Hot Dam! Researchers reverse diabetes in mice

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admin@ng2000.com - 16 Dec 2006 07:51 GMT

(Reuters via Yahoo! News) Nerve cells in the pancreas may be a cause
of type-1 diabetes in mice --a finding that could provide new ways to
treat the disease in humans, Canadian and U.S. scientists said on
Friday.

http://www.ng2000.com/fw.php?tp=diabetes

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% - 16 Dec 2006 07:57 GMT

> (Reuters via Yahoo! News) Nerve cells in the pancreas may be a cause
> of type-1 diabetes in mice --a finding that could provide new ways to
> treat the disease in humans, Canadian and U.S. scientists said on
> Friday.
>
> http://www.ng2000.com/fw.php?tp=diabetes

no no no , hold up there guy ,
the was no US said , its a Canadian invention ,
the US had nothing to do with it

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Wes Groleau - 16 Dec 2006 15:42 GMT

That is the first paragraph of a longer article that says nothing else
about the U.S., but if you follow the second link, it does mention that
some folks from Maine were involved. But that's nit-picking, and since
I'm on a nit-picking roll: I read an abstract on PubMed from _2003_ that
suggested nerve cells in the pancreas caused both type one AND type two.

So it's an inaccurate "nit" to say that these guys in 2006 "discovered"
that nerve cells may be a factor. It's also unfortunate that--as
usual--the media exaggerate and oversimplify to the point of inaccuracy.

I thought it's not hard to believe that a nerve cell in the pancreas
could affect the performance or even the survival of a beta cell, but
for it to influence insulin resistance throughout the body, it would
have to be indirect--by causing the release of something (perhaps
insulin?) that decreases insulin sensitivity.

But not wanting to be entirely negative, I agree that it's progress and
that it's good news.

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Jeff - 16 Dec 2006 16:29 GMT

>> (Reuters via Yahoo! News) Nerve cells in the pancreas may be a cause
>> of type-1 diabetes in mice --a finding that could provide new ways to
[quoted text clipped - 6 lines]
> I'm on a nit-picking roll: I read an abstract on PubMed from _2003_ that
> suggested nerve cells in the pancreas caused both type one AND type two.

It was suggested that the moon is made of cheese. Now, if ROn Evans stepped
off the _Challenger_ and discovered that there was, indeed, cheese on the
moon, whom would you say discovered cheese on the moon? The people who
thought about it in the 1800s, or Mr. Evans, the gentleman who actually
found it?

Suggesting something and actually finding it are two different things.

> So it's an inaccurate "nit" to say that these guys in 2006 "discovered"
> that nerve cells may be a factor. It's also unfortunate that--as
> usual--the media exaggerate and oversimplify to the point of inaccuracy.

And people still eat it up. Funny, you can go to the Sick Kids hospital web
site and get a more accurate representation of the work or go to
www.cell.com and read the actual report by the people from Canada and the US
(and China, too - Look at the names of the authors).

The bottom line here is that you have to seek out accurate info.

> I thought it's not hard to believe that a nerve cell in the pancreas could
> affect the performance or even the survival of a beta cell, but for it to
> influence insulin resistance throughout the body, it would have to be
> indirect--by causing the release of something (perhaps insulin?) that
> decreases insulin sensitivity.

Insulin doesn't crease insulition sensitivity.

You do raise a good question about how insulin sensitivity arises and the
factors that regulate it.

> But not wanting to be entirely negative, I agree that it's progress and
> that it's good news.

That it is.

Jeff

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Wes Groleau - 20 Dec 2006 02:09 GMT

> Insulin doesn't crease insulition sensitivity.

If you look below, you will see NO pertinent citations.
But I have read more than one medical item claiming that
hyperglecemia and/or hyperinsulinemia is suspected of
causing insulin resistance.

More likely the sugar than the insulin, though--my apologies
for too few links in the cause chain.

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surrounding a quote from a literary giant of weeniedom like
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Ha, ha, Dr. ..... Who's Chris Maeda?
-- Wes Groleau

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Ma¢k - 20 Dec 2006 03:35 GMT

[Default] On Wed, 20 Dec 2006 02:09:56 GMT, Wes Groleau
<groleau+news@freeshell.org> Giggled into the madness of usenet:

>> Insulin doesn't crease insulition sensitivity.
>
[quoted text clipped - 5 lines]
>More likely the sugar than the insulin, though--my apologies
>for too few links in the cause chain.

it's the high glucose not the high insulin that increases insulin
resistance. at least in type 1s.

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Jeff - 20 Dec 2006 03:41 GMT

> [Default] On Wed, 20 Dec 2006 02:09:56 GMT, Wes Groleau
> <groleau+news@freeshell.org> Giggled into the madness of usenet:
[quoted text clipped - 11 lines]
> it's the high glucose not the high insulin that increases insulin
> resistance. at least in type 1s.

Actually, it is neither. Obesity, genetics and a host of other factors
appear to create the insulin insenstivity. High glucose and high insulin are
results of this, not the cause.

Jeff

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Ma¢k - 20 Dec 2006 03:57 GMT

[Default] On Wed, 20 Dec 2006 03:41:00 GMT, "Jeff" <jeff@hotmail.com>
Giggled into the madness of usenet:

>> [Default] On Wed, 20 Dec 2006 02:09:56 GMT, Wes Groleau
>> <groleau+news@freeshell.org> Giggled into the madness of usenet:
[quoted text clipped - 17 lines]
>
>Jeff

Jeff,

what I wrote is correct. type 1s can and do experience fluctuations
in insulin resistance based on current BG levels. And no we do not
have to be over weight for this to happen.

In the case of a type 1, insulin resistance can be temporary due to
illness, or high BGs in the absence of illness and in the absence of
being over weight.

You don't have to believe though I will believe my endo.

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Jeff - 20 Dec 2006 04:15 GMT

> [Default] On Wed, 20 Dec 2006 03:41:00 GMT, "Jeff" <jeff@hotmail.com>
> Giggled into the madness of usenet:
[quoted text clipped - 27 lines]
> in insulin resistance based on current BG levels. And no we do not
> have to be over weight for this to happen.

I would like to see the evidence for this, if I understand you correctly. If
I do, it follows that giving people IV glucose (or having them drink glucose
or other sugar) causes insulin resistance.

Jeff

> In the case of a type 1, insulin resistance can be temporary due to
> illness, or high BGs in the absence of illness and in the absence of
> being over weight.
>
> You don't have to believe though I will believe my endo.

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GrandpaChuck - 20 Dec 2006 04:18 GMT

>[Default] On Wed, 20 Dec 2006 03:41:00 GMT, "Jeff" <jeff@hotmail.com>
>Giggled into the madness of usenet:
[quoted text clipped - 32 lines]
>
>You don't have to believe though I will believe my endo.

I have seen T1's that are almost as thin as someone with an eating
disorder. Also, it used to be called Juvenile Diabetes not that long
ago. Most of the kids that were found to be diabetic were not the
least bit overweight.

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% - 20 Dec 2006 04:30 GMT

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