Apolipoprotein (apo) B Levels

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Larry - 04 Apr 2006 16:46 GMT

Here is a short intro on LDLs subparticles and cardiac risk assessment.
It is www.aafp.org/afp/20030315/tips/21.html Apo B levels singles out
higher risk due to risk-increasing small, dense LDL particles and and a
much lower risk from "fluffy" large LDLs.

Larry

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Jefferson - 05 Apr 2006 21:29 GMT

> Here is a short intro on LDLs subparticles and cardiac risk assessment.
> It is www.aafp.org/afp/20030315/tips/21.html Apo B levels singles out
> higher risk due to risk-increasing small, dense LDL particles and and a
> much lower risk from "fluffy" large LDLs.

A definition lifted from Gretchen Becker's First Year book.
Definitions:
"Apolipoprotein. Lipoprotein refers to the whole particle.
Apolipoprotein means just the protein part of the lipoprotein. The
prefix apo comes from the Greek 'separated from.' There are many
different types of apolipoproteins. For example, apolipoprotein A (often
called just apoA) is associated with HDL, and
apolipoprotein B (apoB) is associated with LDL. Sometimes people call
the apolipoproteins just apoprotein.
Lipoprotein(a). Just to make things more confusing, there's a special
kind of LDL called lipoprotein(a), or just Lp(a). This LDL is attached
to an extra glycoprotein (a protein containing some sugar) called
apolipoprotein(a). It's not the same as apolipoprotein A, which is
associated with HDL The amount of Lp(a) seems to depend primarily on
your genetic background, although trans fats may increase it, and high
levels are associated with increased cardiovascular risk."
http://groups.google.com/groups?q=inflammation+markers+frank+roy&hl=e...

A November 2002 thread in this newsgroup on vitamin E and diabetes -
http://tinyurl.com/h63ms. (Note: There was a large negative article on
vitamin E as available in the typical supplements. This does not negate
vitamin E as it is foods such as extra virgin olive oil.)

Inflamation Markers: Diet and Other Therapies - http://tinyurl.com/r9ues.

Frank

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Larry - 06 Apr 2006 22:20 GMT

Hello Frank: I respect your word. I was hoping ApoB ( and ApoA) was a
way to state with little certainty the measurement of fluffy vs small
dense LDL. Is this too simplistic??

Larry

> > Here is a short intro on LDLs subparticles and cardiac risk assessment.
> > It is www.aafp.org/afp/20030315/tips/21.html Apo B levels singles out
[quoted text clipped - 27 lines]
>
> Frank

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Susan - 07 Apr 2006 01:27 GMT

> Hello Frank: I respect your word. I was hoping ApoB ( and ApoA) was a
> way to state with little certainty the measurement of fluffy vs small
> dense LDL. Is this too simplistic??
>
> Larry

There's an interesting thread about this on sci.med.cardiology right
now, where Jim Chinnis makes the case that size of LDL particles
probably shouldn't be the focus, since LDL is such a poor predictor of
CVD, compared to TG/HDL ratio.

Susan

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Jefferson - 07 Apr 2006 02:45 GMT

> Hello Frank: I respect your word. I was hoping ApoB ( and ApoA) was a
> way to state with little certainty the measurement of fluffy vs small
> dense LDL. Is this too simplistic??
>
> Larry

From my lab report below, it looks like it is somewhat.

I was only tested for Apo A-1 and Apo B one time (10/02/02). The lab
showed a range of 110-180 mg/dl for Apo A-1 and 60-140 for Apo B. A
ratio was computed of B/A-1 and the range was 0.0-0.7. The average risk
for males was 0.7 and females 0.6. Two times average risk was 0.9 and 3
times average risk was 1.0. Less risk involves a lower ratio. It looks
like a broad range of individual measures of B and A-1 could compute to
a normal ratio, but a higher A-1 is preferable to get a lower ratio and
less risk.

scholar.google.com - 12 thousand finds - http://tinyurl.com/ottsu

Apo B Apo A-1 ratio - 300 finds - http://tinyurl.com/nu2lx

"Apolipoproteins A" - http://tinyurl.com/qqr2r

"Apolipoproteins B" - http://tinyurl.com/q8j9e

I guess I didn't help you much. Sorry!

Frank

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