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Medical Forum / Diseases and Disorders / Diabetes / March 2006Extended Release capsules
I take 500 mg Metformin Extended Release twice a day. How much of a difference is there between the extended release & the regular one? Does the XR actually help more than the regular one? Asking out of curiousity. > I take 500 mg Metformin Extended Release twice > a day. How much of a difference is there between > the extended release & the regular one? Does the > XR actually help more than the regular one? > > Asking out of curiousity. Anecdotally, I've seen quite a few folks report that the XR is less effective. That doesn't mean it won't work well for you, though. Susan > x-no-archive: yes > [quoted text clipped - 7 lines] > Anecdotally, I've seen quite a few folks report that the XR is less > effective. Is this really true? Do most people here take the XR or the regular & why? > That doesn't mean it won't work well for you, though. > > x-no-archive: yes > > [quoted text clipped - 12 lines] > > > That doesn't mean it won't work well for you, though. I take the regular one. Suzi A1c 6.4 T2 DX 10/2002 Glucophage 2 x 1000mg Lipitor 20mg (3 days a week), Enalapril 20mg Walk 30 minutes per day 7 days a week > Is this really true? Do most people here take the XR or the > regular & why? Why would I lie about having read anecdotes. Yes, it's true. But it's not a universal problem. Susan > x-no-archive: yes > >> Is this really true? Do most people here take the XR or the >> regular & why? > > Why would I lie about having read anecdotes. :-) Didn't mean that - was asking if a lot of people here face the problem. > Yes, it's true. But > it's not a universal problem. What about the opposite? i.e. does anyone face problems in switching from ER to regular? How exactly do the doctors decide whether to prescribe regular or ER? > Didn't mean that - was asking if a lot of people > here face the problem. I googled it up using a variety of strings similar to XR vs. metformin. I found that Chuck on this ng had to switch back to regular due to high bgs on XR, and that some women on the PCOS group had problems, too (which is where I originally heard of it when XR first came out). A lot of folks had problems with generic metformin, too, which may depend upon who the manufacturer was. Mine works great. Many folks found that XR reduced gastric symptoms sometimes associated with metformin. > What about the opposite? > i.e. does anyone face problems in > switching from ER to regular? If they have, I haven't seen them, but that certainly doesn't rule it out. > How exactly do the doctors decide > whether to prescribe regular or ER? I think that's probably highly individual. They may want to see more even medication, or have a forgetful patient, or the patient may ask for it. Or they may rx it to reduce gastric problems. Susan >> x-no-archive: yes >> [quoted text clipped - 17 lines] >How exactly do the doctors decide >whether to prescribe regular or ER? It's an easy decision here. XR isn't available, so I use 2x500mg regular. Also anecdotally, some posters have found that XR is kinder to their GI tract in the early period of adjustment. Cheers, Alan, T2, Australia. d&e, metformin 2x500mg  SignatureEverything in Moderation - Except Laughter. >>> x-no-archive: yes >>> [quoted text clipped - 26 lines] > Cheers, Alan, T2, Australia. > d&e, metformin 2x500mg That's one reason I have stayed with XR...it's easier on my GI tract....and my numbers seem to be doing ok...I am still on 1000mg a day...Not sure how much longer it will last. Before I started XR my readings seemed to be going up...but my A1C seems to still be ok...I think I may be heading for some kind of transition...not for the good either. I've been lucky so far that 1000 mg has helped me keep my numbers down for 8 or so years. We will see when I get my last A1C back. jacquie I take XR, because it seems to work fine for me. YMMV -- Cheri >Is this really true? Do most people here take the XR or the >regular & why? > I take XR, because it seems to work fine for me. YMMV > [quoted text clipped - 3 lines] >> Is this really true? Do most people here take the XR or the >> regular & why? I've taken the regular (1000 two times daily). My doctor prescribed it and I've had very little difficulty with it. TaniO I take the XR. I take it because my doctor prescribed it. >> Anecdotally, I've seen quite a few folks report that the XR is less >> effective. > > Is this really true? Do most people here take the XR or the > regular & why? > Is this really true? Do most people here take the XR or the > regular & why? The XR version is supposedly better for those who have gastric distress when taking metformin. As well as providing a continuous release it minimises side effects R >x-no-archive: yes > [quoted text clipped - 7 lines] >Anecdotally, I've seen quite a few folks report that the XR is less >effective. That doesn't mean it won't work well for you, though. I see just the opposite. Just the point about it being Extended Release is that you take the medication once a day. I take 1500 er after dinner every night. It is not supposed to be broken up. It stays all day or at least is supposed to work for twenty four hours. Loretta -- In tribute to the United States of America and the State of Israel, two bastions of strength in a world filled with strife and terrorism. I take regular Metformin. 2x500Mg. After Alan's observation I too have shifted to taking the first one after my lunch and one just before going to bed. Seems to have better control over morning liver dump effect. Since the regular works for me, that too generic kind, I never explored the ER kind. My diet control is rather tough to follow though...Yes I am keeping up but sleight variations and I get the spikes (160-190). Anil I take mine before dinner....one reason is because I keep the pills in the kitchen and they stare me in the face when I am preparing dinner so it is easier for me to remember....:) One reason I switched to ER is because I would forget to take the morning one...this way I only have to remember once a day. jacquie > Just the point about it being Extended Release is that you take the > medication once a day. I take 1500 er after dinner every night. It is [quoted text clipped - 8 lines] > of Israel, two bastions of strength in a world filled with strife and > terrorism. >I take 500 mg Metformin Extended Release twice >a day. How much of a difference is there between >the extended release & the regular one? Does the >XR actually help more than the regular one? > >Asking out of curiousity. I find ER to the answer to my prayers for finding a solution to my infamous morning spikes. I've been fighting morning spikes for a couple years and have been using Novolog (3 - 5u) to curb the lil buggers. I've been taking 2 500 mg metformin in the AM and 2 more in the PM since DX. The metformin has done little to curb the spikes or much anything else. I just use it since it has anti heart attack features. A couple weeks ago I changed the regimen to 1 metformin + 1 metformin ER in the AM and the same in the PM. The results for me have been nothing but a miracle. I have seen very few BG readings above120 in several weeks. I haven't used Novolog since 2/25/06. Before that, some days I was using Novolog for every meal to keep 1PP below 120. This morning I woke up at 9 AM and FBG = 81. 1PP breakfast = 111 with cheese + yogurt as breakfast. NO SPIKE, yipppppeeeeee. It could be that my liver is behaving itself, or just that nothing is presently stirring up my system, or metformin ER could be my answer. But, whatever the reason, I'm just loving those Looooooooooow numbers. If history is a predictor of the future, typically April and September are my worst nightmares, since bg's become difficult to control. It could be the calm before the April storm. _____________________________________________ http://www.healthdiabeticsoftware.com/ Free >>I take 500 mg Metformin Extended Release twice >>a day. How much of a difference is there between >>the extended release & the regular one? Does the >>XR actually help more than the regular one? I believe doctors prescribe XR because it may cause less gastrointestinal disturbances. Some people quit taking metformin because it upsets their digestive tract too much. I started off taking 500 mg/d of regular metformin and had no problem for 3 years. My former doctor quit practicing medicine and the new one switched me to XR. Regular is at it's optimal effect at 4 hours from intake. Immediatately my BG level increased in the evening. The doc then gave me a script for regular. I have been using 500 mg XR with breakfast and 500 mg regular with dinner ever since and have had good results. I did not have the problem that Hi_Therre mentions below. >>Asking out of curiousity. > [quoted text clipped - 11 lines] > below 120. This morning I woke up at 9 AM and FBG = 81. 1PP > breakfast = 111 with cheese + yogurt as breakfast. NO SPIKE, Frank > I take 500 mg Metformin Extended Release twice > a day. How much of a difference is there between > the extended release & the regular one? Does the > XR actually help more than the regular one? > > Asking out of curiousity. XR didn't work as well for me as the regular stuff. Guess we're all different. SignatureSee my webpage: http://mysite.verizon.net/juliebove/index.htm |
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