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Medical Forum / Diseases and Disorders / Diabetes / March 2006Aspart*me hunger
Aspart*me appears to trigger an insulin response and, in some, triggers greater hunger later on. The authors suggest the effect is correlated with the perceived degree of sweetness. I found this by accident while looking for something else; I'm not at all interested in the aspart*me wars, hence the asterisks. Just an FYI because I found it interesting. Susan Br J Nutr. 1999 Dec;82(6):437-46. Related Articles, Links Comment in: • Br J Nutr. 1999 Dec;82(6):427-9. Blood glucose and meal patterns in time-blinded males, after aspartame, carbohydrate, and fat consumption, in relation to sweetness perception. Melanson KJ, Westerterp-Plantenga MS, Campfield LA, Saris WH. Department of Human Biology, Maastricht University, The Netherlands. In a study of the impact of aspartame, fat, and carbohydrate on appetite, we monitored blood glucose continuously for 431 (SE 16) min. Ten healthy males (19-31 years) participated in three time-blinded visits. As blood glucose was monitored, appetite ratings were scored at randomized times. On the first meal initiation, volunteers consumed one of three isovolumetric drinks (aspartame, 1 MJ simple carbohydrate, and 1 MJ high-fat; randomized order). High-fat and high-carbohydrate foods were available ad libitum subsequently. Blood glucose patterns following the carbohydrate drink (+1.78 (SE 0.28) mmol/l in 38 (SE 3) min) and high-fat drink (+0.83 (SE 0.28) mmol/l in 49 (SE 6) min) were predictive of the next intermeal interval (R 0.64 and R 0.97 respectively). Aspartame ingestion was followed by blood glucose declines (40% of subjects), increases (20%), or stability (40%). These patterns were related to the volunteers' perception of sweetness of the drink (R 0.81, P = 0.014), and were predictive of subsequent intakes (R -0.71, P = 0.048). For all drinks combined, declines in blood glucose and meal initiation were significantly associated (chi 2 16.8, P < 0.001), the duration of blood glucose responses and intermeal intervals correlated significantly (R 0.715, P = 0.0001), and sweetness perception correlated negatively with hunger suppression (R -0.471, P = 0.015). Effects of fat, carbohydrate, and aspartame on meal initiation, meal size, and intermeal interval relate to blood glucose patterns. Varied blood glucose responses after aspartame support the controversy over its effects, and may relate to sweetness perception. Publication Types: • Clinical Trial • Randomized Controlled Trial PMID: 10690159 [PubMed - indexed for MEDLINE] :: x-no-archive: yes :: :: Aspart*me appears to trigger an insulin response and, in some, :: triggers greater hunger later on. The authors suggest the effect is :: correlated with the perceived degree of sweetness. If that's the case, would we not expect the same thing with other sweeteners, like Splenda? > If that's the case, would we not expect the same thing with other > sweeteners, like Splenda? It's possible, as some folks have always proposed, that the body responds to perceived sweetness with an insulin response. I guess that means it's possible with any sweetener, but I didn't accidentally stumble across a Splenda test. :-) Susan >:: x-no-archive: yes >:: [quoted text clipped - 4 lines] >If that's the case, would we not expect the same thing with other >sweeteners, like Splenda? Hey Roger, Splenda and aspertame are two completely different chemical substances. Splenda contains a synthetic molecule that is designed to mimic sugar, I think the exact name is sucralose, which does not absorb in the same way that sugar does, and which passes harmlessly through your body The chemical name is 1,6-dichloro-1,6-dideoxy-ß-D-fructo-furanosyl 4-chloro-4-deoxy-a-D-galactopyranoside.... It simply does not metabolize. It is produced by the selective chlorination of sucrose, by which three of sucrose's hydroxyl groups are substituted with chlorine atoms. Aspertame, on the other hand, is the chemical aspartyl-phenylalanine-1-methyl ester, and it breaks down into metablolites, some of which are phenylalanine, that in some people may cause major problems. Others report no problems at all.... Both products contain either NO, or virtually NO calories that would be recognizable as carbs. I think one whole cup of Splenda contains fewer than 100 carbs..... The problem with aspertame, for some individuals, is that it may be related to neuropathy, but the jury is still out on that. Also, aspertame would seem to be contra indicated for those suffering from a tendency to phenlyketonuria. Will, T2 >>:: x-no-archive: yes >>:: [quoted text clipped - 26 lines] > be recognizable as carbs. I think one whole cup of Splenda contains > fewer than 100 carbs..... Jeez, I'd hope it's less than that!! The problem with bulk Splenda is all the high GI carbs from the bulking agent maltodextrin. And, for me, the taste. > The problem with aspertame, for some individuals, is that it may be > related to neuropathy, but the jury is still out on that. Also, > aspertame would seem to be contra indicated for those suffering from a > tendency to phenlyketonuria. > > Will, T2 The problem in this study was that perceived sweetness triggered an insulin release. That could be expected to happen with any sweetener in susceptible folks, if the sweetness is the trigger for the body's response. Susan > x-no-archive: yes > [quoted text clipped - 43 lines] > > Susan SHEESH what bullcrap FIRST: Splenda IS sugar, and is absorbed by the body just fine. The chlorine makes it wxtrordinarly sweet, so you only need small amo8unts, it does Hhave calories and carbs, but in very small amounts, SECOND: There are NO bad effects from Aspartame, and no "jury is out" all that bullcrap is from Betty Martini. It has been PROVED that there are no ill effectc otyer than psychological. THIRD: d0o you have a CLUE# what PKU is? MOST foods effect people with PKU. They have to stay on an incredibly limited diet. As for the "study", there are many studies contradicting it and, a study with only TEN MALES and NO CONTROLS with only THREE data points could prove aything. The "study" is worthless. >SHEESH >what bullcrap [quoted text clipped - 13 lines] >study with only TEN MALES and NO CONTROLS with only THREE data points >could prove aything. The "study" is worthless. I have to almost completely agree with Ted. All of us speculate but we simply do not have enough facts. My perception of all things are very biased by MY experiences Scientists have to stick to logical principles and factual data to avoid the dream world idea we see spread liberally. It is no sin to say--I do not know. It is a good attribute to say--I will try like hell to find out. It is horrible unhuman thing to say --can I make a fast easy buck off some ones misfortune. Guy >x-no-archive: yes > [quoted text clipped - 51 lines] > >PMID: 10690159 [PubMed - indexed for MEDLINE] Thanks ever so much, Susan... I have been saying this for months, but I have not been able to come up with a study... In my personal anecdotal experience, it makes sense.. Doing splenda is not the same thing, however... I think splenda does not deserve to be tarred with the same brush. Many of us enjoy it, and I have not noticed the same problems, personally... Again, my own experience, strictly anecdotal. As Loretta says, everyone is different. Will, T2 > Thanks ever so much, Susan... > [quoted text clipped - 7 lines] > experience, strictly anecdotal. As Loretta says, everyone is > different. As with everything! For instance, I get an awful aftertaste from Splenda, no gastric effects from sugar alcohols, and I don't like intensely sweet tastes. It's an explanation, I think, for those who have the problem, not a warning to those who don't. Susan So do I, and it's almost impossible to get rid of it for a couple of hours or so. -- Cheri >As with everything! For instance, I get an awful aftertaste from >Splenda, no gastric effects from sugar alcohols, and I don't like [quoted text clipped - 4 lines] > >Susan cc'd by email <troll droppings deleted> more crap from one of Momma Betty's trolls As I suggested before Susan - why don't you take your scamming and f.ck off Ted, Susan is NOT a troll, but you already know that. I think it would be more helpful if you saved that stuff for the real trolls, not that you care what I think, but I'm just sayin. :-) -- Cheri >cc'd by email >more crap from one of Momma Betty's trolls > Ted, Susan is NOT a troll, but you already know that. I think it would > be more helpful if you saved that stuff for the real trolls, not that [quoted text clipped - 5 lines] > >>more crap from one of Momma Betty's trolls Cheri, It walks like a troll It talks like a troll It acts like a troll It posts misleading tripe to the NG Just because she also posts to another group doesn't make her any less an Aspartame troll On Mon, 20 Mar 2006 18:38:11 -0500, ted rosenberg <tedrosenberg@iname.com> Huffed and Puffed the following into the madness of usenet: >> Ted, Susan is NOT a troll, but you already know that. I think it would >> be more helpful if you saved that stuff for the real trolls, not that [quoted text clipped - 13 lines] >Just because she also posts to another group doesn't make her any less >an Aspartame troll Ted, your attacking a known diabetic and regular poster.  SignatureMâck©® Deltec CoZmore Pumper Type 1 since 1975 http://www.alt-support-diabetes.org http://www.diabetic-talk.org http://www.insulin-pumpers.org "To announce that there must be no criticism of the President, or that we are to stand by the President right or wrong, is not only unpatriotic and servile, but is morally treasonable to the American public." ...Theodore Roosevelt (o ô) --ooO-(_)-Ooo-------------------- "I don't know half of you half as well as I should like; and I like less than half of you half as well as you deserve." ....Bilbo Baggins Jesus never hated anyone. DISCLAIMER If you find a posting or message from me offensive, inappropriate, or disruptive, please ignore it. If you don't know how to ignore a posting, complain to me and I will be only too happy to demonstrate... . Mack, I am attacking someone who is posting spurious "studies" . Try googling her and SEE all the proof she is an Aspartame troll > On Mon, 20 Mar 2006 18:38:11 -0500, ted rosenberg > <tedrosenberg@iname.com> Huffed and Puffed the following into the > madness of usenet: <snip> >>Cheri, >>It walks like a troll [quoted text clipped - 5 lines] > > Ted, your attacking a known diabetic and regular poster. Ted........ Susan uses x-no archives you can't google her! kate SignatureJoin us in the Diabetic-Talk Chatroom on UnderNet /server irc.undernet.org --- /join #Diabetic-Talk More info: http://www.diabetic-talk.org/ http://www.diabetic-talk.org/freeveggies.htm I have no medical qualifications beyond my own experience. Choose your advisers carefully, because experience can be an expensive teacher. > Mack, I am attacking someone who is posting spurious "studies" . Try > googling her and SEE all the proof she is an Aspartame troll [quoted text clipped - 12 lines] > > > > Ted, your attacking a known diabetic and regular poster. > Ted........ Susan uses x-no archives > > you can't google her! > > kate But you could probably google up posts where folks've quoted me. You might turn up 3-5 aspartame related posts in 10 years, if that many. Only someone with a serious disconnect from objective reality could possibly consider me a usenet troll, especially on the topic of aspartame. Susan > x-no-archive: yes > [quoted text clipped - 9 lines] > Only someone with a serious disconnect from objective reality could > possibly consider me a usenet troll, especially on the topic of aspartame. Good description of Ted. Priscilla, who's also been targeted by that particular loon > > x-no-archive: yes > > [quoted text clipped - 13 lines] > > Priscilla, who's also been targeted by that particular loon Absolutely. To use a metaphor that's probably inappropriate for this newsgroup, too much chaff and not enough wheat. SignatureAF On Tue, 21 Mar 2006 11:37:54 -0500, ted rosenberg <tedrosenberg@iname.com> Huffed and Puffed the following into the madness of usenet: >Mack, I am attacking someone who is posting spurious "studies" . Try >googling her and SEE all the proof she is an Aspartame troll Ted you are off base. she was in no way attacking aspartame or feeding into the mad betti martini antiaspartame conspiracy nuttery. The reaction to the sweetener as discussed in the study, a hunger response, can be triggered by anything sweet in many people. You didn't bother to read through any of the study or to read through all of what she actually wrote. If you had I find it impossible that you would have jumped to these wrong conclusions. Don't back yourself so far into a corner that you leave yourself only one way out, to come out fighting with everyone. SignatureMâck©® Deltec CoZmore Pumper Type 1 since 1975 http://www.alt-support-diabetes.org http://www.diabetic-talk.org http://www.insulin-pumpers.org "To announce that there must be no criticism of the President, or that we are to stand by the President right or wrong, is not only unpatriotic and servile, but is morally treasonable to the American public." ...Theodore Roosevelt (o ô) --ooO-(_)-Ooo-------------------- "I don't know half of you half as well as I should like; and I like less than half of you half as well as you deserve." ....Bilbo Baggins Jesus never hated anyone. DISCLAIMER If you find a posting or message from me offensive, inappropriate, or disruptive, please ignore it. If you don't know how to ignore a posting, complain to me and I will be only too happy to demonstrate... . > Ted you are off base. she was in no way attacking aspartame or > feeding into the mad betti martini antiaspartame conspiracy nuttery. > The reaction to the sweetener as discussed in the study, a hunger > response, can be triggered by anything sweet in many people. Exactly. And it didn't trigger it in all the study participants. Susan > On Tue, 21 Mar 2006 11:37:54 -0500, ted rosenberg > <tedrosenberg@iname.com> Huffed and Puffed the following into the [quoted text clipped - 13 lines] > Don't back yourself so far into a corner that you leave yourself only > one way out, to come out fighting with everyone. Mack - Unlike most, I DID read the "study" I HAVE seen worse tripe posted as a "study" but not for years.. It was not a randomized double blind study. It only had TEN male individules in it, and they were tested THREE times. tHAT IS NOT DATA, THAT IS ANECDOTES! GEE, If I THINK I ate cars, then I spike?? I guess that if we eat carbs and think they are no-calorie, then our BG will go DOWN? > > Ted you are off base. she was in no way attacking aspartame or > > feeding into the mad betti martini antiaspartame conspiracy nuttery. > > The reaction to the sweetener as discussed in the study, a hunger > > response, can be triggered by anything sweet in many people. ......<snip> > Mack - Unlike most, I DID read the "study" I HAVE seen worse tripe > posted as a "study" but not for years.. Ted, with all due respect, the issue is not whether or not you have read the article, or study. When you came out attacking someone who has been a very valuable contributor to this group, and who on the whole, is very well regarded by most of us, it comes off as being well off the mark, and really does reflect rather badly upon you....... Susan merely presented what she thought was interesting information about something she had come across, that's all.... She certainly did not deserve the abuse she got from you. We are all free to take what is useful to us personally from the article, if it aids our understanding or piques our interest, and we are free to disregard anything that is not useful. People may freely discuss and express agreement with the article, or not, as they choose. Quite frankly, I applaud Susan for her post, even if you and possibly some others find flaws in it. I don't use aspertame, either, for what it may be worth, and I rarely use any sweeteners at all, because I have discovered that they make me more hungry than I experience if I use no sweeters at all. There is some basis for speculating that in some, at least, the autonomic nervous system, with all of its complicated biochemistry may actually cause insulin release in some people that is experienced as feelings of hunger. More research needs to be done into this, I submit. In the meantime, for whoever wants to use sweeteners, go for it.:-) Will, T2 >>>Ted you are off base. she was in no way attacking aspartame or >>>feeding into the mad betti martini antiaspartame conspiracy nuttery. [quoted text clipped - 29 lines] > > Will, T2 No, just because you have a half baked- demonstrably false idea doesn't mean that "more study is needed" PLENTY of LEGITIMATE study has been done, and no amount of bullcrap and phony studies changes that. Bye, Ted... Your language is unbecoming of a decent, thinking human, and most illogical. It would seem that YOU are the one with the agenda, here. Please, by all means, load up on sweeteners. I don't care. Once again, I applaud Susan for the positive and constructive role she takes in this group. Will, T2 . > Bye, Ted... > > Your language is unbecoming of a decent, thinking human, and most illogical. I haven't seen his posts, but that sure sounds like him. ;-D > It would seem that YOU are the one with the agenda, here. Please, by all > means, load up on sweeteners. I don't care. Whatever he's loaded up on, it isn't helping. > Once again, I applaud Susan for the positive and constructive role she takes > in this group. > > Will, T2 > > . Will, thanks and all, but don't even try to reason with the unreasonable. I've had the lunatic KF'ed for years, ever since he sent me profane, threatening email in response to a post of mine. Susan On Tue, 21 Mar 2006 13:12:30 -0500, ted rosenberg <tedrosenberg@iname.com> Huffed and Puffed the following into the madness of usenet: >> On Tue, 21 Mar 2006 11:37:54 -0500, ted rosenberg >> <tedrosenberg@iname.com> Huffed and Puffed the following into the [quoted text clipped - 23 lines] >GEE, If I THINK I ate cars, then I spike?? I guess that if we eat >carbs and think they are no-calorie, then our BG will go DOWN? did you at any time see her post about the legitimacy or the accuracy of the study? no, you didn't. you are reading things into this that are simply not there. SignatureMâck©® Deltec CoZmore Pumper Type 1 since 1975 http://www.alt-support-diabetes.org http://www.diabetic-talk.org http://www.insulin-pumpers.org "To announce that there must be no criticism of the President, or that we are to stand by the President right or wrong, is not only unpatriotic and servile, but is morally treasonable to the American public." ...Theodore Roosevelt (o ô) --ooO-(_)-Ooo-------------------- "I don't know half of you half as well as I should like; and I like less than half of you half as well as you deserve." ....Bilbo Baggins Jesus never hated anyone. DISCLAIMER If you find a posting or message from me offensive, inappropriate, or disruptive, please ignore it. If you don't know how to ignore a posting, complain to me and I will be only too happy to demonstrate... . >Cheri, >It walks like a troll [quoted text clipped - 3 lines] >Just because she also posts to another group doesn't make her any less >an Aspartame troll Ted, to a newby wandering in here, the most troll-like posts in this thread are the angry ones full of bad language. Imagine you're a newby. Read the thread again. The least believable and most emotional comments all come from the same poster -and most newbies would ignore him from now on. I don't disagree with your technical comments on the subject (not that I'm competent to anyway) but you diminish your effectiveness by attacking scatter-gun style. If you're just interested in venting - you're doing great. If you're actually trying to influence people's decisions on sweeteners - I doubt that you're achieving your aim. Myself, I'll still add Splenda, aspartame, and any other standard sweetener to my foods when appropriate. Cheers, Alan, T2, Australia. d&e, metformin 2x500mg SignatureEverything in Moderation - Except Laughter. I have diabetes and it has been hell. A lot of the problem was the result of no information or misinformation. So a few of us try to discourage the games peoples play with other peoples health. These groups were setup for a specific purpose and it was clear at one time. When I first noted Ted I was appalled. Then as time went by I slowly saw the value of his postings. He may use language I rarely use, but I see it is needed here. some people abuse others for their own satisfaction. Some are trying to use these diabetic group for advertising. of some crap product, some that will; do harm. Others with no background try to be Mister diabetes. Seem to try to impress with "language" Ted does discourage some of them. Ego things are very low on my agenda. Getting sleep tonight is very high but lacking. If Ted manages to dampen some things that might send other to my fate, I will support him. I find Ted is very technically correct in the areas he posts information. We have a lot of good people that contribute to the proper function of the group. We have a few cases where the agenda is to impress. N my opinion , I want some real research for the public money spent instead of a great golf round. I have heard " I worked for my degree and now I am special and do to have to produce." too many times. My Research director had a way of discouraging that attitude We are here for a purpose and not for the entertainment of a few. Diabetes does kill.. The count is fifteen acquaintances is this small Texas town . Guy , >>Cheri, >>It walks like a troll [quoted text clipped - 24 lines] >Cheers, Alan, T2, Australia. >d&e, metformin 2x500mg > Myself, I'll still add Splenda, aspartame, and any other > standard sweetener to my foods when appropriate. Alan, in no way was that post anti sweetener, I posted it because it was interesting information I stumbled across as I looked for something else. I'm not anti aspartame (though I don't use it) or anti anything else folks choose for themselves. I'm very pro knowledge. Clearly, not all the study subjects had the reaction of increased appetite, but it does confirm the fact that in some, the sensation of sweetness (from any sweetener of any kind, I suspect) can cause an insulin response and reactive hunger in some folks. It's just information, which is neutral, not a position staked out. Susan > > Ted, Susan is NOT a troll, but you already know that. I think it would > > be more helpful if you saved that stuff for the real trolls, not that [quoted text clipped - 13 lines] > Just because she also posts to another group doesn't make her any less > an Aspartame troll Ted, I certainly am no fan of Susan's posts but she is not in any way shape or form a troll. She posts daily and has for a long time, on a variety of diabetes subjects, and some have stated she has given them good helpful diabetes information. You've taken one subject of the many she discusses and have labeled her a troll based on that? Jesus, man, get a grip. Many of us here might disagree on diabetes issues but when it comes to fighting off the real trolls and spammers, we need to stick together. Kurt >cc'd by email > [quoted text clipped - 3 lines] > >As I suggested before Susan - why don't you take your scamming and f.ck off Ted, Go Im..Peach yourself... Will, T2 |
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