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Medical Forum / Diseases and Disorders / Diabetes / December 2006when to take Metformin
Hi all; I'm taking one pill/500 mg Metformin per day. Does it matter when I take ti? Morning,night? Split it? Thanks a heap -jbb 52 yrs old, northern CA T2, Dx 9/8/2006; a1c 6.3 11/16/06 d&e, Metformin 500 mg; Lisinopril, Lovastatin, Armour (thyroid) > Hi all; > > I'm taking one pill/500 mg Metformin per day. > > Does it matter when I take ti? Morning,night? Split it? At breakfast time. I don't think it really matters but that's the recommendation. C > Thanks a heap > -jbb > > 52 yrs old, northern CA > T2, Dx 9/8/2006; a1c 6.3 11/16/06 > d&e, Metformin 500 mg; Lisinopril, Lovastatin, Armour (thyroid) J.B. Bobbitt wrote in message ... >Hi all; > [quoted text clipped - 8 lines] >T2, Dx 9/8/2006; a1c 6.3 11/16/06 >d&e, Metformin 500 mg; Lisinopril, Lovastatin, Armour (thyroid) Metformin tends to inhibit the digestion of carb and sometimes causes bloating, gas and diarrhea. Many folks have remarked that taking their metformin with a very low carb meal helps (if they are susceptible. . .some folks aren't) Since breakfast is the meal with the most potential for causing runaway blood sugars when we eat too many carbs; many diabetics try to eat as few carbs, even no carbs at breakfast. That makes breakfast a good time for a metformin dose. Note that the recommended clinical maintenance dose of metformin is 1500 mg/day. If your doc doesn't see the results he wants from 1 pill a day, he may up you to 3 pills a day. Metformin is the type of pill which takes days, even weeks to become effective; and days, even weeks to lose effect if we stop taking it. Thus, many folks find that "when" you take the pill doesn't matter that much. Regards Old Al > J.B. Bobbitt wrote in message ... >>Hi all; [quoted text clipped - 31 lines] > Regards > Old Al Are you really sure about that? I once did a one day layoff and my numbers were up considerably the next day. ray wrote in message ... ... . . .(snip). . . >> Metformin is the type of pill which takes days, even weeks to become >> effective; and days, even weeks to lose effect if we stop taking it. [quoted text clipped - 6 lines] >Are you really sure about that? I once did a one day layoff and my numbers >were up considerably the next day. Can't point to a citation, just remarks by posters to these groups. I went directly from metformin to insulin so I never tested the concept. Regards Old Al i take the metformin twice a day i forgot one of the day's pills and experienced no negative change due to that kate  SignatureJoin us in the Diabetic-Talk Chatroom on UnderNet /server irc.undernet.org --- /join #Diabetic-Talk More info: http://www.diabetic-talk.org/ http://www.diabetic-talk.org/freeveggies.htm I have no medical qualifications beyond my own experience. Choose your advisers carefully, because experience can be an expensive teacher. > ray wrote in message ... > ... . . .(snip). . . [quoted text clipped - 15 lines] > Regards > Old Al > i take the metformin twice a day > > i forgot one of the day's pills and experienced no > negative change due to that > > kate I don't seem to notice a difference if I skip one or two of my four per day, but if I skip all four (done only once as an experiment) I jumped about 40 points by the next morning. > ray wrote in message ... > [quoted text clipped - 16 lines] > Regards > Old Al Interestingly, when I was seeking the various maximum doses online yesterday, I found that the drug manufacturer's info specifically states that there is no one therapeutic level, that it's a highly individual matter. I suspect there are studies finding more folks getting more effect from 1500 than lower doses, but that's not how the prescribing information reads. Susan > Metformin tends to inhibit the digestion of carb and sometimes causes > bloating, gas and diarrhea. Many folks have remarked that taking their > metformin with a very low carb meal helps (if they are susceptible. . .some > folks aren't) (snipped) > Note that the recommended clinical maintenance dose of metformin is 1500 > mg/day. If your doc doesn't see the results he wants from 1 pill a day, > he may up you to 3 pills a day. I took 500 mg/day for 3 years. The last several years, I took 1000 mg/day. I am experiment with 1500 mg/day since I can no longer get Ultralente which I low dosed at about 10 units at bedtime. DHEA at 50 mg/day can reduce visceral fat and have about the same effect as the TZDs, Actos and Avandia. I tried to use 2000 mg/day, 500 mg at breakfast, lunch, dinner, and bedtime for about 7 days. I suspect that the AMPK activation of metformin excited my system too much and I had trouble sleeping so I cut it back to 1500. That is a speculation on my part. Frank > I took 500 mg/day for 3 years. The last several years, I took 1000 > mg/day. I am experiment with 1500 mg/day since I can no longer get > Ultralente which I low dosed at about 10 units at bedtime. DHEA at 50 > mg/day can reduce visceral fat and have about the same effect as the > TZDs, Actos and Avandia. I have but haven't used, custom compounded DHEA transdermal cream. I won't touch it til I have my hypercortisolism sorted out. > I tried to use 2000 mg/day, 500 mg at breakfast, lunch, dinner, and > bedtime for about 7 days. I suspect that the AMPK activation of > metformin excited my system too much and I had trouble sleeping so I cut > it back to 1500. That is a speculation on > my part. Frank, sleeplessness was one of the symptoms I experienced on metformin as I became adrenally suppressed on it (after years of low dose steroid use, too). On 1500 mg per day, I couldn't sleep at all without pills. The day after I quit metformin I was able to eat a meal for the first time in months and fall asleep for the first time in just as long. Susan Frank/Susan: This AMPK and insomnia stuff is maybe my problem. Is it a well establish AE for metformin? Larry > x-no-archive: yes > [quoted text clipped - 20 lines] > > Susan > Frank/Susan: This AMPK and insomnia stuff is maybe my problem. Is it a > well establish AE for metformin? I don't know, I never looked it up because I was already adrenally suppressed before I took it, and the increased insulin sensitivity was just the proverbial straw that broke the camel's back. One of the things it did to me at the same time was cause massive foot and leg cramps, and many folks report that, and it is in the literature. Why not try experimenting to see if you sleep better with a dose reduction for a day? I got relief the next day, when I was able to eat and fall asleep for the first time in months. Susan On Sun, 03 Dec 2006 06:31:59 -0800, J.B.Bobbitt wrote: > Hi all; > [quoted text clipped - 8 lines] > T2, Dx 9/8/2006; a1c 6.3 11/16/06 > d&e, Metformin 500 mg; Lisinopril, Lovastatin, Armour (thyroid) Dr. Bernstein, in his "Diabetes Solution" seems to recommend just before bed. He indicates that maximum amount in you bloodstream (assuming you're using the extended release) occurs about seven hours after taking it. I take 2 500's @ breakfast & 2 500's @ dinner time. I don't have any trouble sleeping. I try to walk on the TM for about 30min. a day. I use the extended release. Nana > On Sun, 03 Dec 2006 06:31:59 -0800, J.B.Bobbitt wrote: > [quoted text clipped - 14 lines] > bed. He indicates that maximum amount in you bloodstream (assuming you're > using the extended release) occurs about seven hours after taking it. > I take 2 500's @ breakfast & 2 500's @ dinner time. I don't have any > trouble sleeping. I try to walk on the TM for about 30min. a day. I use > the extended release. That's exactly what I do. Minus the TM. I prefer to walk the streets ;-) TaniO > Nana > [quoted text clipped - 16 lines] >> bed. He indicates that maximum amount in you bloodstream (assuming you're >> using the extended release) occurs about seven hours after taking it. I live in a not too safe neighbor hood:-( So I have to walk in doors. If we lived close, we cloud walk together! Nana >> I take 2 500's @ breakfast & 2 500's @ dinner time. I don't have any >> trouble sleeping. I try to walk on the TM for about 30min. a day. I use [quoted text clipped - 26 lines] >>> you're >>> using the extended release) occurs about seven hours after taking it. > I live in a not too safe neighbor hood:-( So I have to walk in doors. If > we lived close, we cloud walk together! Best offer I've had in years;) TaniO > Nana > [quoted text clipped - 8 lines] >> >>> Nana >> I live in a not too safe neighbor hood:-( So I have to walk in >> doors. If we lived close, we cloud walk together! > > Best offer I've had in years;) lol |
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