Medical Forum / Diseases and Disorders / Diabetes / October 2003
T2 Risk Factors
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c sabourin - 06 Oct 2003 01:52 GMT About 6 months ago I was diagnosed as T2 and haven't been able to understand the reasons for this happening. I have no family history whatsoever of Diabetes and am not overweght or obese(BMI 20).Can someone explain the possible risk factors that made this possible? Thanks Charles
J.C. Hartmann - 06 Oct 2003 03:15 GMT > About 6 months ago I was diagnosed as T2 and haven't been able to > understand the reasons for this happening. I have no family history > whatsoever of Diabetes and am not overweght or obese(BMI 20).Can someone > explain the possible risk factors that made this possible? > Thanks > Charles You didn't state your age, but some docs immediately (and incorrectly) assume that the onset of diabetes in adulthood is automatically Type-2.
Usually Type-2s have inherited the "tendency" and it appears later in life after they have packed on a few pounds. The fact that you do not fit the usual mold here means that perhaps you are really a LADA, or an adult onset Type-1.
This is something you should discuss with your doc, and if you don't get satisfactory answers, like "let's run some antibody tests", you should find yourself an endocrinologist for a second opinion.
Jim
t2_lurking - 06 Oct 2003 03:29 GMT Were you ever really sick with a immune system illness, like chickenpox? Plus, the family history thing can be really problematic. If someone had undiagnosed diabetes and dies from a heart attack who would know? Autopsies aren't usually done if it looks cut & dried. How old are you? How about your racial makeup? Had a major surgery? Anything that stresses the insulin system and the beta cells is a risk factor. I'm not trying to be snotty but, didn't you get a chance to talk to a diabetes educator? Of course this all IMHO. Doing even a quick search for "diabetes reasons for" yields some interesting stuff.
Now comes the part you're not going to like: if you don't feel that you meet any of these conditions you might want to see your Dr. tout-de-suite. Could be something major wrong with your pancreas that they didn't catch when they dxed you T2.
 Signature t2_lurking geabbottATabbottandabbottDOTcom Do not mail to t2_lurking (auto-delete) =============================== The mature man lives quietly, does good privately, assumes personal responsibility for his actions, treats others with friendliness and courtesy, finds mischief boring and keeps out of it. Without this hidden conspiracy of good will, society would not endure an hour. --- Kenneth Rexroth ---
> About 6 months ago I was diagnosed as T2 and haven't been able to > understand the reasons for this happening. I have no family history > whatsoever of Diabetes and am not overweght or obese(BMI 20).Can someone > explain the possible risk factors that made this possible? > Thanks > Charles Helen - 06 Oct 2003 10:20 GMT > Were you ever really sick with a immune system illness, like chickenpox? > Plus, the family history thing can be really problematic. If someone had > undiagnosed diabetes and dies from a heart attack who would know? Autopsies Funny you should say that. When my son was two ( now five, diagnosed with type one six weeks ago) he suffered from the chicken pox and was very ill, he had to be hospitalised as he was so dehydrated.Shocking fever and head aches. He took a while to get over it. My older son got,it but no where near as severely. We also have type one in the family, my father in law is type one. SO I just wonder whether the chicken pox virus and genetic factors contributed in some way.......
Sleepyman - 06 Oct 2003 13:39 GMT >> Were you ever really sick with a immune system illness, like chickenpox? >> Plus, the family history thing can be really problematic. If someone had [quoted text clipped - 9 lines] >just wonder whether the chicken pox virus and genetic factors contributed in >some way....... There is a much more defined genetic link between T2s, than T1s. T2 is not auto immune. Some recent thinking, is that an immune system disease early in life, may be the trigger for T1.
Sleepy
======== COWBOY UP! ========
Eldritch - 06 Oct 2003 19:50 GMT > Funny you should say that. When my son was two ( now five, diagnosed with > type one six weeks ago) he suffered from the chicken pox and was very ill, > he had to be hospitalised as he was so dehydrated.Shocking fever and head > aches. From what I've heard, there could be a link. I don't believe this has been proven or anything, but some people believe that a viral infection, such as chickenpox, may trigger the immune system response which ultimately destroys the beta cells.
E
Nan Eklund - 06 Oct 2003 19:56 GMT I never thought of chickenpox! I had it twice as a child (yes, I know, you are not supposed to get it twice, but my father was a doctor so my pediatrician was the best in town and he said chickenpox). But that was 50 to 60 years before I was diagnosed with diabetes. Can it lurk that long? Nan, Type 2 since 1990 or so.
Pete - 06 Oct 2003 20:12 GMT >I never thought of chickenpox! I had it twice as a child (yes, I know, you are >not supposed to get it twice, but my father was a doctor so my pediatrician was >the best in town and he said chickenpox). But that was 50 to 60 years before I >was diagnosed with diabetes. Can it lurk that long? >Nan, Type 2 since 1990 or so. Dunno but there is one thing I found out which surprised me. The doc thought I might have Lung Cancer or Diabetes, anyway the various tests took ages to resolve. The X-ray showed something odd, odd enough to warrant a Scan which then showed loads of little dots all over the place. The specialist I saw then informed me that the spots were Chickenpox scarring inside the lungs. It seems that you get the pox internal as well.
Pete
Frank Roy - 06 Oct 2003 23:50 GMT > I never thought of chickenpox! I had it twice as a child (yes, I know, you are > not supposed to get it twice, but my father was a doctor so my pediatrician was > the best in town and he said chickenpox). But that was 50 to 60 years before I > was diagnosed with diabetes. Can it lurk that long? > Nan, Type 2 since 1990 or so. Shingles http://www.skinsite.com/info_herpes_zoster.htm I. Definition:
Shingles (herpes zoster) is a nerve infection caused by the chicken-pox virus. Shingles results from reactivation of the chicken-pox virus that remained in your body since you had chicken pox--perhaps many years ago.
II. Causes:
Herpes zoster (shingles) is caused by the chicken-pox virus.
III. Symptoms:
The rash of shingles begins as red patches that soon develop blisters, often on one side of the body. The blisters may remain small or can become large. They heal in two to four weeks. They may leave scars. Many patients mistakenly believe that "nervousness" causes shingles. this is wrong; shingles is a viral infection of a nerve ... --- Frank
K'neH'a'Iw - 08 Oct 2003 00:27 GMT > I never thought of chickenpox! I had it twice as a child (yes, I know, you are > not supposed to get it twice, but my father was a doctor so my pediatrician was > the best in town and he said chickenpox). But that was 50 to 60 years before I > was diagnosed with diabetes. Can it lurk that long? > Nan, Type 2 since 1990 or so. Pretty much everybody got it when I was a child, it was a sort of rite of passage. I don't think that's the answer for Type 2. I think the link? theory? is for Type 1, where the autoimmune system get a little over enthusiastic and attacks the pancreas.
 Signature K'neH'a'Iw
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Eldritch - 08 Oct 2003 05:23 GMT > I never thought of chickenpox! I had it twice as a child (yes, I know, you are > not supposed to get it twice, but my father was a doctor so my pediatrician was > the best in town and he said chickenpox). But that was 50 to 60 years before I > was diagnosed with diabetes. Can it lurk that long? > Nan, Type 2 since 1990 or so. A viral infection is thought to be associated with Type 1. It's not said to be related to Type 2.
E
Mack - 08 Oct 2003 08:32 GMT >> I never thought of chickenpox! I had it twice as a child (yes, I know, you are >> not supposed to get it twice, but my father was a doctor so my pediatrician was [quoted text clipped - 6 lines] > > E it's not any specific viral infection or a viral infection per se. It can be almost anything that causes the immune system to kick in.
Mack Type 1 since 1975 http://www.alt-support-diabetes.org http://www.insulin-pumpers.org
In tribute to the United States of America and the State of Israel, two bastions of strength in a world filled with strife and terrorism.
Quentin Grady - 06 Oct 2003 07:17 GMT This post not CC'd by email On Sun, 5 Oct 2003 20:52:48 -0400 (EDT), csabourin@webtv.net (c sabourin) wrote:
>About 6 months ago I was diagnosed as T2 and haven't been able to >understand the reasons for this happening. I have no family history >whatsoever of Diabetes and am not overweght or obese(BMI 20).Can someone >explain the possible risk factors that made this possible? >Thanks >Charles G'day G'day Charles,
You haven't by any chance been treated with high dose prednisone or similar steroid?
Best wishes,
 Signature Quentin Grady ^ ^ / New Zealand, >#,#< [ / \ /\ "... and the blind dog was leading."
http://homepages.paradise.net.nz/quentin
Al Hardy - 06 Oct 2003 07:49 GMT > About 6 months ago I was diagnosed as T2 and haven't been able to > understand the reasons for this happening. I have no family history > whatsoever of Diabetes and am not overweght or obese(BMI 20).Can someone > explain the possible risk factors that made this possible? > Thanks > Charles On very rare occasions, it it simply blind chance falling the wrong way. However, your doc ought to agree if you ask him to check HLA-DR3 and HLA-DR4, which will tell whrther you are t2, LADA, or late-onset t1 still in honeymoon.
Al.
Peter C - 06 Oct 2003 09:56 GMT The causes of Diabetes are unknown. This makes it an incurable disease and the treatment just management of the main symptom. One theory we haven't heard much of recently is that T2 is genetic and is so widespread that it must actually be a beneficial gene/s from the Stone Age. Redundant in the present era. As for it not being in your family, who were your 16 great-great-grandparents and what did they die of ? Many of them, although carrying the genes for diabetes, would not have lived long enough to develop it themselves - they just stored it up for you.
Bob - 07 Oct 2003 02:09 GMT > One theory we haven't heard much of recently is that > T2 is genetic and is so widespread that it must actually be a > beneficial gene/s from the Stone Age. Redundant in the > present era. That's probably because your theory is a heap of old toss (as we say). T2 dm may be genetic, but if it appears after child bearing age, then it gets passed on very successfully down the generations.
 Signature Bob Dx T1 4/4/2003, Insulatard & NovoRapid (trying zeroish carb - kiddies, do not try this at home)
doe - 07 Oct 2003 02:35 GMT >Subject: Re: T2 Risk Factors >From: "Bob" Bob@bob.com [quoted text clipped - 9 lines] >T2 dm may be genetic, but if it appears after child bearing age, then it >gets passed on very successfully down the generations. And so the fact those with genetic iron overload manifest T2 .. is NOT .. 'genetically' .. caused .. then?
AND the mutation IS .. hypothesised to BE due to >> beneficial gene/s from the Stone Age. Redundant in the
>> present era. Who loves ya. Tom
 Signature Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
Bob - 07 Oct 2003 03:12 GMT > And so the fact those with genetic iron overload manifest T2 .. is NOT > 'genetically' .. caused .. then? > > AND the mutation IS .. hypothesised to BE due to >> beneficial gene/s > from the Stone Age. Redundant in the present era. . . . by who? homer simpson? get a grip man.
Let me start again. Well hello Tom, this is the first time i've actually talked to a real nut head. I just looked at the 3 web links you have in your sig and most amusing they are too. I just hope you have them there for our amusement, 'cos if you don't . . . I once saw a site with singing hamsters, that was funny too.
Now i begin to see why guy, ted, mack and jbove, etc keep an eye on the "strange" posters. I think you're probably harmless and i'm ready to listen. What was it you had to say?.
 Signature Bob Dx T1 4/4/2003, Insulatard & NovoRapid (trying zeroish carb - kiddies, do not try this at home)
doe - 07 Oct 2003 06:06 GMT >Subject: Re: T2 Risk Factors >From: "Bob" Bob@bob.com >Date: 10/6/2003 8:12 PM Mountain Daylight Time >Message-id: <blt7ep$ga3ak$1@ID-189936.news.uni-berlin.de>
>Now i begin to see why guy, ted, mack and jbove, etc keep an eye on the >"strange" posters. I think you're probably harmless and i'm ready to >listen. What was it you had to say?. Listen to .. mack ..
He'll get ya to where YOU should .. be ..
Who loves ya. Tom
 Signature Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
Peter C - 07 Oct 2003 16:36 GMT "Bob" <Bob@bob.com> wrote in message era.
> . . . by who? homer simpson? By several geneticists e.g. Gary Ruvkun, Harvard Medical School writing in Science in August 1997 .. He says, "Many animals hibernate, some for extended periods of time, and those animals that undergo longer periods of metabolic shutdown may be better able to survive tough periods of drought or cold in which food supplies are scarce. While humans don't hibernate, we may find that past adaptations in groups of people who periodically experienced food shortages might underlie the prevalence of diabetes in certain populations. For example, almost half of the Pima Indians in Arizona, who have high levels of obesity, develop diabetes. These characteristics may be the legacy of this group's past history of famine and drought. What was once a beneficial mutation, allowing people to store enough fat to survive and reproduce, could now be a cause of disease when food is plentiful."
The argument being that T2 was a beneficial gene/s which helped people survive drought, famine etc. In addition older members of a tribe ( perhaps past the "child-bearing age" you mentioned ) might be helped by these genes if they could no longer hunt and were on a marginal diet.
Pete - 07 Oct 2003 18:10 GMT >"Bob" <Bob@bob.com> wrote in message era. [snip]
>we may find that past >adaptations in groups of people who periodically experienced food shortages >might underlie the prevalence of diabetes in certain populations. [snip]
Mankind pre dating 'Lucy' and towards the near extinction of the race, was in a long period of food scarcity. It was this that forced adaptation. We developed imagination which allowed us to plan.
Pete
Bob - 07 Oct 2003 20:14 GMT > >we may find that past adaptations in groups of people who > >periodically experienced food shortages might underlie [quoted text clipped - 4 lines] > this that forced adaptation. We developed imagination which > allowed us to plan. Or we may just find it's just another random mutation that affects people after child bearing age and doesn't affect their ability to reproduce.
 Signature Bob Dx T1 4/4/2003, Insulatard & NovoRapid (trying zeroish carb - kiddies, do not try this at home)
gman99@canada.com - 06 Oct 2003 12:56 GMT > About 6 months ago I was diagnosed as T2 and haven't been able to > understand the reasons for this happening. I have no family history > whatsoever of Diabetes and am not overweght or obese(BMI 20).Can someone > explain the possible risk factors that made this possible? > Thanks > Charles BMI is a useless measure...body fat percentage would be more indicative of obeisity. Sure you weren't adopted ? If there's no history you might be on the look out for T1.
The main risk factors are obeisity and family history.
louisejoi - 06 Oct 2003 13:12 GMT > About 6 months ago I was diagnosed as T2 and haven't been able to > understand the reasons for this happening. I have no family history > whatsoever of Diabetes and am not overweght or obese(BMI 20).Can someone > explain the possible risk factors that made this possible? Perhaps there were recessive genes on both sides of the family. Also in years past, diagnostic BG levels were much higher, people were told they had a "little bit of sugar" (not realizing they were diabetic), and health care wasn't as available or sophisticated so there were a lot of people walking around with diabetes that didn't know it.
That said, did you have 2 tests done and are you sure from your home testing that you are really diabetic? One of my inlaws, who has no family history and is very fit, had a FBG of 180 or so. They tested him a couple weeks later and his results were under 100. Since then he's had a few other tests and he's totally normal. The lab had screwed up.
Also, as others have said, Type 1 could be a possibility.
-- Best wishes Louise
Type 2 since 2000, controlling by diet and exercise
Annette - 06 Oct 2003 14:27 GMT > About 6 months ago I was diagnosed as T2 and haven't been able to > understand the reasons for this happening. I have no family history > whatsoever of Diabetes and am not overweght or obese(BMI 20).Can someone > explain the possible risk factors that made this possible? > Thanks > Charles Hi there Charles,
First up, let me say welcome to the group!
As you can see, there's a lot of people here ready to help out and offer ideas and suggestions. One of the advantages of coming into a thread a bit later than others is being able to look over what everyone else has suggested to see if any possiblities have not yet been mentioned.
One rare condition that has not been brought up yet, is Haemochromatosis. This is a condition where the body stores up too much iron, and it also can cause high blood sugar levels. Did your doctor do any general blood tests? Or alternatively, have you ever been a blood donor? They test the blood for iron levels etc before drawing any blood. As I said, it's rare, but just another possibility.
You've sure got a lot to think about now!
Do post again, and tell us how you're going with management etc of your diabetes. Don't be worried about asking any questions, no matter how silly or "dumb" they may seem. As you may have noticed, this is a SUPPORT group, and we will be happy to help in what ever way we can. We don't diagnose or prescribe meds, that's your doctor's job, but there are a lot of things to learn about everyday living with the disease.
All the best,
Annette
Tom Joy - 06 Oct 2003 15:08 GMT > About 6 months ago I was diagnosed as T2 and haven't been able to > understand the reasons for this happening. I have no family history > whatsoever of Diabetes and am not overweght or obese(BMI 20).Can someone > explain the possible risk factors that made this possible? > Thanks > Charles I too was diagnosed less than a month ago. They haven't told me yet what type I am. They have me on insulin now; in the morning and evening. I have no history of diabetes in my family either. I was a little overweight for a few years. Not too much though. I'm 44, caucasian, and have never had the chicken pox, any surgeries (oral, wisdom teeth when I was 22), never taken steroids and have enjoyed good health till my diagnosis. I have never been on any medication till now. The hospital took blood many different times and haven't told me what they've found. My diagnosis came when I became dehydrated and my blood sugar shot way up and I collapsed. I talked to an educator at the hospital who said I may be able to get off the insulin if I watch my diet, etc.. I live in a small town and am thinking that I should go to a specialist in a nearby city. The doctor wrote down that I take 10 units in the evening and the hospital and pharmacy wrote that I should take 12 in the evening. I told my doctor about this on the first visit and he shrugged and said it didn't matter that much. That seemed to me to be a cavalier attitude that rubbed me the wrong way. We're talking about my life here! Anyway, the next visit I will ask what type I am and anything else I can think of. I always think of more questions once out of the office...
t2_lurking - 06 Oct 2003 15:34 GMT By all means you need a new Dr. for this. If they haven't even TOLD you what kind of diabetic are. I may be going out on a limb here but, I'm pretty sure you're a T2 (Type 2). You're not taking much insulin (what kind?) and you haven't said how many times a day you're measuring your Blood Glucose (BG). If you are a T2 then you might want to look for the Gretchen Becker book "The First Year Type 2 Diabetes: An Essential Guide for the Newly Diagnosed" . Its a big help when you are first dxed and have lots of questions. It's handy to have around as a reference also. Two good websites (since you're on the net) are the www.alt.support.diabetes.org and www.mendosa.com.
If you have questions Ask Away! The newsgroup of course isn't your medical Dr., but it can provide lots of good info. You catching diabetes early, A GOOD THING. Check back often.
 Signature t2_lurking geabbottATabbottandabbottDOTcom Do not mail to t2_lurking (auto-delete) =============================== The Joy that isn't shared, I've heard, dies young. ---- Anne Sexton ----
> > About 6 months ago I was diagnosed as T2 and haven't been able to > > understand the reasons for this happening. I have no family history [quoted text clipped - 21 lines] > Anyway, the next visit I will ask what type I am and anything else I can > think of. I always think of more questions once out of the office... Tom Joy - 06 Oct 2003 17:03 GMT > By all means you need a new Dr. for this. > If they haven't even TOLD you what kind of diabetic are. [quoted text clipped - 47 lines] > > Anyway, the next visit I will ask what type I am and anything else I can > > think of. I always think of more questions once out of the office... I was looking on the ADA web site and think I may have hemachromatosis. I have all the symptoms of it and it says it's severely underdiagnosed. It goes on to say that if people with diabetes resulting from pancreatic damage usually see an improvement if not a reversal of their diabetes, depending on how much damage has occurred. Anyway, I'm gonna ask the doctor about this. I fit the mold. More information can be had at: http://www.diabetes.org/info/hemochromatosis.jsp
Chakolate - 06 Oct 2003 16:54 GMT > Anyway, the next visit I will ask what type I am and anything else I can > think of. I always think of more questions once out of the office... I always ask my doctor for an e-mail address. Then I can ask those questions that don't occur until I get home. Of course, for urgent questions, you'd call the clinic.
Chakolate
 Signature It's amazing how many people think "freedon of speech" is some kind of obligation for you to listen to them. --Chris Malcolm
Jenny - 06 Oct 2003 15:31 GMT I started showing abnormal blood sugars long before I had a weight problem. In fact, the weight problem only came on after my blood sugars deteriorated to near-diabetic levels.
Genes is my guess since a lot of my relatives on both sides (none of them obese) died of heart disease and kidney failure. Five years ago I was told I was NOT diabetic. Now with the same numbers I am. The diagnostic standards for Type II were MUCH higher even 10 years ago so only one of these relatives (a grandmother) ever got a diabetes diagnosis, but I suspect the rest of her children were spiking and running over normal fasting blood sugars too (as I do.)
The good news is that with much earlier diagnosis you have a chance to control your blood sugar before terrible damage is done to your various organs like eyes, kidneys and vascular system. -- Jenny
168.5/137
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> About 6 months ago I was diagnosed as T2 and haven't been able to > understand the reasons for this happening. I have no family history > whatsoever of Diabetes and am not overweght or obese(BMI 20).Can someone > explain the possible risk factors that made this possible? > Thanks > Charles Loretta Eisenberg - 06 Oct 2003 16:25 GMT I just learned that very high tryglcerides could be an indication of approaching diabetes. Not everyone fits the mold . I guess it just happens
Are you over forty
Loretta
-- In tribute to the United States of America and the State of Israel, two bastions of strength in a world filled with strife and terrorism.
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