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Medical Forum / Diseases and Disorders / Diabetes / March 2006Diabetis Cured - So why 3-5 years?
In another thread I commented on our top notch Diabetes Research Team in the city I live in (Edmonton, Alberta Canada). The Team previously (in 2000) pioneered islet cell transplants (from the pancreas of a dead body into the liver of a diabetic, where they take root and begin producing insulin). Yesterday they released a study where they have cured diabetes in monkeys. It is here... http://www.canada.com/edmontonjournal/news/story.html?id=5bef8d1e-77f9-4d7d-8eaf -7abbba82319c They now want Canadian Gov. and FDA approval to begin testing on humans. They don't expect the FDA to allow the transplant to the human liver but such is life I guess. This morning's TV News... "They expect to be testing on humans in Three to Five Years! and here... http://www.redherring.com/Article.aspx?a=15881&hed=Pig+Cells+Cure+Monkey+Diabete s§or=Industries&subsector=Biosciences "It's hoped within the next three to five years, we will begin testing neonatal porcine islet transplants in human patients," said Dr. Rajotte, founder and director of the University of Alberta's Islet Transplantation Group. WOW! Three to Five years to start testing and then how many years for the test? I should drive over and ask Dr. Rajotte what in the world takes so long... especially if you have such positive results. I'm sure there are people in Edmonton that would show up tomorrow if the testing started. -- Dave, T2, Canada > In another thread I commented on our top notch Diabetes Research Team in > the [quoted text clipped - 10 lines] > They don't expect the FDA to allow the transplant to the human liver but > such is life I guess. Stuff like this will always be done in other countries well before the USA. > This morning's TV News... > "They expect to be testing on humans in Three to Five Years! [quoted text clipped - 12 lines] > in > Edmonton that would show up tomorrow if the testing started. It's to bad these things take so god awful long. Some people don't have that kind of time to wait around for a possible cure. I too would be there in a heart beat to try if my condition was to the point that this would possible help me. > -- > Dave, T2, Canada  SignatureJoe W T2 Nov '05 30mg Actos, 3gr(1/2 tsp or 500mg pill) Cinnamon, Diet(>100 carbs) & 30 minute walk(everyday) & BowFlex 3x/week *****Diabetes, be proactive, not reactive.***** >>In another thread I commented on our top notch Diabetes Research Team in >>the [quoted text clipped - 37 lines] >>-- >>Dave, T2, Canada First - it takes a long time to find out if these are at all safe second, it is hard to find people with bad enough control to take the draconian treatment of islet cell transplant. Most of us would MUCH prefer taking insulin to taking a lifetime of anti-rejection drugs,with all the immune system damage they do, and most of us would not be willing to take the increased mortality and morbity caused by transplant surgery, Now, SOME people ARE in that bad shape, for them it is a possible boon, but to call it a "cure" is just plain fraudulent hype. > First - it takes a long time to find out if these are at all safe > second, it is hard to find people with bad enough control to take the > draconian treatment of islet cell transplant. That's because there is no money in a "cure", the money is in research & drugs. > Most of us would MUCH prefer taking insulin to taking a lifetime of > anti-rejection drugs,with all the immune system damage they do, and most > of us would not be willing to take the increased mortality and morbity > caused by transplant surgery, > Now, SOME people ARE in that bad shape, for them it is a possible boon, > but to call it a "cure" is just plain fraudulent hype. I'd like to think of it as hope, not hype and if someone puts the word "cure" in front of it, that gives me hope. I try not to think of everything with fatalistic view, especially diabetes. That seems to be the job of the medical community.(IMO) SignatureJoe W T2 Nov '05 30mg Actos, 3gr(1/2 tsp or 500mg pill) Cinnamon, Diet(>100 carbs) & 30 minute walk(everyday) & BowFlex 3x/week *****Diabetes, be proactive, not reactive.***** >> First - it takes a long time to find out if these are at all safe >> second, it is hard to find people with bad enough control to take the >> draconian treatment of islet cell transplant. > > That's because there is no money in a "cure", the money is in > research & drugs. Only in the US, the rest of the world doesn't have the drug cost to consider. > I'd like to think of it as hope, not hype and if someone puts the word > "cure" in front of it, that gives me hope. > I try not to think of everything with fatalistic view, especially > diabetes. That seems to be the job of the medical community.(IMO) There is already a cure for type 2, it's called prevention. Plenty of research is being done on finding a way to prevent type 1 also. -- Joe W T2 Nov '05 30mg Actos, 3gr(1/2 tsp or 500mg pill) Cinnamon, Diet(>100 carbs) & 30 minute walk(everyday) & BowFlex 3x/week *****Diabetes, be proactive, not reactive.***** >>> First - it takes a long time to find out if these are at > all safe [quoted text clipped - 20 lines] > Plenty of research is being done on finding a way to prevent > type 1 also. no doubt :-) Joe, it can be said there is no cure for many diseases because the human race is stupid and lazy. We actually believe the TV crap. My grandparents believed n Cinderella Diabetes is a tough nut Making war machines and TV shows is easy. >> First - it takes a long time to find out if these are at all safe >> second, it is hard to find people with bad enough control to take the [quoted text clipped - 14 lines] >I try not to think of everything with fatalistic view, especially diabetes. >That seems to be the job of the medical community.(IMO) >>First - it takes a long time to find out if these are at all safe >>second, it is hard to find people with bad enough control to take the [quoted text clipped - 14 lines] > I try not to think of everything with fatalistic view, especially diabetes. > That seems to be the job of the medical community.(IMO) No stupid the ongoing cost of transplant drugs is much more than that for diabetic treatment >>>First - it takes a long time to find out if these are at all safe >>>second, it is hard to find people with bad enough control to take the [quoted text clipped - 18 lines] >the ongoing cost of transplant drugs is much more than that for diabetic >treatment Ted, you don't appreciate how much more powerful that statement would be without the first two words. I agree with your comment, but not the preamble. "Cure", to a person with three incurable diseases, is a four-letter word. Control, mitigate, treat, manage, improve, symptomless - those are words I have no problem with. But "cure", used loosely, causes me to see red too. Cheers, Alan, T2, Australia. d&e, metformin 2x500mg SignatureEverything in Moderation - Except Laughter. >Most of us would MUCH prefer taking insulin to taking a lifetime of >anti-rejection drugs,with all the immune system damage they do, and most >of us would not be willing to take the increased mortality and morbity >caused by transplant surgery, Exactly! It's no "cure" when the tradeoff is suppressing one's immune system. Anyway, I've been hearing such reports of "cures" being just around the corner ever since I was first diagnosed, more than 40 years ago. Nothing ever seems to pan out. These stories come out because journalists like a "scoop," and they -- and the general public -- know next to nothing about diabetes. In the meantime, however, we've had a lot of real progress in the day-to-day *management* of diabetes, even though it doesn't qualify as a "cure." BG self-testing, Humalog, Lantus, pumps -- the list goes on and on. If management improves further (for example, with an implantable pump with real-time BG sensor feedback), it would be almost indistinguishable from a "cure." This is where the research dollars should be concentrated. > In another thread I commented on our top notch Diabetes Research Team in > the [quoted text clipped - 10 lines] > They don't expect the FDA to allow the transplant to the human liver but > such is life I guess. I'm sure somebody is isolating islets and injecting them into the liver already - Mexico, maybe? And I have a vague recollection of them being wrapped in seaweed? I might be confusing several threads here! Anyway, good luck to the Edmonton guys! Nicky. SignatureA1c 10.5/5.4/<6 T2 DX 05/2004 1g Metformin, 100ug Thyroxine 95/74/72Kg > In another thread I commented on our top notch Diabetes Research Team in the > city I live in (Edmonton, Alberta Canada). The Team previously (in 2000) [quoted text clipped - 25 lines] > especially if you have such positive results. I'm sure there are people in > Edmonton that would show up tomorrow if the testing started. I'm guessing it has to do with xenotransplantation. How would this effect the human-animal disease barrier? If a porcine disease can jump to a human who has a porcine transplant (and a compromised immune system), can it then be easly transmitted other humans? In this case I don't think the extra time is a bad thing. |
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