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Medical Forum / Diseases and Disorders / Diabetes / October 2003

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T2 Risk Factors

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c sabourin - 06 Oct 2003 01:52 GMT
About 6 months ago I was diagnosed as T2 and haven't been able to
understand the reasons for this happening. I have no family history
whatsoever of Diabetes and am not overweght or obese(BMI 20).Can someone
explain the possible risk factors that made this possible?
Thanks
Charles
J.C. Hartmann - 06 Oct 2003 03:15 GMT
> About 6 months ago I was diagnosed as T2 and haven't been able to
> understand the reasons for this happening. I have no family history
> whatsoever of Diabetes and am not overweght or obese(BMI 20).Can someone
> explain the possible risk factors that made this possible?
> Thanks
> Charles

You didn't state your age, but some docs immediately (and incorrectly)
assume that the onset of diabetes in adulthood is automatically Type-2.

Usually Type-2s have inherited the "tendency" and it appears later in
life after they have packed on a few pounds. The fact that you do not
fit the usual mold here means that perhaps you are really a LADA, or an
adult onset Type-1.

This is something you should discuss with your doc, and if you don't get
satisfactory answers, like "let's run some antibody tests", you should
find yourself an endocrinologist for a second opinion.

Jim
t2_lurking - 06 Oct 2003 03:29 GMT
Were you ever really sick with a immune system illness, like chickenpox?
Plus, the family history thing can be really problematic. If someone had
undiagnosed diabetes and dies from a heart attack who would know? Autopsies
aren't usually done if it looks cut & dried.
How old are you?
How about your racial makeup?
Had a major surgery?
Anything that stresses the insulin system and the beta cells is a risk
factor.
I'm not trying to be snotty but, didn't you get a chance to talk to a
diabetes educator?
Of course this all IMHO.
Doing even a quick search for "diabetes reasons for" yields some interesting
stuff.

Now comes the part you're not going to like:
if you don't feel that you meet any of these conditions you might want to
see your Dr. tout-de-suite.
Could be something major wrong with your pancreas that they didn't catch
when they dxed you T2.
Signature

t2_lurking
geabbottATabbottandabbottDOTcom
Do not mail to t2_lurking (auto-delete)
===============================
The mature man lives quietly, does good privately,
assumes personal responsibility for his actions,
treats others with friendliness and courtesy,
finds mischief boring and keeps out of it.
Without this hidden conspiracy of good will,
society would not endure an hour.
 --- Kenneth Rexroth ---

> About 6 months ago I was diagnosed as T2 and haven't been able to
> understand the reasons for this happening. I have no family history
> whatsoever of Diabetes and am not overweght or obese(BMI 20).Can someone
> explain the possible risk factors that made this possible?
> Thanks
> Charles
Helen - 06 Oct 2003 10:20 GMT
> Were you ever really sick with a immune system illness, like chickenpox?
> Plus, the family history thing can be really problematic. If someone had
> undiagnosed diabetes and dies from a heart attack who would know? Autopsies

Funny you should say that. When my son was two ( now five, diagnosed with
type one six weeks ago)  he suffered from the chicken pox and was very ill,
he had to be hospitalised as he was so dehydrated.Shocking fever and head
aches. He took a while to get over it. My older son got,it but no where near
as severely.
We also have type  one in the family, my father in law is type one. SO I
just wonder whether the chicken pox virus and genetic factors contributed in
some way.......
Sleepyman - 06 Oct 2003 13:39 GMT
>> Were you ever really sick with a immune system illness, like chickenpox?
>> Plus, the family history thing can be really problematic. If someone had
[quoted text clipped - 9 lines]
>just wonder whether the chicken pox virus and genetic factors contributed in
>some way.......

There is a much more defined genetic link between T2s, than T1s. T2 is
not auto immune. Some recent thinking, is that an immune system
disease early in life, may be the trigger for T1.

Sleepy

========
COWBOY UP!
========
Eldritch - 06 Oct 2003 19:50 GMT
> Funny you should say that. When my son was two ( now five, diagnosed with
> type one six weeks ago)  he suffered from the chicken pox and was very ill,
> he had to be hospitalised as he was so dehydrated.Shocking fever and head
> aches.

    From what I've heard, there could be a link.  I don't believe this has
been proven or anything, but some people believe that a viral infection,
such as chickenpox, may trigger the immune system response which
ultimately destroys the beta cells.

           

                E
Nan Eklund - 06 Oct 2003 19:56 GMT
I never thought of chickenpox!  I had it twice as a child (yes, I know, you are
not supposed to get it twice, but my father was a doctor so my pediatrician was
the best in town and he said chickenpox).  But that was 50 to 60 years before I
was diagnosed with diabetes.  Can it lurk that long?
Nan, Type 2 since 1990 or so.
Pete - 06 Oct 2003 20:12 GMT
>I never thought of chickenpox!  I had it twice as a child (yes, I know, you are
>not supposed to get it twice, but my father was a doctor so my pediatrician was
>the best in town and he said chickenpox).  But that was 50 to 60 years before I
>was diagnosed with diabetes.  Can it lurk that long?
>Nan, Type 2 since 1990 or so.

Dunno but there is one thing I found out which surprised me.
The doc thought I might have Lung Cancer or Diabetes, anyway
the various tests took ages to resolve. The X-ray showed
something odd, odd enough to warrant a Scan which then
showed loads of little dots all over the place. The
specialist I saw then informed me that the spots were
Chickenpox scarring inside the lungs. It seems that you get
the pox internal as well.

Pete
Frank Roy - 06 Oct 2003 23:50 GMT
> I never thought of chickenpox!  I had it twice as a child (yes, I know, you are
> not supposed to get it twice, but my father was a doctor so my pediatrician was
> the best in town and he said chickenpox).  But that was 50 to 60 years before I
> was diagnosed with diabetes.  Can it lurk that long?
> Nan, Type 2 since 1990 or so.

Shingles
http://www.skinsite.com/info_herpes_zoster.htm
I. Definition:

Shingles (herpes zoster) is a nerve infection caused by the
chicken-pox virus. Shingles results from reactivation of the
chicken-pox virus that remained in your body since you had
chicken pox--perhaps many years ago.

II. Causes:

Herpes zoster (shingles) is caused by the chicken-pox virus.

III. Symptoms:

The rash of shingles begins as red patches that soon develop
blisters, often on one side of the body. The blisters may
remain small or can become large. They heal in two to four
weeks. They may leave scars. Many patients mistakenly believe
that "nervousness" causes shingles. this is wrong; shingles
is a viral infection of a nerve ...
---
Frank
K'neH'a'Iw - 08 Oct 2003 00:27 GMT
> I never thought of chickenpox!  I had it twice as a child (yes, I know, you are
> not supposed to get it twice, but my father was a doctor so my pediatrician was
> the best in town and he said chickenpox).  But that was 50 to 60 years before I
> was diagnosed with diabetes.  Can it lurk that long?
> Nan, Type 2 since 1990 or so.

Pretty much everybody got it when I was a child, it was a sort of rite of passage. I don't think that's the answer for Type 2. I think the link? theory? is for Type 1, where the autoimmune system get a little over enthusiastic and attacks the pancreas.
Signature

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Uncloaking, Shields up.

Eldritch - 08 Oct 2003 05:23 GMT
> I never thought of chickenpox!  I had it twice as a child (yes, I know, you are
> not supposed to get it twice, but my father was a doctor so my pediatrician was
> the best in town and he said chickenpox).  But that was 50 to 60 years before I
> was diagnosed with diabetes.  Can it lurk that long?
> Nan, Type 2 since 1990 or so.

    A viral infection is thought to be associated with Type 1.   It's not
said to be related to Type 2.

            E
Mack - 08 Oct 2003 08:32 GMT
>> I never thought of chickenpox!  I had it twice as a child (yes, I know, you are
>> not supposed to get it twice, but my father was a doctor so my pediatrician was
[quoted text clipped - 6 lines]
>
>            E

it's not any specific viral infection or a viral infection per se.  It
can be almost anything that causes the immune system to kick in.

Mack
Type 1 since 1975
http://www.alt-support-diabetes.org
http://www.insulin-pumpers.org

In tribute to the United States of America and the State
of Israel, two bastions of strength in a world filled with strife and
terrorism.
Quentin Grady - 06 Oct 2003 07:17 GMT
This post not CC'd by email
On Sun, 5 Oct 2003 20:52:48 -0400 (EDT), csabourin@webtv.net (c
sabourin) wrote:

>About 6 months ago I was diagnosed as T2 and haven't been able to
>understand the reasons for this happening. I have no family history
>whatsoever of Diabetes and am not overweght or obese(BMI 20).Can someone
>explain the possible risk factors that made this possible?
>Thanks
>Charles

G'day G'day Charles,

You haven't by any chance been treated with high dose prednisone or
similar steroid?

Best wishes,

Signature

Quentin Grady       ^  ^  /
New Zealand,       >#,#< [
                   / \ /\    
"... and the blind dog was leading."

http://homepages.paradise.net.nz/quentin

Al Hardy - 06 Oct 2003 07:49 GMT
> About 6 months ago I was diagnosed as T2 and haven't been able to
> understand the reasons for this happening. I have no family history
> whatsoever of Diabetes and am not overweght or obese(BMI 20).Can someone
> explain the possible risk factors that made this possible?
> Thanks
> Charles

On very rare occasions, it it simply blind chance falling the wrong way.
However, your doc ought to agree if you ask him to check HLA-DR3 and
HLA-DR4, which will tell whrther you are t2, LADA, or late-onset t1 still in
honeymoon.

Al.
Peter C - 06 Oct 2003 09:56 GMT
The causes of Diabetes are unknown.
This makes it an incurable disease
and the treatment just management of the
main symptom.
One theory we haven't heard much of recently is that
T2 is genetic and is so widespread that it must actually be a beneficial
gene/s from the Stone Age. Redundant in the present era.
As for it not being in your family, who were your 16
great-great-grandparents and what did they die of ?
Many of them, although carrying the genes for diabetes, would not have lived
long enough to develop it themselves - they just stored it up for you.
Bob - 07 Oct 2003 02:09 GMT
> One theory we haven't heard much of recently is that
> T2 is genetic and is so widespread that it must actually be a
> beneficial gene/s from the Stone Age. Redundant in the
> present era.

That's probably because your theory is a heap of old toss (as we say).
T2 dm may be genetic, but if it appears after child bearing age, then it
gets passed on very successfully down the generations.

Signature

Bob
Dx T1 4/4/2003, Insulatard & NovoRapid
(trying zeroish carb - kiddies, do not try this at home)

doe - 07 Oct 2003 02:35 GMT
>Subject: Re: T2 Risk Factors
>From: "Bob" Bob@bob.com
[quoted text clipped - 9 lines]
>T2 dm may be genetic, but if it appears after child bearing age, then it
>gets passed on very successfully down the generations.

And so the fact those with genetic iron overload manifest T2 .. is NOT ..
'genetically' .. caused .. then?

AND the mutation IS .. hypothesised to BE due to >> beneficial gene/s from the
Stone Age. Redundant in the
>> present era.

Who loves ya.
Tom
Signature

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Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

Bob - 07 Oct 2003 03:12 GMT
> And so the fact those with genetic iron overload manifest T2 .. is NOT
> 'genetically' .. caused .. then?
>
> AND the mutation IS .. hypothesised to BE due to >> beneficial gene/s
> from the Stone Age. Redundant in the present era.

. . . by who?  homer simpson? get a grip man.

Let me start again.  Well hello Tom, this is the first time i've
actually talked to a real nut head.  I just looked at the 3 web links
you have in your sig and most amusing they are too.  I just hope you
have them there for our amusement, 'cos if you don't . . .   I once saw
a site with singing hamsters, that was funny too.

Now i begin to see why guy, ted, mack and jbove, etc keep an eye on the
"strange" posters.  I think you're probably harmless and i'm ready to
listen.  What was it you had to say?.

Signature

Bob
Dx T1 4/4/2003, Insulatard & NovoRapid
(trying zeroish carb - kiddies, do not try this at home)

doe - 07 Oct 2003 06:06 GMT
>Subject: Re: T2 Risk Factors
>From: "Bob" Bob@bob.com
>Date: 10/6/2003 8:12 PM Mountain Daylight Time
>Message-id: <blt7ep$ga3ak$1@ID-189936.news.uni-berlin.de>

>Now i begin to see why guy, ted, mack and jbove, etc keep an eye on the
>"strange" posters.  I think you're probably harmless and i'm ready to
>listen.  What was it you had to say?.

Listen to .. mack ..

He'll get ya to where YOU should .. be ..

Who loves ya.
Tom
Signature

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Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

Peter C - 07 Oct 2003 16:36 GMT
"Bob" <Bob@bob.com> wrote in message era.

> . . . by who?  homer simpson?

By several geneticists e.g. Gary Ruvkun, Harvard Medical School writing in
Science in August 1997 ..
He says, "Many animals hibernate, some for extended periods of time, and
those animals that undergo longer periods of metabolic shutdown may be
better able to survive tough periods of drought or cold in which food
supplies are scarce. While humans don't hibernate, we may find that past
adaptations in groups of people who periodically experienced food shortages
might underlie the prevalence of diabetes in certain populations. For
example, almost half of the Pima Indians in Arizona, who have high levels of
obesity, develop diabetes. These characteristics may be the legacy of this
group's past history of famine and drought. What was once a beneficial
mutation, allowing people to store enough fat to survive and reproduce,
could now be a cause of disease when food is plentiful."

The argument being that T2 was a beneficial gene/s which helped people
survive drought, famine etc. In addition older members of a tribe ( perhaps
past the "child-bearing age" you mentioned ) might be helped by these genes
if they could no longer hunt and were on a marginal diet.
Pete - 07 Oct 2003 18:10 GMT
>"Bob" <Bob@bob.com> wrote in message era.

[snip]

>we may find that past
>adaptations in groups of people who periodically experienced food shortages
>might underlie the prevalence of diabetes in certain populations.

[snip]

Mankind  pre dating 'Lucy' and towards the near extinction
of the race, was in a long period of food scarcity. It was
this that forced adaptation. We developed imagination which
allowed us to plan.

Pete
Bob - 07 Oct 2003 20:14 GMT
> >we may find that past adaptations in groups of people who
> >periodically experienced food shortages might underlie
[quoted text clipped - 4 lines]
> this that forced adaptation. We developed imagination which
> allowed us to plan.

Or we may just find it's just another random mutation that affects
people after child bearing age and doesn't affect their ability to
reproduce.

Signature

Bob
Dx T1 4/4/2003, Insulatard & NovoRapid
(trying zeroish carb - kiddies, do not try this at home)

gman99@canada.com - 06 Oct 2003 12:56 GMT
> About 6 months ago I was diagnosed as T2 and haven't been able to
> understand the reasons for this happening. I have no family history
> whatsoever of Diabetes and am not overweght or obese(BMI 20).Can someone
> explain the possible risk factors that made this possible?
> Thanks
> Charles

BMI is a useless measure...body fat percentage would be more indicative of
obeisity. Sure you weren't adopted ? If there's no history you might be on
the look out for T1.

The main risk factors are obeisity and family history.
louisejoi - 06 Oct 2003 13:12 GMT
> About 6 months ago I was diagnosed as T2 and haven't been able to
> understand the reasons for this happening. I have no family history
> whatsoever of Diabetes and am not overweght or obese(BMI 20).Can someone
> explain the possible risk factors that made this possible?

Perhaps there were recessive genes on both sides of the family.  Also in
years past, diagnostic BG levels were much higher, people were told they had
a "little bit of sugar" (not realizing they were diabetic), and health care
wasn't as available or sophisticated so there were a lot of people walking
around with diabetes that didn't know it.

That said, did you have 2 tests done and are you sure from your home testing
that you are really diabetic?  One of my inlaws, who has no family history
and is very fit, had a FBG of 180 or so.  They tested him a couple weeks
later and his results were under 100.  Since then he's had a few other tests
and he's totally normal.  The lab had screwed up.

Also, as others have said, Type 1 could be a possibility.

--
Best wishes
Louise

Type 2 since 2000, controlling by diet and exercise
Annette - 06 Oct 2003 14:27 GMT
> About 6 months ago I was diagnosed as T2 and haven't been able to
> understand the reasons for this happening. I have no family history
> whatsoever of Diabetes and am not overweght or obese(BMI 20).Can someone
> explain the possible risk factors that made this possible?
> Thanks
> Charles

Hi there Charles,

First up, let me say welcome to the group!

As you can see, there's a lot of people here ready to help out and
offer ideas and suggestions. One of the advantages of coming into a
thread a bit later than others is being able to look over what
everyone else has suggested to see if any possiblities have not yet
been mentioned.

One rare condition that has not been brought up yet, is
Haemochromatosis.  This is a condition where the body stores up too
much iron, and it also can cause high blood sugar levels.  Did your
doctor do any general blood tests?  Or alternatively, have you ever
been a blood donor?  They test the blood for iron levels etc before
drawing any blood.  As I said, it's rare, but just another
possibility.

You've sure got a lot to think about now!

Do post again, and tell us how you're going with management etc of
your diabetes.  Don't be worried about asking any questions, no
matter how silly or "dumb" they may seem.  As you may have noticed,
this is a SUPPORT group, and we will be happy to help in what ever
way we can. We don't diagnose or prescribe meds, that's your
doctor's job, but there are a lot of things to learn about everyday
living with the disease.

All the best,

Annette
Tom Joy - 06 Oct 2003 15:08 GMT
> About 6 months ago I was diagnosed as T2 and haven't been able to
> understand the reasons for this happening. I have no family history
> whatsoever of Diabetes and am not overweght or obese(BMI 20).Can someone
> explain the possible risk factors that made this possible?
> Thanks
> Charles

I too was diagnosed less than a month ago. They haven't told me yet what
type I am. They have me on insulin now; in the morning and evening. I have
no history of diabetes in my family either. I was a little overweight for a
few years. Not too much though. I'm 44, caucasian, and have never had the
chicken pox, any surgeries (oral, wisdom teeth when I was 22), never taken
steroids and have enjoyed good health till my diagnosis. I have never been
on any medication till now. The hospital took blood many different times and
haven't told me what they've found. My diagnosis came when I became
dehydrated and my blood sugar shot way up and I collapsed. I talked to an
educator at the hospital who said I may be able to get off the insulin if I
watch my diet, etc.. I live in a small town and am thinking that I should go
to a specialist in a nearby city. The doctor wrote down that I take 10 units
in the evening and the hospital and pharmacy wrote that I should take 12 in
the evening. I told my doctor about this on the first visit and he shrugged
and said it didn't matter that much. That seemed to me to be a cavalier
attitude that rubbed me the wrong way. We're talking about my life here!
Anyway, the next visit I will ask what type I am and anything else I can
think of. I always think of more questions once out of the office...
t2_lurking - 06 Oct 2003 15:34 GMT
By all means you need a new Dr. for this.
If they haven't even TOLD you what kind of diabetic are.
I may be going out on a limb here but, I'm pretty sure you're a T2 (Type 2).
You're not taking much insulin (what kind?) and you haven't said how many
times a day you're measuring your Blood Glucose (BG).
If you are a T2 then you might want to look for the Gretchen Becker book
"The First Year Type 2 Diabetes: An Essential Guide for the Newly Diagnosed"
.
Its a big help when you are first dxed and have lots of questions. It's
handy to have around as a reference also.
Two good websites (since you're on the net) are the
www.alt.support.diabetes.org and www.mendosa.com.

If you have questions Ask Away!
The newsgroup of course isn't your medical Dr., but it can provide lots of
good info.
You catching diabetes early, A GOOD THING.
Check back often.
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Do not mail to t2_lurking (auto-delete)
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dies young.
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> > About 6 months ago I was diagnosed as T2 and haven't been able to
> > understand the reasons for this happening. I have no family history
[quoted text clipped - 21 lines]
> Anyway, the next visit I will ask what type I am and anything else I can
> think of. I always think of more questions once out of the office...
Tom Joy - 06 Oct 2003 17:03 GMT
> By all means you need a new Dr. for this.
> If they haven't even TOLD you what kind of diabetic are.
[quoted text clipped - 47 lines]
> > Anyway, the next visit I will ask what type I am and anything else I can
> > think of. I always think of more questions once out of the office...

I was looking on the ADA web site and think I may have hemachromatosis. I
have all the symptoms of it and it says it's severely underdiagnosed. It
goes on to say that if people with diabetes resulting from pancreatic damage
usually see an improvement if not a reversal of their diabetes, depending on
how much damage has occurred. Anyway, I'm gonna ask the doctor about this. I
fit the mold. More information can be had at:
http://www.diabetes.org/info/hemochromatosis.jsp
Chakolate - 06 Oct 2003 16:54 GMT
> Anyway, the next visit I will ask what type I am and anything else I can
> think of. I always think of more questions once out of the office...

I always ask my doctor for an e-mail address.  Then I can ask those
questions that don't occur until I get home.  Of course, for urgent
questions, you'd call the clinic.

Chakolate

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Jenny - 06 Oct 2003 15:31 GMT
I started showing abnormal blood sugars  long before I had a weight problem.
In fact, the weight problem only came on after my blood sugars deteriorated
to near-diabetic levels.

Genes is my guess since a lot of my relatives on both sides (none of them
obese) died of heart disease and kidney failure. Five years ago I was told I
was NOT diabetic. Now with the same numbers I am.  The diagnostic standards
for Type II were MUCH higher even 10 years ago so only one of these
relatives (a grandmother) ever got a diabetes diagnosis, but I suspect the
rest of her children were spiking and running over normal fasting blood
sugars too (as I do.)

The good news is that with much earlier diagnosis you have a chance to
control your blood sugar before terrible damage is done to your various
organs like eyes, kidneys and vascular system.
-- Jenny

168.5/137

Low Carb 9/1998 - 8/2001 and 11/10/02 - Now

http://www.geocities.com/jenny_the_bean
How to calculate your need for protein * How much people really lose each
month *  Water Weight Gain & Loss * The "Two Gram Cure" for Hunger Cravings
* Characteristics of Successful Dieters * Indispensible Low Carb Treats *
Should You Count that Low Impact Carb? * Curing Ketobreath * Exercise
Starting from Zero *  NEW! Do Starch Blockers Work?

> About 6 months ago I was diagnosed as T2 and haven't been able to
> understand the reasons for this happening. I have no family history
> whatsoever of Diabetes and am not overweght or obese(BMI 20).Can someone
> explain the possible risk factors that made this possible?
> Thanks
> Charles
Loretta Eisenberg - 06 Oct 2003 16:25 GMT
I just learned that very high tryglcerides could be an indication of
approaching diabetes.  Not everyone fits the mold .  I guess it just
happens

Are you over forty

Loretta

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