Analgesic effect of vitamin E is mediated by reducing central
sensitization in neuropathic pain.
Kim HK, Kim JH, Gao X, Zhou JL, Lee I, Chung K, Chung JM
Pain. 2006 Mar 6;

Recent studies suggest that reactive oxygen species (ROS) are
critically involved in neuropathic pain. Although vitamin E is a
well-known antioxidant, its efficacy on chronic pain is not known. This
study investigated the efficacy and mechanisms of vitamin E analgesia
in a rat model of neuropathic pain produced by spinal nerve ligation.
The effects of vitamin E were investigated using behavioral testing,
electrophysiological recording of dorsal horn neurons, and
determinations of phosphorylated NMDA receptor subunit 1 (pNR1) levels
in the spinal dorsal horn. Results showed that a systemic single
injection of a high dose or repetitive daily injections of low doses of
vitamin E significantly reduced neuropathic pain behaviors. Vitamin E
was also effective in producing analgesia by intrathecal injection,
suggesting the importance of spinal mechanisms. In spinal dorsal horn
neurons, vitamin E reduced evoked responses to mechanical stimuli as
well as the sizes of their receptive fields. In addition, levels of
pNR1 in neuropathic rats were also reduced by vitamin E injection.
These data suggest that vitamin E produces analgesia in neuropathic
rats that is, at least in part, mediated by reducing central
sensitization which, in turn, is induced by peripheral nerve injury.

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking