mostly manage not to do that anymore. Sure - but I never got the signals. It was like a lightbulb went on when I started actually feeling full, BEFORE I'd stuffed my gut. Quite amazing. Nicky. T2 dx 05/04 + underactive thyroid D&E, 100ug thyroxine Last A1c 5.6% BMI 25 > "GysdeJongh" <jongh711@planet.nl> wrote in part: > Very, very interesting. Does the hypothalamus respond with inhibited > firing > to glucose or to insulin? I assume the former, but I'm a novice in this > area. Hi Jim Chinnis, To both these and a zillion other signals..... The human body a a very perfect survival machine.It is geared to getting enough food and reproduction.Most of the signals are unconscious and we only find out if there is something wrong :( I seem to remember that you are a statistician than regard it as a multivariate optimization problem which , as ussual , ended up in a local maximum.So we are all different in that we are all different walking local maximum solutions of the survival problem that evolution found :) Cholecytostokin is a signal which terminates an ongoing meal signalling : "Hey stop now we have eaten enough" The CCK signal is provoked most strongly by proteins , also by _some_ fats and just a little bit by carbohydrates.Unfortunately CCK is not evoked at all in T2D.So.....they are far better of with (branced) amino acids and good fats because , for them the vicious circle : inject insulin , eat carbs , get more hugry because of the insulin and the carbs , eat more carbs will get them in even more problems There are very nice articles on this.Look for "The Brain-Gut axis" Here is an exceprt from the article and a nice colourfull review The brain plays a central role in the regulation of food intake and energy balance (1). Hypothalamic- and brain stem nuclei perceive and integrate circulating metabolic (glucose, lipids) and hormonal (e.g. leptin, insulin, and various gut peptides) cues reflecting available fuel sources. Indeed, an oral glucose load acutely mitigates hypothalamic neuronal activity in healthy humans (2). Efferent neuroendocrine ensembles subsequently orchestrate food intake and fuel metabolism so as to maintain energy homeostasis (1;3). Energy imbalance and anomalous fuel flux are metabolic hallmarks of obesity and type 2 diabetes mellitus. In view of the critical role of the brain in the control of metabolism alluded to above, inappropriate hypothalamic processing of signals indicating disruption of energy homeostasis could contribute to such metabolic anomalies. We hypothesized that hypothalamic neuronal activity in response to glucose ingestion would be altered in patients with DM2, reflecting aberrant perception of current metabolic status Free review : J Clin Invest. 2007 Jan;117(1):24-32. The role of gut hormones in glucose homeostasis. Drucker DJ. The gastrointestinal tract has a crucial role in the control of energy homeostasis through its role in the digestion, absorption, and assimilation of ingested nutrients. Furthermore, signals from the gastrointestinal tract are important regulators of gut motility and satiety, both of which have implications for the long-term control of body weight. Among the specialized cell types in the gastrointestinal mucosa, enteroendocrine cells have important roles in regulating energy intake and glucose homeostasis through their actions on peripheral target organs, including the endocrine pancreas. This article reviews the biological actions of gut hormones regulating glucose homeostasis, with an emphasis on mechanisms of action and the emerging therapeutic roles of gut hormones for the treatment of type 2 diabetes mellitus. PMID: 17200703 hth Gys >> "GysdeJongh" <jongh711@planet.nl> wrote in part: Whoops Sorry.... :) This one (however the other is also very much worth reading) : J Clin Invest. 2007 Jan;117(1):13-23. Gastrointestinal regulation of food intake. Despite substantial fluctuations in daily food intake, animals maintain a remarkably stable body weight, because overall caloric ingestion and expenditure are exquisitely matched over long periods of time, through the process of energy homeostasis. The brain receives hormonal, neural, and metabolic signals pertaining to body-energy status and, in response to these inputs, coordinates adaptive alterations of energy intake and expenditure. To regulate food consumption, the brain must modulate appetite, and the core of appetite regulation lies in the gut-brain axis. This Review summarizes current knowledge regarding the neuroendocrine regulation of food intake by the gastrointestinal system, focusing on gastric distention, intestinal and pancreatic satiation peptides, and the orexigenic gastric hormone ghrelin. We highlight mechanisms governing nutrient sensing and peptide secretion by enteroendocrine cells, including novel taste-like pathways. The increasingly nuanced understanding of the mechanisms mediating gut-peptide regulation and action provides promising targets for new strategies to combat obesity and diabetes. PMID: 17200702 Gys > This article concludes that only if T2D your brain will not signal that you > eat glucose or any other carbohydrate (?) , so you keep eating , so you get [quoted text clipped - 35 lines] > > PMID: 17670916 There is no evidence that glucose not inhibiting hypothalamic neuronal activity is a bad thing. Indeed, this difference between type-2 diabetics and non-diabetics may be compensatory for the benefit of type-2 diabetics for greater hypothalamic tolerance of hyperglycemia. Be hungry... be healthy... be blessed: http://HeartMDPhD.com/PressRelease Prayerfully in Jesus' awesome love, Andrew<>< -- Andrew B. Chung, MD/PhD Cardiologist Sock Notice: The readers of SMC would like nothing less than to congratulate the father on the birth of Sock heartdoc18 who has come to join his siblings heartdoc(s) 9 through 17 in their continued spamming. Heartdoc18 weighed in at only 2lbs and so may be the runt of the litter, only time will tell. In the meantime, he's made a less than promising start with: snip > http://HeartMDPhD.com/PressRelease SCAM ALERT SPAM SPAM SPAM To complain about the excessive use of socks and the spamming of above url: multiple Google accounts. All of these @emorycardiology.com, i.e. heartdoc9@emorycardiology.com: ------------------------------------------------------------ andrew heartdoc9 heartdoc11 heartdoc12 heartdoc13 heartdoc14 heartdoc15 heartdoc16 heartdoc17 heartdoc18 Complain to:groups-abuse@google.com posted to Usenet sent via bellsouth IP addresses 68.211.197.166 or 67.34.27.12 or 68.19.48.236 : ----------------------------------------------- RAbuseHandle: ABUSE81-ARIN RAbuseName: Abuse Group RAbusePhone: +1-404-499-5224 RAbuseEmail: abuse@bellsouth.net heartmdphd.com appears to be hosted by Softcom: ---------------------------------------------- RTechHandle: TY12-ARIN RTechName: Yustein, Tony RTechPhone: +1-416-957-7400 RTechEmail: tony@softcomca.com emorycardiology.com appears to be hosted by godaddy: ---------------------------------------------------- OrgAbuseHandle: ABUSE51-ARIN OrgAbuseName: Abuse Department OrgAbusePhone: +1-480-624-2505 OrgAbuseEmail: abuse@godaddy.com Judge for yourself the quality of our resident spam-boi: http://groups.google.co.uk/group/alt.support.diabetes/msg/d559bc684dd89f72 ?hl=en& Andy is Evil |
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