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Medical Forum / Diseases and Disorders / Diabetes / June 2006Low Carb Diet and Alzheimers
Some of you may recall that a few months ago, there was some mention in the news and in this newsgroup about a possible connection or common factor between Alzheimers and Diabetes.... Today, I just happened to come across this information about work being done at Mount Sinai School of Medicine in New York City that seems to suggest that one effective defense against Alzheimers may be a low carb, low saturated fat diet. Here is a link that gives a digested summary of an article that appears in the July issue of the Journal of Biological Chemistry. http://www.stjohn.org/HealthInfoLib/swArticle.aspx?6,533356 Will, T2 > Some of you may recall that a few months ago, there was some mention in > the [quoted text clipped - 4 lines] > New York City that seems to suggest that one effective defense against > Alzheimers may be a low carb, low saturated fat diet. A low carb, low calorie diet : ( There's some places I'm not prepared to go... > Here is a link that gives a digested summary of an article that appears in > the July issue of the Journal of Biological Chemistry. > http://www.stjohn.org/HealthInfoLib/swArticle.aspx?6,533356 Nicky.  SignatureA1c 10.5/5.4/<6 T2 DX 05/2004 1g Metformin, 100ug Thyroxine 95/73/72Kg >> Some of you may recall that a few months ago, there was some mention in >> the [quoted text clipped - 7 lines] > A low carb, low calorie diet : ( There's some places I'm not prepared to > go... Why not? Any diet that leads to weight loss should be considered low calorie, IMO. Otherwise, what does low calorie mean? Using a low carb diet to help Alzheimers sounds reasonable, but I don't see how it can be considered low calorie indefinitely.... > Using a low carb diet to help Alzheimers sounds reasonable, but I don't > see how it can be considered low calorie indefinitely.... Yeah, there's the rub - they're talking about the kind of calorific restriction that extends life in mammalian models. It's way below the kind of level I'm prepared to go, if you extend it to humans. Nicky. SignatureA1c 10.5/5.4/<6 T2 DX 05/2004 1g Metformin, 100ug Thyroxine 95/73/72Kg ::: Using a low carb diet to help Alzheimers sounds reasonable, but I ::: don't see how it can be considered low calorie indefinitely.... :: :: Yeah, there's the rub - they're talking about the kind of calorific :: restriction that extends life in mammalian models. It's way below :: the kind of level I'm prepared to go, if you extend it to humans. ah....CR! I never have quite understood CR for life extention. If one is always in a state of restricted calories, then it seems to me that one is always losing weight. if one is not, then one is not restricting calories, for one is eating at maintenance. Unless, of course, one is constantly thriving to lower maintenance calories toward zero. Some life. On 27-Jun-2006, ray <ray@zianet.com> wrote: > That's all relative, I guess. As long as you take in fewer calories than > you burn, you'll lose weight. There are at least two ways to do that: take > in less or burn more. I find that vigorous bicycling (snowshoeing in the > winter) burns a lot of calories. Hi Roger, I think that in the end we shall discover what many of us have felt for a long time.... It is really a question of balance in nutritional values and overall calorie consumption.... Ideally, I think, one should get at what is a healthy weight for their individual body and characteristics, and maintain that weight, with portion and calorie control, while getting at least moderate exercise and maintaining glucose levels in line with what Jennifer and Susan suggest (i.e., no more than 140 1 hr PP, 120 2hr PP, and below 100 for FBG)...... Not everyone can do this, obviously, because different folks have their own unique limitations and metabolic concerns, ranging from allergies and food intolerances, to differing levels of function of beta cells, to differing factors of insulin resistance.... and, some people are just more active than others. And as we all know, T1s can get on a real roller-coaster ride, with all sorts of factors contributing to de-stabilization of BG levels. Having said all the foregoing, however, it is becoming more and more well-established that glucose control is a very big health concern, and it is something for everyone to consider, not just "diabetics". Will, T2 > ::: Using a low carb diet to help Alzheimers sounds reasonable, but I > ::: don't see how it can be considered low calorie indefinitely.... > :: > :: Yeah, there's the rub - they're talking about the kind of calorific > :: restriction that extends life in mammalian models. It's way below > :: the kind of level I'm prepared to go, if you extend it to humans. > ah....CR! I never have quite understood CR for life extention. If one is > always in a state of restricted calories, then it seems to me that one is > always losing weight. if one is not, then one is not restricting calories, > for one is eating at maintenance. Unless, of course, one is constantly > thriving to lower maintenance calories toward zero. Some life. You assume a constant metabolic rate. Many animals adapt to more food by becoming more active, less food by becoming less active. In my youth that's how I was, the more I ate the more fidgety and bouncy I became. I couldn't put on a single pound of weight no matter whow much I ate. And I did try! In those days I took it extremely seriously that women told me I was too skinny, and sometimes really stuffed myself for weeks trying to become more attractive. It doesn't seem unreasonable to me that slowing down metabolic rate would result in living longer. Even works for cars: tread lightly on the gas pedal and the gas comsumption goes down and the engine lasts longer. SignatureChris Malcolm cam@infirmatics.ed.ac.uk +44 (0)131 651 3445 DoD #205 IPAB, Informatics, JCMB, King's Buildings, Edinburgh, EH9 3JZ, UK [http://www.dai.ed.ac.uk/homes/cam/] :: Roger Zoul <rogerzoul2@hotmail.com> wrote: ::: Nicky wrote: [quoted text clipped - 15 lines] :: :: You assume a constant metabolic rate. Did you read the last two sentences. If you lower maintenance calories, then indeed you are lowering metabolic rate. My point then is: some life! Many animals adapt to more food :: by becoming more active, less food by becoming less active. In my :: youth that's how I was, the more I ate the more fidgety and bouncy I [quoted text clipped - 5 lines] :: It doesn't seem unreasonable to me that slowing down metabolic rate :: would result in living longer. It seems unnatural to me to want to induce coma to live longer! IMO, the goal should be to live a robust, active life, more than to live long but don't do much. To each his/her own, though. :: Even works for cars: tread lightly on :: the gas pedal and the gas comsumption goes down and the engine lasts :: longer. Yes, well, gas consumption goes down. But IME, cars have a bad habit of working better if you use them, than if left sitting. > :: Roger Zoul <rogerzoul2@hotmail.com> wrote: > ::: Nicky wrote: > ::: ah....CR! I never have quite understood CR for life extention. If > ::: one is always in a state of restricted calories, then it seems to [quoted text clipped - 4 lines] > :: > :: You assume a constant metabolic rate. > Did you read the last two sentences. If you lower maintenance calories, > then indeed you are lowering metabolic rate. My point then is: some life! If one gets into starvation mode, then one gets listless and depressed. I've never been sure whether the CR for life extension needed to get that low. > Many animals adapt to more food > :: by becoming more active, less food by becoming less active. In my [quoted text clipped - 6 lines] > :: It doesn't seem unreasonable to me that slowing down metabolic rate > :: would result in living longer. > It seems unnatural to me to want to induce coma to live longer! IMO, the > goal should be to live a robust, active life, more than to live long but > don't do much. To each his/her own, though. > :: Even works for cars: tread lightly on > :: the gas pedal and the gas comsumption goes down and the engine lasts > :: longer. > Yes, well, gas consumption goes down. But IME, cars have a bad habit of > working better if you use them, than if left sitting. Rather like people :-) SignatureChris Malcolm cam@infirmatics.ed.ac.uk +44 (0)131 651 3445 DoD #205 IPAB, Informatics, JCMB, King's Buildings, Edinburgh, EH9 3JZ, UK [http://www.dai.ed.ac.uk/homes/cam/] New BP Drug More Effective Novartis has announced that its new drug Rasilez proved more effective in reducing blood pressure than the older anti-hypertensive drug ramipril in people who also suffer from diabetes. Tackling high blood pressure in diabetics is important, because their risk of cardiovascular complications from the condition is two to four times higher than normal. Rasilez is the first in a new class of blood-pressure drugs called renin inhibitors that could offer additional health benefits compared to older medicines. I got this information from http://epsdrugstore.com/6-29eps-new_BP_drug_more_effective.htm They seem to have detail information on it... let me know if it is helpful > > :: Roger Zoul <rogerzoul2@hotmail.com> wrote: > > ::: Nicky wrote: [quoted text clipped - 43 lines] > IPAB, Informatics, JCMB, King's Buildings, Edinburgh, EH9 3JZ, UK > [http://www.dai.ed.ac.uk/homes/cam/] >> Some of you may recall that a few months ago, there was some mention in >> the [quoted text clipped - 7 lines] > A low carb, low calorie diet : ( There's some places I'm not prepared to > go... That's all relative, I guess. As long as you take in fewer calories than you burn, you'll lose weight. There are at least two ways to do that: take in less or burn more. I find that vigorous bicycling (snowshoeing in the winter) burns a lot of calories. > That's all relative, I guess. As long as you take in fewer calories than > you burn, you'll lose weight. There are at least two ways to do that: take > in less or burn more. I find that vigorous bicycling (snowshoeing in the > winter) burns a lot of calories. Well, I think a big part of the message is the importance of avoiding spikes in blood glucose.... All of us who have done even a minimum of reading in the area of carb metabolism and who have regularly used our meters to test our own blood glucose after consuming various types of carbs know about spikes and how they affect us. Alzheimers is becoming more recognized as very similar to diabetes.... Indeed current research shows demonstrable low levels of insulin inside the brain in alzheimers patients, and there seems to be some correlation between high levels of glucose, inflammations, and buildup of amyloid plaques in the brain.... Many of us diabetics are well-familiar with the inflammations caused by persistent high levels of blood glucose in our bodily tissues. It has been suggested that similar inflammatory processes at work in the brain related to excessive blood glucose levels contribute to alzheimers and the buildup of those plaques. Thus, the knowledge gleaned from this research may point the way to prevention, and perhaps a kind of cure, for alzheimers.... This is heady stuff! Will, T2 >> New York City that seems to suggest that one effective defense against >> Alzheimers may be a low carb, low saturated fat diet. > "Nicky" <ukc802466929@btconnect.com> wrote in message >A low carb, low calorie diet : ( There's some places I'm not prepared to >go... > Nicky. Why do you think a low carb diet that is also low in Saturated fat is a low calorie diet? :::: New York City that seems to suggest that one effective defense :::: against Alzheimers may be a low carb, low saturated fat diet. [quoted text clipped - 7 lines] :: Why do you think a low carb diet that is also low in Saturated fat :: is a low calorie diet? Probably because the article says this: "FRIDAY, June 23 (HealthDay News) -- A low-calorie diet, particularly one that's low in carbohydrates, may reduce or even reverse the symptoms of Alzheimer's disease, a new study in mice suggests." > Probably because the article says this: > > "FRIDAY, June 23 (HealthDay News) -- A low-calorie diet, particularly one > that's low in carbohydrates, may reduce or even reverse the symptoms of > Alzheimer's disease, a new study in mice suggests." Which is consistent with these findings: Dement Geriatr Cogn Disord 2000 May-Jun;11(3):176-80 Related Articles, Links Alzheimer disease and vascular dementia: relationships with fasting glucose and insulin levels. Carantoni M, Zuliani G, Munari MR, D'Elia K, Palmieri E, Fellin R. Department of Internal Medicine II, University of Ferrara School of Medicine, Ferrara, Italy. Cerebrovascular disease and Alzheimer disease are the leading causes of dementia in elderly subjects. In spite of it, relatively little is known about the pathogenesis and risk factors for dementia. We evaluated fasting plasma glucose and insulin, albumin, lipids, Lp(a) and uric acid levels in nondiabetic patients of both sexes affected by vascular dementia (VD) and senile dementia of the Alzheimer type (SDAT) as well as in a control group of age-matched nondemented subjects. Following a covariance analysis by gender, body mass index, albumin levels and prevalence of arterial hypertension, total and LDL cholesterol as well as HDL cholesterol levels were not significantly different among the three groups. Fasting glucose (p < 0.001 and p < 0.005, respectively) and insulin levels (p < 0.05 for both differences) were higher in patients with VD and SDAT than in control subjects. Our data show that nondiabetic patients with VD or SDAT have higher fasting glucose and insulin levels than healthy control subjects. These metabolic characteristics were not influenced by differences in gender, adiposity, nutritional status, lipids or presence of arterial hypertension. Copyright 2000 S. Karger AG, Basel PMID: 10765049 [PubMed - indexed for MEDLINE] Susan > x-no-archive: yes > [quoted text clipped - 38 lines] > > Susan This study rang a bell for me. I took care of my mother in law who had alzheimers disease for several years until she died. During that time she developed high glucose problems and was put on Amaryl. (I begged her doctor to give her something other than metformin, because I just could NOT deal with it if she got the metformin trots, since she was completely urinary incontinent and occasionally would not be able to make the bathroom in time for a bm.) It turns out that some of the medications used in treating alzheimer patients have a side effect of running high blood glucose, and even developing diabetes, like my mother in law did. Considering this, could it not be that they are putting the proverbial cart before the horse? Is it possible they were using test patients who were not on alzheimer medications? Were they using test patients who did not have alzheimers and later developed it? Lots of questions come to mind..... SignatureBest Regards, Evelyn (to reply to me personally, remove 'sox') |
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