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Medical Forum / Diseases and Disorders / Diabetes / September 2006

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Glipizide XL and Type 1?

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- 29 Sep 2006 23:11 GMT
Hey!

My doc just perscribed Glipizide XL for me.  But, I'm a type 1?  Why?

I'm not in bad control.  Usually around 7 on the H1C readings.  Lately I've had
issues due to work stress, which gave me a 7.6 H1C, but should be able to get
it down easily.  I've been a type 1 for almost 40 years now and no issues due
to the diabetes so far.

So why would my doc perscribe this drug normally used in Type 2?
Kurt - 29 Sep 2006 23:19 GMT
> Hey!
>
[quoted text clipped - 6 lines]
>
> So why would my doc perscribe this drug normally used in Type 2?

Sounds like the only person that can answer this for you is your
doctor.  What did he say when he prescribed it?  

Best,
Kurt
Jefferson - 29 Sep 2006 23:54 GMT
wrote:
> Hey!
>
[quoted text clipped - 6 lines]
>
> So why would my doc perscribe this drug normally used in Type 2?

It could be that your doctor suspects a misclassification of your diabetes.

Jenny posted in a thread titled "MODY not Type 1 was Re: 'Miracle'
Unfolds for Diabetic Girl" addresses a situation where a person with
MODY was misdiagnosed as type 1 - http://tinyurl.com/zhta5.

A scholar.google.com search for the terms A.T.+Hattersley+MODY+HNF4 -
http://tinyurl.com/g298c.

Frank
- 30 Sep 2006 05:20 GMT
>> Hey!
>>
[quoted text clipped - 20 lines]
>
>Frank

I wish!  Did  you guys read the latest ADA newsletter where they found a rare
thing where Type1 could be turned into type2 by combating a different problem?  
It affects only 1% or 2% of type 1s, but it's an interesting idea.  I don't
think this drug is used to determine that as a possibility.  It takes a special
test.  Would be nice in my case though.
Julie Bove - 30 Sep 2006 00:14 GMT
> Hey!
>
[quoted text clipped - 6 lines]
>
> So why would my doc perscribe this drug normally used in Type 2?

As the other poster said...  Only your Dr. could answer this.  Either you're
not really a type 1, your Dr. is mistaken, or there's some other reason.

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http://mysite.verizon.net/juliebove/index.htm

Alice Faber - 30 Sep 2006 00:20 GMT
> Hey!
>
[quoted text clipped - 7 lines]
>
> So why would my doc perscribe this drug normally used in Type 2?

Type 1 and Type 2 diabetes are two different metabolic disorders
(sharing a symptom of elevated blood sugar). If you've been T1 for
40-years, you're hitting the age at which insulin resistance starts to
be a problem for non-T1s. A little googling on the mechanism by which
Glipizide works suggests that, even though it's a sulfonylurea, it may
act by reducing insulin resistance.

This is just a WAG (and all I read was a few abstracts). You might want
to quiz your doctor before you take a new med, though, just to make sure
you're not dealing with a new doctor who, instead of reading your file,
sees a slightly pudgy middle-aged diabetic and ASSUMES type 2!

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AF
"Non Sequitur U has a really, really lousy debate team."
             --artyw raises the bar on rec.sport.baseball

- 30 Sep 2006 05:18 GMT
>> Hey!
>>
[quoted text clipped - 21 lines]
>you're not dealing with a new doctor who, instead of reading your file,
>sees a slightly pudgy middle-aged diabetic and ASSUMES type 2!

That's kinda what I was thinking, that it was to couter insulin resistance.  
Though I don't see much sign of that, more a sign of my depression over work
and life etc etc...

She did perscribe a small dose, 10mg so it may be just a test.  (shrug)
oldal4865 - 30 Sep 2006 11:50 GMT
wrote in message ...
>Hey!
>
[quoted text clipped - 6 lines]
>
>So why would my doc perscribe this drug normally used in Type 2?

    If you're a Type 1,  then you are injecting insulin several times a day
and have done so for "almost 40 years now".     If you are not using an
insulin pump,  those shots include two types of insulin,   a fast insulin
for meals and a slow insulin for your basal metabolism  (basal/bolus
regime).   If you miss a single shot,   your sugars skyrocket.

If all of the above are not true,  then I doubt that you are Type 1.

When you were younger,  you injected about 0.5 units/(day-kg body weight).
Now that you are older,  you are injecting somewhere between 0.5 (non-obese,
physically active)  and 0.7 units/(day-kg body weight).    (putting on some
weight,  doing more sitting)

If the above are not true,  more doubts arise though there's a lot of YMMV
in the daily dose levels.

Umm. . .my boring metformin rant follows:

My reading of the medical sites suggests that the commonly prescribed blood
sugar control med metformin  (Glucophage,  Glucophage XL) has strong
anti-heart attack effects in most diabetics and probably has weak to medium
anti-heart attack effects for the remainder.   If your doc wants to use
pills at this stage,  metformin should be the leading candidate.

Regards
 Old Al
 
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