More cites on Tylenol & Kidney Damage

Thread view:

Enable EMail Alerts

Start New Thread

Thread rating:

Jenny - 09 Mar 2006 14:32 GMT

Here is an older Journal of Nutrition article linking kidney damage to
the use of Tylenol.

Use of acetaminophen linked to kidney disease
Nutrition Health Review, Summer, 1989
http://calbears.findarticles.com/p/articles/mi_m0876/is_n51/ai_8540843

Here is the NIDDK statement on how Tylenol damages kidneys.

http://kidney.niddk.nih.gov/kudiseases/pubs/analgesicnephropathy/index.htm

Here is another NIDDK publication "Kidney Disease in Diabetes" that
specifically mentions the "lifetime load" of Tylenol and its impact on
the diabetic kidney.

http://diabetes.niddk.nih.gov/dm/pubs/america/pdf/chapter16.pdf.
From that article:

"Annual intakes of 105-365
acetaminophen pills doubled the odds of ESRD [end stage renal
disease--a.k.a. kidney failure] in 242
patients with diabetes, and a cumulative lifetime in-
take of greater or equal to 1,000 tablets nearly tripled the odds (Table
16.11)"
=====

--Jenny

http://www.phlaunt.com/diabetes Diabetes Info

http://www.alt-support-diabetes.org/newlydiagnosed.htm Get Your Blood
Sugar Under Control

--Jenny

http://www.phlaunt.com/diabetes Diabetes Info

http://www.alt-support-diabetes.org/newlydiagnosed.htm Get Your Blood
Sugar Under Control

Reply to this Message

Evelyn Ruut - 09 Mar 2006 14:54 GMT

> Here is an older Journal of Nutrition article linking kidney damage to the
> use of Tylenol.
[quoted text clipped - 35 lines]
> http://www.alt-support-diabetes.org/newlydiagnosed.htm Get Your Blood
> Sugar Under Control

Hi Jenny,

I have only been posting here for a couple of years, but I know you always
have good backup for what you say. :-)

As a matter of fact the Tylenol/kidney disease link was in the newspapers
not all that long ago, especially if taken with alcohol. As I understand
it taking alcohol and then ibuprofen or tylenol is very hard on the kidneys.

No, I don't have any links to post about it......
I really am not all that computer literate to search all that stuff out.

Have a great day and don't let anyone get you down.

:-)

Signature

Best Regards,

Evelyn
(to reply to me personally, remove 'sox')

Reply to this Message

Jenny - 09 Mar 2006 17:57 GMT

>> Here is an older Journal of Nutrition article linking kidney damage to the
>> use of Tylenol.
[quoted text clipped - 44 lines]
> not all that long ago, especially if taken with alcohol. As I understand
> it taking alcohol and then ibuprofen or tylenol is very hard on the kidneys.

Evelyn,

Fortunately, for everyone who tried to get me down, there's someone else
whose kind words put me back up.

If I recall correctly, the connection between alcohol and Tylenol is
that combining the two can, in unfortunate circumstances, destroy the
liver (not the kidneys.)

This has been known for a long time, but the point that was made in the
press coverage was that the public was unaware of this, and didn't
realize how many over the counter medicines contained Tylenol, so they'd
take a couple Tylenols, and a cough medicine with Tylenol in it, and
maybe a decongestant with some Tylenol in it and then slug down a couple
beers while watching the game and wake up needing a liver transplant.

--Jenny

http://www.phlaunt.com/diabetes Diabetes Info

http://www.alt-support-diabetes.org/newlydiagnosed.htm Get Your Blood
Sugar Under Control

Reply to this Message

Ozgirl - 09 Mar 2006 20:37 GMT

>>> Here is an older Journal of Nutrition article linking kidney damage
>>> to the use of Tylenol.
>>>
>>> Use of acetaminophen linked to kidney disease
>>> Nutrition Health Review, Summer, 1989

http://calbears.findarticles.com/p/articles/mi_m0876/is_n51/ai_8540843

>>> Here is the NIDDK statement on how Tylenol damages kidneys.

http://kidney.niddk.nih.gov/kudiseases/pubs/analgesicnephropathy/index.htm

>>> Here is another NIDDK publication "Kidney Disease in Diabetes" that
>>> specifically mentions the "lifetime load" of Tylenol and its impact
>>> on the diabetic kidney.

http://diabetes.niddk.nih.gov/dm/pubs/america/pdf/chapter16.pdf.

>>> From that article:
>>>
[quoted text clipped - 28 lines]
>> As a matter of fact the Tylenol/kidney disease link was in the
>> newspapers not all that long ago, especially if taken

with alcohol.

>> As I understand it taking alcohol and then ibuprofen or

tylenol is

>> very hard on the kidneys.
>>
[quoted text clipped - 6 lines]
> that combining the two can, in unfortunate circumstances, destroy the
> liver (not the kidneys.)

It is well documented that excess paracetamol can cause
liver failure without alcohol being in the equation. There
was a case of a boy dying here in Oz recently from sudden
liver failure in hospital while being treated with
paracetamol. He is only the tip of the iceberg. Taken as
prescribed and short term there shouldn't be a problem. It
was a murky situation concerning the boy, there were hint of
overdose, but the boy was big, with kids they give x amount
per kg. Perhaps they calculated that to be a dose larger
than a child's liver can handle.

Reply to this Message

Dennis R - 10 Mar 2006 04:15 GMT

> It is well documented that excess paracetamol can cause
> liver failure without alcohol being in the equation. There
[quoted text clipped - 6 lines]
> per kg. Perhaps they calculated that to be a dose larger
> than a child's liver can handle.

When I was reviewing some of the abstracts in MEDLINE, there were
several studies of liver toxicity when acetaminophen and alcohol were
combined. I believe one was a study of 4 years of cases at an Australian
hospital, which covered accidental and non-accidental overdoses in
adults and children. Some other studies saw little difference between
overdoses of acetaminophen only compared to when combined with alcohol,
while others noted liver toxicity at half the FDA recommended maximum
daily dose of 4 grams. I believe those studies were noted in the
underlying meetings to draft the FDA letter I quoted previously:

http://www.fda.gov/cder/drug/analgesics/letter.htm

They also noted in the drafting meetings that several studies seemed to
indicate that overdoses sometimes occurred at levels below the
recommended limit, which seemed to be from co-existing medical
conditions, or just normal YMMV. (My paraphrasing).

Dennis (Type 2)

Reply to this Message

wmmckee@cox.net - 09 Mar 2006 16:55 GMT

> Here is an older Journal of Nutrition article linking kidney damage to
> the use of Tylenol.
[quoted text clipped - 4 lines]
>
> Here is the NIDDK statement on how Tylenol damages kidneys.

Thanks so much for this info, Jenny. You deserve immense credit for helping
to make this group what it is! :-)

Will, T2

Reply to this Message