1: Curr Atheroscler Rep. 2006 Nov;8(6):472-6. Links
Effects of Macronutrient Excess and Composition on Oxidative Stress:
Relevance to Diabetes andCardiovascular Disease.Ceriello A.
Clifford Bridge Road, Coventry CV2 2DX, United Kingdom.
antonio.ceriello@warwick.ac.uk.

Type 2 diabetes is a disease that is increasing in prevalence
worldwide. In genetically predisposed patients, the combination of
excess caloric intake and reduced physical activity induces a state of
insulin resistance. When beta-cells are not able to compensate for
insulin resistance by adequately increasing insulin production,
impaired glucose tolerance occurs, which is characterized by excessive
postprandial hyperglycemia. Impaired glucose tolerance may evolve into
overt diabetes. These three conditions (ie, insulin resistance,
impaired glucose tolerance, and overt diabetes) are associated with an
increased risk of cardiovascular disease. Intervention trials have
demonstrated that diabetes can be prevented by means of lifestyle
modifications, antidiabetic drugs directed against insulin resistance
or simply postprandial hyperglycemia, and cardiovascular drugs devoid
of effects on blood glucose levels. All of these have intracellular
antioxidant effects. Evidence on the efficacy of antioxidant
interventions is accumulating, and oxidative stress may be a
therapeutic target to prevent diabetes as well as cardiovascular
complications.

PMID: 17045073 [PubMed - in process]

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