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Medical Forum / Diseases and Disorders / Diabetes / March 2006Avandia and Macular Edema
Did any of you see an article today in the NY Times about Avandia and the other forms of the drug in combination with metformin and another with a sulf? The doing papers now warn tht Avandia may increase the chance of getting diabetic macular edema and MD's have been sent notices alerting them to this. Altough Actos works similarly to Avandia, it's manufacturer says it has seen no incidence of increased mcular edema with the use of Actos, white the Avandia company is behind this warning about its own drug. There was some discussion , in the article, about not being sure if this is actually something asociated with the underlying diabetes or if the drug is actually causing the increaseed risk. I am sure somene else willl find the URL for this article or for the original notice, but I did think it worth bringing to the attention of the group. Wendy Wendy, When this first came out about a month ago, the reports said there was a 1 in 10,000 chance of this happening, and that usually it was assocaited with edema in, if I recall correctly, the legs. I asked my retinologist about it; he had seen the reports but he didn't think there was reason for me to worry. Morris > Did any of you see an article today in the NY Times about Avandia and the > other forms of the drug in combination with metformin and another with a [quoted text clipped - 15 lines] > > Wendy > Wendy, > [quoted text clipped - 3 lines] > retinologist about it; he had seen the reports but he didn't think > there was reason for me to worry. This didn't "First come out" a month ago. An ophthalmologist reported on seeing it in a passel of patients at a major medical conference more than 2 years ago. It was written up at the time in the "Diabetes in Control" newsletter and appeared on my web page discussing the pluses and minuses of oral drugs for diabetes. All that has happened now is that enough cases have been reported that the makers of Avandia are scared of a major lawsuit and are taking corrective action. Actos isn't prescribed nearly as frequently as Avandia, which may be the reason that the problem hasn't surfaced there. It took over 6 years for it to surface with Avandia. In a previous message someone asked how I could know more than doctors about drug side effects. The answer is because I take the time to read medical newsletters specializing in Diabetes research which busy doctors in general practice don't have time to do. This is a good example of how useful that can be. --Jenny http://www.phlaunt.com/diabetes Diabetes Info http://www.alt-support-diabetes.org/newlydiagnosed.htm Get Your Blood Sugar Under Control Wendy, thanks for sharing this information with us. It doesnt affect me personally as I dont take avandia, but there might be others that do. They will be contacting their doctors. Loretta -- In tribute to the United States of America and the State of Israel, two bastions of strength in a world filled with strife and terrorism. : Did any of you see an article today in the NY Times about Avandia and the : other forms of the drug in combination with metformin and another with a : sulf? The doing papers now warn tht Avandia may increase the chance of : getting diabetic macular edema and MD's have been sent notices alerting : them to this. : Altough Actos works similarly to Avandia, it's manufacturer says it has : seen no incidence of increased mcular edema with the use of Actos, white : the Avandia company is behind this warning about its own drug. : There was some discussion , in the article, about not being sure if this : is actually something asociated with the underlying diabetes or if the : drug is actually causing the increaseed risk. : I am sure somene else willl find the URL for this article or for the : original notice, but I did think it worth bringing to the attention of the : group. : Wendy A little Oops here. The article I saw was in the newest issue of the ADA's Diabetic Forcast on page 16. It arrived today and I was reading it whie I was also reading the newspaper. As both were in another room than my computer, I cited the wrong source. the information is the same as I wrote though. Wendy > Did any of you see an article today in the NY Times about Avandia and the > other forms of the drug in combination with metformin and another with a [quoted text clipped - 15 lines] > > Wendy For several years it's been known that Avandia can cause edema in certain patients. My DH went into CHF from it.  Signature----------- Janet Wilder The Road Princess http://janetwilder.blogspot.com : > Did any of you see an article today in the NY Times about Avandia and the : > other forms of the drug in combination with metformin and another with a [quoted text clipped - 15 lines] : > : > Wendy : For several years it's been known that Avandia can cause edema in : certain patients. My DH went into CHF from it. This is referring specifically to MACULAR EDEMA in the eye. the general problem of actos and avandia with bodily and heart edema is well known and has been discussed on this list in the past. The particular application to the diabetic eye, which is prone to this condition, was not included in previous discussion here aobut edema in general or congestive heart failure. Wendy > This is referring specifically to MACULAR EDEMA in the eye. the general > problem of actos and avandia with bodily and heart edema is well known and > has been discussed on this list in the past. The particular application > to the diabetic eye, which is prone to this condition, was not included in > previous discussion here aobut edema in general or congestive heart > failure. Edema in the macula was described in the conference presentation reported some years ago by Diabetes in Control. They have the best coverage of diabetes topics of any online resource I've found. For those who aren't familiar with this newsletter, it is free and is sent to your email from http://www.diabetesincontrol.com . Each week the most recent diabetes research findings and convention presentations are summarized on this site. I used to use Medscape but I find Diabetes in Control gives better coverage. Signature--Jenny http://www.phlaunt.com/diabetes Diabetes Info http://www.alt-support-diabetes.org/newlydiagnosed.htm Get Your Blood Sugar Under Control |
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