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Medical Forum / Diseases and Disorders / Diabetes / April 2006

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Prednisone in pre-diabetic

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Laura@notmy.com - 30 Mar 2006 21:05 GMT
I am currently not diagnosed with diabetes nor pre-diabetes, however,
with a history of hypoglycemia as a child (which was later abandoned
by the medicos), "borderline" GD (1984, wonder what the boundaries
were then?) and being hypothyroid, I've been keeping tabs on my
glucose reponses and find that if nothing else I appear to have
Insulin Resistant traits.  My FBG are also in the 80's -- the highest
I've ever had has been in the low 90's from a sleep in weekend.

I am also currently undergoing epidural treatment for severe neck and
arm pain.  I know that the steroids used in the shots are known to
kick up BG in diabetics.  I assume they do also in non diabetics.

I had my shot at 8 am this morning and was given a diet soda and
peanut butter crackers at about 9:30 when they brought me out of the
snooze of the versad.  ( that stuff is awsome)  Any way, two and a
half hours post crackers I was 180....that's quite a hike ....the
highest I've seen so far has been a 1 hour 165 after eating a bagel
w/Cream Cheese (yeah...bad food choice, I plead temporary insanity).
Three hours post crackers I had 141.

What I am curious to know after blathering this far, is if it is
possible for steroid treatments to kick someone who has IR/IGT over
the edge to where the body won't revert back to simply having the
IR/IGT and give it the shove it takes to create full blown diabetes?

My last shot (in January) did bump things up for about three days but
then things settled down.  I'm hopeful that this too will calm down.

I've lost 22 pounds since January with careful observance of what I
eat and how my numbers look in an effort to perhaps reverse the IR
(that is possible isn't it?  to reverse IR?)  I would be really sad to
find out that treating one pain could create a bigger one.

Thanks
Laura
David - 30 Mar 2006 21:59 GMT
> I am currently not diagnosed with diabetes nor pre-diabetes, however,
> with a history of hypoglycemia as a child (which was later abandoned
[quoted text clipped - 31 lines]
> Thanks
> Laura
Laura, your bg's should return to typical between 3 and 10 days, from
what I've seen happen to my wife and I after receiving those shots.
YMMV, but I wouldn't worry about it causing DM!

Dave
Laura@notmy.com - 30 Mar 2006 22:10 GMT
>> I am currently not diagnosed with diabetes nor pre-diabetes, however,
>> with a history of hypoglycemia as a child (which was later abandoned
[quoted text clipped - 36 lines]
>
>Dave

Thanks, Dave.
Perhaps it's a dose of worry-wartitis as I'm working pretty hard at
staying behind the border of IGT and diabetes by watching my diet and
exercise and reducing my weight.  The shots (this is the third) have
been the last ditch in avoiding surgery, and if they do the trick, I
may have the shots periodically if symptoms return.  I am not fearful
of surgery in general, but of having them messing around in my neck in
particular.  The prednisone tablet treatment did little to nothing to
help, and aside from the rotten shakes during and after the last days
of the treatment had little affect at all.
Billie - 30 Mar 2006 22:41 GMT
Yes, I wanted to make it clear that I did not move into the full-blown category until I started
taking **40 mg daily**.  It was this prophylactic use for my asthma, and connective tissue
diseases.  I still have to get the injections periodically.  Those few minutes of discomfort are
definitely well worth it!

I share your feelings of someone bothering with your neck/back.  I had a fractured vertebra, and
had kyphoplasty surgery on it with great results.  It helped allay my fears considerably.

Billie in AR

bh-wages at swbell.net
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

: : >Dave
:
[quoted text clipped - 8 lines]
: help, and aside from the rotten shakes during and after the last days
: of the treatment had little affect at all.
David - 31 Mar 2006 00:03 GMT
>>>I am currently not diagnosed with diabetes nor pre-diabetes, however,
>>>with a history of hypoglycemia as a child (which was later abandoned
[quoted text clipped - 48 lines]
> help, and aside from the rotten shakes during and after the last days
> of the treatment had little affect at all.
Laura, I had 2 spinal fusions and I wouldn't recommend it except when
all else fails.  My neck barely moves since the second fusion.  I had a
fusion in '88 and the next one in '97.  The surgeon even suggested it
isn't such a great idea to get the first one, because movement puts
great strain on the neck immediately above and below the fused area,
because it is rigid.

My bg's hit 300 and rarely dropped below 200 for 9  straight days, a few
months back, when I had another bulging disk.  (It sucks to get old,
huh?  I know, I know, the alternative is worse. <g> )

dave
David - 30 Mar 2006 22:11 GMT
> I am currently not diagnosed with diabetes nor pre-diabetes, however,
> with a history of hypoglycemia as a child (which was later abandoned
[quoted text clipped - 31 lines]
> Thanks
> Laura
to continue what I was saying: the shots aren't going to damage your
pancreas or beta cells.  the stuff is causing a release of glucose for
days.  You'll find many complaints about that on Google if you search
for "cortisone shot glucose"

dave
Ozgirl - 31 Mar 2006 00:09 GMT
"David" <David@invalid.com> wrote in message

> to continue what I was saying: the shots aren't going to damage your
> pancreas or beta cells.  the stuff is causing a release of glucose for
> days.  You'll find many complaints about that on Google if you search
> for "cortisone shot glucose"

I beg to differ Dave.

http://www-ermm.cbcu.cam.ac.uk/00001861h.htm :
"Adverse effects of current immunosuppressive protocols
Immunosuppressive drugs are needed to prevent rejection in transplantation. However, current immunosuppressive regimes that are based on corticosteroids, cyclosporin and tacrolimus (FK 506) are far from satisfactory in islet transplantation since all of these drugs have been shown to induce diabetes on their own (Table 1; tab001dgo; Ref. 16). In addition, they have side effects that preclude their use in all but life-threatening situations. The increased risk of infection and malignancy (Refs 17, 18), as well as the risk of stunting normal growth and development, preclude the use of these drugs in children who are not suffering life-threatening organ failure or other serious complications of diabetes (Ref. 19).

The direct and indirect effects of corticosteroids on pancreatic b cells are well documented. In an in vitro study using human cells, corticosteroids have been shown to induce a state of reduced insulin responsiveness by increasing the amount of insulin needed to suppress glycolysis and gluconeogenesis (Ref. 20). Corticosteroids reduce the number and affinity of insulin receptors, impair glucose uptake by muscle, and activate the glucose-free fatty acid cycle to synthesise glucose from acetyl CoA and free fatty acids (Refs 21, 22). In addition, corticosteroids inhibit insulin secretion in humans (Ref. 23) and insulin synthesis in rat pancreatic islet cells (Ref. 24)."
David - 31 Mar 2006 00:21 GMT
>  
> "David" <David@invalid.com <mailto:David@invalid.com>> wrote in message
[quoted text clipped - 5 lines]
> I beg to differ Dave.
>  

You spend too much time looking up medical information on the web in
order to argue.  The FACT is the OP is prediabetic.  chances are she
will become diabetic.  A cortisone shot or two isn't going to MAKE her
diabetic, so stop trying to scare her and being argumentative, to boot.
 Sometimes I HATE the web, because everyone thinks they are an expert
in every subject, because they find something to quote.  GIVE IT UP!!
Besides which, getting the shots is necessary, to avoid, if possible,
neck surgery.

Dave
Ozgirl - 31 Mar 2006 00:37 GMT
> > "David" <David@invalid.com <mailto:David@invalid.com>> wrote in message
> >
[quoted text clipped - 12 lines]
> Besides which, getting the shots is necessary, to avoid, if possible,
> neck surgery.

I didn't *have* to look it up on the web. 10 years ago my
daughter's pediatrician told me that we would curb the use
of prednisone for her asthma as much as possible (without
putting her life in danger) because it could cause her to
become diabetic. I had that confirmed by my endocrinologist.
As explained by my endo, no one knows at what point steroids
will cause diabetes in an individual, it's a lottery. It
could happen after 2 sessions or never. On the rare
occasions we have had to use it (for 3 days at a time) her
bg's went as high as your 300.

I am not disputing the necessity of the need for steroids in
some circumstances, and I will continue to give it to my
daughter if she needs it to survive but it doesn't alter the
facts. You posted something wrong. You were called on it.
Get over it.

I wouldn't be accusing people of spending time to find
things to support an argument if I were you when you did it
yourself:

"You'll find many complaints about that on Google if you
search for "cortisone shot glucose"".
David - 31 Mar 2006 04:07 GMT
>>>"David" <David@invalid.com <mailto:David@invalid.com>>
>
[quoted text clipped - 68 lines]
> "You'll find many complaints about that on Google if you
> search for "cortisone shot glucose"".

The OP and I were discussing shots.  I might win the lottery, too, but
the chances are quite slim.  Getting a few epidural shots is not any
more likely to CAUSE diabetes than a guy taking Viagra likely to have a
heart attack.  Stop trying to freak out the OP with long shots.  Long
term prednisone is another matter.

Dave
Ozgirl - 31 Mar 2006 06:28 GMT
"David" <David@invalid.com> wrote in message

Getting a few epidural shots is not any
> more likely to CAUSE diabetes than a guy taking Viagra likely to have a
> heart attack.  Stop trying to freak out the OP with long shots.  Long
> term prednisone is another matter.

Strangely not even the researchers can pinpoint at what
point it causes diabetes. But you can bet your sweet bippy
that someone who already has dead or impaired beta cells
(e.g. IGT, pre diabetic) is going to get there a lot
quicker.  Just because you and Mary had steroids and came
back to normal ranges doesn't mean everyone will. The OP
would be served better by having all the information
presented than perpetuating the Easter Bunny myth. Then it
becomes her choice to risk or not to risk. Steroids can and
do cause diabetes or worsen it and no one knows the ifs and
whens.
Chris Malcolm - 31 Mar 2006 09:34 GMT
> "David" <David@invalid.com> wrote in message

>  Getting a few epidural shots is not any
>> more likely to CAUSE diabetes than a guy taking Viagra
> likely to have a
>> heart attack.  Stop trying to freak out the OP with long
> shots.  Long
>> term prednisone is another matter.

> Strangely not even the researchers can pinpoint at what
> point it causes diabetes. But you can bet your sweet bippy
[quoted text clipped - 7 lines]
> do cause diabetes or worsen it and no one knows the ifs and
> whens.

Various docs and consultants concur that the pred which stopped my
ulcerative colitis dead in its tracks probably kicked my genetic
predispositions over the edge into diabetes. I didn't know about that
risk at the time, but if I had, I would still have gone for the pred
treatment. If that treatment swopped diabetes for ulcerative colitis
I'm happy with the deal.

Signature

Chris Malcolm cam@infirmatics.ed.ac.uk +44 (0)131 651 3445 DoD #205
IPAB,  Informatics,  JCMB, King's Buildings, Edinburgh, EH9 3JZ, UK
[http://www.dai.ed.ac.uk/homes/cam/]

Ozgirl - 31 Mar 2006 11:00 GMT
"Chris Malcolm" <cam@holyrood.ed.ac.uk> wrote in

> Various docs and consultants concur that the pred which stopped my
> ulcerative colitis dead in its tracks probably kicked my genetic
> predispositions over the edge into diabetes. I didn't know about that
> risk at the time, but if I had, I would still have gone for the pred
> treatment. If that treatment swopped diabetes for ulcerative colitis
> I'm happy with the deal.

Which I am sure applies to a lot of folk who have problems
that need prednisone.
wascally_wabbit_@hotmail.com - 31 Mar 2006 09:05 GMT
> The OP and I were discussing shots.  I might win the lottery, too, but
> the chances are quite slim.  Getting a few epidural shots is not any
[quoted text clipped - 3 lines]
>
> Dave

I don't usually post, I just read but this is so totally wrong.
I was confirmed as being diabetic in 2001 after only two prednisone
shots for a slow healing sprained ankle. Before that my biggest problem
was low blood sugar.
You should get your facts straight before advising people.

Jacqui
David - 31 Mar 2006 16:29 GMT
>>The OP and I were discussing shots.  I might win the lottery, too, but
>>the chances are quite slim.  Getting a few epidural shots is not any
[quoted text clipped - 11 lines]
>
> Jacqui

Prove that the shots caused your DM.

I think drinking too many sodas caused mine.  Or maybe it was agent
orange.  Or maybe it was bad genes. or maybe it was a virus.

did you sue anyone?

Dave
wascally_wabbit_@hotmail.com - 31 Mar 2006 17:39 GMT
My doctor warned me before the shots that there was a risk and she was
right, only it wasn't slight in my case. I wasn't diabetic before the
shots, and within weeks after the shots I was, and there were no other
changes in health, diet or lifestyle. Since I have been a diabetic I
have met several other people who have also become diabetic from
cortisone injections. In fact whenever I meet a skinny diabetic I ask
them if they got it from steroids and in many cases the answer is yes.

i have just googled you and several things are really apparent about
you. You never admit when you are wrong, no matter how many people
prove it to you, you are rude and insulting to many people and from
what I can see you are not liked or respected. I don't think that there
is any point in answering you any more, you seem to be just a childish
jerk.

Jacqui
David - 31 Mar 2006 17:52 GMT
 I don't think that there
> is any point in answering you any more, you seem to be just a childish
> jerk.
>
> Jacqui

You just LOVE to name call.  Adios.

dave
Alan S - 31 Mar 2006 22:54 GMT
>Prove that the shots caused your DM.
>
>I think drinking too many sodas caused mine.

Yours and his are totally different conditions. You may as
well be comparing warts and diarrhea.

Cheers, Alan, T2, Australia.
d&e, metformin 2x500mg
Signature

Everything in Moderation - Except Laughter.

Laura@notmy.com - 01 Apr 2006 01:08 GMT
Hi Everyone.

I want  to say thanks to  all who weighed in, Billie, Ozgirl, J. David
and David, if I missed anyone I'm sorry, the shots don't take the pain
away immediately and the meds I was on yesterday seem to act as a kind
of amnesiac or something, can't count the number of times I went
looking for something yesterday that I couldn't find because it was
sitting right in front of me.

I know from research I've done that long time use of steroids can
induce diabetes.  And that short time use in short courses like the
one I had a few months ago that did nothing greater than give me
horrendous tremors, and the injections can boost BG levels into
undesireable zones.  They only give this warning out to diagnosed
diabetics, and not the the un-diagnosed folks who may be heading that
way.

The positive affects of the injections thus far -- I have feeling back
in my left hand, my left arm no longer aches, the right arm and hand
are back in action.  All that's left is the interminible chronic pain
in the neck and shoulder.  With luck, this last shot will forestall
the surgery they keep talking about and I will continue to avoid
unless this thing totally incapacitates me.  The doc yesterday
mentioned that if the epidural intralaminar/intraforamal (hope I got
all that spelling right) didn't do the trick in the nect, he might
move on to injecting into the facet joints.

My question arose from a curiousity as to how many times you can
"tease" the system with the shots before it finally gives up the
fight.  I really didn't mean to start a small firestorm between the
regulars.  But I guess when you ask a question to which the true
answer is "who really knows?" a little bit of spitting is to be
expected.

I really appreciate the answers and the efforts made in the giving
them.  I have a lot of respect and appreciation for all of you and
what you each have endured to get where you are today.

Billie, you welcomed me to your world off the side corridor to
diabetes.  Love your heart, and I admire your spirit.  But heaven help
me dear lady, if I had to endure what you do, I just don't know if I
could do it.

J. David Anderson, I'm sorry that you had to go through one hell and
back just to enter a different kind.  I hope you stay well for a long
time.

Ozgirl, your help in the ways of RH and then full blown T2 is always a
welcome read.

David, I don't know enough of your story.  But if I ever end up
pumping, I know who I will contact.

Thanks to all of you.
David - 01 Apr 2006 17:12 GMT
> Hi Everyone.
>
[quoted text clipped - 50 lines]
>
> Thanks to all of you.

Laura, I hope that the effects of the shot continue to improve your
condition.  I had 2 shots and the first one didn't help much, but the
second one gave me a lot of relief.  I'm not experiencing severe pain
any longer, which is great, because I don't want to get a 3rd shot that
will send my bg's up to 300!  Let us know in the coming days and weeks
how you are feeling.  oh, and keep a close eye on your bg's.  My wife
saw just a bit of an uptick in bg levels from her shots and only for 2-3
days.

Dave
Laura@notmy.com - 01 Apr 2006 21:15 GMT
>Laura, I hope that the effects of the shot continue to improve your
>condition.  I had 2 shots and the first one didn't help much, but the
[quoted text clipped - 6 lines]
>
>Dave

Thanks, Dave.
I hope they do the trick, too.  The shots have so far always given me
a couple of hard days where the pain kicks up a few notches and then
settles down.  The numbers appear to be coming back down.  My fasting
this morning was 84 which is where it usually is.  My post meal
numbers are creeping back in line as well.  I think the 180 I saw on
that first day really kind of tripped me out.  I know for a lot of
folks that's nothing to worry too much about, but for someone who's
not yet got the diagnosis it's kind of a mind bend.
David - 02 Apr 2006 03:12 GMT
>>Laura, I hope that the effects of the shot continue to improve your
>>condition.  I had 2 shots and the first one didn't help much, but the
[quoted text clipped - 16 lines]
> folks that's nothing to worry too much about, but for someone who's
> not yet got the diagnosis it's kind of a mind bend.

Laura, I understand where you are coming from.  Having the dx hanging
over you has got to be quite a stressor.  Keep checking bgs, watch your
weight, stay active, don't eat a lot of fatty foods and no matter what
happens with your beta cells, you'll stay healthier, diagnosis or not.
How's your pain tonight?  I think your post is about 6 hours old.

dave
Laura@notmy.com - 02 Apr 2006 03:44 GMT
>Laura, I understand where you are coming from.  Having the dx hanging
>over you has got to be quite a stressor.  Keep checking bgs, watch your
[quoted text clipped - 3 lines]
>
>dave

I actually had a really great day :)  Thanks for asking.  I got a lot
of errands run.  I'm paying for it a bit tonight, but that's what I've
got the tramadol for.  I'm just looking forward to getting back to a
regular dose of ibuprofen and the occassional muscle relaxant at
night.

The true test will be when I go back to work for a full day of sitting
at computer screens doing my research.  The trick is to remember to
get up and move.

I'm looking forward to forestalling the diagnosis for as long as
possible.  I rewarded my efforts today with a new pair of jeans since
my others are too big. Beats the ice cream I sort of promised myself
before I discovered I could get into the smaller size.  Nothing like a
little positive reinforcement !

The message is to Wendy:
I sure hope the second shot works for you.  I dealt with sciatica
several years ago.  (I'm too young to be this old!)  I was fortunate
that physical therepy nipped that in the bud for me. A friend of mine
had great success with the shots for his sciatica, and he did two
rather than three shots.

Sciatica is no fun at all.  Added to the eye troubles, bah!  I think
you're a pretty tough lady.  My thoughts are with you.
W. Baker - 02 Apr 2006 00:10 GMT
: Laura, I hope that the effects of the shot continue to improve your
: condition.  I had 2 shots and the first one didn't help much, but the
[quoted text clipped - 4 lines]
: saw just a bit of an uptick in bg levels from her shots and only for 2-3
: days.

: Dave

David,

How lon ago did yu have the second shot?  I have had my first for he
sciatica adn it is only a marginal help, but am due for a second in a few
weeks.  It is good to hear tht you seem to have had some kidn of
cumulative effect.  I ws fortunate as it did not seem to raise my bgs mre
than a few points on the evening of he shot, itself.  I had my meter with
my endd lined up to give me an insulin pen prescrption , watched my
carbs like a hawk,and, fortuntely, didn't need any extra help.  I will do
the same for teh second shot, a there is no guarantee that it will be he
same fo rthe next shot.

Wendy    
David - 02 Apr 2006 03:16 GMT
> : Laura, I hope that the effects of the shot continue to improve your
> : condition.  I had 2 shots and the first one didn't help much, but the
[quoted text clipped - 20 lines]
>
> Wendy    
Wendy, my last shot was in November and I'm doing pretty well right now.
 I got more relief than from the first one.  I agree that one shot's
bg's raising effect may not match the next shot's effect.  My first shot
induced hyperglycemia for many days less than the second one. Let us
know how that next one goes, which I hope is GREAT!

dave
J. David Anderson - 01 Apr 2006 18:31 GMT
> Hi Everyone.
>
[quoted text clipped - 4 lines]
> looking for something yesterday that I couldn't find because it was
> sitting right in front of me.

> J. David Anderson, I'm sorry that you had to go through one hell and
> back just to enter a different kind.  I hope you stay well for a long
> time.

Hi Laura.

Didn't mean to sound deserving of pathos, it was just more of life's
experiences, and all is going well now. The effort taken to confront the
various problems has resulted in me being fitter and healthier than I
otherwise would have expected - a fringe benefit so to speak. I am sure
that in ten or fifteen years I will regard the experience as fortuitous
in that it provided permanent motivation to stay fit, watch my health
closely and not let things slide. I just have to keep an eye on
secondaries, modern medicine ensures that it is not too hard to catch
them in time, and manage my diabetes which is effectively "non-existent"
as long as I watch diet and exercise.

I have no cause for complaint.

Regards

David

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Laura@notmy.com - 01 Apr 2006 21:30 GMT
>Hi Laura.
>
[quoted text clipped - 14 lines]
>
>David

Hi, David,

No pathos then.  Just a healthy respect for what you've been through
and the great attitude you've got about it all.  With that on your
side, I expect a pretty long healthy future for you.

Thanks for the insights

Laura
J. David Anderson - 31 Mar 2006 01:11 GMT
>>  
>> "David" <David@invalid.com <mailto:David@invalid.com>> wrote in message
[quoted text clipped - 16 lines]
>
> Dave

I would suggest that you spend a little more time "looking up medical
information" and less time arguing before posting erroneous medical data.

From the "Side Effects and Drug Interactions" data. (My emphasis.)

http://tinyurl.com/ookc4

****
Endocrine: Menstrual irregularities; development of Cushingoid state;
secondary adrenocortical and pituitary unresponsiveness, particularly in
times of stress, as in trauma, surgery or illness; suppression of growth
of children; decreased carbohydrate tolerance; * manifestations of
latent diabetes mellitus;* increased requirements for insulin or oral
hypoglycemic agents in diabetics.

****

Regards

David

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W. Baker - 31 Mar 2006 18:53 GMT
: >  
: > "David" <David@invalid.com <mailto:David@invalid.com>> wrote in message
[quoted text clipped - 5 lines]
: > I beg to differ Dave.
: >  

: You spend too much time looking up medical information on the web in
: order to argue.  The FACT is the OP is prediabetic.  chances are she
[quoted text clipped - 4 lines]
: Besides which, getting the shots is necessary, to avoid, if possible,
: neck surgery.

: Dave

We have had a number of people in this group in the past who were on oral
steriod or shots, not epidurals, who had become diabeticas a result.  some
were able to get back to a non-diabetic state, but othes, who had been on
the drug for a longer eriod, remained diabetic.  

With epidurals, ( I just had my first for sciatica) the higher bgs usually
last about 3 days and a type 2 may need insulin.  I was fortunate that it
didn;t happen to me, but, so far, the epidural doesn't seem to have done
much anyway:-(  

Wendy
David - 31 Mar 2006 19:19 GMT
> : >  
> : > "David" <David@invalid.com <mailto:David@invalid.com>> wrote in message
[quoted text clipped - 28 lines]
>
> Wendy

My high bg's lasted 9 long days after the second shot.  That made me
reluctant to agree to a third shot. I eventually ruled it out.  If my
symptoms return I'll have a different procedure that I can't spell so I
won't try! :)

dave
Billie - 30 Mar 2006 22:31 GMT
Welcome to my world, Laura.  *s*  Another room off the corridor of basic diabetes.  I have been
doing the steroid injections for over ten years now.  I, too, was given a hypoglycemia diagnosis
in '71, but those numbers today would give me a full diabetes diagnosis.  It was treated with a
*diabetic diet* and that was sufficient, along with my lifestyle, to hold it at bay until I
started taking Prednisone daily back in the mid to late 90's.  After a few years of the orals,
it did come on like a locomotive about five years ago, plowing right into me, and I'm still
trying to get that train under control!  I'm sure the mechanics are different in each body, but
if it were me again, and I had this much advance notice, I'd surely be being *very* proactive.
Because of all my other illnesses, it kinda snuck up on us, and it's been an ongoing battle ever
since.  I did not have all the information that you have at this point, so you *do* have that on
your side.  Good luck.......... *s*

Billie in AR

Oh, and I did not have a meter, of course, during those years of injections before the
full-blown diabetes, so have no idea what effect they had on my bg.  All I know is that they
*sure* did help the problem(s) that they were used for.

bh-wages at swbell.net
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

: What I am curious to know after blathering this far, is if it is
: possible for steroid treatments to kick someone who has IR/IGT over
: the edge to where the body won't revert back to simply having the
: IR/IGT and give it the shove it takes to create full blown diabetes?

I would be really sad to
: find out that treating one pain could create a bigger one.
:
: Thanks
: Laura
J. David Anderson - 31 Mar 2006 00:54 GMT
> I am currently not diagnosed with diabetes nor pre-diabetes, however,
> with a history of hypoglycemia as a child (which was later abandoned
[quoted text clipped - 31 lines]
> Thanks
> Laura

Hi Laura.

Contrary to what the first David says, Prednisone *can* induce diabetes.
It is listed as a potential side effect on the patient warning insert
that comes with the drug, but it is, like almost everything else, a YMMV
response.

I was hospitalised for cancer surgery in 2003, treated for a few weeks
with Prednisone by injection. Later in 2003 I had a rather severe
motorcycle accident requiring a good deal of reconstructive surgery and
bone grafts, once again requiring Prednisone, first by injection, then a
course of oral tablets. I was, like you, hypoglycemic for most of my
life, but while still receiving treatment I experienced what I now know
to be classic DM symptoms, raging thirst, constant urination, vision
problems and neuropathic pain in my right foot.

I had a medical workup shortly before being diagnosed with cancer
(Melanoma, the workup was where they discovered the cancer) that
included BG fasting tests. I have a checkup twice a year, always have,
and I was hypo, not hyper. I was however, after the two courses of
Prednisone, diabetic, not only diabetic, but what was referred to by my
Endocrinologist, as having "aggressive" diabetes, rapidly progressing
diabetes.

In view of my medical history and regular BG checks, it was assumed by
the the Endocrinologist that I was was one of those people who responded
to Prednisone by developing diabetes. The hosptial Endocrinologist and
the private one I found later both said that in their experience people
who were hypoglycemic were more likely to develop DM as a response to
Prednisone than those who weren't, but even so, only a small percentage
of hypoglycemics teated with Prednisone went on to contract DM. I was
one of the unlucky ones.

I doubt if there is any way to determine if you are likely to respond in
a similar manner, but I would, if I had my time over again, have opted
for an alternative drug to the Prednisone. There were, in my case at
least, other drugs that could have been used. Also, I didn't have just
one or two shots, I had two very long courses of Prednisone, that in all
likelihood would make a difference.

Regards

David

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Mary - 31 Mar 2006 01:28 GMT
The op is talking about a single steroid injection.  Rarely do the docs
do more than three in succession over a few months period.  This is NOT
the same as the way in which prednisone is used for days and weeks at a
time (or more) to treat asthma or other chronic problems.  Dave was not
stating that prednisone never causes diabetes--he knows otherwise as in
the case of a close family member who has severe asthma.

Mary

>> I am currently not diagnosed with diabetes nor pre-diabetes, however,
>> with a history of hypoglycemia as a child (which was later abandoned
[quoted text clipped - 74 lines]
>
> David
Ozgirl - 31 Mar 2006 01:54 GMT
> The op is talking about a single steroid injection.  Rarely do the docs
> do more than three in succession over a few months period.  This is NOT
[quoted text clipped - 4 lines]
>
> Mary

Mary, I think you have selective reading comprehension. If
Dave hadn't made the comments he did, I wouldn't have needed
to call him on them:

"Laura, your bg's should return to typical between 3 and 10
days, from  what I've seen happen to my wife and I after
receiving those shots.
YMMV, but I wouldn't worry about it causing DM!"

"to continue what I was saying: the shots aren't going to
damage your  pancreas or beta cells.  the stuff is causing a
release of glucose for days."
David - 31 Mar 2006 04:08 GMT
>>The op is talking about a single steroid injection.
>
[quoted text clipped - 32 lines]
> damage your  pancreas or beta cells.  the stuff is causing a
> release of glucose for days."

so, what's erroneous in that??
Ozgirl - 31 Mar 2006 06:40 GMT
"David" <David@invalid.com> wrote in message

"Dave was not stating that prednisone never causes diabetes"

"to continue what I was saying: the shots aren't going to
damage your pancreas or beta cells"

> so, what's erroneous in that??

The above two comments from you and Mary.
David - 31 Mar 2006 04:07 GMT
>> I am currently not diagnosed with diabetes nor pre-diabetes, however,
>> with a history of hypoglycemia as a child (which was later abandoned
[quoted text clipped - 74 lines]
>
> David

We were talking about SHOTS!!!!  HELLO!

Dave
J. David Anderson - 31 Mar 2006 04:38 GMT
>> I doubt if there is any way to determine if you are likely to respond
>> in a similar manner, but I would, if I had my time over again, have
[quoted text clipped - 10 lines]
>
> Dave

Hello.

The company that makes the drug states that a *possible* side effect is
DM, without specifying that a minimum amount is involved. My
Endocrinologist has seen and heard of cases where anything from one to
three shots has resulted in DM. I imagine they will be most surprised to
learn that a person with such impressive credentials as yours has
decided that they are wrong. Just think, they can stop going to all the
bother of warning people about these potential side effects. That should
save them a little time and money.

I know who I prefer to take notice of, and surprise, it isn't you.

I agree that it is unlikely, but it is not as impossible as you seem to
believe, particularly not when the person involved has a history of
hypoglycemia. I was not happy when told I had diabetes and what caused
it and had a fairly extensive interchange with the drug distributor and
manufacturer. They insisted that the primary reason for my
susceptibility was my previous hypoglycemic status. I guess that
(according to you) they were wrong. After all, what would they know
about the drug? They only manufacture, test and distribute it, so
probably not much at all.

BTW, I though you were the very vocal opponent of people posting poor
medical advice. Wasn't it you who insisted, loudly and often, that
people only listen to the professionals? I guess that it must have been
another Dave, one who looked a lot like you. Or are you now a
professional? If so, congratulations. When did you graduate?

Regards

David

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Ozgirl - 31 Mar 2006 06:40 GMT
"David" <David@invalid.com> wrote in message

> We were talking about SHOTS!!!!  HELLO!

Tell me you are not claiming that steroid shots DON'T raise
bg's?
Billie - 31 Mar 2006 14:12 GMT
Just for a little bit of clarification, there are two different *Prednisone shots*.  One is the
injection into the joints, which is what I read Laura to have received.  The other are the
injections such as Decadron which are IM, often given for asthmatic, and other breathing
treatments.  I was told that the joint injections do not have the impact on the body that those
like Decadron and oral Prednisone have.  There are also two different oral treatments, one for
the acute situation, and the other chronic and ongoing.  Otherwise, all I have is anecdotal
information, and I know that I am here today because of my steroid treatments which I now need
to keep me alive, to the point that it is on my medic alert bracelet that I am steroid
dependent; my doctor has warned me that I cannot go more than three days without it without
serious consequences.  Unfortunately, diabetes is not the only progressive disease with an
enormous impact on our bodies.  :(

If you have asthma and connective tissue diseases, there is nothing in this world better than a
Decadron shot!!!  LOL  You can come to a point in life where you have to weigh the odds, and
unfortunately the odds in my situation demand the steroids.  :(

Billie in AR

bh-wages at swbell.net
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Mary - 02 Apr 2006 02:55 GMT
Yes, Billie.  Nothing is more essential than breathing.

Mary

> Just for a little bit of clarification, there are two different *Prednisone shots*.  One is the
> injection into the joints, which is what I read Laura to have received.  The other are the
[quoted text clipped - 16 lines]
> bh-wages at swbell.net
> ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
 
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