Can imbalance/instability in any ICF prminient constitutent as
Potassium caused by added/reduced injected insulin be a reason to show
acute effects of instablities of that constituent? Whether
Hypoglycemia's symptoms resembles with some symptoms of potassium, Mg,
Phosphate instabilities?

Whether lantus is in monomerized form before injected?

Is it possible that solubility/availability of polymerized insulin is
different in different people? If yes how?

Thanks for much information.

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"Actions on cellular and metabolic level

Effect of insulin on glucose uptake and metabolism. Insulin binds to
its receptor (1) which in turn starts many protein activation cascades
(2). These include: translocation of Glut-4 transporter to the plasma
membrane and influx of glucose (3), glycogen synthesis (4), glycolysis
(5) and fatty acid synthesis (6).The actions of insulin on the global
human metabolism level include:

Control of cellular intake of certain substances, most prominently
glucose in muscle and adipose tissue (about ⅔ of body cells).
Increase of DNA replication and protein synthesis via control of amino
acid uptake.
Modification of the activity of numerous enzymes (allosteric effect).
The actions of insulin on cells include:

Increased glycogen synthesis – insulin forces storage of glucose in
liver (and muscle) cells in the form of glycogen; lowered levels of
insulin cause liver cells to convert glycogen to glucose and excrete
it into the blood. This is the clinical action of insulin which is
directly useful in reducing high blood glucose levels as in diabetes.
Increased fatty acid synthesis – insulin forces fat cells to take in
blood lipids which are converted to triglycerides; lack of insulin
causes the reverse.
Increased esterification of fatty acids – forces adipose tissue to
make fats (ie, triglycerides) from fatty acid esters; lack of insulin
causes the reverse.
Decreased proteinolysis – forces reduction of protein degradation;
lack of insulin increases protein degradation.
Decreased lipolysis – forces reduction in conversion of fat cell lipid
stores into blood fatty acids; lack of insulin causes the reverse.
Decreased gluconeogenesis – decreases production of glucose from
various substrates in liver; lack of insulin causes glucose production
from assorted substrates in the liver and elsewhere.
Increased amino acid uptake – forces cells to absorb circulating amino
acids; lack of insulin inhibits absorption.
Increased potassium uptake – forces cells to absorb serum
potassium[some other mineral also dependant on K homeostatis]; lack of
insulin inhibits absorption.
Arterial muscle tone – forces arterial wall muscle to relax,
increasing blood flow, especially in micro arteries; lack of insulin
reduces flow by allowing these muscles to contract.
http://en.wikipedia.org/wiki/Insulin "

In nature, in normal person, insulin may not be exposed continually
and more. As such and in view of above indicated actions of insulin,
how more and continual exposure of insulin can effect adversely?