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Medical Forum / Diseases and Disorders / Diabetes / January 2006

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Going on Metformin - what to do about ketons?

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Jim Jaworski - 29 Jan 2006 18:08 GMT
In early November I was experiencing tingly and cold feet. Oh no!

At first I chalked it up to mean I wasn't putting any socks on at home
and my computer desk sits near the window. So I began putting on socks.

That wasn't the end of it though. Prior to this I was getting a very dry
mouth when I woke up. This was odd.

I was also downing 2 litres of choc. soy milk in a day. Not good, 1
litre of no-name apple beverage, and Cheerios. But the worse thing I
probably did was to drink 2 cans of Coke in a day at work, with 1 choc.
bar. I was depressed over other things, so this is what I felt like
eating. No salads.

So when the symptoms seemed to get worse -- I was looking forward to
putting warm water on my feet to warm them up 3x a day, a co-worker
suggested I get tested for diabetes.

Wow, was I in for a shock. 27 mmol/l.

I bought a BG meter on Christmas Eve and have been testing 2x per day --
 the fasting # (7.30 a.m.) and the evening # (11 p.m.). I haven't seen
anything lower than 10.6. If you want a scan of my numbers, I am placing
a PDF from OpenOffice Spreadsheet at:

http://www.mts.net/~jjaworsk/diabetes/bloodsugarlevel.pdf

Notice that out of the 50 or so readings, 1/5th of them don't show
Ketones in the display. All the others do.

So my current Doc. at the walk-in clinic says he's going to put me on
500 mgs of Metformin.

I did some checking on the net about side effects of this drug, and
specifically that people who have ketones in their blood to NOT take
Metformin.

Everybody I've talked to says not to worry about it...even the doctors.

My aunt says it is "for research purposes".

I don't want to die from taking this stuff, but also if I don't my liver
and kidneys could give out. Not good either.

So I need some advice on what to tell doctors and others who have
diabetes on what I should be doing.

If there is a build-up of acids in the body, I would think that low-acid
foods like vegetable salads would lower this, and also drinking enough
water (5-8 cups/day).

Jim Jaworski
jjaworsk @ mts.net
Paul M. Cook - 29 Jan 2006 18:22 GMT
> In early November I was experiencing tingly and cold feet. Oh no!
>
[quoted text clipped - 46 lines]
> foods like vegetable salads would lower this, and also drinking enough
> water (5-8 cups/day).

When your body cannot get energy from glucose, it takes it from fat.
Ketones are produced when fat is metabolized.  Do not confuse ketones with
ketoacidosis.  Not the same.  Metformin decreases insulin resistance so the
body can better use available glucose - among other things.  So Metformin
helps the base problem.  I'm not a doctor, just a recently diagnosed T2.  I
am on metformin myself.  I have had several urine tests lately and some have
been positive for ketones.  It's nothing I worry about as I understand it -
I am testing once a day for protein in the urine.  My endo is far more
concerned with my kidney health.

Paul
RK - 29 Jan 2006 18:27 GMT
| In early November I was experiencing tingly and cold feet. Oh no!
|
[quoted text clipped - 49 lines]
| Jim Jaworski
| jjaworsk @ mts.net

Well first off, what type of meter did you buy? Because iirc theres only
only meter that checks blood ketones, and you need a special strip to
test for that.

Secondly, if you were having ketones all this time, at that high of glucose
you'd pretty much be dropping weight like crazy, which you don't mention
at all.

You also don't mention your age or weight.

Also, no eating foods low in "acid" will not remove ketones from the blood
the only way to do that is to inject insulin, rehydrate the body and reduce
the
glucose, often other things are needed but can only be given by IV...
ketones
in the blood like that also is a medical emergency known as DKA, which
you've
not mentioned any of those symptoms either.

I think you're doctor was right, you need the metformin, you also need to
learn
a new way of eating, start to exercise as well.

Best of luck to you, hang around ask questions theres some good advice as
long
as you ignore the trolls.

RK, T1 Pumper
Jim Jaworski - 30 Jan 2006 19:15 GMT
> | In early November I was experiencing tingly and cold feet. Oh no!
> |
[quoted text clipped - 78 lines]
>
> RK, T1 Pumper

The meter I bought was the OneTouch Ultra.

I don't know what DKA is so I wouldn't know the related symptoms.

I'm 39 (40 in June) and am 5'10" and 170 pounds (usually 175).

Jim
RK - 30 Jan 2006 19:31 GMT
| > | In early November I was experiencing tingly and cold feet. Oh no!
| > |
[quoted text clipped - 86 lines]
|
| Jim

Thanks Jim,

Just as well suspected, the meter isn't "showing' you have ketones, it's
just telling you, you should test for them.  It doesn't mean you have them
and more then likely you don't.  You can get some ketosix at walmart for
$6.99 and test.  If you are low carbing though, it might show ketones, in
which case that has nothing to do with DKA.

But like I said, you aren't exhibiting any symptoms that you mentioned that
goes with DKA.  There are average weight T2's, not all that aren't
overweight
are T1's.

You should do as your doctor instructed and take the metformin, it's not
a research drug.. Just beware of gas and trots from it.. some are effected
quite a bit.

Let us know how you're doing.. As Ozgirl suggested, you might want to
list your meals so others can help you get started with making your own.

Best of luck

Signature

----
RK - Animas IR1250 pumper
... having fun with autoimmune diseases NOT!
dx 5/00 - last a1c 6.3

Jim Jaworski - 31 Jan 2006 22:48 GMT
> | > | In early November I was experiencing tingly and cold feet. Oh no!
> | > |
[quoted text clipped - 116 lines]
> a research drug.. Just beware of gas and trots from it.. some are effected
> quite a bit.

I wasn't quoting the other person saying they thought Metforming was a
research drug, but rather that the "ketones?" display was "for research
purposes".

I had diarrhea on Sunday afternoon, but not since then.

I've taken the Metformin again Monday night (6.30 p.m.), this morning at
10 a.m. and again just now (4.30 p.m.)

When it says to take twice a day is 10 a.m. and 6.30 p.m. too close
together, or should I take the evening one later on? I don't want to
harm myself by OD'ing.

> Let us know how you're doing.. As Ozgirl suggested, you might want to
> list your meals so others can help you get started with making your own.

I've had a dietitian, who is connected to work, and she filled out the
chart from the Canadian Diabetes Assoc. I had left it at work on Friday
and picked it up today.

> Best of luck

Jim
David - 30 Jan 2006 19:38 GMT
>> | In early November I was experiencing tingly and cold feet. Oh no!
>> |
[quoted text clipped - 93 lines]
>
> Jim
Pick up a book or two on diabetes, Jim.  It's a scary thought to me that
a diabetic doesn't know what DKA is!

You picked an excellent meter.  The UltraSmart includes a lighted screen
and other features like graphs (which I never use).  the light is handy.
 for checking in near or total darkness (like at the movies) the Flash
meter works well.

dave
Ma¢k - 30 Jan 2006 20:25 GMT
>The meter I bought was the OneTouch Ultra.
>
[quoted text clipped - 3 lines]
>
>Jim

Diabetic Ketoacidosis

more common in type 1s but can on occasion occur in type 2s-especially
when they are losing beta cells.

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Type 1 since 1975
http://www.alt-support-diabetes.org
http://www.diabetic-talk.org
http://www.insulin-pumpers.org

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--ooO-(_)-Ooo--------------------

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sharppointy1 - 29 Jan 2006 18:43 GMT
Dear Jim
My meter says "Ketones" when my blood sugar is over 250 (American
measure, sorry, I don't know the conversion to your measure).  It DOES
NOT mean there are ketones in my blood, it means that the meter is
reminding me to check my urine for ketones.  Please check the owner's
manual of your meter to see if this is also true for your meter.
oldal4865 - 29 Jan 2006 19:50 GMT
Jim Jaworski wrote in message ...
>In early November I was experiencing tingly and cold feet. Oh no!
>
[quoted text clipped - 49 lines]
>Jim Jaworski
>jjaworsk @ mts.net

   Your meter said "ketones" because that is an important (and  standard
warning) for Type 1 diabetics who have blood sugars that high.

Your meter did not measure ketones.    Nobody knows if you had ketones or
not.    You measure ketones with a urine sample.  The meter manufacturer
merely programmed the meter to warn about ketones as a courtesy for Type 1
diabetics.

Your doctor seems to think that you are a Type 2 diabetic.    Type 2
diabetics rarely have problems with ketones.   Those who do have had the
disease for a very long time.     You do not qualify.

I seriously doubt that you have ketones.    If you are still worried,  buy
some ketones-in-urine test strips from your local pharmacy and test.

Metformin is not a research drug.  It has been used to treat diabetics for
over 40 years and has one of the best safety records of all the
anti-diabetes drugs.

The recommended clinical maintenance dose of metformin is 1500 mg/day.
However,  the doctors are supposed to walk the dose up from 500 mg/day in
order to minimize diarrhea and gas problems.   Therefore,  do not be alarmed
if it doesn't seem to help at first.

Your doctor is being very conservative.   Actually,  I think he is being too
conservative.     Here is an example of another doctor's approach to a
person in your situation.   Note that Gary's reading of 270 mg/dL in U.S.
units corresponds to 15 mmol/L  in the units used by your meter

"From: Gary Pewitt <gpewitt@execpc.com>
Newsgroups: alt.support.diabetes
Date: Tuesday, February 25, 2003 11:46 PM

>My doctor caught my diabetes on the first visit and had me in
> the hospital the same day for multiple tests including x-ray
[quoted text clipped - 3 lines]
> glyburide by half four times, discontinued the Avandia (due to
> swollen legs) and started me on Glucophage [metformin]. . ."

Gary's doc was aggressive.   He attacked Gary's high sugars really hard with
most of the anti-diabetic drugs around,  then backed off after he got Gary's
sugars out of the danger range.

Note that your sugars are well into the danger range.    If I see a 10.6 I
immediately take emergency action.  I inject insulin, then exercise.

Keep coming back.   Diabetes is one of those odd diseases in which the
patient does all the work and most of the management.  The docs mostly sit
on the sidelines cheering us on and writing the occasional prescription.
Reading the diabetes newsgroups every night has produced substantial
improvements in my health,  my standard of living,  and,  I'm sure,  my life
expectancy.

If you are interested in reading up on Metformin,  try reading these
discussions:

a. Metformin reduces blood sugars

http://www.diabetesnet.com/diabetes_treatments/metformin.php

b. Metformin improves cholesterol and triglycerides

http://tinyurl.com/5errv

c. Metformin cuts heart attack risk in T2

http://www.diabetesincontrol.com/issue132/item2.shtml

(   http://tinyurl.com/akgrl   )

d. Actually, Metformin just plain reduces overall mortality rates among T2
diabetics

http://tinyurl.com/69yjd

Regards
 Old Al
Loretta Eisenberg - 29 Jan 2006 20:49 GMT
Thanks old Al for confirming that Type IIs rarely get ketones.  I was
insecure in my answer, but since you are so knowledgeable, I feel
better.

Loretta

--
In tribute to the United States of America and the State
of Israel, two bastions of strength in a world filled with strife and
terrorism.
oldal4865 - 29 Jan 2006 23:32 GMT
Loretta Eisenberg wrote in message
<23312-43DD2A44-90@storefull-3231.bay.webtv.net>...
Thanks old Al for confirming that Type IIs rarely get ketones.  I was
insecure in my answer, but since you are so knowledgeable, I feel
better.

Loretta

    Very stringent low carbers can "get ketones" but it is not the
dangerous "ketoacidosis" which the meters warn about.  Nico wrote a very
good explanation of the differences but I can't find it anymore.

It's sort of interesting.    Once upon a time,   (if what I read was
correct), diabetics were the primary users of ketone-in-urine strips.
Nowadays,  it's the low carbers.

O.P. Jim was not particularly low carbing  so I used the shorthand
"ketones"  to refer to the dangerous ketones + acidosis which is brought
about by a serious lack of insulin.    Type 2 can encounter that kind of
lack of insulin and can develop DKA but not usually in early days  (i.e.
doesn't apply to Jim if he is in early days T2 as his doctor believes).
T2 have to lose a lot,  perhaps most of their beta cells through the Type 2
Diabetic Progression.

Some comments on T2 suffering from Diabetic Ketoacidosis

http://www.medscape.com/viewarticle/490205?src=mp

". . .Compared with type 1 diabetes patients, type 2 diabetes patients with
DKA were more likely to be Latino American or African American,   to have
infections (48.4%) , and to have a body mass index greater than 27 (70% ). .
. ."

". . . .. Noncompliance with medication use was involved in . . .69.2% in
the type 2 diabetes group.. . ."

In theory,  all T2 are headed for a lack of beta cells which qualifies them
for risk of ketoacidosis.   However,  that time could easily come on their
120th birthdays.

What I forgot to post, however,  is a warning about what to do if he buys
and uses ketone-in-urine strips and obtains a strong positive result  for
ketones-in-urine.   Such a positive result, ( in the absence of stringent
low carbing of course),  raises the question that,  contrary to his doc's
opinion,  O.P. Jim is actually an Adult Onset Type 1.    If so,  a positive
test for ketones obtained from ketone-in-urine strips is a call for action.

IOW,  the blood sugar meter ketone warning means little but he had better
talk to his doc ASAP about any positive ketone-in-urine test strip results.

Regards
 Old Al
Jennifer - 29 Jan 2006 19:51 GMT
Jim...

Meters cannot tell you IF there are ketones present.

When your meter sees that you have very high glucose levels, it  puts
"Ketones" on the screen.  It's telling you, you should check your urine
(with a ketone dip stick) for ketones.   You may or may not have them.

The complication of ketoacidosis and Metformin, is very serious... but
it is also very rare.

You need the metformin.  I looked at the chart you made...  Your numbers
are way too high.  They are continuing to cause the damage that is
creating the pains in your feet.  And they are doing the same things to
your eyes and kidneys.  I'm sorry to be so blunt.  But they are.  If
those are your fasting and bedtime numbers (and many were over 20, some
close to 30!)... then your post meal numbers will likely be even higher.
  That must become unacceptable to you.   I do see you're making
progress...  You need to take strong action.  Today.

What, besides taking your blood glucose levels twice a day, are you
doing to get control of this disease?  What food plan?  What exercise plan?

Here's the advice I give all those who want to get control of their
diabetes.  Stick around here and tell us how you're doing!

Sounds like you're planning a move to take control of your diabetes... good
for you.

There is so much to absorb... you don't have to rush into anything.  Begin
by using your best weapon in this war, your meter.   You won't keel over
today, you have time to experiment, test, learn, test and figure out just
how your body and this disease are getting along.  The most important
thing you can do to learn about yourself and diabetes is test test  test.

More than most anything, what you eat will affect your diabetes and
your blood glucose numbers.

And more than anything you eat, carbs will affect your diabetes and
your blood glucose numbers.

So, the most important information you can begin to compile about
yourself, is how your body handles carbs.

This sounds like you would need a low carb food plan right?

You don't... what you need to uncover is YOUR   Personalized Carb Number.

Which actually works better for most everyone.  Because low to one
person is wildly high to another, but waaaaay too low for someone
else.

Is low carb less than 30g a day?   Is it anything less than the
Pyramid reccomendations?

Finding your Personalized Carb Number is easy.

Here's how you can figure out your own Personalized Carb Number.

The single biggest question a diabetic has to answer is:

What do I eat?

Unfortunately, the answer is pretty confusing.

What confounds us all is the fact that different diabetics can get great
results on wildly different food plans.  Some of us here achieve
great blood glucose control eating a high complex carbohydrate diet.
Others find that anything over 75 - 100g of carbs a day is too
much.  Still others are somewhere in between.

At the beginning all of us felt frustrated.  We wanted to be handed
THE way to eat, to ensure our continued health.  But we all
learned that there is no one way.  Each of us had to find our own path,
using the experience of those that went before, but still having
to discover for ourselves how OUR bodies and this disease were coexisting.

Ask questions, but remember each of us discovered on our own what works best
for us.  You can use our experiences as jumping off points, but eventually
you'll work up a successful plan that is yours alone.

What you are looking to discover is how different foods affect you.  As I'm
sure you've read, carbohydrates (sugars, wheat, rice... the things our
Grandmas called "starches") raise blood sugars the most rapidly.  Protein
and fat do raise them, but not as high and much more slowly... so if you're
a T2, generally the insulin your body still makes may take care of the rise.

You might want to try some  experiments.

First:  Eat whatever you've been
currently eating... but write it all down.
Test yourself at the following times:

Upon waking (fasting)
1 hour after each meal
2 hours after each meal
At bedtime

That means 8 x each day.  What you will discover by this is how long
after a meal your highest reading comes... and how fast you return to
"normal".  Also, you may see that a meal that included bread, fruit or
other carbs gives you a higher reading.

Then for the next few days, try to curb your carbs.  Eliminate breads,
cereals, rices, beans, any wheat products, potato, corn, fruit... get all
your carbs from veggies.  Test at the same schedule above.

If you try this for a few days, you may find some pretty damn good
readings.  It's worth a few days to discover.

Eventually you can slowly add back carbs until you see them affecting your
meter.

The thing about this disease... though we share much in common and we
need to
follow certain guidelines... in the end, each of our bodies dictate our
treatment and our success.

The closer we get to non-diabetic numbers, the greater chance we have of
avoiding horrible complications.  The key here is AIM... I know that
everyone is at a different point in their disease... and it is progressive.
But, if we aim for the best numbers and do our best, we give ourselves the
best shot at heath we've got.
That's all we can do.

Here's my opinion on what numbers to aim for, they are non-diabetic numbers.

FBG                          under 100
One hour after meals       under 140
Two hours after meals     under 120

or for those in the mmol parts of the world:

Fasting                              Under 6
One hour after meals         Under 8
Two hours after meals       Under 6.5

Recent studies have indicated that the most important numbers are your
"after meal" numbers. They may be the most indicative of future
complications, especially heart problems.

Listen to your doctor, but you are the leader of your diabetic
care team.  While his /her advice is learned, it is not absolute.   You
will end up knowing much more about your body and how it's handling
diabetes than your doctor will.   Your meter is your best weapon.

Just remember, we're not in a race or a competition with anyone but
ourselves... Play around with your food plan... TEST TEST TEST.  Learn what
foods cause spikes, what foods cause cravings... Use your body as a science
experiment.

You'll read about a lot of different ways people use to control their
diabetes... Many are diametrically opposed. After awhile you'll learn that
there is no one size fits all around here.  Take some time to experiment
and you'll soon discover the plan that works for you.

Best of luck!

Jennifer
wmmckee@cox.net - 29 Jan 2006 20:00 GMT
Ketones are not always a big deal for a T2.... Although you should be
mindful of them.

The big thing to watch out for is ketoacidosis, which is more of a risk for
T1's.... A T2 has to be pretty far gone to be in ketoacidosis, from what I
gather. On the other hand, if you have ever done Atkins, his diet plan and
books do discuss deliberately induced "ketosis"which is different from
"ketoacidosis"..Ketosis may be OK in a T2, or in anyone on a diet and
exercise plan following a particular approach. Simply put, ketosis results
from a low carb regimen, with the result of the body burning more proteins,
rather than so much glucose. In the end, it is a question of balance.

One word of caution, however, would be that for a T2 with impaired kidney
function/kidney damage, it is not a good idea to induce ketosis.... If that
is the situation, be careful.... That, presumably, is why you have a
competent doctor who has ordered lots of tests to monitor you.

Just some thoughts.

Will, T2
Nicky - 29 Jan 2006 20:35 GMT
> I bought a BG meter on Christmas Eve and have been testing 2x per day --
>  the fasting # (7.30 a.m.) and the evening # (11 p.m.). I haven't seen
> anything lower than 10.6.

Jim - print Jennifer's reply off and put it on your fridge door. Read it
often - it's a lifesaver. It'll help you to help your meter to stop
complaining about ketones : )  I remember feeling a bit miffed when mine
stopped saying Hi...

You're a Type 2. The ketones panic is for Type 1s. Take the metformin, and
try and walk it up to at least the 1000mg mark, maybe more - until your
numbers are between 4-7 at most times, and never more than 8.

The other leg of diabetes control is exercise - what are you doing about
that? And have you been told when not to exercise, whilst you're running
high numbers? A gentle walk after lunch and dinner would be really
beneficial, but don't try anything more energetic if your BG is over 12.

Nicky.

Signature

A1c 10.5/5.4/<6  T2 DX 05/2004
1g Metformin, 100ug Thyroxine
95/73/72Kg

Loretta Eisenberg - 29 Jan 2006 20:37 GMT
JIm, I dont believe that type II diabetes have ketones.  It will be fine
for you to take the metformin,  I wonder if he will increase in time
because 500 is a very low dose.

Others more knowledgeable will tell you the real story behind the
ketones but from my recollection, I think I am right.  I have never
spilled a ketone in over 6 years of being a type II.

Loretta

--
In tribute to the United States of America and the State
of Israel, two bastions of strength in a world filled with strife and
terrorism.
Alan S - 29 Jan 2006 22:44 GMT
>In early November I was experiencing tingly and cold feet. Oh no!
>
[quoted text clipped - 49 lines]
>Jim Jaworski
>jjaworsk @ mts.net

Hi Jim

First - welcome to the club.  I know you didn't really want
to qualify for membership, but at least you've come to the
right place.

You've had some excellent replies. I won't repeat them all
but I strongly recommend that you go back and re-read two in
particular, from Jennifer and OldAl.

I had a look at your *.pdf and a few things stand out.

That list of foods is probably the worst menu I've seen for
a diabetic in quite a while. In the whole list the only food
I can eat without spiking (getting a high blood glucose) is
the garden salad. The rest are like a guide for "what not to
eat".

Read Jennifer's advice again, print it out, and then put it
into practice and you'll start to see why I said that. And
please - don't buy any more bananas, apple pies, muffins,
lentil soup, Cheerios...the list goes on. Buy lots of green
veges, fish, meat (or alternative protein if you're
vegetarian - I noticed there were no meats in your menu).

I'm rarely this definite - but find a new doctor as a matter
of urgency, preferably one who specialises in diabetes. If
your doctor was fully aware of those numbers and simply
dispensed a daily 500mg metformin - belatedly - with no
further advice or referrals then you need to get good advice
rapidly. I would guess that your A1c is well into double
digits, and I'd be worrying more about glucose toxicity than
possible metformin side-effects. You may need to be on
insulin, at least until those numbers become more
manageable. You are already experiencing the consequences of
those high numbers.

I also think you may need further testing as to your type.
As others noted, you didn't mention your age or weight.

Make an appointment to see a competent doctor ASAP.

And put Jennifer's advice on testing into practice while you
wait for the appointment.

Cheers Alan, T2, Australia.
Signature

I have no medical qualifications beyond my own experience.
Choose your advisers carefully, because experience can be
an expensive teacher.

Everything in Moderation - Except Laughter.

Ozgirl - 29 Jan 2006 23:48 GMT
> So I need some advice on what to tell doctors and others who have
> diabetes on what I should be doing.

First up, what have you been told and what are you doing now
since diagnosis. Has your diet and exercise levels changed?
If so, in what way? What are eating these days? Testing
twice a day will not give you a clue on what foods are doing
to your numbers by the way. You need to test before each
meal and snack and test 1 and 2 hours after for the time
being. You adjust your carb levels according to the results
of the tests. But first up, I for one would like to see what
you are eating right now, a daily food plan with food types
and amounts. See what you are up to at the point ;)
 
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