Home | Contact Us | FAQ | Search & Site Map | Link to Us
Sign In | Join | Other 45 Sites in Network
Home
Discussion Groups
General
GeneralCardiologyVisionDentistryPharmacyLaboratoryNutritionAlternative
Diseases and Disorders
AIDSAlzheimer'sArthritisAsthmaCancerBreast CancerDiabetesEpilepsyGlaucomaHepatitisHerpesLupusProstate BPHProstate CancerProstatitisSinusitisTinnitus

Medical Forum / Diseases and Disorders / Diabetes / February 2006

Tip: Looking for answers? Try searching our database.

Bloodwork Results

Thread view: 
Enable EMail Alerts  Start New Thread
Thread rating: 
wmmckee@cox.net - 24 Feb 2006 15:19 GMT
Hello everyone,

I just got my bloodwork results. There was good news and not so good.... The
good was that the a1c is still 5.6. :-)
The bad was that the total cholesterol was back up to 206.... Gotta bring
that down. :-(
LDL was 127, and HDL was 57.

Signature

":Souffrons, mais souffrons sur les cimes."
    -If we must suffer, let us suffer nobly.-

        Victor Hugo (1802-1885)

wmmckee@cox.net - 24 Feb 2006 15:29 GMT
Then, again, the sentiment of the Victor Hugo quote might also be stated,

"Si nous devons souffrir, permettez-nous de souffrir noblement." But then,
it would not be Victor Hugo.

The point, I think, is that we just have to keep at it and not let down our
guard, and at the same time, we must continue to live our lives with all the
dignity and quality of which we are capable.... That is our real challenge
as diabetics.

Have a great day, everyone!

Will, T2
Susan - 24 Feb 2006 15:36 GMT
> Hello everyone,
>
[quoted text clipped - 3 lines]
> that down. :-(
> LDL was 127, and HDL was 57.

My doctor and I were very happy with TC of 226, since my ratios were
good.  Your HDL/TC ratio isn't bad, either.  You don't mention
triglycerides, which are a very important measure in terms of IR and CVD
risk prediction.

Not much bad news, Will.

Susan
wmmckee@cox.net - 24 Feb 2006 16:08 GMT
> You don't mention
> triglycerides, which are a very important measure in terms of IR and CVD
> risk prediction.

HI Susan,

Thanks for the encouragement...  :-)  I was so bummed at going back up with
the Total Cholesterol, that I forgot to even ask George, my doctor, about
the triglycerides. I have to call him back.

Will, T2
Susan - 24 Feb 2006 16:20 GMT
>>You don't mention
>>triglycerides, which are a very important measure in terms of IR and CVD
[quoted text clipped - 7 lines]
>
> Will, T2

Thing is, if your total went up due to an elevation in HDL, that would
be a good sign.  If your TGLs are low and your ratio of TGL/HDL is good,
that would indicate that your LDL is more likely the non
oxidizing/damaging kind.

There's still improvement to be made in your HbA1c, but I don't know how
long you've been controlling carbs or what meds or supplements you've
taken or for how long.

Susan
wmmckee@cox.net - 24 Feb 2006 16:34 GMT
You make very good points, Susan.... I started on Avandamet a year ago, with
near disastrous results for my eyes. I switched to Metformin (500mg x2
daily) last May, and have been doing well on it, ever since. I am not taking
much right now, in the way of supplements, except a little B complex and
folic acid.... I have been watching carbs seriously since May, 2005. Also, I
lost 50 lbs last year, after being diagnosed. Now, I weigh about 180.

Will, T2

Signature

"One should never put on one's best trousers
 to go out to battle for freedom and truth."

                                                   -- HENRIK IBSEN--
                                                         (1828-1906)
"Health consists of having the same diseases as one's neighbors."
                -- Quentin Crisp---

Susan - 24 Feb 2006 16:44 GMT
> You make very good points, Susan.... I started on Avandamet a year ago, with
> near disastrous results for my eyes. I switched to Metformin (500mg x2
[quoted text clipped - 4 lines]
>
> Will, T2

WOW.  You're making incredible progress.  If your doctor agrees, it
might be worth trying to increase your metformin to 1500 per day.  It
took five months to fully kick in for me, but it knocked my TGLs down
from 126 to 95.  Fish oil supplementatin lowers TGLs, too, or a diet
high in oily fish.

Your ratios, as presented by Al, indicate below average CVD risk.  :-)

Susan
oldal4865 - 24 Feb 2006 16:22 GMT
wmmckee@cox.net wrote in message ...

>> You don't mention
>> triglycerides, which are a very important measure in terms of IR and CVD
[quoted text clipped - 7 lines]
>
>Will, T2

Most of the time,   they don't really assay LDL.    They do "Total",   HDL
and triglycerides then bring them all together with the formula:

    Total Cholesterol = LDL + HDL + Triglycerides/5

IOW,   your trigs ought to be about 115.  Your critical ratios look good:

Trig/HDL  < 3,   you = 2.0

 LDL/ HDL < 3,   you = 2.2

Total/HDL < 4,    you = 3.6

An HDL of 57 is high for a guy.   You're doing something right.    Keep on
doing it.

Regards
 Old Al
Joe - 24 Feb 2006 16:17 GMT
> Hello everyone,
>
[quoted text clipped - 4 lines]
> that down. :-(
> LDL was 127, and HDL was 57.

Hey,  2 out of 3 ain't bad. ;-)

Signature

Joe W
T2 Nov '05
30mg Actos, 3gr(1/2 tsp or 500mg pill) Cinnamon, Diet(>100 carbs) &
30 minute walk(everyday) & BowFlex 3x/week
*****Diabetes, be proactive, not reactive.*****

Hi_Therre - 24 Feb 2006 16:32 GMT
>Hello everyone,
>
[quoted text clipped - 3 lines]
>that down. :-(
>LDL was 127, and HDL was 57.

Are you on a statin?  My new GP says LDL should be <= 70 for us
diabetics, mine was 79.  I'm on 20 mg Lovastatin.  How does your
kidneys look?  Every time I see a GP I have him check cholesterol,
kidneys, and A1c.  Very important.  I hope you are keeping track of
all these numbers.
_____________________________________________
http://www.healthdiabeticsoftware.com/  Free
Anil - 24 Feb 2006 19:09 GMT
Hi Will,

As others have pointed out you do have good numbers. But the story of
Cholesterol is far more controversial due to all the recent research.
As far as I am concern I will take Vitamin D along with doing what ever
I can to keen my numbers above safety. Being a Vegan its a bit easier I
guess although I am not convinced that less cholesterol in diet
reflects it in the blood. Compound the facts with what the big pharmas
want to sell by raising big warnings one really needs to look at the
deeper issues. Alan S had posted an excellent reference here  about
size of LDL molecule (indirectly seen by Trig/HDL ratio) was another
risk predictor!

Anyway here is another link that supports the Vitamin D theory!

http://drcranton.com/Cholesterol_myth.htm

Anil
Dx: July 2005,
Total Ch 181/ LDL 110 / HDL 55 / Trig 80
HbA1C 5.7/ weight 165/ Height 5'11" Total Veg except milk in Tea!
Peter Bowditch - 25 Feb 2006 06:09 GMT
>Hi Will,
>
[quoted text clipped - 12 lines]
>
>http://drcranton.com/Cholesterol_myth.htm

Dr Cranton is a quack of the top echelon. Click on the Topics button to see a list of
frauds and quackeries. The top one, and the subject of his best-selling book is an
untested method of preventing people with arterial plaques from getting proper treatment.

He also does the hyperbaric oxygen and mercury removal frauds. This is a man who never saw
someone else's wallet without coveting its contents.

>Anil
>Dx: July 2005,
>Total Ch 181/ LDL 110 / HDL 55 / Trig 80
>HbA1C 5.7/ weight 165/ Height 5'11" Total Veg except milk in Tea!
Signature

Peter Bowditch aa #2243
The Millenium Project http://www.ratbags.com/rsoles
Australian Council Against Health Fraud http://www.acahf.org.au
Australian Skeptics http://www.skeptics.com.au
To email me use my first name only at ratbags.com

Michelle - 24 Feb 2006 16:56 GMT
Gee Will, I don't really see much bad news there at all.  It's the
ratios that count, and an HDL of 57 in a man is pretty awesome.  A lot
of guys' HDLs run in the 30's, and even those who take meds to improve
their ratios seldom get an HDL that high.  I know many who would be
very envious of yours.

It's evident to me that you're doing things right.  :-)

And I'll second Susan's praises of fish oil.  My mother's triglycerides
have a tendency to be a little high, but if she takes fish oil, the
number is much improved.  Fish oil capsules, along with a fishy diet
(like 3 times per week) is a staple in our household.

Michelle
wmmckee@cox.net - 24 Feb 2006 17:25 GMT
> And I'll second Susan's praises of fish oil.  My mother's triglycerides
> have a tendency to be a little high, but if she takes fish oil, the
> number is much improved.  Fish oil capsules, along with a fishy diet
> (like 3 times per week) is a staple in our household.

Thanks for the support, Michelle. And a big "thank you" also goes out to Al,
Joe, Bruce, Susan, and all the rest of you wonderful people! :-)

... Off and on, I have taken either fish oil, or flax seed oil.... I just
hate taking so many pills, though. Since I live by the seaside, so to speak,
there is always plenty of fresh fish around. So, we normally have seafood at
least 2-3 times a week. I am also a big salad eater, and I like antipasto
salads, as well.... Mostly in the seafood department, I have a lot of
salmon, flounder, and occasionally some crab and shrimp. Maybe the seafood
has made a positive difference. I understand shrimp can be bad for
cholesterol, though, and I also enjoy some cheese, every now and then, so
that could be part of the explanation of the increase in the total
cholesterol...

Will, T2
Susan - 24 Feb 2006 17:46 GMT
>>And I'll second Susan's praises of fish oil.  My mother's triglycerides
>>have a tendency to be a little high, but if she takes fish oil, the
[quoted text clipped - 16 lines]
>
> Will, T2

Shrimp is almost pure protein and no fat.  It has cholesterol, but the
cholesterol you eat isn't what does damage, that's caused by the
cholesterol your metabolism produces when you don't take steps to
correct your IR.

Susan
Sleepyman - 24 Feb 2006 22:05 GMT
>> And I'll second Susan's praises of fish oil.  My mother's triglycerides
>> have a tendency to be a little high, but if she takes fish oil, the
[quoted text clipped - 16 lines]
>
>Will, T2

Fried shrimp can most certainly be bad for you... (As if you didn't
know)

Sleepy

------------------------------------------------------------------
It is easier to make a saint out of a libertine than out of a prig.
-George Santayana (1863-1952)
------------------------------------------------------------------
wmmckee@cox.net - 24 Feb 2006 23:13 GMT
On 24-Feb-2006, Ronetta@webtv.net (Loretta Eisenberg) wrote:

> Amy, as soon as I can find a deli, I will think of you.  It is a dying
> trade.  They were practically in every corner when I was a kid.  I have
> nathans, but it isnt the same as a kosher deli.  The nearest one is
> about two miles away.  I go there when I get my hair done.

You are so right, Sleepy. That's why I usually have steamed shrimp!

Will, T2
Alan S - 25 Feb 2006 02:43 GMT
>Fried shrimp can most certainly be bad for you... (As if you didn't
>know)

Not when I deep-fry it, in a light beer batter in peanut
oil.

I think I just decided what's for dinner - thanks Sleepy.

Cheers, Alan, T2, Australia.
d&e, metformin 2x500mg
Signature

Everything in Moderation - Except Laughter.

Sleepyman - 25 Feb 2006 04:18 GMT
>>Fried shrimp can most certainly be bad for you... (As if you didn't
>>know)
[quoted text clipped - 6 lines]
>Cheers, Alan, T2, Australia.
>d&e, metformin 2x500mg

Enjoy!

I bought a microwave popcorn popper that can be used either with, or
without oil. I have been using peanut oil to pop with. Gives it a
little different flavor.

Sleepy

------------------------------------------------------------------
It is easier to make a saint out of a libertine than out of a prig.
-George Santayana (1863-1952)
------------------------------------------------------------------
Sleepyman - 24 Feb 2006 22:03 GMT
>Gee Will, I don't really see much bad news there at all.  It's the
>ratios that count, and an HDL of 57 in a man is pretty awesome.  A lot
[quoted text clipped - 10 lines]
>
>Michelle

Agreed on the fish oil Michelle. See I'm not against *all*
supplements! Niacin can help too...

Sleepy

------------------------------------------------------------------
It is easier to make a saint out of a libertine than out of a prig.
-George Santayana (1863-1952)
------------------------------------------------------------------
Michelle - 25 Feb 2006 06:54 GMT
>Agreed on the fish oil Michelle. See I'm not against *all*
>supplements! Niacin can help too...

>Sleepy

:-)  :-)
Agreed on the niacin too.
Michelle
Susan - 25 Feb 2006 13:20 GMT
>>Agreed on the fish oil Michelle. See I'm not against *all*
>>supplements! Niacin can help too...
[quoted text clipped - 4 lines]
> Agreed on the niacin too.
> Michelle

Niacin, unfortunately, elevates blood glucose.  I stopped being able to
take it years ago for that reason.

Susan
Michelle - 25 Feb 2006 19:19 GMT
>Niacin, unfortunately, elevates blood glucose.  I stopped being able to
>take it years ago for that reason.

>Susan

How interesting.  I wonder what the mechanism behind that effect is.

I used to take niacin for allergies, striving for the famous niacin
flush.  The niacin flush is caused by a histamine reaction.  If I could
get the flush and use great gobs of histamine at one time, my allergies
were better for a day or two.  Eventually, I found the flush too harsh
to continue this and of course, it wasn't really "recommended".

Michelle
Susan - 25 Feb 2006 19:26 GMT
> How interesting.  I wonder what the mechanism behind that effect is.
>
> I used to take niacin for allergies, striving for the famous niacin
> flush.  The niacin flush is caused by a histamine reaction.

I used to take 6 grams at a time for the flush, which wears off as your
body gets used to it.  Great sleep inducer.

 > If I could
> get the flush and use great gobs of histamine at one time, my allergies
> were better for a day or two.  Eventually, I found the flush too harsh
> to continue this and of course, it wasn't really "recommended".

I loved the flush, felt very cleansing or something.  I can't say I
noticed whether it improved my allergies.  Your flush didn't wear off in
time?

Susan
Michelle - 25 Feb 2006 19:34 GMT
>I used to take 6 grams at a time for the flush, which wears off as your
>body gets used to it.  Great sleep inducer.

Agreed!

>I loved the flush, felt very cleansing or something.  I can't say I
>noticed whether it improved my allergies.  Your flush didn't wear off in
>time?

I didn't take the niacin long enough for the flush to wear off.  I had
one particularly bad, itchy episode--red and itchy from head to
toe--that was rather uncomfortable and slightly scary, so I quit.

Michelle
Peter G. (Bigbird) - 25 Feb 2006 19:43 GMT
> >Niacin, unfortunately, elevates blood glucose.  I stopped being able to
>>take it years ago for that reason.
>
>>Susan

Susan, do you happen to have any citations on the niacin = elevated bg
effect?  I'm curious....

When I insisted I cease taking Lovastatin, my doc put me on Niacin, 500mg x
4. I use a "flush-free" type, Inositol Hexaniacinate. My lipids aren't as
good but still low risk. I didn't notice any changes in my fbg or pp
numbers, however (fbg now in the 90's) I added Pantethine to improve lipids
but haven't had a test since.

Peter G.

I've experienced that niacin rush........ can't see how anyone could enjoy
it.   :))
Susan - 25 Feb 2006 21:16 GMT
> Susan, do you happen to have any citations on the niacin = elevated bg
> effect?  I'm curious....

You can just google it up; it's a completely well accepted and
documented phenomenon.

> When I insisted I cease taking Lovastatin, my doc put me on Niacin, 500mg x
> 4. I use a "flush-free" type, Inositol Hexaniacinate. My lipids aren't as
> good but still low risk. I didn't notice any changes in my fbg or pp
> numbers, however (fbg now in the 90's) I added Pantethine to improve lipids
> but haven't had a test since.

I hope your pantethine is liquid capsules and not tablets?  The tablet
one I bought didn't work at all.  I tried to flush them yesterday, and
they took hours to dissolve in the toilet.

Susan
Peter G. (Bigbird) - 25 Feb 2006 21:42 GMT
> x-no-archive: yes
<<snip>>

> I hope your pantethine is liquid capsules and not tablets?  The tablet one
> I bought didn't work at all.  I tried to flush them yesterday, and they
> took hours to dissolve in the toilet.
>
> Susan

Yes, I have the "Softgel" form. What I'm still in doubt about is the dose. I
take 300mg x 2. I've read other sources say to take up to 1500mg/da total. I
guess this is another YMMV thing...

PG
Susan - 25 Feb 2006 21:47 GMT
> Yes, I have the "Softgel" form. What I'm still in doubt about is the dose. I
> take 300mg x 2. I've read other sources say to take up to 1500mg/da total. I
> guess this is another YMMV thing...

The studies(and I, with dramatic results) used 450 mg twice per day.
Some used 300mg 3X per day.  I guess 900 mg per day is the consensus dose.

Susan
Sleepyman - 25 Feb 2006 20:29 GMT
>x-no-archive: yes
>
[quoted text clipped - 11 lines]
>
>Susan

That is a rather generalized statement don't you think Susan? Niacin
raised *your* bg. It didn't raise mine.

Sleepy

------------------------------------------------------------------
It is easier to make a saint out of a libertine than out of a prig.
-George Santayana (1863-1952)
------------------------------------------------------------------
mrslang - 25 Feb 2006 20:43 GMT
> >x-no-archive: yes
> >
[quoted text clipped - 14 lines]
> That is a rather generalized statement don't you think Susan? Niacin
> raised *your* bg. It didn't raise mine.

how dare you question the great and wonderful susan who knows
everything!  she thinks EVERYONE is exactly like her and should do what
SHE does.  be prepared for some study report that will be harder to
understand than the dead sea scrolls as her proof.  lol

Sally
Susan - 25 Feb 2006 21:17 GMT
> That is a rather generalized statement don't you think Susan? Niacin
> raised *your* bg. It didn't raise mine.

Look it up.

Susan
Sleepyman - 26 Feb 2006 02:41 GMT
>x-no-archive: yes
>
[quoted text clipped - 4 lines]
>
>Susan

Why should I?
A) I didn't make the clain
and
B) I have no bg increase on it.

Sleepy

------------------------------------------------------------------
It is easier to make a saint out of a libertine than out of a prig.
-George Santayana (1863-1952)
------------------------------------------------------------------
Susan - 26 Feb 2006 02:52 GMT
> Why should I?

Because you objected to the statement, but presented no evidence.  It's
very hard to avoid finding it if you care to be informed, rather than to
merely bark at the fence.

> A) I didn't make the clain

You did make a recommendation of niacin without, apparently, informing
yourself that it elevates blood glucose.

I didn't make a "claim," I quoted the scienctific literature about a
fact very commonly known to anyone who's looked into niacin.

> and
> B) I have no bg increase on it.

Your personal anecdote is no basis to make a supplement recommendation
without knowledge and citations to back up its safety.

Susan
Harold Groot - 26 Feb 2006 03:39 GMT
>x-no-archive: yes
>
[quoted text clipped - 19 lines]
>
>Susan

I gotta go with Sleepyman on this one.  It's at least in the YMMV
category.  As for a cite, here's one.  It mostly deals with
cholesterol but it mentions improvements in HBA1C as well.

NIACIN TREATS DIABETES AND CHOLESTEROL

Gabe Mirkin, M.D.

A recent study in the medical journal, Diabetes, Obesity and
Metabolism shows that niacin, one of the B vitamins, can treat most
abnormalities in cholesterol associated with diabetes.

Diabetics not only have high blood levels of sugar, they also often
have high blood levels of the bad LDL, triglycerides and Lp(a); and
low levels of the good HDL cholesterol. In this study, 80 percent of
the patients who took the niacin had a lowering of the small, dense
LDL particle that cause heart attacks and a raising of blood levels of
the exceptionally good, HDL2 that prevents heart attacks. Niacin also
lowers blood levels of the bad clotting factor, Lp(a) and the fatty
triglycerides, that cause heart attacks. The most important test to
measure diabetic control is called HBA1C, and it improved
significantly during treatment with niacin. Twenty-one percent of the
patients were unable to tolerate niacin.

Niacin treatment of the atherogenic lipid profile and Lp(A) in
diabetes. Diabetes Obesity & Metabolism, 2002, Vol 4, Iss 4, pp
255-261. J Pan, M Lin, RL Kesala, J Van, MA Charles. Charles MA, 2492
Walnut Ave, Suite 130, Tustin,CA 92780 USA
Susan - 26 Feb 2006 15:11 GMT
>>x-no-archive: yes
>>
[quoted text clipped - 48 lines]
> 255-261. J Pan, M Lin, RL Kesala, J Van, MA Charles. Charles MA, 2492
> Walnut Ave, Suite 130, Tustin,CA 92780 USA

You can choose up sides if you like.  But the irony of Sleepy, of all
folks, recommending a supplement without the proviso that it's known to
elevate blood glucose, is truly rich.

Susan
Sleepyman - 27 Feb 2006 21:26 GMT
>x-no-archive: yes
>
[quoted text clipped - 56 lines]
>
>Susan

It is not proven that it raises blood glucose. That is your
unsubstantiated claim.

Sleepy

------------------------------------------------------------------
It is easier to make a saint out of a libertine than out of a prig.
-George Santayana (1863-1952)
------------------------------------------------------------------
Sleepyman - 27 Feb 2006 21:25 GMT
>x-no-archive: yes
>
[quoted text clipped - 3 lines]
>very hard to avoid finding it if you care to be informed, rather than to
>merely bark at the fence.

You made a general statement. We have covered this same question in
previous threads. Your reaction was by no means universal, and IIRC a
distinct minority one.

>> A) I didn't make the clain
>
>You did make a recommendation of niacin without, apparently, informing
>yourself that it elevates blood glucose.

I didn't make any claim one way or the other concerning glucose. You
did.

>I didn't make a "claim," I quoted the scienctific literature about a
>fact very commonly known to anyone who's looked into niacin.

It is not a fact, and not commonly known because of that. You are
dealing in generalities again Susan.

>> and
>> B) I have no bg increase on it.
>
>Your personal anecdote is no basis to make a supplement recommendation
>without knowledge and citations to back up its safety.

Niacin (Niaspan in my case) is prescribed for lipid control is it not?
That is what I referred to. You jumped in with your size 12s with a
claim of a causal effect between niacin and glucose increase. When I
called you on it, you are the one who told me to look it up. My
response strands.

Sleepy

------------------------------------------------------------------
It is easier to make a saint out of a libertine than out of a prig.
-George Santayana (1863-1952)
------------------------------------------------------------------
Kurt - 26 Feb 2006 04:22 GMT
> >x-no-archive: yes
> >
[quoted text clipped - 11 lines]
>
> Sleepy

Sleepy, niacin doesn't raise my bgs at all either. But it's usually a
no win situation when you're dealing with Susan. That's two of us...so
whatever "study" she's bragging about is not absolute, is it. :)

Best,
Kurt
Ozgirl - 26 Feb 2006 05:28 GMT
> > >x-no-archive: yes
> > >
[quoted text clipped - 15 lines]
> no win situation when you're dealing with Susan. That's two of us...so
> whatever "study" she's bragging about is not absolute, is it. :)

http://jama.ama-assn.org/cgi/content/full/284/10/1263  (need
subscription - I will only post a few parts).

Effect of Niacin on Lipid and Lipoprotein Levels and
Glycemic Control in Patients With Diabetes and Peripheral
Arterial Disease

"Glucose levels were modestly increased by niacin (8.7 and
6.3 mg/dL [0.4 and 0.3 mmol/L]; P = .04 and P<.001) in
participants with and without diabetes, respectively."

"Fasting blood glucose levels were monitored at 6-week
intervals throughout the follow-up period. If the fasting
blood glucose level was higher than 189 mg/dL (10.5 mmol/L),
the HbA1c level was then measured, and if this was higher
than 10.0%, the dosage of niacin (or its placebo) was
down-titrated. Niacin down-titration was also performed if
any routine HbA1c level (measured at study weeks 6, 24, and
48) was higher than 10.0%."

"Effect of Niacin on Glycemic Status and Safety Parameters

Fasting glucose and HbA1c levels were monitored as indices
of glycemic status during niacin treatment. Table 3 presents
the glucose, HbA1c, and uric acid levels at baseline and the
average of 6 postrandomization values. Niacin use resulted
in a small but statistically significant increase in average
glucose levels in participants both with (8.1 mg/dL [0.4
mmol/L]) and without diabetes (6.3 mg/dL [0.3 mmol/L]; P =
.04 and P<.001, respectively). The effect of niacin on
glucose was greater in participants with diabetes than
without (P = .04)."

This study was conducted to determine the efficacy and
safety of lipid-modifying dosages of niacin in patients with
diabetes because "current guidelines do not recommend use of
niacin in patients with diabetes because of concerns about
adverse effects on glycemic control; however, this is based
on limited clinical data."

"Conclusions  Our study suggests that lipid-modifying
dosages of niacin can be safely used in patients with
diabetes and that niacin therapy may be considered as an
alternative to statin drugs or fibrates for patients with
diabetes in whom these agents are not tolerated or fail to
sufficiently correct hypertriglyceridemia or low HDL-C
levels."

So whilst the study does show that niacin elevates bg's, for
most people it may not be significant. I think Susan just
needed to add a YMMV tag on her statement. Once again this
study seems to show averages rises which always skews
results as far as I am concerned. If one person has a
significant rise and another a small rise it doesn't give a
true picture. Some people may weigh up the benefit of lipid
lowering against a bg rise and choose to continue. Others
may not.  A significant thing was that the diabetic group
had a very significant rise of bg at week 18 when the dose
had it's final titration upwards (to 3,000mg). By week 24
bg's dropped dramatically (lower than their baseline) then
went up again. By week 48 (the end of the study) the fasting
bg's were back to where they started. Perhaps those with a
bg elevation effect could try weathering the rise for 6
weeks to see if there is a change.
Kurt - 26 Feb 2006 05:38 GMT
> > > On Sat, 25 Feb 2006 16:17:21 -0500, Susan
> <nevermind@nomail.com>
[quoted text clipped - 88 lines]
> bg elevation effect could try weathering the rise for 6
> weeks to see if there is a change.

This is the way studies should be posted IMHO - the technical
information followed by a summary from a layperson's POV.  That way we
understand where the person is coming from in relation to WHY they
posted the study and a summarization of how they viewed the
results...in plain language, without the condescending attitude, that
all can understand.  Thanks for doing this, Ozgirl.

Best,
Kurt
Peter G. (Bigbird) - 26 Feb 2006 06:23 GMT
Susan,

I'm glad the subject of Niacin came up.  My search substantiates your
position that Niacin can raise bg and/or fbg in many people. Four scholarly
sources all agree that this effect is very much a YMMV thing. Lucky me, I
seem generally immune to this side effect.

I learned a lot more about B vitamins in general and that there are side
benefits beyond the lipid improvements. It improves osteoarthritis in many.
It helps reduce depression. It can help reduce inflammation. and other
lesser benefits

The down side? In therapeutic dosages (>1.5g divided over the day) it can be
hard on the liver. Then there is the famous Niacin flush. Inositol
Hexaniacinate can reduce both side effects. You absolutely need to discuss
this approach with your doctor.

I also discovered that high dose Niacin is antagonistic to chloestyramine,
something my doctor prescribed that I tolerate poorly. Hmm, I
wonder.......... why didn't she tell me about that?

Peter G.
Susan - 26 Feb 2006 15:16 GMT
> Susan,
>
[quoted text clipped - 18 lines]
>
> Peter G.

As compared to pantethine lipid lowering and anti inflammatory
properties, and pantethine's potential to restore hepatic function in
some studies, and no side effects, niacin hasn't nearly as good a
risk/benefit ratio, especially given its potential for hepatic damage.

Your body, your science experiment. :-)

Susan
Sleepyman - 27 Feb 2006 22:09 GMT
>x-no-archive: yes
>
[quoted text clipped - 29 lines]
>
>Susan

While I have read many a good thing about pantethine, it is still an
unregulated diet supplement. Until there are some "real" studies done
on Pantethine, I will continue to take my prescription Niaspan BTW. I
think Old Al is one of the many that take straight Niacin as there is
an insurance conflict. Any substance can have a "potential" to damage
organs. but I don't see you in here telling the wine drinkers they
shouldn't indulge "given its potential for hepatic damage".

Sleepy

------------------------------------------------------------------
It is easier to make a saint out of a libertine than out of a prig.
-George Santayana (1863-1952)
------------------------------------------------------------------
Susan - 27 Feb 2006 22:20 GMT
> While I have read many a good thing about pantethine, it is still an
> unregulated diet supplement. Until there are some "real" studies done
> on Pantethine, I will continue to take my prescription Niaspan

Are you saying that studies are only real if they are conducted in the
U.S.?

 BTW. I
> think Old Al is one of the many that take straight Niacin as there is
> an insurance conflict. Any substance can have a "potential" to damage
> organs.

Off the point.  You did what you constantely attack me for.  You
recommended a supplement without knowing its risks or safety and
potential to harm diabetics.  Pantethine has actually been found to
improve hepatic function, in vitro.  It never harms it, unlike Niacin.

 but I don't see you in here telling the wine drinkers they
> shouldn't indulge "given its potential for hepatic damage".

Off the point.

I can respect those who admit their mistakes.  Not those who
can't/won't.  We all make them; not owning them is what's not right.

Susan
Sleepyman - 27 Feb 2006 21:57 GMT
>> > > On Sat, 25 Feb 2006 16:17:21 -0500, Susan
>> <nevermind@nomail.com>
[quoted text clipped - 99 lines]
>Best,
>Kurt

I agree all the way. I sometimes (often?) get so caught up in the
nomenclature that by the time I finish reading a study, I can't see
the forest for the trees. Also anything scientific is not my cuppa
tea.

Sleepy

------------------------------------------------------------------
It is easier to make a saint out of a libertine than out of a prig.
-George Santayana (1863-1952)
------------------------------------------------------------------
Susan - 26 Feb 2006 15:14 GMT
> So whilst the study does show that niacin elevates bg's, for
> most people it may not be significant. I think Susan just
[quoted text clipped - 12 lines]
> bg elevation effect could try weathering the rise for 6
> weeks to see if there is a change.

There is so much evidence for the bg elevating properties of niacin that
there is a company spending $$$ for trials to produce a form that
doesn't raise bg.

Dosage is a big issue here; it takes  a  high doses to get lipid benefits.

I did not claim that niacin would raise bg to unacceptable levels in
everyone taking it, but pointed out that it has this property.

I would think the President of the No Supplements Club would've wanted
to use YMMV and a proviso in giving it his endorsement.

Susan
Sleepyman - 27 Feb 2006 22:13 GMT
>x-no-archive: yes
>
[quoted text clipped - 28 lines]
>
>Susan

I have stated many times that I take 4 supplements a day. I don't have
a supplement orgy every day like some here. If anyone should have had
a YMMV after a statement, it is you. You made the blanket statement.I
said Niacin "can" help. Not that it "causes" anything.

You may want to continue this thread so you can get the last word. Go
right ahead, I think we have covered all there is to cover.

Sleepy

------------------------------------------------------------------
It is easier to make a saint out of a libertine than out of a prig.
-George Santayana (1863-1952)
------------------------------------------------------------------
bj - 26 Feb 2006 17:56 GMT
> http://jama.ama-assn.org/cgi/content/full/284/10/1263  > >
> Effect of Niacin on Lipid and Lipoprotein Levels and
[quoted text clipped - 13 lines]
> any routine HbA1c level (measured at study weeks 6, 24, and
> 48) was higher than 10.0%."

I can't help wondering what else they were doing to help the patients get
their fbg &/or A1c down. Were they that high before the trial?

> "Conclusions  Our study suggests that lipid-modifying
> dosages of niacin can be safely used in patients with
[quoted text clipped - 3 lines]
> sufficiently correct hypertriglyceridemia or low HDL-C
> levels."

I guess at the 189/10% level, a few more points don't matter all that much.
??
bj
Sleepyman - 27 Feb 2006 21:55 GMT
>> > On Sat, 25 Feb 2006 16:17:21 -0500, Susan
><nevermind@nomail.com>
[quoted text clipped - 88 lines]
>bg elevation effect could try weathering the rise for 6
>weeks to see if there is a change.

All I said to her that her statement was a generalized one. 3000mg is
a huge dose also. I don't subscribe to JAMA, but would like to know
how many people were studied, and if they remained on a dosage of
3,000mgs.The participants also averaged an A1c of 8.1. I also wonder
if this high an A1c was a factor also. I take 2000mg of Niaspan, the
max recommended dose, myself. I don't know if there would be a greater
recommended dose for strait niacin as opposed to Niaspan (time
released to avoid the flush) but I would tend to doubt it. Thanks for
the info Jan.

Sleepy

------------------------------------------------------------------
It is easier to make a saint out of a libertine than out of a prig.
-George Santayana (1863-1952)
------------------------------------------------------------------
Sleepyman - 27 Feb 2006 21:27 GMT
>> >x-no-archive: yes
>> >
[quoted text clipped - 18 lines]
>Best,
>Kurt

She doesn't even have a study this time. She is caliming "common
knowledge".

Sleepy

------------------------------------------------------------------
It is easier to make a saint out of a libertine than out of a prig.
-George Santayana (1863-1952)
------------------------------------------------------------------
Susan - 27 Feb 2006 21:35 GMT
> She doesn't even have a study this time. She is caliming "common
> knowledge".

I have them, and you would too, if you'd googled it, much less checked
Medline.  You recommended niacin, not Niaspan, BTW.

Susan <over this waste of time>
Loretta Eisenberg - 24 Feb 2006 18:44 GMT
Will, the a1c is great and so is the hdl.  the total cholesterol is too
high but not out of this world.  are you on a statin such as lipitor.

ldl is also too high.  It should be under 100 my lab says 75 for
diabetics.

Loretta

--
In tribute to the United States of America and the State
of Israel, two bastions of strength in a world filled with strife and
terrorism.
Julie Bove - 24 Feb 2006 21:19 GMT
> Hello everyone,
>
[quoted text clipped - 3 lines]
> that down. :-(
> LDL was 127, and HDL was 57.

Do you perchance have a thyroid problem?  When my thyroid is out of whack,
so is my cholesterol.

Signature

See my webpage:
http://mysite.verizon.net/juliebove/index.htm

wmmckee@cox.net - 24 Feb 2006 21:28 GMT
> Do you perchance have a thyroid problem?  When my thyroid is out of whack,
> so is my cholesterol.

Good question, Julie. I don't think so.... I think they would have caught
that.  Maybe I'll ask George, my doctor, that next time I talk with him,
though. It really helps knowing my doctor socially. He has been a good
friend for over 15 years.

Will, T2
Sleepyman - 24 Feb 2006 21:49 GMT
>Hello everyone,
>
[quoted text clipped - 3 lines]
>that down. :-(
>LDL was 127, and HDL was 57.

All in all I would say you did very well.
You don't use a statin by chance do you?
Wondering what your triglycerides were.
Just my opinion, but I think Total Cholesterol and LDL are amongst the
easiest things to treat.
Your HDL is very good.

Keep up the good work!

Sleepy

------------------------------------------------------------------
It is easier to make a saint out of a libertine than out of a prig.
-George Santayana (1863-1952)
------------------------------------------------------------------
wmmckee@cox.net - 24 Feb 2006 23:17 GMT
> All in all I would say you did very well.
> You don't use a statin by chance do you?
[quoted text clipped - 6 lines]
>
> Sleepy

Thanks, Sleepy... I still fret a little bit over the higher than desirable
LDL. Not on statins.... George did not want to go that route. He thinks it
was mostly due to the holidays and a lower level of exercise due to the
winter conditions that have been prevailing around here lately. I guess I
just have to watch it and try to shape up. He said he would be worried,
except the HDL was really so good that the ratio was acceptable.

Will, T2
Sleepyman - 24 Feb 2006 21:55 GMT
>Hello everyone,
>
[quoted text clipped - 3 lines]
>that down. :-(
>LDL was 127, and HDL was 57.

OT, Just wondering if you have been watching the Michael Wood series
on PBS called "In Search of Myths and Heroes"? Fantastic stuff. IIRC
this is the 4th or 5th series of his I have seen. They are all equally
well done and fascinating. If you haven't seen it check it out, it's
right up your alley.

Sleepy

------------------------------------------------------------------
It is easier to make a saint out of a libertine than out of a prig.
-George Santayana (1863-1952)
------------------------------------------------------------------
wmmckee@cox.net - 24 Feb 2006 23:20 GMT
> OT, Just wondering if you have been watching the Michael Wood series
> on PBS called "In Search of Myths and Heroes"? Fantastic stuff. IIRC
> this is the 4th or 5th series of his I have seen. They are all equally
> well done and fascinating. If you haven't seen it check it out, it's
> right up your alley.

Hey, thanks for the tip. I was not aware that it was running:-) Most of the
time in the evenings, I just read, watch the news, or do a little writing.

Will, T2
Sleepyman - 25 Feb 2006 01:11 GMT
>> OT, Just wondering if you have been watching the Michael Wood series
>> on PBS called "In Search of Myths and Heroes"? Fantastic stuff. IIRC
[quoted text clipped - 6 lines]
>
>Will, T2

It's on at 8:00pm on Thursday nights with the inevitible re-runs in
Boston area. Don't know when it would be on or even if it is on in Va.
Worth a look at the PBS site IMO.

Sleepy

------------------------------------------------------------------
It is easier to make a saint out of a libertine than out of a prig.
-George Santayana (1863-1952)
------------------------------------------------------------------
Chris J. - 26 Feb 2006 02:50 GMT
>Hello everyone,
>
[quoted text clipped - 3 lines]
>that down. :-(
>LDL was 127, and HDL was 57.

Keep up the good work! Sure, there may be room for improvement, but
overall I think this is great!!  
sharppointy1 - 26 Feb 2006 13:11 GMT
Hi Will
Happy day on your A1c :-) ... damned cholesterol numbers!  I just
finished a year long study that compared using zocor alone versus zocor
and  tricor together in T2 with hyperlipidemia.  I had good results on
both arms of the study.  Bless my parents for my familial
hyperlipidemia.....
I see the doc 3/6 and am a bit worried as i just had to do a week of
oral prednisone for an asthma exacerbation.  With the Byetta, my BS
numbers were better than they have been in the past on pred, but there
were still some in the 200's, aarrgghh.
God, I sound sickly!!  Fortunately I FEEL better than I sound.
Have a lovely sunday (supposed to be 60 & sunny here in Salt Lake City!
Barbara
W.M.McKee - 26 Feb 2006 14:08 GMT
>Hi Will
>Happy day on your A1c :-) ... damned cholesterol numbers!  I just
[quoted text clipped - 9 lines]
>Have a lovely sunday (supposed to be 60 & sunny here in Salt Lake City!
>Barbara

Great hearing from you Barbara. Sorry to hear about your continuing
struggle with the BG, in the aftrmath of the prednisone. One of my
children has asthma really bad from time to time, so I know a lot
about that and the associated problems.
All in all, how is the Byetta working from you? It sounds like you've
made some progress!

I guess the cholesterol is going to be a lifelong problelm for both of
us. I don't think I have ever been near as low with the total
cholesterol as some of our friends in asd. Maybe a diet enriched with
sawdust would help ;-) You never hear of termites with cholesterol
problems.....

Have a wonderful Sunday, Barbara... It is cold here today, with a
chance of snow this afternoon.... New England is really  supposed to
get it, I hear!

Will, T2
 
Sign In
Join
My Latest Posts
My Monitored Threads
My Blog
My Photo Gallery
My Profile
My Homepage

Start New Thread
Enable EMail Alerts
Rate this Thread



©2008 Advenet LLC   Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.