Home | Contact Us | FAQ | Search & Site Map | Link to Us
Sign In | Join | Other 45 Sites in Network
Home
Discussion Groups
General
GeneralCardiologyVisionDentistryPharmacyLaboratoryNutritionAlternative
Diseases and Disorders
AIDSAlzheimer'sArthritisAsthmaCancerBreast CancerDiabetesEpilepsyGlaucomaHepatitisHerpesLupusProstate BPHProstate CancerProstatitisSinusitisTinnitus

Medical Forum / Diseases and Disorders / Diabetes / February 2007

Tip: Looking for answers? Try searching our database.

Protein Linked To Elevated Body Mass Index

Thread view: 
Enable EMail Alerts  Start New Thread
Thread rating: 
Kurt - 24 Feb 2007 09:21 GMT
http://diabetes.org/diabetesnewsarticle.jsp?storyId=14493089&filename=20070222/c
omtex20070222up00000001bcusbmiproteinewEDIT.xml


or

http://tinyurl.com/2ywawr

MINNEAPOLIS, Feb 22, 2007 (UPI via COMTEX) -- U.S. scientists say
they've discovered an abnormal protein is linked with elevated body
mass index in people of American Indian and Mexican ancestry.

Professor Gary Nelsestuen and colleagues at the University of
Minnesota found the variant of a common blood protein, apolipoprotein
C1, is also linked with obesity and type 2 diabetes.
Chris Malcolm - 24 Feb 2007 11:21 GMT
> http://diabetes.org/diabetesnewsarticle.jsp?storyId=14493089&filename=20070222/c
omtex20070222up00000001bcusbmiproteinewEDIT.xml

> or

> http://tinyurl.com/2ywawr

> MINNEAPOLIS, Feb 22, 2007 (UPI via COMTEX) -- U.S. scientists say
> they've discovered an abnormal protein is linked with elevated body
> mass index in people of American Indian and Mexican ancestry.

> Professor Gary Nelsestuen and colleagues at the University of
> Minnesota found the variant of a common blood protein, apolipoprotein
> C1, is also linked with obesity and type 2 diabetes.

IMHO we should avoid getting too excited by these "Scientists have
found a gene!" reports. This particular report confirms the findings
about this specific gene which had previously been reported in
specific fat metabolism experiments with transgenic mice.

However, according to the human genome mapping gang, there are
hundreds of genes associated with obesity and T2 diabetes. And unusual
proneness to obesity and T2 diabetes are also found in human
populations with other obesity/T2 genetic factors than this one at
work, such as the Pima Indians and the Pacific Islanders.

The general interesting point seems to be that human populations
regularly exposed to episodes of famine not surprisingly develop
tendencies to pile on the fat unusually quickly in times of
plenty. Unfortunately when these populations don't get exposed to
episodes of starvation in between the episodes of plenty they just
pile on the fat, and pile on the fat, and pile on the fat.

It seems to be the case that there's quite a lot of genetic routes in
this rapid fattening when well fed direction, and at least many of
them seem to be associated with a prevalence towards T2 diabetes if
the tendencies to pile on the fat aren't controlled.  Visceral adipose
tissue (aka tummy fat) has bad effects on the progression of T2
diabetes and its complications regardless of which specific genetic
abnormalities helped your body to pile in the pounds.

In other words, when we talk about "good numbers" and "good control",
we're shouldn't just be talking about BGs and blood lipids. Weight
matters too.

Signature

Chris Malcolm        cam@infirmatics.ed.ac.uk              DoD #205
IPAB,  Informatics,  JCMB, King's Buildings, Edinburgh, EH9 3JZ, UK
[http://www.dai.ed.ac.uk/homes/cam/]

 
Sign In
Join
My Latest Posts
My Monitored Threads
My Blog
My Photo Gallery
My Profile
My Homepage

Start New Thread
Enable EMail Alerts
Rate this Thread



©2008 Advenet LLC   Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.