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Medical Forum / Diseases and Disorders / Diabetes / November 2005Metformin trots
For the last week I've had the trots, so bad I've been staying home close to the John. Today I was refilling my one week pill organizer. While I was putting the pills in the little compartments I noticed that my metformin pills looked different. They were "Metformin HCL ER 500MG Tablets". Express Scripts, where I get my Rx filled, had substituted them for Glucophage XR. I have always taken Glucophage XR before. Now I am sure it is this generic metformin that has given me the trots. I am going to the doctor next week and will get a Rx for Glucophage XR with no substation. Anon Anon, I was on glucophage XR and was substituted with metformin ER. I personally found no difference, but everyone is different. Loretta -- In tribute to the United States of America and the State of Israel, two bastions of strength in a world filled with strife and terrorism. : Anon, I was on glucophage XR and was substituted with metformin ER. I : personally found no difference, but : everyone is different. : Loretta : -- : In tribute to the United States of America and the State : of Israel, two bastions of strength in a world filled with strife and : terrorism. I was on Metformin, not extended release adn had awful trots and I couldn't leave home without immodium working in my sstem. When I ws switched to the Metformin extended release, form Express Scrips, I stopped haivng trots adn can go around the cit freely. YMMV. Keep us informed if using the Glucophage makes a difference. Wendy > Anon, I was on glucophage XR and was substituted with metformin ER. > I personally found no difference, but everyone is different. On the regular Drain-O (er, Metformin) I have found that what part of the meal I take it with is important. It seems that during digestion the concentration of carbs in the gut surrounding the Metformin is important, the higher the carb concentration the worse the effects are. YMMV but here is a typical example: Chicken in white sauce, boiled potatoes, peas and carrots. If I take the Metformin with the chicken I'm perfectly fine, however if I take the Metformin with the potatoes I get the full Drain-O effect. I've seen some supporting evidence on ASD (forget where), my doc has never heard of that effect but it consistently works for me. HTH, Bastian. 1g Metformin + 1g Cinnamon >> Anon, I was on glucophage XR and was substituted with metformin ER. >> I personally found no difference, but everyone is different. [quoted text clipped - 15 lines] >HTH, >Bastian. 1g Metformin + 1g Cinnamon Another users (me) feedback (as it were<g>): I am currently up to 2 grams of Metformin daily. (2x500mg, AM and PM.) I have no problem taking it on an empty stomach btw. (But I usually do eat something at or near the same time.) ANYway, my problem only happens if I eat *too much* at a meal. Doesn't really matter if it's mainly carbs, protein or fat. Within 20 minutes to an hour, full on diarrhea :( If I eat a reasonable meal / portion I don't get the problem. ... I'm on the reg Metformin 500mg twice a day. When I first started I had the trots for a long while...Imodium was my best buddy for a while:) I no longer have attacks..well not to often, but my problem is forgetting to take that second pill...I have a Dr's appt tomorrow and am going to ask for the XR. I still have nausea, but I also have gallstones so not sure what's doing it:) I do take the pills with food tho.  Signaturejacquie I don't suffer from insanity.... I enjoy every minute of it! On Mon, 31 Oct 2005 10:38:59 GMT, Bastian <bastian@blueyonder.co.uk> wrote: >Loretta Eisenberg wrote: >> Anon, I was on glucophage XR and was substituted with metformin ER. [quoted text clipped - 16 lines] >HTH, >Bastian. 1g Metformin + 1g Cinnamon Another users (me) feedback (as it were<g>): I am currently up to 2 grams of Metformin daily. (2x500mg, AM and PM.) I have no problem taking it on an empty stomach btw. (But I usually do eat something at or near the same time.) ANYway, my problem only happens if I eat *too much* at a meal. Doesn't really matter if it's mainly carbs, protein or fat. Within 20 minutes to an hour, full on diarrhea :( If I eat a reasonable meal / portion I don't get the problem. ... >I'm on the reg Metformin 500mg twice a day. When I first started I had the >trots for a long while...Imodium was my best buddy for a while:) I no longer >have attacks..well not to often, but my problem is forgetting to take that >second pill...I have a Dr's appt tomorrow and am going to ask for the XR. I >still have nausea, but I also have gallstones so not sure what's doing it:) >I do take the pills with food tho. Hi Jacquie I'm also on 500mgx2; I started only last month and I've switched from breakfast and dinner to lunch and supper. I had no GI problems at all. I suspect that's down to two things. First, control by diet - my breakfast is almost zero carb and lunch is <10gms. Dinner is my main carby meal, supper is about 25-30gms. Before starting metformin, I had got to the point where I rarely saw a number over 7(125) after those meals unless I had over-eaten on carbs. The supper I eat with the evening pill includes psyllium husk for extra fibre. Secondly, I started eating regular snacks of yoghurt and berries or fruit a month before I started the met. However, from the reports of others the reaction to metformin seems to be a very individual thing; for some, no problem regardless of diet and control, for others they need to carry a porta-potti wherever they go for the first few weeks. Maybe we were just lucky. Cheers, Alan, T2, Australia. SignatureEverything in Moderation - Except Laughter. >The supper I eat with the evening pill includes psyllium >husk for extra fibre. Alan, I don't know whether this applies to you or not, but just in case, I wanted to mention that many fiber supplements, such as metimucil (psyllium husk) have a warning on the label not to take them within two hours of a medication. I'm not sure if they just slow the release, or partially negate it. >>The supper I eat with the evening pill includes psyllium >>husk for extra fibre. [quoted text clipped - 4 lines] >within two hours of a medication. I'm not sure if they just slow the >release, or partially negate it. "a medication" seems a little imprecise to me. I was adding psyllium to my evening cereal for over a year before I started on Metformin. The only change I've noted since starting was some occasional irregularity, some changes in the timing of events, and some change in the consistency of the "output". A little gas in the early days, but nothing sufficient to cause discomfort or embarrassment. When I changed to later pill-popping timing, there was some improvement in FBG initially, but that seems to have disappeared. The A1c in a couple of weeks should be interesting. Cheers, Alan, T2, Australia. SignatureEverything in Moderation - Except Laughter. >>>The supper I eat with the evening pill includes psyllium >>>husk for extra fibre. [quoted text clipped - 8 lines] >psyllium to my evening cereal for over a year before I >started on Metformin. The gist of it was the idea that the fiber would absorb the medication when taken close together. I have no idea if this is true or not, it's just something I got from reading the label, and some posts here. >, The only change I've noted since >starting was some occasional irregularity, some changes in >the timing of events, and some change in the consistency of >the "output". A little gas in the early days, but nothing >sufficient to cause discomfort or embarrassment. I recall one intestinal cramp the night I got out of hospital, severe enough to wake me up but gone in a minute. It could have been due to other things such as antibiotics or stress, too. Other than that, I've noticed no trouble from the Met. I'm glad that you also seem to be tolerating it very well. >When I changed to later pill-popping timing, there was some >improvement in FBG initially, but that seems to have >disappeared. The A1c in a couple of weeks should be >interesting. I played around with timing a lot, but got such slight results that they may well have been meter variances, as no clear trend showed up. I'm on 2000 mg a day, two pills per day. I now just take them late morning and late evening, and don't worry if they are close to a meal or not as I've never seen an impact on my BG's either way regarding timing. All I aim for is to get them reasonably close to 12 hours apart. Good luck on the A1C... BTW, any chance that your two prior ones were done by different labs? I've heard that different labs can generate slightly different numbers. >Good luck on the A1C... BTW, any chance that your two prior ones were >done by different labs? I've heard that different labs can generate >slightly different numbers. Nope. I wish. Same lab. All of the labs I've used in Oz have the same reference ranges, upper limit 6. Cheers, Alan, T2, Australia. SignatureEverything in Moderation - Except Laughter. >>Good luck on the A1C... BTW, any chance that your two prior ones were >>done by different labs? I've heard that different labs can generate >>slightly different numbers. > >Nope. I wish. Same lab. All of the labs I've used in Oz have >the same reference ranges, upper limit 6. I wasn't thinking of the ref ranges so much as the process itself. If (this is a big if) I've heard correctly, the number for an identical sample of blood can very a little from lab to lab. Also, A1c can vary between two people with identical meter readings by as much as 1%. I've been on Metformin for about 6 or 7 years now so I would say my body is has accepted it ...the first few months was the pits. I think I will have to up it after my next A1c...My meter is showing higher numbers not real high but higher then I am used to. I had a 200 hundred the other day after trying a new cereal... 200 is the highest I have ever been. For breakfast this morning I had one slice of whole wheat toast with a teaspoon of no sugar jam...and hour after breakfast my reading was 174...and two hours after it was 139.. My last A1c was like 5.7 which is good I get another one today so am anxious to see if it went up or not. Signaturejacquie I don't suffer from insanity.... I enjoy every minute of it! On Mon, 31 Oct 2005 22:19:38 GMT, "jacquie" <happikat694@nospam.net> wrote: >I'm on the reg Metformin 500mg twice a day. When I first started I had the >trots for a long while...Imodium was my best buddy for a while:) I no [quoted text clipped - 3 lines] >still have nausea, but I also have gallstones so not sure what's doing it:) >I do take the pills with food tho. Hi Jacquie I'm also on 500mgx2; I started only last month and I've switched from breakfast and dinner to lunch and supper. I had no GI problems at all. I suspect that's down to two things. First, control by diet - my breakfast is almost zero carb and lunch is <10gms. Dinner is my main carby meal, supper is about 25-30gms. Before starting metformin, I had got to the point where I rarely saw a number over 7(125) after those meals unless I had over-eaten on carbs. The supper I eat with the evening pill includes psyllium husk for extra fibre. Secondly, I started eating regular snacks of yoghurt and berries or fruit a month before I started the met. However, from the reports of others the reaction to metformin seems to be a very individual thing; for some, no problem regardless of diet and control, for others they need to carry a porta-potti wherever they go for the first few weeks. Maybe we were just lucky. Cheers, Alan, T2, Australia. SignatureEverything in Moderation - Except Laughter. >I've been on Metformin for about 6 or 7 years now so I would say my body is >has accepted it ...the first few months was the pits. I think I will have to [quoted text clipped - 5 lines] >was 139.. My last A1c was like 5.7 which is good I get another one today so >am anxious to see if it went up or not. Hi Jacquie You said "I had a 200 hundred the other day after trying a new cereal... 200 is the highest I have ever been. For breakfast this morning I had one slice of whole wheat toast with a teaspoon of no sugar jam...and hour after breakfast my reading was 174...and two hours after it was 139." I like your sig. When I was a kid, I learned that one of the definitions of insanity was to keep doing what you are doing - and expect a different result. Have you considered trying bacon and eggs tomorrow? Or an omelette? Or anything that doesn't have lots of carbs in it? Just for a day, see if you can create a breakfast with none of the following ingredients: Bread, toast, rolls - anything from a bakery Milk Juice - fruit or vege Fruit Jam Pasta Cereal Corn Potato Rice Then test at one hour and two hours afterwards. Cheers, Alan, T2, Australia. SignatureEverything in Moderation - Except Laughter. Hi Alan I do eat bacon and eggs at times it's just that it is such a hassle to make...I have soft boiled eggs allot or sometimes I will make a ham and onion and cheese omelet. I was just surprised that I went up with the piece of toast because it has never done that before. I'll try what you said and see. I won't get my A1c until next week...because she wants my lipids done too and that means fasting...so I will go into Tucson next week for my blood test and my flu shot. She put in a referral about getting my cataracs removed....and the big colon check...at least I will be sedated for that one :)She also put me on Metformin XR...No one told me they were horse pills....LOL The Pharmacist told me to make sure I take them with food...which I do anyway:) My signature was copied from a Tee-Shirt I have :) Signaturejacquie I don't suffer from insanity.... I enjoy every minute of it! On Tue, 01 Nov 2005 19:11:17 GMT, "jacquie" <happikat694@nospam.net> wrote: >I've been on Metformin for about 6 or 7 years now so I would say my body is >has accepted it ...the first few months was the pits. I think I will have [quoted text clipped - 7 lines] >was 139.. My last A1c was like 5.7 which is good I get another one today so >am anxious to see if it went up or not. Hi Jacquie You said "I had a 200 hundred the other day after trying a new cereal... 200 is the highest I have ever been. For breakfast this morning I had one slice of whole wheat toast with a teaspoon of no sugar jam...and hour after breakfast my reading was 174...and two hours after it was 139." I like your sig. When I was a kid, I learned that one of the definitions of insanity was to keep doing what you are doing - and expect a different result. Have you considered trying bacon and eggs tomorrow? Or an omelette? Or anything that doesn't have lots of carbs in it? Just for a day, see if you can create a breakfast with none of the following ingredients: Bread, toast, rolls - anything from a bakery Milk Juice - fruit or vege Fruit Jam Pasta Cereal Corn Potato Rice Then test at one hour and two hours afterwards. Cheers, Alan, T2, Australia. SignatureEverything in Moderation - Except Laughter. > For the last week I've had the trots, so bad I've been staying home close to > the John. Today I was refilling my one week pill organizer. While I was [quoted text clipped - 6 lines] > given me the trots. I am going to the doctor next week and will get a Rx for > Glucophage XR with no substation. Express scripts will not allow this because XR is more expensive. In Christ's love and service forevermore, Andrew -- Andrew B. Chung, MD/PhD Board-Certified Cardiologist ** Suggested Reading: (1) http://makeashorterlink.com/?G1D5217EA (2) http://makeashorterlink.com/?W13A4250B (3) http://makeashorterlink.com/?X1C62661A (4) http://makeashorterlink.com/?U1E13130A (5) http://makeashorterlink.com/?K6F72510A (6) http://makeashorterlink.com/?I24E5151A (7) http://makeashorterlink.com/?I22222129 : > For the last week I've had the trots, so bad I've been staying home close to : > the John. Today I was refilling my one week pill organizer. While I was [quoted text clipped - 6 lines] : > given me the trots. I am going to the doctor next week and will get a Rx for : > Glucophage XR with no substation. : Express scripts will not allow this because XR is more expensive. Even with a DAW box checked? I wsa asking aobu tLipitor and the generic Gravacol that will be on the market in a few months and havign the prescription automatically changed. The person I spoke with thought that Express Scrips woudl likely make the change, but would honor a DAW box check. Wendy > : > For the last week I've had the trots, so bad I've been staying home close to > : > the John. Today I was refilling my one week pill organizer. While I was [quoted text clipped - 10 lines] > > Even with a DAW box checked? They reserve the right to make formulary changes and to not honor DAW instructions from doctors. In Christ's love and service forevermore, Andrew -- Andrew B. Chung, MD/PhD Board-Certified Cardiologist ** Suggested Reading: (1) http://makeashorterlink.com/?G1D5217EA (2) http://makeashorterlink.com/?W13A4250B (3) http://makeashorterlink.com/?X1C62661A (4) http://makeashorterlink.com/?U1E13130A (5) http://makeashorterlink.com/?K6F72510A (6) http://makeashorterlink.com/?I24E5151A (7) http://makeashorterlink.com/?I22222129 I've been taking the generic stuff since Dx in June. I can't put anything on my schedule for mornings before 10am. For the first month I couldn't leave the house *at all* because I never knew when something explosive would happen ;P +++++++++++++ Reply to the list as I do not publish an email address to USENET. This practice has cut my spam by more than 95%. Of course, I did have to abandon a perfectly good email account... : I've been taking the generic stuff since Dx in June. I can't put : anything on my schedule for mornings before 10am. For the first month : I couldn't leave the house *at all* because I never knew when : something explosive would happen ;P I found a half dose of immodium helped immeasurably. Wendy > For the last week I've had the trots, so bad I've been staying home close to > the John. Today I was refilling my one week pill organizer. While I was [quoted text clipped - 6 lines] > given me the trots. I am going to the doctor next week and will get a Rx for > Glucophage XR with no substation. Interesting. I was given a two month supply of Fortamet, the same as glucophage XR. I ran out and my new script was for metformin 1x500 twice a day. That started Thursday of last week. Last two days I have had a case of the galloping trots like I have never known possible. Should I ask for a new script for the XR? Does this subside in time? Paul : > For the last week I've had the trots, so bad I've been staying home close : to [quoted text clipped - 9 lines] : for : > Glucophage XR with no substation. : Interesting. I was given a two month supply of Fortamet, the same as : glucophage XR. I ran out and my new script was for metformin 1x500 twice a : day. That started Thursday of last week. Last two days I have had a case : of the galloping trots like I have never known possible. : Should I ask for a new script for the XR? Does this subside in time? : Paul For me, the trots got worse and worse on the regular Metformin and have stopped on the extended release generic Metformin frm Express Scrips. If you didn't have trot on the extended release ask for a prescroption fo rit, specifically! Wendy I went to the doctor yesterday. I informed her of the problem with the generic metformin. She said there was no studies comparing side effects between generic brands and original. She wrote me a Rx for Glucophage XR and write on it "do not substitute, letter of medical expedience will be provided if necessary". My last A1c was 5.9, not as good as I expected but I hope the one they took today will be better since I have added the Novolog pre-meal for high carb meals. We got into a discussion about "straining at your stool" as she put it, when we were talking about my trots. I had read on this forum that it might be dangerous and she agrees. She said that straining could raise pressures to the brain to dangerous levels. It could cause strokes or damage vessels that would cause strokes later. She said people who strain to initiate movement, the point that their face gets flushed, may be in the danger zone. She suggested using glycerin suppositories to initiate movement when necessary, to avoid straining. She gave me the ok to use pre-meal Novolog for all meals at my discretion. I still use Starlix for breakfast and lunch. Anon > For the last week I've had the trots, so bad I've been staying home close > to the John. Today I was refilling my one week pill organizer. While I was [quoted text clipped - 8 lines] > > Anon We live near Tucson Az, and have many SnowBirds here....My brother was with the Tucson Police Force for Twenty years he said you wouldn't believe how many calls they got a year of older folk having a stroke on the toilet. So I am very careful on the pot...I would hate to be one of those calls and being talked about...LOL:) I take Vicodine for my arthritic knees, and it has a tendancy to constipate, so I always have the suppositories close by. When my mother was on Moriphine for her Cancer she took two senokots a day it helped keep her regular...Later on when she had to take more moriphine they put her on Milk of Magnesia. So far I haven't had problems with the Metformin xr...knock on wood:) Signaturejacquie I don't suffer from insanity.... I enjoy every minute of it! I went to the doctor yesterday. I informed her of the problem with the generic metformin. She said there was no studies comparing side effects between generic brands and original. She wrote me a Rx for Glucophage XR and write on it "do not substitute, letter of medical expedience will be provided if necessary". My last A1c was 5.9, not as good as I expected but I hope the one they took today will be better since I have added the Novolog pre-meal for high carb meals. We got into a discussion about "straining at your stool" as she put it, when we were talking about my trots. I had read on this forum that it might be dangerous and she agrees. She said that straining could raise pressures to the brain to dangerous levels. It could cause strokes or damage vessels that would cause strokes later. She said people who strain to initiate movement, the point that their face gets flushed, may be in the danger zone. She suggested using glycerin suppositories to initiate movement when necessary, to avoid straining. She gave me the ok to use pre-meal Novolog for all meals at my discretion. I still use Starlix for breakfast and lunch. Anon "Anon" <anon4592004@yahoo.com> wrote in message news:HYGdnR9XUJbcrvjenZ2dnUVZ_sudnZ2d@giganews.com... > For the last week I've had the trots, so bad I've been staying home close > to the John. Today I was refilling my one week pill organizer. While I was [quoted text clipped - 8 lines] > > Anon |
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